JP2004509870A - ヒスタミンｈ１およびヒスタミンｈ３双方のアゴニストまたはアンタゴニストとしての置換イミダゾール - Google Patents

ヒスタミンｈ１およびヒスタミンｈ３双方のアゴニストまたはアンタゴニストとしての置換イミダゾール Download PDF

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Publication number
JP2004509870A
JP2004509870A JP2002529070A JP2002529070A JP2004509870A JP 2004509870 A JP2004509870 A JP 2004509870A JP 2002529070 A JP2002529070 A JP 2002529070A JP 2002529070 A JP2002529070 A JP 2002529070A JP 2004509870 A JP2004509870 A JP 2004509870A
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JP
Japan
Prior art keywords
compound
compounds
group
alkyl
lower alkyl
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Pending
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JP2002529070A
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English (en)
Japanese (ja)
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JP2004509870A5 (enExample
Inventor
アスラニアン，　ロバート　ジー．
ローセンブラム，　スチュアート　ビー．
ムタヒ，　ムワンギ　ワ
シー，　ネン−ヤン
ピウィンスキ，　ジョン　ジェイ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2004509870A publication Critical patent/JP2004509870A/ja
Publication of JP2004509870A5 publication Critical patent/JP2004509870A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2002529070A 2000-09-20 2001-09-18 ヒスタミンｈ１およびヒスタミンｈ３双方のアゴニストまたはアンタゴニストとしての置換イミダゾール Pending JP2004509870A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23404000P 2000-09-20 2000-09-20
PCT/US2001/029064 WO2002024658A2 (en) 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists

Publications (2)

Publication Number Publication Date
JP2004509870A true JP2004509870A (ja) 2004-04-02
JP2004509870A5 JP2004509870A5 (enExample) 2008-09-11

Family

ID=22879630

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002529070A Pending JP2004509870A (ja) 2000-09-20 2001-09-18 ヒスタミンｈ１およびヒスタミンｈ３双方のアゴニストまたはアンタゴニストとしての置換イミダゾール

Country Status (14)

Country Link
US (1) US6518287B2 (enExample)
EP (1) EP1318983B1 (enExample)
JP (1) JP2004509870A (enExample)
CN (1) CN1461299A (enExample)
AR (1) AR032895A1 (enExample)
AT (1) ATE411983T1 (enExample)
AU (1) AU2001292723A1 (enExample)
CA (1) CA2421823A1 (enExample)
DE (1) DE60136284D1 (enExample)
ES (1) ES2313985T3 (enExample)
HK (1) HK1052181A1 (enExample)
MX (1) MXPA03002447A (enExample)
MY (1) MY129677A (enExample)
WO (1) WO2002024658A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512378A (ja) * 2004-09-03 2008-04-24 セルジーン・コーポレーション 置換複素環式化合物及びその使用
JP2009522246A (ja) * 2005-12-30 2009-06-11 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプターアンタゴニスト
JP2010511624A (ja) * 2006-12-01 2010-04-15 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050090527A1 (en) * 2003-01-28 2005-04-28 Schering Corporation Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236771A (ja) * 1985-04-02 1986-10-22 ホイマン　フアルマ　ゲーエムベーハー　ウント　チエオー イミダゾリルアルキルグアニジン誘導体、その製法およびこれらの化合物を含有する医薬製剤
JPS6383072A (ja) * 1986-09-15 1988-04-13 ホイマン・ファーマ・ジー・エム・ビー・エイチ・アンド・カンパニー 新規イミダゾリルグアニジン誘導体、その製造法及びその化合物を含有する医薬
JPH0789939A (ja) * 1990-03-30 1995-04-04 Heumann Pharma Gmbh & Co ニューロペプチド−ｙ（ｎｐｙ）拮抗活性を有するグアニジン誘導体医薬製剤組成物
WO2000053596A2 (en) * 1999-03-08 2000-09-14 Schering Corporation Imidazole compounds as histamine h3 ligands

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586562B1 (fr) 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
GB8916947D0 (en) 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
GB9115740D0 (en) 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
ATE128708T1 (de) 1991-12-18 1995-10-15 Schering Corp Imidazolylalkyl- piperazin und -diazepin derivate als histamin h3 agonisten/antagonisten.
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
JPH09505298A (ja) 1993-11-15 1997-05-27 シェーリング コーポレイション Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
WO1998058646A1 (en) 1997-06-24 1998-12-30 Novo Nordisk A/S Use of somatostatin agonists and antagonists for treating diseases related to the eye
US5869479A (en) 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236771A (ja) * 1985-04-02 1986-10-22 ホイマン　フアルマ　ゲーエムベーハー　ウント　チエオー イミダゾリルアルキルグアニジン誘導体、その製法およびこれらの化合物を含有する医薬製剤
JPS6383072A (ja) * 1986-09-15 1988-04-13 ホイマン・ファーマ・ジー・エム・ビー・エイチ・アンド・カンパニー 新規イミダゾリルグアニジン誘導体、その製造法及びその化合物を含有する医薬
JPH0789939A (ja) * 1990-03-30 1995-04-04 Heumann Pharma Gmbh & Co ニューロペプチド−ｙ（ｎｐｙ）拮抗活性を有するグアニジン誘導体医薬製剤組成物
WO2000053596A2 (en) * 1999-03-08 2000-09-14 Schering Corporation Imidazole compounds as histamine h3 ligands

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512378A (ja) * 2004-09-03 2008-04-24 セルジーン・コーポレーション 置換複素環式化合物及びその使用
JP2009522246A (ja) * 2005-12-30 2009-06-11 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプターアンタゴニスト
JP2010511624A (ja) * 2006-12-01 2010-04-15 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体

Also Published As

Publication number Publication date
CN1461299A (zh) 2003-12-10
MXPA03002447A (es) 2003-07-21
AU2001292723A1 (en) 2002-04-02
MY129677A (en) 2007-04-30
US20020103235A1 (en) 2002-08-01
ATE411983T1 (de) 2008-11-15
EP1318983A2 (en) 2003-06-18
WO2002024658A2 (en) 2002-03-28
ES2313985T3 (es) 2009-03-16
US6518287B2 (en) 2003-02-11
CA2421823A1 (en) 2002-03-28
DE60136284D1 (de) 2008-12-04
EP1318983B1 (en) 2008-10-22
HK1052181A1 (zh) 2003-09-05
WO2002024658A3 (en) 2002-07-11
AR032895A1 (es) 2003-12-03

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