IT1301965B1 - Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. - Google Patents
Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.Info
- Publication number
- IT1301965B1 IT1301965B1 IT1998MI001748A ITMI981748A IT1301965B1 IT 1301965 B1 IT1301965 B1 IT 1301965B1 IT 1998MI001748 A IT1998MI001748 A IT 1998MI001748A IT MI981748 A ITMI981748 A IT MI981748A IT 1301965 B1 IT1301965 B1 IT 1301965B1
- Authority
- IT
- Italy
- Prior art keywords
- benzothiazepine
- pyrol
- antipsychotic
- atypical activity
- compounds
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- RZQBDIZIQNASEL-UHFFFAOYSA-N 1,3-benzothiazepine Chemical compound S1C=NC=CC2=CC=CC=C12 RZQBDIZIQNASEL-UHFFFAOYSA-N 0.000 title 1
- GSSXLFACIJSBOM-UHFFFAOYSA-N 2h-pyran-2-ol Chemical compound OC1OC=CC=C1 GSSXLFACIJSBOM-UHFFFAOYSA-N 0.000 title 1
- 230000000561 anti-psychotic effect Effects 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027776 Extrapyramidal disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 150000007657 benzothiazepines Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001748A IT1301965B1 (it) | 1998-07-28 | 1998-07-28 | Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. |
| HK01105573.3A HK1036793B (en) | 1998-07-28 | 1999-07-27 | Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity |
| EP99936971A EP1100803B1 (en) | 1998-07-28 | 1999-07-27 | Pyrrolo [2,1-b] [1,3]benzothiazepines with atypical antipsychotic activity |
| CA002338651A CA2338651C (en) | 1998-07-28 | 1999-07-27 | Pyrrolo[2,1-b][1,3]benzothiazepines with atypical antipsychotic activity |
| SI9930110T SI1100803T1 (en) | 1998-07-28 | 1999-07-27 | Pyrrolo (2,1-b) (1,3)benzothiazepines with atypical antipsychotic activity |
| DK99936971T DK1100803T3 (da) | 1998-07-28 | 1999-07-27 | Pyrrolo[2,1-b][1,3]benzothiazepiner med atypisk antipsykotisk aktivitet |
| AT99936971T ATE225352T1 (de) | 1998-07-28 | 1999-07-27 | Pyrrolo(2,1-b)(1,3)benzothiazepine mit atypisch antipsychotischer wirkung |
| DE69903321T DE69903321T2 (de) | 1998-07-28 | 1999-07-27 | Pyrrolo[2,1-b][1,3]benzothiazepine mit atypisch antipsychotischer wirkung |
| KR1020017001214A KR100642730B1 (ko) | 1998-07-28 | 1999-07-27 | 비정형적인 향정신성 작용을 갖는피롤로[2,1-ｂ][1,3]벤조티아제핀 |
| AU51933/99A AU762021B2 (en) | 1998-07-28 | 1999-07-27 | Pyrrolo(2,1-B)(1,3)benzothiazepines with atypical antipsychotic activity |
| ES99936971T ES2185384T3 (es) | 1998-07-28 | 1999-07-27 | Pirrolo(2,1-b)(1,3)benzodiazepinas con actividad antipsicotica atipica. |
| PT99936971T PT1100803E (pt) | 1998-07-28 | 1999-07-27 | Pirrolo¬2,1-b|¬1,3|benzotiazepinas com actividade antipsicotica atipica |
| PCT/IT1999/000240 WO2000006579A2 (en) | 1998-07-28 | 1999-07-27 | Pyrrolo[2,1-b][1,3]benzothiazepines with atypical antipsychotic activity |
| JP2000562378A JP4523160B2 (ja) | 1998-07-28 | 1999-07-27 | 非定型抗精神病薬活性を有するピロロ［２，１−ｂ］［１，３］ベンゾチアゼピン |
| US09/769,740 US6391870B2 (en) | 1998-07-28 | 2001-01-26 | Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001748A IT1301965B1 (it) | 1998-07-28 | 1998-07-28 | Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI981748A0 ITMI981748A0 (it) | 1998-07-28 |
| ITMI981748A1 ITMI981748A1 (it) | 2000-01-28 |
| IT1301965B1 true IT1301965B1 (it) | 2000-07-20 |
Family
