JP2004511527A - ワクチン - Google Patents

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Publication number
JP2004511527A
JP2004511527A JP2002535687A JP2002535687A JP2004511527A JP 2004511527 A JP2004511527 A JP 2004511527A JP 2002535687 A JP2002535687 A JP 2002535687A JP 2002535687 A JP2002535687 A JP 2002535687A JP 2004511527 A JP2004511527 A JP 2004511527A
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JP
Japan
Prior art keywords
neu
prostase
antigen
cpg
adjuvant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002535687A
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English (en)
Japanese (ja)
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JP2004511527A5 (enExample
Inventor
ガルコン,ナタリー
ジェラール,カトリーヌ,マリー,ギースレーヌ
ステファンヌ,ジャン
Original Assignee
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/690,921 external-priority patent/US6544518B1/en
Priority claimed from GB0025574A external-priority patent/GB0025574D0/en
Priority claimed from GB0025573A external-priority patent/GB0025573D0/en
Application filed by グラクソスミスクライン バイオロジカルズ ソシエテ アノニム filed Critical グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
Publication of JP2004511527A publication Critical patent/JP2004511527A/ja
Publication of JP2004511527A5 publication Critical patent/JP2004511527A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001184Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2002535687A 2000-10-18 2001-10-16 ワクチン Pending JP2004511527A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/690,921 US6544518B1 (en) 1999-04-19 2000-10-18 Vaccines
GB0025574A GB0025574D0 (en) 2000-10-18 2000-10-18 Vaccine
GB0025573A GB0025573D0 (en) 2000-10-18 2000-10-18 Vaccine
PCT/EP2001/011984 WO2002032450A2 (en) 2000-10-18 2001-10-16 Vaccines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008126888A Division JP2008285487A (ja) 2000-10-18 2008-05-14 ワクチン

Publications (2)

Publication Number Publication Date
JP2004511527A true JP2004511527A (ja) 2004-04-15
JP2004511527A5 JP2004511527A5 (enExample) 2005-12-22

Family

ID=27255945

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002535687A Pending JP2004511527A (ja) 2000-10-18 2001-10-16 ワクチン

Country Status (18)

Country Link
EP (2) EP1326638B9 (enExample)
JP (1) JP2004511527A (enExample)
KR (1) KR100860893B1 (enExample)
CN (1) CN100548373C (enExample)
AU (2) AU2002244337B2 (enExample)
BR (1) BR0114786A (enExample)
CA (1) CA2425358C (enExample)
CZ (1) CZ302449B6 (enExample)
DK (1) DK1326638T3 (enExample)
ES (1) ES2295229T3 (enExample)
HU (1) HU229642B1 (enExample)
IL (1) IL155282A0 (enExample)
MX (1) MXPA03003408A (enExample)
NO (1) NO335919B1 (enExample)
NZ (1) NZ525320A (enExample)
PL (1) PL208755B1 (enExample)
SI (1) SI1326638T1 (enExample)
WO (1) WO2002032450A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008506789A (ja) * 2004-07-18 2008-03-06 シーエスエル、リミテッド インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物
JP2008531637A (ja) * 2005-03-03 2008-08-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 水疱−帯状疱疹ウイルスワクチン
JP2016503029A (ja) * 2012-12-13 2016-02-01 アデュロ バイオテック,インコーポレイテッド 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法
JP2016534977A (ja) * 2013-09-19 2016-11-10 ゾエティス・サービシーズ・エルエルシー 油性アジュバント
US10131686B2 (en) 2013-04-29 2018-11-20 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
JP4620251B2 (ja) 1998-08-10 2011-01-26 アンチジェニックス・インコーポレイテッド Cpgおよびサポニンアジュバントの組成物並びにその方法
WO2000048630A1 (en) 1999-02-17 2000-08-24 Csl Limited Immunogenic complexes and methods relating thereto
US20030099668A1 (en) 2001-09-14 2003-05-29 Cytos Biotechnology Ag Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
AU2002357359B2 (en) 2001-12-21 2009-01-08 Csl Limited Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
KR100456681B1 (ko) 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
BR0311995A (pt) * 2002-06-20 2005-04-05 Cytos Biotechnology Ag Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso
AU2003259374A1 (en) * 2002-08-30 2004-03-19 Glaxo Group Limited Vaccine comprising il-13 and an adjuvant
KR101107818B1 (ko) 2003-10-30 2012-01-31 콜레이 파마시티컬 그룹, 인코포레이티드 향상된 면역자극 효능을 가진 c-부류 올리고뉴클레오티드유사체
WO2006050116A1 (en) * 2004-11-02 2006-05-11 Biomedical Research Models, Inc. Methods of cancer treatment/prevention using cancer cell-specific surface antigens
US11707520B2 (en) 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
ES2420829T3 (es) 2005-11-04 2013-08-27 Novartis Vaccines And Diagnostics S.R.L. Vacunas adyuvantadas con antígeno de no virión preparadas a partir de virus de la gripe cultivados en cultivo celular
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
SI2068918T2 (sl) 2006-09-26 2024-10-30 Access To Advanced Health Institute Sestavek za cepljenje, ki vsebuje sintetična pomagala
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
CN102307590A (zh) 2009-02-10 2012-01-04 诺华有限公司 具有减少量的角鲨烯的流感疫苗
PT2437753T (pt) 2009-06-05 2016-11-23 Infectious Disease Res Inst Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos
WO2011005761A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc Novel nucleic acid prodrugs and methods use thereof
WO2011150264A2 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Synthetic nanocarrier combination vaccines
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
US9044420B2 (en) 2011-04-08 2015-06-02 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
EP2734208B1 (en) 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CA2843274A1 (en) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
CA2844793A1 (en) * 2011-08-31 2013-03-07 Oncocyte Corporation Methods and compositions for the treatment and diagnosis of cancer
NZ701881A (en) 2012-05-16 2016-10-28 Immune Design Corp Vaccines for hsv-2
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
AU2013287630B2 (en) * 2012-07-13 2017-05-25 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
CN104661664B (zh) 2012-07-13 2020-07-03 波涛生命科学有限公司 手性控制
EP2777711A1 (en) * 2013-03-11 2014-09-17 Icon Genetics GmbH Her2/Neu cancer vaccine
EP2986303B1 (en) 2013-04-18 2020-02-26 Immune Design Corp. Gla monotherapy for use in cancer treatment
CU24377B1 (es) 2013-05-18 2018-12-05 Aduro Biotech Inc Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
BR112022011445A2 (pt) 2019-12-13 2022-08-30 Grand Theravac Life Science Nanjing Co Ltd Composição imunoestimuladora e uso da mesma

