JP2004502441A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004502441A5 JP2004502441A5 JP2002508311A JP2002508311A JP2004502441A5 JP 2004502441 A5 JP2004502441 A5 JP 2004502441A5 JP 2002508311 A JP2002508311 A JP 2002508311A JP 2002508311 A JP2002508311 A JP 2002508311A JP 2004502441 A5 JP2004502441 A5 JP 2004502441A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- oligonucleotides
- oligonucleotide
- microarray
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 25
- 108091034117 Oligonucleotide Proteins 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 6
- 238000002493 microarray Methods 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000011534 incubation Methods 0.000 claims 3
- 108010058532 UTP-hexose-1-phosphate uridylyltransferase Proteins 0.000 claims 2
- 102000006321 UTP-hexose-1-phosphate uridylyltransferase Human genes 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000003205 genotyping method Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/613,006 US6913879B1 (en) | 2000-07-10 | 2000-07-10 | Microarray method of genotyping multiple samples at multiple LOCI |
| PCT/US2001/021163 WO2002003849A2 (en) | 2000-07-10 | 2001-07-03 | Microarray method of genotyping multiple samples at multiple loci |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502441A JP2004502441A (ja) | 2004-01-29 |
| JP2004502441A5 true JP2004502441A5 (https=) | 2005-04-14 |
| JP4175884B2 JP4175884B2 (ja) | 2008-11-05 |
Family
ID=24455485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002508311A Expired - Fee Related JP4175884B2 (ja) | 2000-07-10 | 2001-07-03 | 複数の遺伝子座で複数のサンプルを遺伝子タイピングするマイクロアレイ方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6913879B1 (https=) |
| EP (1) | EP1343911B1 (https=) |
| JP (1) | JP4175884B2 (https=) |
| KR (1) | KR100756015B1 (https=) |
| CN (1) | CN100520401C (https=) |
| AT (1) | ATE363543T1 (https=) |
| AU (2) | AU1874002A (https=) |
| CA (1) | CA2414105C (https=) |
| DE (1) | DE60128720T2 (https=) |
| IL (2) | IL153848A0 (https=) |
| IS (1) | IS2651B (https=) |
| NO (1) | NO20030101L (https=) |
| NZ (1) | NZ523560A (https=) |
| RU (1) | RU2003103771A (https=) |
| TW (1) | TWI280282B (https=) |
| WO (1) | WO2002003849A2 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10000001A1 (de) * | 2000-01-01 | 2001-07-19 | Agrobiogen Gmbh | DNA-Matrizes und deren Verwendung zur Untersuchung von Individuen einer Population |
| US6913879B1 (en) * | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
| GB0208364D0 (en) * | 2002-04-11 | 2002-05-22 | Sec Dep For The Home Departmen | Improvements in and relating to methods and apparatus for genotyping |
| AU2003283575A1 (en) * | 2002-11-14 | 2004-06-03 | John Nicholas Housby | Polymorphism assay |
| US7097070B2 (en) | 2003-08-15 | 2006-08-29 | Protedyne Corporation | Method and apparatus for handling small volume fluid samples |
| JP4458327B2 (ja) * | 2003-08-28 | 2010-04-28 | キヤノン株式会社 | 標的物質の定量方法および該方法に用いるプローブ担体 |
| US7108979B2 (en) * | 2003-09-03 | 2006-09-19 | Agilent Technologies, Inc. | Methods to detect cross-contamination between samples contacted with a multi-array substrate |
| US20080220420A1 (en) * | 2004-11-19 | 2008-09-11 | Shimadzu Corporation | Method of Detecting Gene Polymorphism, Method of Diagnosing, Apparatus Therefor, and Test Reagent Kit |
| RU2348695C2 (ru) | 2006-05-23 | 2009-03-10 | Закрытое акционерное общество "Молекулярно-медицинские технологии" | Дифференцирующий и специфический олигонуклеотиды для идентификации последовательностей днк инфекционных агентов в биологических материалах, способ видовой идентификации инфекционных агентов, биочип и набор для осуществления этого способа |
| GB0618514D0 (en) * | 2006-09-20 | 2006-11-01 | Univ Nottingham Trent | Method of detecting interactions on a microarray using nuclear magnetic resonance |
