JP2004505090A - ピロロ［２，１−ｂ］［１，３］ベンゾチアゼピンおよび抗精神病活性を有する薬剤の調製のためのその使用 - Google Patents
ピロロ［２，１−ｂ］［１，３］ベンゾチアゼピンおよび抗精神病活性を有する薬剤の調製のためのその使用 Download PDFInfo
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- JP2004505090A JP2004505090A JP2002515904A JP2002515904A JP2004505090A JP 2004505090 A JP2004505090 A JP 2004505090A JP 2002515904 A JP2002515904 A JP 2002515904A JP 2002515904 A JP2002515904 A JP 2002515904A JP 2004505090 A JP2004505090 A JP 2004505090A
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- 125000004193 piperazinyl group Chemical group 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 210000002442 prefrontal cortex Anatomy 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 229950001675 spiperone Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000432A IT1317884B1 (it) | 2000-08-01 | 2000-08-01 | Pirrolo (2,1-b)(1,3)benzotiazepine e loro uso per la preparazione dimedicamenti ad attivita' antipsicotica classica. |
| PCT/IT2001/000406 WO2002010175A1 (en) | 2000-08-01 | 2001-07-26 | PYRROLO[2,1-b][1,3]BENZOTHIAZEPINES AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS WITH ANTIPSYCHOTIC ACTIVITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505090A true JP2004505090A (ja) | 2004-02-19 |
| JP2004505090A5 JP2004505090A5 (de) | 2008-09-11 |
Family
ID=11454865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515904A Withdrawn JP2004505090A (ja) | 2000-08-01 | 2001-07-26 | ピロロ［２，１−ｂ］［１，３］ベンゾチアゼピンおよび抗精神病活性を有する薬剤の調製のためのその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6710041B2 (de) |
| EP (1) | EP1307463B1 (de) |
| JP (1) | JP2004505090A (de) |
| KR (1) | KR100826304B1 (de) |
| CN (1) | CN1264848C (de) |
| AT (1) | ATE287890T1 (de) |
| AU (2) | AU8439101A (de) |
| BR (1) | BR0112843A (de) |
| CA (1) | CA2415475C (de) |
| CZ (1) | CZ299340B6 (de) |
| DE (1) | DE60108642T2 (de) |
| DK (1) | DK1307463T3 (de) |
| ES (1) | ES2236291T3 (de) |
| HK (1) | HK1059774A1 (de) |
| IT (1) | IT1317884B1 (de) |
| MX (1) | MXPA03000775A (de) |
| PL (1) | PL203096B1 (de) |
| PT (1) | PT1307463E (de) |
| SK (1) | SK287248B6 (de) |
| WO (1) | WO2002010175A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040178A1 (it) * | 2004-04-07 | 2004-07-07 | Sigma Tau Ind Farmaceuti | Composti ad attivita' antipsicotica atipica. |
| ITRM20040222A1 (it) * | 2004-05-07 | 2004-08-07 | Sigma Tau Ind Farmaceuti | Derivati dealchilati di pirrolo[2,1-b]benzotiazepine ad attivita' antipsicotica atipica. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1301965B1 (it) | 1998-07-28 | 2000-07-20 | Sigma Tau Ind Farmaceuti | Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. |
-
2000
- 2000-08-01 IT IT2000RM000432A patent/IT1317884B1/it active
-
2001
- 2001-07-26 WO PCT/IT2001/000406 patent/WO2002010175A1/en active IP Right Grant
- 2001-07-26 JP JP2002515904A patent/JP2004505090A/ja not_active Withdrawn
- 2001-07-26 SK SK130-2003A patent/SK287248B6/sk not_active IP Right Cessation
- 2001-07-26 CA CA2415475A patent/CA2415475C/en not_active Expired - Fee Related
- 2001-07-26 KR KR1020037000934A patent/KR100826304B1/ko not_active IP Right Cessation
- 2001-07-26 US US10/343,627 patent/US6710041B2/en not_active Expired - Fee Related
- 2001-07-26 MX MXPA03000775A patent/MXPA03000775A/es active IP Right Grant
- 2001-07-26 EP EP01963371A patent/EP1307463B1/de not_active Expired - Lifetime
- 2001-07-26 PT PT01963371T patent/PT1307463E/pt unknown
- 2001-07-26 AU AU8439101A patent/AU8439101A/xx active Pending
- 2001-07-26 AU AU2001284391A patent/AU2001284391B2/en not_active Ceased
- 2001-07-26 DK DK01963371T patent/DK1307463T3/da active
- 2001-07-26 AT AT01963371T patent/ATE287890T1/de not_active IP Right Cessation
- 2001-07-26 DE DE60108642T patent/DE60108642T2/de not_active Expired - Lifetime
- 2001-07-26 ES ES01963371T patent/ES2236291T3/es not_active Expired - Lifetime
- 2001-07-26 BR BR0112843-4A patent/BR0112843A/pt not_active Application Discontinuation
- 2001-07-26 PL PL365008A patent/PL203096B1/pl not_active IP Right Cessation
- 2001-07-26 CN CNB018133886A patent/CN1264848C/zh not_active Expired - Fee Related
- 2001-07-26 CZ CZ20030012A patent/CZ299340B6/cs not_active IP Right Cessation
-
2004
- 2004-02-06 HK HK04100773A patent/HK1059774A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK287248B6 (sk) | 2010-04-07 |
| CN1264848C (zh) | 2006-07-19 |
| PT1307463E (pt) | 2005-04-29 |
| DK1307463T3 (da) | 2005-05-23 |
| KR100826304B1 (ko) | 2008-04-29 |
| ITRM20000432A0 (it) | 2000-08-01 |
| US6710041B2 (en) | 2004-03-23 |
| ATE287890T1 (de) | 2005-02-15 |
| HK1059774A1 (en) | 2004-07-16 |
| EP1307463A1 (de) | 2003-05-07 |
| CA2415475C (en) | 2010-09-28 |
| PL203096B1 (pl) | 2009-08-31 |
| ITRM20000432A1 (it) | 2002-02-01 |
| DE60108642T2 (de) | 2006-06-14 |
| AU2001284391B2 (en) | 2006-09-28 |
| SK1302003A3 (en) | 2003-05-02 |
| CZ200312A3 (cs) | 2003-05-14 |
| IT1317884B1 (it) | 2003-07-15 |
| CN1444588A (zh) | 2003-09-24 |
| DE60108642D1 (de) | 2005-03-03 |
| KR20030019598A (ko) | 2003-03-06 |
| MXPA03000775A (es) | 2003-10-15 |
| BR0112843A (pt) | 2003-04-22 |
| ES2236291T3 (es) | 2005-07-16 |
| PL365008A1 (en) | 2004-12-27 |
| AU8439101A (en) | 2002-02-13 |
| WO2002010175A1 (en) | 2002-02-07 |
| CZ299340B6 (cs) | 2008-06-25 |
| EP1307463B1 (de) | 2005-01-26 |
| CA2415475A1 (en) | 2002-02-07 |
| US20030186959A1 (en) | 2003-10-02 |
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