NZ525320A - Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvants - Google Patents
Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvantsInfo
- Publication number
- NZ525320A NZ525320A NZ525320A NZ52532001A NZ525320A NZ 525320 A NZ525320 A NZ 525320A NZ 525320 A NZ525320 A NZ 525320A NZ 52532001 A NZ52532001 A NZ 52532001A NZ 525320 A NZ525320 A NZ 525320A
- Authority
- NZ
- New Zealand
- Prior art keywords
- antigen
- prostase
- neu
- fusion partner
- cpg
- Prior art date
Links
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- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- RUNWDIHBXBYUGE-UHFFFAOYSA-N tetracosa-2,6,10,14,18,22-hexaene Chemical compound CC=CCCC=CCCC=CCCC=CCCC=CCCC=CC RUNWDIHBXBYUGE-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 229940093609 tricaprylin Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 239000000522 vaginal cream Substances 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/690,921 US6544518B1 (en) | 1999-04-19 | 2000-10-18 | Vaccines |
| GB0025574A GB0025574D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| GB0025573A GB0025573D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| PCT/EP2001/011984 WO2002032450A2 (en) | 2000-10-18 | 2001-10-16 | Vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ525320A true NZ525320A (en) | 2004-10-29 |
Family
ID=27255945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ525320A NZ525320A (en) | 2000-10-18 | 2001-10-16 | Combinations of immunostimulatory oligonucleotides (CpG), saponin and optionally lipopolysaccharides as potent vaccine adjuvants |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP1326638B9 (enExample) |
| JP (1) | JP2004511527A (enExample) |
| KR (1) | KR100860893B1 (enExample) |
| CN (1) | CN100548373C (enExample) |
| AU (2) | AU2002244337B2 (enExample) |
| BR (1) | BR0114786A (enExample) |
| CA (1) | CA2425358C (enExample) |
| CZ (1) | CZ302449B6 (enExample) |
| DK (1) | DK1326638T3 (enExample) |
| ES (1) | ES2295229T3 (enExample) |
| HU (1) | HU229642B1 (enExample) |
| IL (1) | IL155282A0 (enExample) |
| MX (1) | MXPA03003408A (enExample) |
| NO (1) | NO335919B1 (enExample) |
| NZ (1) | NZ525320A (enExample) |
| PL (1) | PL208755B1 (enExample) |
| SI (1) | SI1326638T1 (enExample) |
| WO (1) | WO2002032450A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4620251B2 (ja) | 1998-08-10 | 2011-01-26 | アンチジェニックス・インコーポレイテッド | Ｃｐｇおよびサポニンアジュバントの組成物並びにその方法 |
| WO2000048630A1 (en) | 1999-02-17 | 2000-08-24 | Csl Limited | Immunogenic complexes and methods relating thereto |
| US20030099668A1 (en) | 2001-09-14 | 2003-05-29 | Cytos Biotechnology Ag | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| AU2002357359B2 (en) | 2001-12-21 | 2009-01-08 | Csl Limited | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| BR0311995A (pt) * | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
| AU2003259374A1 (en) * | 2002-08-30 | 2004-03-19 | Glaxo Group Limited | Vaccine comprising il-13 and an adjuvant |
| KR101107818B1 (ko) | 2003-10-30 | 2012-01-31 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 향상된 면역자극 효능을 가진 ｃ-부류 올리고뉴클레오티드유사체 |
| WO2007026190A2 (en) * | 2004-07-18 | 2007-03-08 | Csl Limited | Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses |
| WO2006050116A1 (en) * | 2004-11-02 | 2006-05-11 | Biomedical Research Models, Inc. | Methods of cancer treatment/prevention using cancer cell-specific surface antigens |
| GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| ES2420829T3 (es) | 2005-11-04 | 2013-08-27 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas adyuvantadas con antígeno de no virión preparadas a partir de virus de la gripe cultivados en cultivo celular |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| SI2068918T2 (sl) | 2006-09-26 | 2024-10-30 | Access To Advanced Health Institute | Sestavek za cepljenje, ki vsebuje sintetična pomagala |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| CN102307590A (zh) | 2009-02-10 | 2012-01-04 | 诺华有限公司 | 具有减少量的角鲨烯的流感疫苗 |
| PT2437753T (pt) | 2009-06-05 | 2016-11-23 | Infectious Disease Res Inst | Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos |
| WO2011005761A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc | Novel nucleic acid prodrugs and methods use thereof |
| WO2011150264A2 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Synthetic nanocarrier combination vaccines |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| US9044420B2 (en) | 2011-04-08 | 2015-06-02 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| EP2734208B1 (en) | 2011-07-19 | 2017-03-01 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| CA2844793A1 (en) * | 2011-08-31 | 2013-03-07 | Oncocyte Corporation | Methods and compositions for the treatment and diagnosis of cancer |
| NZ701881A (en) | 2012-05-16 | 2016-10-28 | Immune Design Corp | Vaccines for hsv-2 |
| AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| AU2013287630B2 (en) * | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| CN104661664B (zh) | 2012-07-13 | 2020-07-03 | 波涛生命科学有限公司 | 手性控制 |
| WO2014093936A1 (en) * | 2012-12-13 | 2014-06-19 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| EP2986303B1 (en) | 2013-04-18 | 2020-02-26 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| MX374828B (es) | 2013-04-29 | 2025-03-06 | Memorial Sloan Kettering Cancer Center | Composiciones y metodos para alterar la señalizacion del segundo mensajero. |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| CN109675026A (zh) * | 2013-09-19 | 2019-04-26 | 硕腾服务有限责任公司 | 油基佐剂 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| CN113278617A (zh) | 2014-01-16 | 2021-08-20 | 波涛生命科学有限公司 | 手性设计 |
| BR112022011445A2 (pt) | 2019-12-13 | 2022-08-30 | Grand Theravac Life Science Nanjing Co Ltd | Composição imunoestimuladora e uso da mesma |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| JP4768121B2 (ja) * | 1998-02-05 | 2011-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Ｍａｇｅファミリーからの腫瘍関連抗原及びそれらをコードする核酸配列、融合タンパク質の及びワクチン接種のための組成物の調製のための使用 |
| DE69932717T2 (de) * | 1998-05-22 | 2007-08-09 | Ottawa Health Research Institute, Ottawa | Methoden und produkte zur induzierung mukosaler immunität |
| JP4620251B2 (ja) * | 1998-08-10 | 2011-01-26 | アンチジェニックス・インコーポレイテッド | Ｃｐｇおよびサポニンアジュバントの組成物並びにその方法 |
| CZ20012587A3 (cs) * | 1999-01-29 | 2002-05-15 | Corixa Corporation | Izolovaný protein, nukleová kyselina, virový vektor, farmaceutický prostředek, izolovaná populace T buněk, způsob posílení imunitní odpovědi, způsob odstranění nádorových buněk, způsob stimulace a/nebo namnoľení T buněk a způsob přípravy fúzního proteinu |
| JP2002542203A (ja) * | 1999-04-19 | 2002-12-10 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| JP2003527352A (ja) * | 2000-01-13 | 2003-09-16 | アンティジェニクス インコーポレーテッド | Ｃｐｇおよびサポニンの自然免疫刺激化合物、ならびにそれらの方法 |
| ES2307568T3 (es) * | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
-
2001
- 2001-10-16 IL IL15528201A patent/IL155282A0/xx unknown
- 2001-10-16 DK DK01987671T patent/DK1326638T3/da active
- 2001-10-16 ES ES01987671T patent/ES2295229T3/es not_active Expired - Lifetime
- 2001-10-16 SI SI200130800T patent/SI1326638T1/sl unknown
- 2001-10-16 BR BR0114786-2A patent/BR0114786A/pt not_active IP Right Cessation
- 2001-10-16 EP EP01987671A patent/EP1326638B9/en not_active Expired - Lifetime
- 2001-10-16 JP JP2002535687A patent/JP2004511527A/ja active Pending
- 2001-10-16 EP EP07121675A patent/EP1889630B1/en not_active Expired - Lifetime
- 2001-10-16 NZ NZ525320A patent/NZ525320A/en not_active IP Right Cessation
- 2001-10-16 KR KR1020077026150A patent/KR100860893B1/ko not_active Expired - Fee Related
- 2001-10-16 WO PCT/EP2001/011984 patent/WO2002032450A2/en not_active Ceased
- 2001-10-16 MX MXPA03003408A patent/MXPA03003408A/es active IP Right Grant
- 2001-10-16 CN CNB018206611A patent/CN100548373C/zh not_active Expired - Fee Related
- 2001-10-16 PL PL365598A patent/PL208755B1/pl unknown
- 2001-10-16 AU AU2002244337A patent/AU2002244337B2/en not_active Ceased
- 2001-10-16 CA CA2425358A patent/CA2425358C/en not_active Expired - Fee Related
- 2001-10-16 HU HU0402067A patent/HU229642B1/hu not_active IP Right Cessation
- 2001-10-16 AU AU4433702A patent/AU4433702A/xx active Pending
- 2001-10-16 CZ CZ20031093A patent/CZ302449B6/cs not_active IP Right Cessation
-
2003
- 2003-04-11 NO NO20031705A patent/NO335919B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1889630A1 (en) | 2008-02-20 |
| WO2002032450A3 (en) | 2002-10-10 |
| CN100548373C (zh) | 2009-10-14 |
| IL155282A0 (en) | 2003-11-23 |
| NO335919B1 (no) | 2015-03-23 |
| CZ20031093A3 (cs) | 2003-08-13 |
| HU229642B1 (en) | 2014-03-28 |
| EP1326638B1 (en) | 2007-11-28 |
| KR20070114230A (ko) | 2007-11-29 |
| EP1889630B1 (en) | 2011-11-23 |
| NO20031705D0 (no) | 2003-04-11 |
| AU4433702A (en) | 2002-04-29 |
| NO20031705L (no) | 2003-06-14 |
| DK1326638T3 (da) | 2008-03-25 |
| PL365598A1 (en) | 2005-01-10 |
| BR0114786A (pt) | 2003-08-12 |
| EP1326638A2 (en) | 2003-07-16 |
| ES2295229T3 (es) | 2008-04-16 |
| AU2002244337B2 (en) | 2005-08-11 |
| CA2425358C (en) | 2012-08-21 |
| CA2425358A1 (en) | 2002-04-25 |
| MXPA03003408A (es) | 2005-06-30 |
| HUP0402067A3 (en) | 2012-09-28 |
| HUP0402067A2 (hu) | 2005-01-28 |
| KR100860893B1 (ko) | 2008-09-29 |
| PL208755B1 (pl) | 2011-06-30 |
| JP2004511527A (ja) | 2004-04-15 |
| CN1481255A (zh) | 2004-03-10 |
| WO2002032450A2 (en) | 2002-04-25 |
| SI1326638T1 (sl) | 2008-04-30 |
| EP1326638B9 (en) | 2008-02-20 |
| CZ302449B6 (cs) | 2011-05-25 |
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