| DK2099935T3 (da) * | 2006-11-30 | 2014-04-07 | Univ California | Array for detektion af mikrober |
| EP2148885A4 (en) * | 2007-05-31 | 2010-12-15 | Monsanto Technology Llc | SOYBEAN POLYMORPHISMS AND METHOD FOR THEIR GENOTYPIZATION |
| EP2476763A3 (en) | 2007-08-29 | 2013-03-06 | Monsanto Technology LLC | Methods and compositions for breeding for preferred traits |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| WO2009132089A2 (en) | 2008-04-24 | 2009-10-29 | Monsanto Technology Llc | A method to identify asian soybean rust resistance quantitative trait loci in soybean and compositions thereof |
| US9393566B2 (en) | 2008-06-23 | 2016-07-19 | Canon U.S. Life Sciences, Inc. | System and method for temperature referencing for melt curve data collection |
| EP2425240A4 (en) | 2009-04-30 | 2012-12-12 | Good Start Genetics Inc | METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| US20100299773A1 (en) * | 2009-05-20 | 2010-11-25 | Monsanto Technology Llc | Methods and compositions for selecting an improved plant |
| BR112012001077A2 (pt) | 2009-07-16 | 2020-08-11 | The General Hospital Corporation | extração de ácido nucleico, métodos para avaliar a qualidade de uma extração de ácido nucleico e de uma amostra biológica, para ober ácido nucleico a partir de uma amostra biológica, para analisar rna de microvesículas e para diagnosticar e monitorar um indivíduo, e, kit |
| WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| JP6219721B2 (ja) | 2010-11-10 | 2017-10-25 | エキソソーム ダイアグノスティックス インコーポレイテッド | 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法 |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| US10172305B2 (en) | 2011-04-29 | 2019-01-08 | Monsanto Technology Llc | Diagnostic molecular markers for seed lot purity traits in soybeans |
| CA2835641C (en) | 2011-05-11 | 2019-05-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| EP3492606B1 (en) | 2011-08-22 | 2023-10-04 | Exosome Diagnostics, Inc. | Urine biomarkers |
| PT3517615T (pt) | 2011-08-31 | 2022-08-09 | Seminis Vegetable Seeds Inc | Métodos e composições para a firmeza da melancia |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| EP2776587A4 (en) | 2011-11-10 | 2015-07-15 | Exosome Diagnostics Inc | LIQUOR ASSAY |
| US20130184165A1 (en) * | 2012-01-13 | 2013-07-18 | Data2Bio | Genotyping by next-generation sequencing |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| CN104995311A (zh) | 2012-08-30 | 2015-10-21 | 外来体诊断公司 | 用于核酸测定的对照 |
| CA2887058C (en) | 2012-10-03 | 2022-02-22 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
| EP2917368A1 (en) | 2012-11-07 | 2015-09-16 | Good Start Genetics, Inc. | Methods and systems for identifying contamination in samples |
| GB201220924D0 (en) | 2012-11-21 | 2013-01-02 | Cancer Res Inst Royal | Materials and methods for determining susceptibility or predisposition to cancer |
| CA2892926C (en) * | 2012-12-03 | 2023-02-21 | Statens Serum Institut | Method of diagnosing galactosemia in neonatal screening |
| US10314253B2 (en) | 2012-12-04 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and compositions for watermelon sex expression |
| WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| US10294489B2 (en) | 2013-03-15 | 2019-05-21 | Board Of Trustees Of Southern Illinois University | Soybean resistant to cyst nematodes |
| US8847799B1 (en) | 2013-06-03 | 2014-09-30 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
| US10059999B2 (en) | 2013-06-10 | 2018-08-28 | Monsanto Technology Llc | Molecular markers associated with soybean tolerance to low iron growth conditions |
| AU2014305994B2 (en) | 2013-08-06 | 2019-02-21 | Exosome Diagnostics, Inc. | Urine biomarker cohorts, gene expression signatures, and methods of use thereof |
