NZ525320A - Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvants - Google Patents
Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvantsInfo
- Publication number
- NZ525320A NZ525320A NZ525320A NZ52532001A NZ525320A NZ 525320 A NZ525320 A NZ 525320A NZ 525320 A NZ525320 A NZ 525320A NZ 52532001 A NZ52532001 A NZ 52532001A NZ 525320 A NZ525320 A NZ 525320A
- Authority
- NZ
- New Zealand
- Prior art keywords
- antigen
- prostase
- neu
- fusion partner
- cpg
- Prior art date
Links
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- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- RUNWDIHBXBYUGE-UHFFFAOYSA-N tetracosa-2,6,10,14,18,22-hexaene Chemical compound CC=CCCC=CCCC=CCCC=CCCC=CCCC=CC RUNWDIHBXBYUGE-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 229940093609 tricaprylin Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 239000000522 vaginal cream Substances 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/690,921 US6544518B1 (en) | 1999-04-19 | 2000-10-18 | Vaccines |
| GB0025573A GB0025573D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| GB0025574A GB0025574D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| PCT/EP2001/011984 WO2002032450A2 (en) | 2000-10-18 | 2001-10-16 | Vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ525320A true NZ525320A (en) | 2004-10-29 |
Family
ID=27255945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ525320A NZ525320A (en) | 2000-10-18 | 2001-10-16 | Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvants |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP1326638B9 (enExample) |
| JP (1) | JP2004511527A (enExample) |
| KR (1) | KR100860893B1 (enExample) |
| CN (1) | CN100548373C (enExample) |
| AU (2) | AU2002244337B2 (enExample) |
| BR (1) | BR0114786A (enExample) |
| CA (1) | CA2425358C (enExample) |
| CZ (1) | CZ302449B6 (enExample) |
| DK (1) | DK1326638T3 (enExample) |
| ES (1) | ES2295229T3 (enExample) |
| HU (1) | HU229642B1 (enExample) |
| IL (1) | IL155282A0 (enExample) |
| MX (1) | MXPA03003408A (enExample) |
| NO (1) | NO335919B1 (enExample) |
| NZ (1) | NZ525320A (enExample) |
| PL (1) | PL208755B1 (enExample) |
| SI (1) | SI1326638T1 (enExample) |
| WO (1) | WO2002032450A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE315405T1 (de) | 1998-08-10 | 2006-02-15 | Antigenics Inc | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| DE60044236D1 (de) | 1999-02-17 | 2010-06-02 | Csl Ltd | Immunogene komplexe und methoden in bezug auf diese |
| EP1450856B1 (en) | 2001-09-14 | 2009-11-11 | Cytos Biotechnology AG | Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use |
| US20060210555A1 (en) | 2001-12-21 | 2006-09-21 | Antigenics, Inc. | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| ATE489969T1 (de) * | 2002-06-20 | 2010-12-15 | Cytos Biotechnology Ag | Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung |
| JP2006501249A (ja) * | 2002-08-30 | 2006-01-12 | グラクソ グループ リミテッド | ワクチン |
| NZ546275A (en) | 2003-10-30 | 2009-05-31 | Coley Pharm Gmbh | C-class oligonucleotides analogs with enhanced immunostimulatory potency |
| JP2008506789A (ja) * | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
| EP1812052A1 (en) * | 2004-11-02 | 2007-08-01 | Biomedical Research Models, Inc. | Methods of cancer treatment/prevention using cancer cell-specific surface antigens |
| GB0504436D0 (en) * | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| WO2007052055A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| EP2468300B1 (en) | 2006-09-26 | 2017-12-20 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| EA023662B1 (ru) | 2009-02-10 | 2016-06-30 | Новартис Аг | Вакцины против гриппа со сниженным количеством сквалена |
| CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| CN107029223A (zh) | 2010-05-26 | 2017-08-11 | 西莱克塔生物科技公司 | 合成纳米载体联合疫苗 |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| NZ616304A (en) | 2011-04-08 | 2016-01-29 | Immune Design Corp | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア |
| AU2012301664A1 (en) * | 2011-08-31 | 2014-02-27 | Oncocyte Corporation | Methods and compositions for the treatment and diagnosis of cancer |