ID=11380538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1998MI001748A IT1301965B1 (it) | 1998-07-28 | 1998-07-28 | Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6391870B2 (it) |
| EP (1) | EP1100803B1 (it) |
| JP (1) | JP4523160B2 (it) |
| KR (1) | KR100642730B1 (it) |
| AT (1) | ATE225352T1 (it) |
| AU (1) | AU762021B2 (it) |
| CA (1) | CA2338651C (it) |
| DE (1) | DE69903321T2 (it) |
| DK (1) | DK1100803T3 (it) |
| ES (1) | ES2185384T3 (it) |
| IT (1) | IT1301965B1 (it) |
| PT (1) | PT1100803E (it) |
| WO (1) | WO2000006579A2 (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317886B1 (it) * | 2000-08-01 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di 9,10-diidro-pirrolo (2,1-b)(1,3)benzotiazepine 9-ammino sostituite. |
| IT1317884B1 (it) | 2000-08-01 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Pirrolo (2,1-b)(1,3)benzotiazepine e loro uso per la preparazione dimedicamenti ad attivita' antipsicotica classica. |
| ITRM20040178A1 (it) * | 2004-04-07 | 2004-07-07 | Sigma Tau Ind Farmaceuti | Composti ad attivita' antipsicotica atipica. |
| ITRM20040222A1 (it) | 2004-05-07 | 2004-08-07 | Sigma Tau Ind Farmaceuti | Derivati dealchilati di pirrolo[2,1-b]benzotiazepine ad attivita' antipsicotica atipica. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539573A (en) * | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
-
1998
- 1998-07-28 IT IT1998MI001748A patent/IT1301965B1/it active IP Right Grant
-
1999
- 1999-07-27 KR KR1020017001214A patent/KR100642730B1/ko not_active Expired - Fee Related
- 1999-07-27 DE DE69903321T patent/DE69903321T2/de not_active Expired - Lifetime
- 1999-07-27 AT AT99936971T patent/ATE225352T1/de not_active IP Right Cessation
- 1999-07-27 CA CA002338651A patent/CA2338651C/en not_active Expired - Fee Related
- 1999-07-27 EP EP99936971A patent/EP1100803B1/en not_active Expired - Lifetime
- 1999-07-27 JP JP2000562378A patent/JP4523160B2/ja not_active Expired - Fee Related
- 1999-07-27 PT PT99936971T patent/PT1100803E/pt unknown
- 1999-07-27 ES ES99936971T patent/ES2185384T3/es not_active Expired - Lifetime
- 1999-07-27 DK DK99936971T patent/DK1100803T3/da active
- 1999-07-27 WO PCT/IT1999/000240 patent/WO2000006579A2/en active IP Right Grant
- 1999-07-27 AU AU51933/99A patent/AU762021B2/en not_active Ceased
-
2001
- 2001-01-26 US US09/769,740 patent/US6391870B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1036793A1 (en) | 2002-01-18 |
| AU5193399A (en) | 2000-02-21 |
| EP1100803A2 (en) | 2001-05-23 |
| DE69903321D1 (de) | 2002-11-07 |
| CA2338651C (en) | 2009-05-19 |
| WO2000006579A2 (en) | 2000-02-10 |
| EP1100803B1 (en) | 2002-10-02 |
| JP2002521485A (ja) | 2002-07-16 |
| ITMI981748A0 (it) | 1998-07-28 |
| DE69903321T2 (de) | 2003-06-18 |
| CA2338651A1 (en) | 2000-02-10 |
| US20020006921A1 (en) | 2002-01-17 |
| KR100642730B1 (ko) | 2006-11-03 |
| ATE225352T1 (de) | 2002-10-15 |
| AU762021B2 (en) | 2003-06-19 |
| ITMI981748A1 (it) | 2000-01-28 |
| ES2185384T3 (es) | 2003-04-16 |
| KR20010072090A (ko) | 2001-07-31 |
| DK1100803T3 (da) | 2002-12-30 |
| US6391870B2 (en) | 2002-05-21 |
| WO2000006579A3 (en) | 2000-05-04 |
| JP4523160B2 (ja) | 2010-08-11 |
| PT1100803E (pt) | 2003-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |