JP2004518624A5 - - Google Patents

Download PDF

Info

Publication number
JP2004518624A5
JP2004518624A5 JP2002526332A JP2002526332A JP2004518624A5 JP 2004518624 A5 JP2004518624 A5 JP 2004518624A5 JP 2002526332 A JP2002526332 A JP 2002526332A JP 2002526332 A JP2002526332 A JP 2002526332A JP 2004518624 A5 JP2004518624 A5 JP 2004518624A5
Authority
JP
Japan
Prior art keywords
medicament
compound
subject
administered
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002526332A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004518624A (ja
Filing date
Publication date
Priority claimed from PCT/US2001/002633 external-priority patent/WO2001055439A1/en
Priority claimed from US09/912,824 external-priority patent/US7138119B2/en
Application filed filed Critical
Publication of JP2004518624A publication Critical patent/JP2004518624A/ja
Publication of JP2004518624A5 publication Critical patent/JP2004518624A5/ja
Withdrawn legal-status Critical Current

Links

JP2002526332A 2000-09-15 2001-09-14 Hiv−1感染を阻害する組成物および方法 Withdrawn JP2004518624A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66321900A 2000-09-15 2000-09-15
PCT/US2001/002633 WO2001055439A1 (en) 2000-01-28 2001-01-26 Compositions and methods for inhibition of hiv-1 infection
US26673801P 2001-02-06 2001-02-06
US09/912,824 US7138119B2 (en) 2000-09-15 2001-07-25 Compositions and methods for inhibition of HIV-1 infection
PCT/US2001/028756 WO2002022077A2 (en) 2000-09-15 2001-09-14 Compositions and methods for inhibition of hiv-1 infection

Publications (2)

Publication Number Publication Date
JP2004518624A JP2004518624A (ja) 2004-06-24
JP2004518624A5 true JP2004518624A5 (https=) 2008-11-06

Family

ID=27485936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002526332A Withdrawn JP2004518624A (ja) 2000-09-15 2001-09-14 Hiv−1感染を阻害する組成物および方法

Country Status (6)

