JP2004509920A - カテコールアミン医薬組成物および方法 - Google Patents
カテコールアミン医薬組成物および方法 Download PDFInfo
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- JP2004509920A JP2004509920A JP2002530053A JP2002530053A JP2004509920A JP 2004509920 A JP2004509920 A JP 2004509920A JP 2002530053 A JP2002530053 A JP 2002530053A JP 2002530053 A JP2002530053 A JP 2002530053A JP 2004509920 A JP2004509920 A JP 2004509920A
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- A61P27/02—Ophthalmic agents
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
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- Reproductive Health (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23675100P | 2000-09-29 | 2000-09-29 | |
| PCT/US2001/030272 WO2002026223A2 (en) | 2000-09-29 | 2001-09-27 | Catecholamine pharmaceutical compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509920A true JP2004509920A (ja) | 2004-04-02 |
| JP2004509920A5 JP2004509920A5 (enExample) | 2005-04-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002530053A Withdrawn JP2004509920A (ja) | 2000-09-29 | 2001-09-27 | カテコールアミン医薬組成物および方法 |
Country Status (6)
| Country | Link |
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| US (1) | US20030216413A1 (enExample) |
| EP (1) | EP1326642A2 (enExample) |
| JP (1) | JP2004509920A (enExample) |
| AU (1) | AU2001294808A1 (enExample) |
| CA (1) | CA2424021A1 (enExample) |
| WO (1) | WO2002026223A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008515824A (ja) * | 2004-10-05 | 2008-05-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ２−イミダゾリン構造を有するα−交感神経興奮薬の新規な使用 |
| JP2016050205A (ja) * | 2014-08-28 | 2016-04-11 | サン、ファーマスーティカル、インダストリーズ、リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． | ノルエピネフリンの注射剤形 |
| US10993921B2 (en) | 2013-10-03 | 2021-05-04 | Harrow Ip, Llc | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
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| EP1877093A2 (en) * | 2005-04-15 | 2008-01-16 | Board of Trustees of Michigan State University | Ascorbate binding peptides |
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| US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
| US9877921B2 (en) | 2005-09-09 | 2018-01-30 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| US20070059361A1 (en) * | 2005-09-09 | 2007-03-15 | University Of Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| WO2013059629A1 (en) | 2011-10-21 | 2013-04-25 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| TW200817049A (en) * | 2006-06-05 | 2008-04-16 | Verus Pharmaceuticals Inc | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
| WO2007143674A2 (en) * | 2006-06-05 | 2007-12-13 | Verus Pharmaceuticals, Inc. | Methods for buccal, lingual or sublingual dosing regimens of epinephrine for the treatment of allergic emergencies |
| ES2350439B1 (es) * | 2007-07-10 | 2011-10-17 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de un derivado del bencil-4,5-dihidro 1h-imidazol y un receptor opioide. |
| EP2014288A1 (en) * | 2007-07-10 | 2009-01-14 | Laboratorios del Dr. Esteve S.A. | Combination of benzyl-4, 5-dihydro-1H-imidazole derivative and an opioid receptor ligand |
| KR20100095437A (ko) * | 2007-11-07 | 2010-08-30 | 아스트라제네카 아베 | 아스코르브산 유도체를 포함하는 건조 분말 제제 |
| US8628805B2 (en) * | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
| RU2527337C9 (ru) | 2009-06-04 | 2014-12-27 | Альк Аг | Стабилизированная композиция, включающая по крайней мере одно адренергическое соединение |
| US20120322884A1 (en) | 2010-03-01 | 2012-12-20 | University Of Manitoba | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| WO2011133226A2 (en) * | 2010-04-22 | 2011-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for enhancing learning and memory impaired by neurodegenerative disorders and compounds and compositions for effecting the same |
| US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| JP2014527999A (ja) * | 2011-09-27 | 2014-10-23 | ヴァージニア コモンウェルス ユニバーシティ | フェニレフリンおよび他のフェノール性生物活性物質の経口生物学的有用性向上への選択的代謝アプローチ |
| CA3169368A1 (en) | 2012-06-15 | 2014-01-09 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| EP2950799B1 (en) | 2013-01-30 | 2019-12-04 | Pharmorx Therapeutics, Inc. | Treatments for depression and other diseases with a low dose agent |
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| EP3122350A4 (en) | 2014-02-18 | 2018-01-10 | The Board of Trustees of The Leland Stanford Junior University | Method of improving cognition and social behavior in humans having deficits therein due to neurological disorders and compounds and compositions therefor |
| WO2015187932A1 (en) * | 2014-06-04 | 2015-12-10 | Mentinova Inc. | Compositions and methods of reducing sedation |
| US11517525B2 (en) * | 2015-09-18 | 2022-12-06 | Hikma Pharmaceuticals Usa Inc. | Epinephrine spray formulations |
| EP3503873A4 (en) | 2016-08-25 | 2020-04-15 | Harrow IP, LLC | EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHOD FOR THE PRODUCTION THEREOF |
| US10952962B1 (en) | 2018-04-11 | 2021-03-23 | QuVa Pharma, Inc. | Ready to use liquid formulation |
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| MX2022012103A (es) * | 2020-04-30 | 2022-10-18 | Purdue Pharma Lp | Composiciones y metodos para rescate de emergencia. |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3122565A (en) * | 1960-10-22 | 1964-02-25 | Eisai Co Ltd | Purification process of tocopherol containing materials |