| NZ630628A (en) | 2013-10-08 | 2015-04-24 | Seminis Vegetable Seeds Inc | Methods and compositions for peronospora resistance in spinach |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US11041203B2 (en) | 2013-10-18 | 2021-06-22 | Molecular Loop Biosolutions, Inc. | Methods for assessing a genomic region of a subject |
| NZ735461A (en) | 2013-11-27 | 2020-05-29 | Seminis Vegetable Seeds Inc | Disease resistance loci in onion |
| BR112016019007B1 (pt) | 2014-02-21 | 2022-05-17 | Syngenta Participations Ag | Métodos para produzir uma planta de milho, que expressa vip3a ou germoplasma de milho com fertilidade masculina aumentada, programa de melhoramento, método para melhorar a produção de sementes de uma planta de milho que expressa vip3a, e programa de produção de sementes |
| NZ630710A (en) | 2014-02-27 | 2016-03-31 | Seminis Vegetable Seeds Inc | Compositions and methods for peronospora resistance in spinach |
| US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
| US10316369B2 (en) | 2014-06-27 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and assays for male sterile watermelon |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| US10429399B2 (en) | 2014-09-24 | 2019-10-01 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| EP3005862A1 (en) | 2014-10-10 | 2016-04-13 | Seminis Vegetable Seeds, Inc. | Melon plants with improved disease tolerance |
| EP4095261B1 (en) | 2015-01-06 | 2025-05-28 | Molecular Loop Biosciences, Inc. | Screening for structural variants |
| PL3289087T3 (pl) | 2015-04-28 | 2021-11-02 | Monsanto Technology Llc | Sposoby i kompozycje dla wytwarzania brachitycznych roślin kukurydzy |
| US10415101B2 (en) | 2015-04-30 | 2019-09-17 | Monsanto Technology Llc | Methods for producing canola plants with clubroot resistance and compositions thereof |
| WO2017031059A1 (en) | 2015-08-18 | 2017-02-23 | Monsanto Technology Llc | Methods for producing cotton plants with enhanced drought tolerance and compositions thereof |
| US10448595B2 (en) | 2015-09-03 | 2019-10-22 | Seminis Vegetable Seeds, Inc. | Downy mildew resistant lettuce plants |
| US10858709B2 (en) | 2015-09-10 | 2020-12-08 | Monsanto Technology Llc | Methods for producing corn plants with downy mildew resistance and compositions thereof |
| WO2017106731A1 (en) | 2015-12-18 | 2017-06-22 | Monsanto Technology Llc | Methods for producing corn plants with northern leaf blight resistance and compositions thereof |
| SG11201809005TA (en) | 2016-04-15 | 2018-11-29 | Exosome Diagnostics Inc | Plasma-based detection of anaplastic lymphoma kinase (alk) nucleic acids and alk fusion transcripts and uses thereof in diagnosis and treatment of cancer |
| AU2017263886B2 (en) | 2016-05-13 | 2023-11-09 | Exosome Diagnostics, Inc. | Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids |
| EP3496528A4 (en) | 2016-08-11 | 2020-03-18 | Monsanto Technology LLC | METHODS AND COMPOSITIONS FOR PRODUCING CORN PLANTS WITH RESISTANCE TO LATE FAILURE |
| AU2017232187B2 (en) | 2016-09-30 | 2023-11-09 | Seminis Vegetable Seeds, Inc. | Xanthomonas resistant brassica oleracea plants |
| US11396676B2 (en) | 2016-10-21 | 2022-07-26 | Exosome Diagnostics, Inc. | Sequencing and analysis of exosome associated nucleic acids |
| JP7280823B2 (ja) | 2016-11-30 | 2023-05-24 | エクソサム ダイアグノスティクス，インコーポレイティド | 非小細胞肺癌患者由来のエクソソームｒｎａ及び無細胞ｄｎａを使用して血漿中の変異を検出するための方法と組成物 |
| US20200149036A1 (en) | 2017-01-02 | 2020-05-14 | Exosome Diagnostics, Inc. | Methods to distinguish rna and dna in a combined preparation |
| US11899024B2 (en) | 2017-07-12 | 2024-02-13 | Exosome Diagnostics, Inc. | Treatment and diagnosis of parkinson's disease using isolated and enriched populations of biofluid-derived extracellular vesicles |
| US11268102B2 (en) | 2018-05-16 | 2022-03-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for identifying and selecting brachytic locus in solanaceae |