Country Link
US (2) US7138119B2 (https=)
EP (1) EP1322332A4 (https=)
JP (1) JP2004518624A (https=)
AU (2) AU9092501A (https=)
CA (1) CA2422275A1 (https=)
WO (1) WO2002022077A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU723158B2 (en) * 1995-06-07 2000-08-17 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of HIV-1 envelope glycoprotein-medicated cell
US7118859B2 (en) 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
AU2001247254A1 (en) * 2000-02-29 2001-09-12 Aaron Diamond Aids Research Centre Sulfated CCR5 peptides for HIV -1 infection
US7138119B2 (en) 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7060273B2 (en) 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US20020146415A1 (en) * 2001-04-06 2002-10-10 Olson William C. Methods for inhibiting HIV-1 infection
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
AU2004238263A1 (en) * 2003-05-06 2004-11-25 Syntonix Pharmaceuticals, Inc. Inhibition of drug binding to serum albumin
PL2298347T3 (pl) * 2003-05-06 2016-03-31 Bioverativ Therapeutics Inc Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
FI20040704A0 (fi) * 2004-05-21 2004-05-21 Ari Hinkkanen Replikatiivisen viruksen tai sen rekombinantin käyttö terapiassa
TW200720289A (en) 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
CA2616189C (en) * 2005-07-22 2019-03-26 Progenics Pharmaceuticals, Inc. Methods for reducing viral load in hiv-1-infected patients
EP2054086A1 (en) 2006-08-17 2009-05-06 F. Hoffmann-Roche AG A conjugate of an antibody against ccr5 and an antifusogenic peptide
TW200817438A (en) * 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
CN101516914A (zh) 2006-09-29 2009-08-26 霍夫曼-拉罗奇有限公司 针对ccr5的抗体及其应用
US20090143288A1 (en) * 2007-03-13 2009-06-04 Roche Palo Alto Llc Peptide-complement conjugates
WO2009014638A2 (en) * 2007-07-19 2009-01-29 Progenics Pharmaceuticals, Inc. Methods of inhibiting infection by diverse subtypes of drug-resistant hiv-1
US20100186234A1 (en) * 2009-01-28 2010-07-29 Yehuda Binder Electric shaver with imaging capability
US8637024B2 (en) 2010-11-12 2014-01-28 The Rockefeller University Fusion antibodies for HIV therapy
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
WO2014144549A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Factor ix polypeptide formulations
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
CA2932405A1 (en) * 2013-12-02 2015-06-11 Aaron Diamond Aids Research Center Improved hiv-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture
UY36990A (es) * 2015-11-21 2017-11-30 Fundació Privada Inst De Recerca De La Sida-Caixa (Irsicaixa) Derivados de anticuerpos contra el vih con actividad dual antiviral e inmunomodulatoria
EP3621649A2 (en) * 2017-05-10 2020-03-18 Albajuna Therapeutics, S.L. Fc-fusion protein derivatives with high dual hiv antiviral and immunomodulatory activity
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886743A (en) * 1985-04-24 1989-12-12 California Institute Of Technology Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5126433A (en) * 1986-08-21 1992-06-30 The Trustees Of Columbia University In The City Of New York Soluble forms of the t cell surface protein cd4
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5854400A (en) * 1987-05-29 1998-12-29 Tanox, Inc. Monoclonal antibodies which neutralize HIV-1 infection
US5215913A (en) * 1987-11-30 1993-06-01 Roger Williams General Hospital IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use
US5071964A (en) * 1988-05-04 1991-12-10 Dana-Farber Cancer Institute, Inc. Protein micelles
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
US5668149A (en) * 1990-01-26 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of human immunodeficiency virus-1 infectivity in human cells
WO1992001451A1 (en) 1990-06-12 1992-02-06 Board Of Regents, The University Of Texas System Method for killing hiv-infected cells
US5440021A (en) * 1991-03-29 1995-08-08 Chuntharapai; Anan Antibodies to human IL-8 type B receptor
US5817767A (en) * 1993-02-24 1998-10-06 Progenics Pharmaceuticals, Inc. Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same
US5449608A (en) * 1993-03-22 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services Parvovirus B19 receptor and parvovirus B19 detection
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US5464963A (en) * 1993-08-27 1995-11-07 Motoman Inc. Sealing arrangement for a laser enclosure
US5603933A (en) * 1993-08-31 1997-02-18 Board Of Regents, The University Of Texas CD4 peptides for binding to viral envelope proteins
US5504003A (en) * 1994-03-08 1996-04-02 Human Genome Sciences, Inc. Macrophage inflammatory protein-3 and -4
FR2727221B1 (fr) 1994-11-23 1996-12-27 Kodak Pathe Procede de communication d'informations numeriques et systeme pour la mise en oeuvre du procede
US6025154A (en) * 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
JPH10510719A (ja) 1995-06-06 1998-10-20 ヒューマン ジノーム サイエンシーズ,インコーポレイテッド ヒトgタンパク質ケモカインレセプターhdgnr10
US20040151719A1 (en) * 1995-06-06 2004-08-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US6743594B1 (en) * 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
EP1149582A3 (en) 1995-06-06 2003-12-10 Human Genome Sciences, Inc. Human G-protein chemokine receptor HDGNR10 (CCR5 receptor). Uses thereof
EP1146122A3 (en) 1995-06-06 2003-12-03 Human Genome Sciences, Inc. Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
AU723158B2 (en) * 1995-06-07 2000-08-17 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of HIV-1 envelope glycoprotein-medicated cell
US6265184B1 (en) * 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
US7118859B2 (en) * 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
WO1997026009A1 (en) 1996-01-17 1997-07-24 Progenics Pharmaceuticals, Inc. Compounds capable of inhibiting hiv-1 infection
DE69731373T2 (de) * 1996-03-01 2006-03-09 Euroscreen S.A. Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US6107019A (en) 1996-06-14 2000-08-22 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
EP0915969A4 (en) 1996-04-02 2002-04-17 Progenics Pharm Inc SUPPRESSION OF CD4 + CELL INFECTION BY HIV
US6258527B1 (en) * 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
WO1997045543A2 (en) * 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Cc chemokine receptor 5, antibodies thereto, transgenic animals
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
EP0956044A4 (en) 1996-06-14 2005-01-05 Progenics Pharm Inc USES OF A CHEMOKIN RECEPTOR TO INHIBIT HIV-1 INFECTION
WO1997049424A1 (en) 1996-06-25 1997-12-31 The Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
US5994515A (en) * 1996-06-25 1999-11-30 Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
US6528625B1 (en) * 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
US6100087A (en) * 1998-03-11 2000-08-08 City Of Hope Ribozymes targeted to human CCR5 mRNA
US6258782B1 (en) * 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
CA2355607A1 (en) 1998-12-16 2000-06-22 Progenics Pharmaceuticals, Inc. Anti-ccr5 antibody
US6692745B2 (en) 2000-01-28 2004-02-17 Arogenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
EP1263791A4 (en) * 2000-02-09 2004-07-07 Human Genome Sciences Inc HUMAN G-PROTEIN CHEMOKIN RECEPTOR HDGNR10 (CCR5 RECEPTOR)
AU2001247254A1 (en) * 2000-02-29 2001-09-12 Aaron Diamond Aids Research Centre Sulfated CCR5 peptides for HIV -1 infection
US7138119B2 (en) * 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
WO2002068608A2 (en) 2001-02-28 2002-09-06 Progenics Pharmaceuticals, Inc. Sulfated ccr5 peptides for hiv-1 infection
US20030003440A1 (en) * 2001-03-14 2003-01-02 Lucia Lopalco Novel CCR5 epitope and antibodies against it
US7060273B2 (en) * 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US20020146415A1 (en) 2001-04-06 2002-10-10 Olson William C. Methods for inhibiting HIV-1 infection
JP2004532224A (ja) * 2001-04-19 2004-10-21 ブリストル−マイヤーズ スクイブ カンパニー Hiv逆転写酵素阻害剤として有用な三環系化合物
US7393934B2 (en) * 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
NZ534947A (en) 2002-02-22 2008-03-28 Progenics Pharm Inc Anti-CCR5 antibody that binds to CCR5 on the surface of a human cell.
RU2353357C2 (ru) * 2003-05-16 2009-04-27 Юниверсити Оф Мэрилэнд Байотекнолоджи Инститьют Композиции для супрессии экспрессии ccr5 и способы их применения
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
EP1723178A4 (en) * 2004-03-12 2007-12-12 Human Genome Sciences Inc HUMAN G-PROTEIN CHEMOKIN RECEPTOR (CCR5) HDGNR10
CA2616189C (en) * 2005-07-22 2019-03-26 Progenics Pharmaceuticals, Inc. Methods for reducing viral load in hiv-1-infected patients