| SMT201800368T1 (it) | 2012-05-16 | 2018-09-13 | Immune Design Corp | Vaccini per l'infezione da virus-2 herpes simplex |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| SG11201500243WA (en) * | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| SG11201502796RA (en) | 2012-12-13 | 2015-05-28 | Aduro Biotech Inc | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| CA2909221A1 (en) | 2013-04-18 | 2014-10-23 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| JP2016524593A (ja) | 2013-04-29 | 2016-08-18 | メモリアル スローン−ケタリング キャンサー センター | セカンドメッセンジャーのシグナル伝達を変えるための組成物及び方法 |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| KR20200039025A (ko) * | 2013-09-19 | 2020-04-14 | 조에티스 서비시즈 엘엘씨 | 유성 아쥬반트 |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3094728B1 (en) | 2014-01-16 | 2022-03-09 | Wave Life Sciences Ltd. | Chiral design |
| AU2020403296B2 (en) | 2019-12-13 | 2025-03-06 | Grand Theravac Life Science (Nanjing) Co., Ltd. | Immunostimulatory composition and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| BR9907691B1 (pt) * | 1998-02-05 | 2011-05-31 | derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina. | |
| DK1077722T3 (da) * | 1998-05-22 | 2006-11-27 | Ottawa Health Research Inst | Fremgangsmåder og produkter til induktion af mukosaimmunitet |
| ATE315405T1 (de) * | 1998-08-10 | 2006-02-15 | Antigenics Inc | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| WO2000044899A1 (en) * | 1999-01-29 | 2000-08-03 | Corixa Corporation | Her-2/neu fusion proteins |
| DK1187629T3 (da) * | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| CA2397374A1 (en) * | 2000-01-13 | 2001-07-19 | Antigenics Inc. | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
| WO2002069369A2 (en) * | 2000-12-08 | 2002-09-06 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
-
2001
- 2001-10-16 IL IL15528201A patent/IL155282A0/xx unknown
- 2001-10-16 KR KR1020077026150A patent/KR100860893B1/ko not_active Expired - Fee Related
- 2001-10-16 NZ NZ525320A patent/NZ525320A/en not_active IP Right Cessation
- 2001-10-16 JP JP2002535687A patent/JP2004511527A/ja active Pending
- 2001-10-16 ES ES01987671T patent/ES2295229T3/es not_active Expired - Lifetime
- 2001-10-16 SI SI200130800T patent/SI1326638T1/sl unknown
- 2001-10-16 AU AU2002244337A patent/AU2002244337B2/en not_active Ceased
- 2001-10-16 DK DK01987671T patent/DK1326638T3/da active
- 2001-10-16 CZ CZ20031093A patent/CZ302449B6/cs not_active IP Right Cessation
- 2001-10-16 WO PCT/EP2001/011984 patent/WO2002032450A2/en not_active Ceased
- 2001-10-16 EP EP01987671A patent/EP1326638B9/en not_active Expired - Lifetime
- 2001-10-16 EP EP07121675A patent/EP1889630B1/en not_active Expired - Lifetime
- 2001-10-16 PL PL365598A patent/PL208755B1/pl unknown
- 2001-10-16 AU AU4433702A patent/AU4433702A/xx active Pending
- 2001-10-16 MX MXPA03003408A patent/MXPA03003408A/es active IP Right Grant
- 2001-10-16 HU HU0402067A patent/HU229642B1/hu not_active IP Right Cessation
- 2001-10-16 CA CA2425358A patent/CA2425358C/en not_active Expired - Fee Related
- 2001-10-16 CN CNB018206611A patent/CN100548373C/zh not_active Expired - Fee Related
- 2001-10-16 BR BR0114786-2A patent/BR0114786A/pt not_active IP Right Cessation
-
2003
- 2003-04-11 NO NO20031705A patent/NO335919B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL208755B1 (pl) | 2011-06-30 |
| HU229642B1 (en) | 2014-03-28 |
| NO20031705L (no) | 2003-06-14 |
| WO2002032450A2 (en) | 2002-04-25 |
| EP1326638A2 (en) | 2003-07-16 |
| ES2295229T3 (es) | 2008-04-16 |
| NO335919B1 (no) | 2015-03-23 |
| CZ20031093A3 (cs) | 2003-08-13 |
| BR0114786A (pt) | 2003-08-12 |
| CZ302449B6 (cs) | 2011-05-25 |
| CA2425358A1 (en) | 2002-04-25 |
| MXPA03003408A (es) | 2005-06-30 |
| WO2002032450A3 (en) | 2002-10-10 |
| JP2004511527A (ja) | 2004-04-15 |
| AU4433702A (en) | 2002-04-29 |
| KR100860893B1 (ko) | 2008-09-29 |
| DK1326638T3 (da) | 2008-03-25 |
| HUP0402067A3 (en) | 2012-09-28 |
| EP1326638B1 (en) | 2007-11-28 |
| NO20031705D0 (no) | 2003-04-11 |
| HUP0402067A2 (hu) | 2005-01-28 |
| AU2002244337B2 (en) | 2005-08-11 |
| CN1481255A (zh) | 2004-03-10 |
| EP1326638B9 (en) | 2008-02-20 |
| EP1889630B1 (en) | 2011-11-23 |
| CA2425358C (en) | 2012-08-21 |
| PL365598A1 (en) | 2005-01-10 |
| IL155282A0 (en) | 2003-11-23 |
| SI1326638T1 (sl) | 2008-04-30 |
| CN100548373C (zh) | 2009-10-14 |
| KR20070114230A (ko) | 2007-11-29 |
| EP1889630A1 (en) | 2008-02-20 |
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| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
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| EXPY | Patent expired |