JP2004504063A5 - - Google Patents

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Publication number
JP2004504063A5
JP2004504063A5 JP2002514175A JP2002514175A JP2004504063A5 JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5 JP 2002514175 A JP2002514175 A JP 2002514175A JP 2002514175 A JP2002514175 A JP 2002514175A JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5
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JP
Japan
Prior art keywords
antibody
seq
polypeptide
mutation
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002514175A
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English (en)
Japanese (ja)
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JP2004504063A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/021738 external-priority patent/WO2002008271A1/en
Publication of JP2004504063A publication Critical patent/JP2004504063A/ja
Publication of JP2004504063A5 publication Critical patent/JP2004504063A5/ja
Pending legal-status Critical Current

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JP2002514175A 2000-07-19 2001-07-10 新規線維芽細胞増殖因子(fgf23)および使用方法 Pending JP2004504063A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21913700P 2000-07-19 2000-07-19
PCT/US2001/021738 WO2002008271A1 (en) 2000-07-19 2001-07-10 Novel fibroblast growth factor (fgf23) and methods for use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008025528A Division JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Publications (2)

Publication Number Publication Date
JP2004504063A JP2004504063A (ja) 2004-02-12
JP2004504063A5 true JP2004504063A5 (https=) 2008-03-27

Family

ID=22818027

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002514175A Pending JP2004504063A (ja) 2000-07-19 2001-07-10 新規線維芽細胞増殖因子(fgf23)および使用方法
JP2008025528A Pending JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008025528A Pending JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Country Status (11)

Country Link
US (5) US7223563B2 (https=)
EP (2) EP1303536B1 (https=)
JP (2) JP2004504063A (https=)
KR (2) KR20090036151A (https=)
CN (1) CN1446227B (https=)
AT (1) ATE461213T1 (https=)
AU (2) AU2001273323B2 (https=)
CA (1) CA2418215A1 (https=)
DE (1) DE60141582D1 (https=)
ES (1) ES2340662T3 (https=)
WO (1) WO2002008271A1 (https=)

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US8012694B2 (en) 2006-09-14 2011-09-06 Immutopics, Inc. Assay for the detection of phosphorylated PTH
US8058015B2 (en) 2007-01-22 2011-11-15 Medizinische Universität Innsbruck Markers for chronic kidney disease
US7883705B2 (en) 2007-02-14 2011-02-08 Kyowa Hakko Kirin Co., Ltd. Anti FGF23 antibody and a pharmaceutical composition comprising the same
WO2009091556A2 (en) * 2008-01-17 2009-07-23 The General Hospital Corporation Diagnostic methods and kits using fibroblast growth factor-23
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) * 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TWI526687B (zh) * 2008-04-29 2016-03-21 諾華公司 生物標記
US8889621B2 (en) * 2009-10-30 2014-11-18 New York University Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
US20110195077A1 (en) 2010-01-29 2011-08-11 Novartis Ag Methods and compositions using fgf23 fusion ppolypeptides
US10422796B2 (en) 2010-08-31 2019-09-24 Kyowa Medex Co., Ltd. Method for measuring fibroblast growth factor-23 and reagent therefor
WO2012055096A1 (zh) * 2010-10-27 2012-05-03 温州医学院生物与天然药物开发中心有限公司 抗fgf-23抗体的制备方法及用途
US20140294820A1 (en) 2011-06-24 2014-10-02 University Of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
CN105601748B (zh) 2011-07-01 2021-08-27 恩格姆生物制药公司 用于代谢病症和疾病治疗的组合物、应用和方法
WO2013027191A1 (en) 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
HK1214832A1 (zh) 2012-11-28 2016-08-05 恩格姆生物制药公司 用於代謝病症和疾病治療的組合物和方法
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
ES2915851T3 (es) 2012-12-27 2022-06-27 Ngm Biopharmaceuticals Inc Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares
US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
CN106164255B (zh) * 2013-09-20 2020-02-14 隆萨有限公司 细胞的核重编程的方法
CA2927592C (en) 2013-10-28 2020-08-18 Ngm Biopharmaceuticals, Inc. Fgf-19 variants for treating a fgf-19 dependent cancer or tumor
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US10464979B2 (en) 2014-03-28 2019-11-05 New York University FGF23 c-tail fusion proteins
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US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
AU2015356643B2 (en) 2014-12-04 2019-01-24 Novartis Ag Methods and compositions using Klotho variant polypeptides
CN105699664A (zh) * 2015-04-13 2016-06-22 陈柏龄 Fgf23检测试剂盒及其制备方法
US10808015B2 (en) 2015-06-25 2020-10-20 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
JP6728352B2 (ja) 2015-11-09 2020-07-22 エヌジーエム バイオファーマシューティカルス,インコーポレーテッド 胆汁酸に関係した障害の治療方法
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CN110494559B (zh) * 2017-03-28 2023-10-31 味之素株式会社 不分化地维持用培养基添加剂
WO2018221544A1 (ja) 2017-05-31 2018-12-06 協和メデックス株式会社 線維芽細胞増殖因子-23の測定方法、測定試薬及び測定キット
WO2020047475A1 (en) * 2018-08-30 2020-03-05 The Uab Research Foundation Drug screening for fgf23-fgfr4 inhibitors
BR112021019337A2 (pt) * 2019-03-29 2021-12-07 Atarga Llc Anticorpo anti-fgf23
JP7654562B2 (ja) * 2019-04-19 2025-04-01 ジェネトン 線維芽細胞増殖因子23関連低リン血症性疾患の遺伝子療法

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