JP2004504323A5 - - Google Patents
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- Publication number
- JP2004504323A5 JP2004504323A5 JP2002512186A JP2002512186A JP2004504323A5 JP 2004504323 A5 JP2004504323 A5 JP 2004504323A5 JP 2002512186 A JP2002512186 A JP 2002512186A JP 2002512186 A JP2002512186 A JP 2002512186A JP 2004504323 A5 JP2004504323 A5 JP 2004504323A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- acid addition
- free base
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 4
- -1 cyano, tetrazolyl Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims 2
- MUCVVURUYXBTPX-UHFFFAOYSA-N 7-(2H-tetrazol-5-ylmethyl)-6H-indolo[1,2-a]quinazolin-5-one Chemical compound C12=CC=CC=C2N2C3=CC=CC=C3C(=O)NC2=C1CC1=NN=NN1 MUCVVURUYXBTPX-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000005184 naphthylamino group Chemical group C1(=CC=CC2=CC=CC=C12)N* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002829 nitrogen Chemical group 0.000 claims 1
- 201000002674 obstructive nephropathy Diseases 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Claims (4)
- 遊離塩基または酸付加塩の形態の式I
Rは−(CH2)n−Xであり、ここでnは1、2または3であり、そしてXは(C1−4)アルキル、(C1−4)アルコキシ、(C2−7)アルケニル、(C2−7)アルキニル、カルボキシ、(C1−4)アルコキシカルボニル、シアノ、テトラゾリル、(C3−7)シクロアルキルアミノまたはイミダゾリル(C1−4)アルキルアミノであるか、
あるいはRは−CH2CON(R1)R2であり、ここでR1およびR2は、独立して、水素、ヒドロキシ、(C1−4)アルキル、ベンジル、ジ(C1−4)アルキルアミノ(C1−4)アルキル、(C2−7)アルケニル、(C2−7)アルキニル、ヒドロキシ(C1−4)アルキル、ジヒドロキシ(C1−4)アルキル、シアノアルキル、カルバモイルアルキル、(C3−7)シクロアルキル、(C3−7)シクロアルキル(C1−4)アルキル、2−オキソ−3−テトラヒドロフリル、(C1−4)アルコキシ(C1−4)アルキル、(C1−4)アルコキシカルボニル(C3−7)シクロアルキル、ナフチルアミノ(C1−4)アルキル、イミダゾリルアミノ(C1−4)アルキル、モルホリニル(C1−4)アルキル、ピロリジニル(C1−4)アルキル、ピペリジニル(C1−4)アルキルまたは(C3−7)シクロアルキルアミノ(C1−4)アルキルであるか、あるいはR1およびR2は、それらが結合している窒素原子と一体となって、モルホリノ、(C1−4)アルキル−ピペラジニル、ヒドロキシ(C1−4)アルキル−ピペラジニル、ピペリジニル、ピロリジニルまたはp−クロロフェニル(C1−4)アルキル−ピペラジニルを形成する。〕
の化合物。 - 遊離塩基または酸付加塩の形態の7−(1H−テトラゾール−5−イルメチル)−6H−インドロ[1,2−a]キナゾリン−5−オン。
- 薬学的担体または希釈剤とともに遊離塩基または薬学的に許容される酸付加塩の形態の請求項1に記載の化合物を含む医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0017508.3A GB0017508D0 (en) | 2000-07-17 | 2000-07-17 | Antimicrobials |
PCT/EP2001/008192 WO2002006284A1 (en) | 2000-07-17 | 2001-07-16 | Indoloquinazolinones |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004504323A JP2004504323A (ja) | 2004-02-12 |
JP2004504323A5 true JP2004504323A5 (ja) | 2005-02-03 |
JP3939246B2 JP3939246B2 (ja) | 2007-07-04 |
Family
ID=9895801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002512186A Expired - Fee Related JP3939246B2 (ja) | 2000-07-17 | 2001-07-16 | インドロキナゾリノン類 |
Country Status (19)
Country | Link |
---|---|
US (1) | US6964960B2 (ja) |
EP (1) | EP1303517B1 (ja) |
JP (1) | JP3939246B2 (ja) |
CN (1) | CN1183136C (ja) |
AR (1) | AR031379A1 (ja) |
AT (1) | ATE262530T1 (ja) |
AU (1) | AU2001279754A1 (ja) |
BR (1) | BR0112521A (ja) |
CA (1) | CA2415683C (ja) |
DE (1) | DE60102473T2 (ja) |
DK (1) | DK1303517T3 (ja) |
ES (1) | ES2218439T3 (ja) |
GB (1) | GB0017508D0 (ja) |
HK (2) | HK1056872A1 (ja) |
MY (1) | MY133969A (ja) |
PE (1) | PE20020210A1 (ja) |
PT (1) | PT1303517E (ja) |
TR (1) | TR200401026T4 (ja) |
WO (1) | WO2002006284A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
EP1603567A4 (en) | 2003-02-28 | 2006-10-18 | Inotek Pharmaceuticals Corp | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF |
JP2008531562A (ja) | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | 四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法 |
EP1937268A4 (en) | 2005-08-24 | 2009-07-22 | Inotek Pharmaceuticals Corp | INDENOISOQUINOLINONE ANALOGUES AND METHODS OF USE |