Similar Documents

Publication Publication Date Title
JP2004518624A5 (https=)
JP2022104941A (ja) ヒト化抗cd73抗体
JP6518199B2 (ja) Micaおよびmicbタンパク質に対する抗体
JP2020120689A5 (https=)
ES2346184T3 (es) Antagonistas de cd30 o cd30l para usar en el tratamiento de enfermedades antiinflamatorias cronicas y autoinmunes.
ES2290241T3 (es) Anticuerpos monoclonales contra el receptor de interferon, con actividad neutralizadora contra el interferon de tipo i.
RU2011110405A (ru) Агенты, связывающие рецептор frizzled и их применение
JP2020513809A5 (https=)
ES2274542T3 (es) Anticuerpos frente al receptor del interferon alfa/beta.
DK1347730T4 (da) Rekombinante anti-CD30-antistoffer og anvendelser deraf
WO1997043316A1 (en) Physiologically active molecules with extended half-lives and methods of using same
JP2005505256A5 (https=)
ES2926511T3 (es) Anticuerpos anti-CLEVER-1 humanizados y utilización de los mismos
RU2012133522A (ru) Новое применение соединений ил-1 бета
PL363071A1 (pl) Sposoby i kompozycje dla zmniejszenia replikacji HIV-1
US20210253713A1 (en) Antibodies targeting a complex comprising non-classical hla-i and neoantigen and their methods of use
KR20180012740A (ko) Psma에 결합하는 항체 치료제
JP2009524428A5 (https=)
CN115335405A (zh) 全人源抗人cd22的嵌合抗原受体及其应用
Chanh et al. Anti-idiotype-based vaccines against biological toxins
JP2002513802A5 (https=)
CN1946740B (zh) 抗人腱生蛋白单克隆抗体
WO1991010742A1 (en) Monoclonal antibody specific for non-immunodominant epitope of hiv proteins
OA10271A (en) Multiple branch peptide constructions for use against hiv
WO1993004693A1 (en) Synergistic inhibition of hiv-1