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59186921A (ja) * 1982-10-18 1984-10-23 ブロル・モレイン 免疫原性複合物
JPH11504020A (ja) * 1995-04-25 1999-04-06 スミスクライン・ビーチャム・バイオロジカルス (ソシエテ・アノニム) サポニンおよびステロールを含有するワクチン
WO1999040188A2 (en) * 1998-02-05 1999-08-12 Smithkline Beecham Biologicals S.A. Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccinations
WO1999061056A2 (en) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methods and products for inducing mucosal immunity
WO2000009159A1 (en) * 1998-08-10 2000-02-24 Aquila Biopharmaceuticals, Inc. Compositions of cpg and saponin adjuvants and methods thereof
WO2000044899A1 (en) * 1999-01-29 2000-08-03 Corixa Corporation Her-2/neu fusion proteins
JP2002542203A (ja) * 1999-04-19 2002-12-10 スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム ワクチン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003527352A (ja) * 2000-01-13 2003-09-16 アンティジェニクス インコーポレーテッド Cpgおよびサポニンの自然免疫刺激化合物、ならびにそれらの方法
ES2307568T3 (es) * 2000-12-08 2008-12-01 Coley Pharmaceutical Gmbh Acidos nucleicos de tipo cpg y metodos de uso de los mismos.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59186921A (ja) * 1982-10-18 1984-10-23 ブロル・モレイン 免疫原性複合物
JPH11504020A (ja) * 1995-04-25 1999-04-06 スミスクライン・ビーチャム・バイオロジカルス (ソシエテ・アノニム) サポニンおよびステロールを含有するワクチン
WO1999040188A2 (en) * 1998-02-05 1999-08-12 Smithkline Beecham Biologicals S.A. Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccinations
WO1999061056A2 (en) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methods and products for inducing mucosal immunity
WO2000009159A1 (en) * 1998-08-10 2000-02-24 Aquila Biopharmaceuticals, Inc. Compositions of cpg and saponin adjuvants and methods thereof
WO2000044899A1 (en) * 1999-01-29 2000-08-03 Corixa Corporation Her-2/neu fusion proteins
JP2002542203A (ja) * 1999-04-19 2002-12-10 スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム ワクチン

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008506789A (ja) * 2004-07-18 2008-03-06 シーエスエル、リミテッド インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物
JP2008531637A (ja) * 2005-03-03 2008-08-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 水疱−帯状疱疹ウイルスワクチン
JP2016503029A (ja) * 2012-12-13 2016-02-01 アデュロ バイオテック,インコーポレイテッド 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法
JP2018135367A (ja) * 2012-12-13 2018-08-30 アデュロ バイオテック,インコーポレイテッド 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法
US10414789B2 (en) 2012-12-13 2019-09-17 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
US10131686B2 (en) 2013-04-29 2018-11-20 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
US10385091B2 (en) 2013-04-29 2019-08-20 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
US11014956B2 (en) 2013-04-29 2021-05-25 Memorial Sloan Kettering Cancer Center; The Rockefeller Compositions and methods for altering second messenger signaling
JP2016534977A (ja) * 2013-09-19 2016-11-10 ゾエティス・サービシーズ・エルエルシー 油性アジュバント

Also Published As

Publication number Publication date
EP1889630A1 (en) 2008-02-20
WO2002032450A3 (en) 2002-10-10
CN100548373C (zh) 2009-10-14
IL155282A0 (en) 2003-11-23
NO335919B1 (no) 2015-03-23
CZ20031093A3 (cs) 2003-08-13
HU229642B1 (en) 2014-03-28
EP1326638B1 (en) 2007-11-28
KR20070114230A (ko) 2007-11-29
EP1889630B1 (en) 2011-11-23
NO20031705D0 (no) 2003-04-11
AU4433702A (en) 2002-04-29
NO20031705L (no) 2003-06-14
DK1326638T3 (da) 2008-03-25
PL365598A1 (en) 2005-01-10
BR0114786A (pt) 2003-08-12
EP1326638A2 (en) 2003-07-16
ES2295229T3 (es) 2008-04-16
AU2002244337B2 (en) 2005-08-11
NZ525320A (en) 2004-10-29
CA2425358C (en) 2012-08-21
CA2425358A1 (en) 2002-04-25
MXPA03003408A (es) 2005-06-30
HUP0402067A3 (en) 2012-09-28
HUP0402067A2 (hu) 2005-01-28
KR100860893B1 (ko) 2008-09-29
PL208755B1 (pl) 2011-06-30
CN1481255A (zh) 2004-03-10
WO2002032450A2 (en) 2002-04-25
SI1326638T1 (sl) 2008-04-30
EP1326638B9 (en) 2008-02-20
CZ302449B6 (cs) 2011-05-25

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