JP5284955B2 (ja) * | 2006-06-20 | 2013-09-11 | アボット・ラボラトリーズ | Parp阻害剤としてのピラゾロキナゾリノン |
GB0615809D0 (en) * | 2006-08-09 | 2006-09-20 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
GB0701273D0 (en) * | 2007-01-24 | 2007-02-28 | Angeletti P Ist Richerche Bio | New compounds |
JP2010520220A (ja) | 2007-02-28 | 2010-06-10 | イノテック ファーマシューティカルズ コーポレイション | インデノイソキノリノン類似体およびその使用方法 |
EP2409700A1 (en) | 2007-05-08 | 2012-01-25 | Schering Corporation | Methods of treatment using intravenous formulations comprising temozolomide |
US9062061B2 (en) | 2011-07-13 | 2015-06-23 | Santen Pharmaceutical Co., Ltd. | Compound having PARP inhibitory activity |
CN102766144B (zh) * | 2012-07-10 | 2014-04-23 | 浙江大学 | 一种吲哚并[1,2-c]喹唑啉化合物的制备方法 |
PT3325623T (pt) | 2015-07-23 | 2019-09-04 | Inst Curie | Utilização de uma combinação de molécula dbait e de inibidores de parp para o tratamento do cancro |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
JP2021515580A (ja) | 2018-03-13 | 2021-06-24 | オンクセオOnxeo | がんの治療における獲得耐性に対抗するdbait分子 |
WO2020109524A1 (de) * | 2018-11-30 | 2020-06-04 | Merck Patent Gmbh | Verbindungen für elektronische vorrichtungen |
WO2020182779A1 (de) * | 2019-03-12 | 2020-09-17 | Merck Patent Gmbh | Materialien für organische elektrolumineszenzvorrichtungen |
CN110357892B (zh) * | 2019-07-10 | 2022-06-07 | 云南大学 | 四氢嘧啶并[1,2-a]吲哚衍生物及其合成方法与应用 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN114195789B (zh) * | 2021-12-15 | 2022-09-09 | 广东海洋大学 | 一种无金属参与的多环吲哚衍生物的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3635966A (en) | 1969-10-22 | 1972-01-18 | Robins Co Inc A H | 6-substituted-indolo(1 2-c)quinazolines |
DE2237372C3 (de) | 1972-07-29 | 1981-07-09 | Basf Ag, 6700 Ludwigshafen | Heterocyclische Farbstoffe, ihre Herstellung und ihre Verwendung |
US5441955A (en) | 1993-11-19 | 1995-08-15 | Pathogenesis Corporation | Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof |
GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
-
2000
- 2000-07-17 GB GBGB0017508.3A patent/GB0017508D0/en not_active Ceased
-
2001
- 2001-07-12 PE PE2001000700A patent/PE20020210A1/es not_active Application Discontinuation
- 2001-07-13 MY MYPI20013343 patent/MY133969A/en unknown
- 2001-07-13 AR ARP010103339A patent/AR031379A1/es not_active Application Discontinuation
- 2001-07-16 JP JP2002512186A patent/JP3939246B2/ja not_active Expired - Fee Related
- 2001-07-16 AT AT01957972T patent/ATE262530T1/de not_active IP Right Cessation
- 2001-07-16 CA CA002415683A patent/CA2415683C/en not_active Expired - Fee Related
- 2001-07-16 EP EP01957972A patent/EP1303517B1/en not_active Expired - Lifetime
- 2001-07-16 WO PCT/EP2001/008192 patent/WO2002006284A1/en active IP Right Grant
- 2001-07-16 DK DK01957972T patent/DK1303517T3/da active
- 2001-07-16 PT PT01957972T patent/PT1303517E/pt unknown
- 2001-07-16 CN CNB018126995A patent/CN1183136C/zh not_active Expired - Fee Related
- 2001-07-16 BR BR0112521-4A patent/BR0112521A/pt not_active Application Discontinuation
- 2001-07-16 US US10/333,186 patent/US6964960B2/en not_active Expired - Fee Related
- 2001-07-16 DE DE60102473T patent/DE60102473T2/de not_active Expired - Lifetime
- 2001-07-16 ES ES01957972T patent/ES2218439T3/es not_active Expired - Lifetime
- 2001-07-16 TR TR2004/01026T patent/TR200401026T4/xx unknown
- 2001-07-16 AU AU2001279754A patent/AU2001279754A1/en not_active Abandoned
-
2003
- 2003-10-15 HK HK03107474A patent/HK1056872A1/xx not_active IP Right Cessation
- 2003-10-22 HK HK03107634A patent/HK1055426A1/xx not_active IP Right Cessation
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