ATE335482T1 - Dermale anästhetika - Google Patents

Dermale anästhetika

Info

Publication number
ATE335482T1
ATE335482T1 AT00941227T AT00941227T ATE335482T1 AT E335482 T1 ATE335482 T1 AT E335482T1 AT 00941227 T AT00941227 T AT 00941227T AT 00941227 T AT00941227 T AT 00941227T AT E335482 T1 ATE335482 T1 AT E335482T1
Authority
AT
Austria
Prior art keywords
compounds
anesthetics
dermal
aminoindane
dermal anesthetics
Prior art date
Application number
AT00941227T
Other languages
English (en)
Inventor
A K Gunnar Aberg
George L Wright
Jan L Chen
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Application granted granted Critical
Publication of ATE335482T1 publication Critical patent/ATE335482T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00941227T 1999-06-10 2000-06-06 Dermale anästhetika ATE335482T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13835399P 1999-06-10 1999-06-10
US17926700P 2000-01-31 2000-01-31

Publications (1)

Publication Number Publication Date
ATE335482T1 true ATE335482T1 (de) 2006-09-15

Family

ID=26836123

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00941227T ATE335482T1 (de) 1999-06-10 2000-06-06 Dermale anästhetika

Country Status (18)

Country Link
US (1) US6413987B1 (de)
EP (1) EP1185267B1 (de)
JP (1) JP2003501469A (de)
CN (1) CN1355700A (de)
AT (1) ATE335482T1 (de)
AU (1) AU777517B2 (de)
BR (1) BR0011028A (de)
CA (1) CA2376819C (de)
CY (1) CY1105721T1 (de)
DE (1) DE60029954T2 (de)
DK (1) DK1185267T3 (de)
ES (1) ES2267546T3 (de)
IL (2) IL146190A0 (de)
MX (1) MXPA01012632A (de)
NO (1) NO323856B1 (de)
NZ (1) NZ515143A (de)
PT (1) PT1185267E (de)
WO (1) WO2000076510A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1321139T3 (da) * 2001-12-21 2007-01-02 Chiesi Farma Spa 2-indanylaminoderivater til behandling af kronisk, akut eller inflammatorisk smerte
WO2004048332A1 (ja) * 2002-11-26 2004-06-10 Maruishi Pharmaceutical Co., Ltd. イソインドリン誘導体
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US20110218218A1 (en) * 2005-09-23 2011-09-08 Bridge Pharma, Inc. Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
US20090137628A1 (en) * 2005-09-23 2009-05-28 Bridge Pharma, Inc. Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
WO2008011161A2 (en) 2006-07-21 2008-01-24 Bridge Pharma, Inc. Dermal anesthetic compounds
WO2009094459A1 (en) * 2008-01-22 2009-07-30 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
CN103547566B (zh) * 2011-02-18 2017-05-31 阿萨纳生物科技有限责任公司 氨基茚满化合物及其治疗疼痛的用途
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
ES2596215T3 (es) 2011-10-24 2017-01-05 Asana Biosciences, Llc Ciclohexilaminas
TWI603957B (zh) * 2012-08-15 2017-11-01 阿沙納生物科學有限責任公司 胺基氫茚化合物用於治療膀胱過動症及間質性膀胱炎之用途
WO2017091739A1 (en) 2015-11-23 2017-06-01 Grace Therapeutics Llc Topical film-forming spray
EP3897603A4 (de) 2018-12-19 2022-09-14 Grace Therapeutics Inc. Therapeutische zusammensetzung von intranasalem lidocain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923813A (en) 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
BE760018A (fr) * 1969-12-19 1971-06-08 Christiaens Sa A Nouveau derives du 2-amino-indane, leur preparation et leur utilisation
AR206505A1 (es) * 1972-09-18 1976-07-30 Christiaens Sa A Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano
ZA738419B (en) * 1972-11-06 1974-09-25 Christiaens Sa A New derivatives of 2-aminoindane,the preparation and use thereof
GB1462036A (en) * 1973-02-05 1977-01-19 Manuf Prod Pharma Aminoindane derivatives
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Also Published As

Publication number Publication date
WO2000076510A1 (en) 2000-12-21
IL146190A0 (en) 2002-07-25
US6413987B1 (en) 2002-07-02
PT1185267E (pt) 2006-12-29
EP1185267B1 (de) 2006-08-09
WO2000076510A9 (en) 2002-07-04
NO20016037L (no) 2002-02-11
DE60029954T2 (de) 2007-03-08
DK1185267T3 (da) 2006-12-11
EP1185267A4 (de) 2003-09-03
EP1185267A1 (de) 2002-03-13
NO323856B1 (no) 2007-07-16
AU5596300A (en) 2001-01-02
CA2376819C (en) 2008-09-02
NZ515143A (en) 2004-05-28
MXPA01012632A (es) 2004-03-19
DE60029954D1 (de) 2006-09-21
NO20016037D0 (no) 2001-12-10
IL146190A (en) 2008-11-03
AU777517B2 (en) 2004-10-21
CA2376819A1 (en) 2000-12-21
ES2267546T3 (es) 2007-03-16
CN1355700A (zh) 2002-06-26
BR0011028A (pt) 2002-02-19
JP2003501469A (ja) 2003-01-14
CY1105721T1 (el) 2010-12-22

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