| US4052506A (en) * | 1975-08-05 | 1977-10-04 | Smithkline Corporation | Pharmaceutical compositions and method of producing anti-parkinsonism activity |
| US4590210A (en) * | 1979-03-09 | 1986-05-20 | Langham Maurice E | Compositions for treatment of ocular hypertension |
| US4550183A (en) * | 1984-08-02 | 1985-10-29 | Henkel Corporation | Purification of tocopherols |
| US4865027A (en) * | 1988-09-27 | 1989-09-12 | The University Of Michigan | Non-rebreathing collapsible chamber continuous aerosol delivery system with infusion port |
| EP0997466A1 (en) * | 1988-10-24 | 2000-05-03 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Novel antimicrobial lactam-quinolones |
| US5409693A (en) * | 1989-10-12 | 1995-04-25 | Perricone; Nicholas V. | Method for treating and preventing sunburn and sunburn damage to the skin |
| US5554647A (en) * | 1989-10-12 | 1996-09-10 | Perricone; Nicholas V. | Method and compositions for treatment and/or prevention of skin damage and aging |
| IT1237118B (it) * | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
| US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| US5186166A (en) * | 1992-03-04 | 1993-02-16 | Riggs John H | Powder nebulizer apparatus and method of nebulization |
| US5355872B1 (en) * | 1992-03-04 | 1998-10-20 | John H Riggs | Low flow rate nebulizer apparatus and method of nebulization |
| US6117976A (en) * | 1993-11-04 | 2000-09-12 | Medical Research Council | Manufacture and use of polypeptides tagged using binding molecules |
| GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
| US5586551A (en) * | 1995-07-17 | 1996-12-24 | Hilliard; Kenneth R. | Oxygen mask with nebulizer |
| US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| US5694920A (en) * | 1996-01-25 | 1997-12-09 | Abrams; Andrew L. | Inhalation device |
| US5738873A (en) * | 1996-09-27 | 1998-04-14 | Herman Bleiweiss | Pharmaceutical formulations and methods for treating patients suffering from diseases that cause muscular hypotonia |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE69739663D1 (de) * | 1996-12-31 | 2009-12-31 | Antioxidant Pharmaceuticals Co | Pharmazeutische glutathionpräparate und methoden zu dern verabreichung |
| US5840278A (en) * | 1997-02-20 | 1998-11-24 | Coleman; Thomas | Nasal spray having a mineral vitamin component, a mineral component and aloe vera |
| US5948787A (en) * | 1997-02-28 | 1999-09-07 | Alza Corporation | Compositions containing opiate analgesics |
| US6284800B1 (en) * | 1997-03-13 | 2001-09-04 | Baker Norton Pharmaceuticals, Inc. | Methods and compositions for treatment of asthma |
| US6248723B1 (en) * | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| DE19847969A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähig flüssige Formulierung mit Formoterol |
| PE20001396A1 (es) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US6242190B1 (en) * | 1999-12-01 | 2001-06-05 | John Hopkins University | Method for high throughput thermodynamic screening of ligands |
| US6340023B2 (en) * | 2000-05-17 | 2002-01-22 | John I. Elkins | Rebreather nebulizer device |
| US6858422B2 (en) * | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
| AU2002214487A1 (en) * | 2000-11-10 | 2002-05-21 | Mitotech Ab | Method for inducing apoptiosis |
| US20020193392A1 (en) * | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
| US6626173B2 (en) * | 2001-01-08 | 2003-09-30 | Iep Pharmaceutical Devices Inc. | Dry powder inhaler |
| US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
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- 2001-09-27 CA CA002424021A patent/CA2424021A1/en not_active Abandoned
- 2001-09-27 AU AU2001294808A patent/AU2001294808A1/en not_active Abandoned
- 2001-09-27 WO PCT/US2001/030272 patent/WO2002026223A2/en not_active Ceased
- 2001-09-27 EP EP01975488A patent/EP1326642A2/en not_active Withdrawn
- 2001-09-27 JP JP2002530053A patent/JP2004509920A/ja not_active Withdrawn
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- 2003-03-28 US US10/401,421 patent/US20030216413A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008515824A (ja) * | 2004-10-05 | 2008-05-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ２−イミダゾリン構造を有するα−交感神経興奮薬の新規な使用 |
| EP1802302B1 (de) | 2004-10-05 | 2016-10-26 | Merck Patent GmbH | NEUE VERWENDUNG FÜR alpha-SYMPATHOMIMETIKA MIT 2-IMIDAZOLINSTRUKTUR |
| US10993921B2 (en) | 2013-10-03 | 2021-05-04 | Harrow Ip, Llc | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| US11045432B2 (en) | 2013-10-03 | 2021-06-29 | Harrow Ip, Llc | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| JP2016050205A (ja) * | 2014-08-28 | 2016-04-11 | サン、ファーマスーティカル、インダストリーズ、リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． | ノルエピネフリンの注射剤形 |
| US11166923B2 (en) | 2014-08-28 | 2021-11-09 | Sun Pharmaceutical Industries Limited | Parenteral dosage form of norepinephrine |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001294808A1 (en) | 2002-04-08 |
| US20030216413A1 (en) | 2003-11-20 |
| EP1326642A2 (en) | 2003-07-16 |
| WO2002026223A3 (en) | 2003-05-08 |
| WO2002026223A2 (en) | 2002-04-04 |
| CA2424021A1 (en) | 2002-04-04 |
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