JP2004509870A5 - - Google Patents
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- Publication number
- JP2004509870A5 JP2004509870A5 JP2002529070A JP2002529070A JP2004509870A5 JP 2004509870 A5 JP2004509870 A5 JP 2004509870A5 JP 2002529070 A JP2002529070 A JP 2002529070A JP 2002529070 A JP2002529070 A JP 2002529070A JP 2004509870 A5 JP2004509870 A5 JP 2004509870A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- allergy
- lower alkyl
- embedded image
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 29
- 125000000217 alkyl group Chemical group 0.000 description 11
- 206010020751 Hypersensitivity Diseases 0.000 description 10
- 230000007815 allergy Effects 0.000 description 10
- 208000026935 allergic disease Diseases 0.000 description 9
- 208000024172 Cardiovascular disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 208000008589 Obesity Diseases 0.000 description 5
- 230000008369 airway response Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 235000020824 obesity Nutrition 0.000 description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
- 206010028735 Nasal congestion Diseases 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000012453 solvate Substances 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 150000001204 N-oxides Chemical class 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000003395 histamine H3 receptor antagonist Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 208000027744 congestion Diseases 0.000 description 1
- -1 cyano, phenyl Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000938 histamine H1 antagonist Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23404000P | 2000-09-20 | 2000-09-20 | |
| PCT/US2001/029064 WO2002024658A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509870A JP2004509870A (ja) | 2004-04-02 |
| JP2004509870A5 true JP2004509870A5 (enExample) | 2008-09-11 |
Family
ID=22879630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002529070A Pending JP2004509870A (ja) | 2000-09-20 | 2001-09-18 | ヒスタミンｈ１およびヒスタミンｈ３双方のアゴニストまたはアンタゴニストとしての置換イミダゾール |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6518287B2 (enExample) |
| EP (1) | EP1318983B1 (enExample) |
| JP (1) | JP2004509870A (enExample) |
| CN (1) | CN1461299A (enExample) |
| AR (1) | AR032895A1 (enExample) |
| AT (1) | ATE411983T1 (enExample) |
| AU (1) | AU2001292723A1 (enExample) |
| CA (1) | CA2421823A1 (enExample) |
| DE (1) | DE60136284D1 (enExample) |
| ES (1) | ES2313985T3 (enExample) |
| HK (1) | HK1052181A1 (enExample) |
| MX (1) | MXPA03002447A (enExample) |
| MY (1) | MY129677A (enExample) |
| WO (1) | WO2002024658A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| BRPI0514857A (pt) * | 2004-09-03 | 2008-05-06 | Celgene Corp | composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central |
| JP2009522246A (ja) * | 2005-12-30 | 2009-06-11 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性レセプターアンタゴニスト |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3512084A1 (de) * | 1985-04-02 | 1986-10-09 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2586562B1 (fr) | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| DK0448765T3 (da) | 1990-03-30 | 1994-09-19 | Heumann Pharma Gmbh & Co | Anvendelse af guanidinderivater til fremstilling af et lægemiddel med NPY-antagonistisk virkning |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| CA2125964C (en) | 1991-12-18 | 2001-06-19 | Neng-Yang Shih | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
| FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| HUT74386A (en) | 1993-11-15 | 1996-12-30 | Schering Corp | Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| DK1019050T3 (da) | 1997-06-24 | 2002-07-08 | Novo Nordisk As | Anvendelse af somatostatinagonister og -antagonister til behandling af sygdomme i forbindelse med øjet |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| US6211182B1 (en) * | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
-
2001
- 2001-09-18 JP JP2002529070A patent/JP2004509870A/ja active Pending
- 2001-09-18 US US09/955,380 patent/US6518287B2/en not_active Expired - Fee Related
- 2001-09-18 AU AU2001292723A patent/AU2001292723A1/en not_active Abandoned
- 2001-09-18 MX MXPA03002447A patent/MXPA03002447A/es active IP Right Grant
- 2001-09-18 AT AT01973110T patent/ATE411983T1/de not_active IP Right Cessation
- 2001-09-18 CA CA002421823A patent/CA2421823A1/en not_active Abandoned
- 2001-09-18 WO PCT/US2001/029064 patent/WO2002024658A2/en not_active Ceased
- 2001-09-18 HK HK03104438.9A patent/HK1052181A1/zh unknown
- 2001-09-18 DE DE60136284T patent/DE60136284D1/de not_active Expired - Lifetime
- 2001-09-18 CN CN01815977A patent/CN1461299A/zh active Pending
- 2001-09-18 AR ARP010104402A patent/AR032895A1/es unknown
- 2001-09-18 EP EP01973110A patent/EP1318983B1/en not_active Expired - Lifetime
- 2001-09-18 ES ES01973110T patent/ES2313985T3/es not_active Expired - Lifetime
- 2001-09-18 MY MYPI20014364A patent/MY129677A/en unknown
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