| WO2020106853A1 (en) | 2018-11-20 | 2020-05-28 | Exosome Diagnostics, Inc. | Compositions and methods for internal controls of microvesicle isolations |
| CA3126761C (en) | 2019-01-15 | 2023-01-10 | Seminis Vegetable Seeds, Inc. | Green bean plants with improved disease resistance |
| SG10202008262UA (en) | 2019-09-26 | 2021-04-29 | Seminis Vegetable Seeds Inc | Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1 |
| AU2021204717A1 (en) | 2020-07-15 | 2022-02-03 | Seminis Vegetable Seeds, Inc. | Green Bean Plants with Improved Disease Resistance |
| US20230193310A1 (en) | 2021-12-10 | 2023-06-22 | Seminis Vegetabe Seeds, Inc. | Lettuce plants having resistance to downy mildew |
| US20230404003A1 (en) | 2022-06-21 | 2023-12-21 | Seminis Vegetable Seeds, Inc. | Novel qtls conferring resistance to cucumber mosaic virus |
| MX2024004405A (es) | 2023-04-14 | 2024-11-08 | Seminis Vegetable Seeds Inc | Métodos y composiciones de resistencia a peronospora en la espinaca |
| WO2026059956A1 (en) | 2024-09-11 | 2026-03-19 | Seminis Vegetable Seeds, Inc. | Qtls conferring resistance to cucurbit aphid-borne yellow virus |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981783A (en) | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| WO1993021345A1 (en) | 1992-04-21 | 1993-10-28 | The Regents Of The University Of California | Multicolor in situ hybridization methods for genetic testing |
| US5403708A (en) | 1992-07-06 | 1995-04-04 | Brennan; Thomas M. | Methods and compositions for determining the sequence of nucleic acids |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5834181A (en) | 1994-07-28 | 1998-11-10 | Genzyme Corporation | High throughput screening method for sequences or genetic alterations in nucleic acids |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5958342A (en) | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
| AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
| US6013449A (en) | 1997-11-26 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
| US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| US6238869B1 (en) | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| AU6163399A (en) | 1998-09-25 | 2000-04-17 | Massachusetts Institute Of Technology | Methods and products related to genotyping and dna analysis |
| US6268147B1 (en) * | 1998-11-02 | 2001-07-31 | Kenneth Loren Beattie | Nucleic acid analysis using sequence-targeted tandem hybridization |
| WO2001061043A2 (en) * | 2000-02-16 | 2001-08-23 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
| US6913879B1 (en) * | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
-
2000
- 2000-07-10 US US09/613,006 patent/US6913879B1/en not_active Expired - Fee Related
-
2001
- 2001-07-03 WO PCT/US2001/021163 patent/WO2002003849A2/en not_active Ceased
- 2001-07-03 CA CA2414105A patent/CA2414105C/en not_active Expired - Fee Related
- 2001-07-03 KR KR1020037000360A patent/KR100756015B1/ko not_active Expired - Fee Related
- 2001-07-03 AT AT01984136T patent/ATE363543T1/de not_active IP Right Cessation
- 2001-07-03 AU AU1874002A patent/AU1874002A/xx active Pending
- 2001-07-03 DE DE60128720T patent/DE60128720T2/de not_active Expired - Lifetime
- 2001-07-03 EP EP01984136A patent/EP1343911B1/en not_active Expired - Lifetime
- 2001-07-03 IL IL15384801A patent/IL153848A0/xx unknown
- 2001-07-03 RU RU2003103771/13A patent/RU2003103771A/ru not_active Application Discontinuation
- 2001-07-03 CN CNB018139728A patent/CN100520401C/zh not_active Expired - Fee Related
- 2001-07-03 NZ NZ523560A patent/NZ523560A/en unknown
- 2001-07-03 JP JP2002508311A patent/JP4175884B2/ja not_active Expired - Fee Related
- 2001-07-03 AU AU2002218740A patent/AU2002218740B2/en not_active Ceased
- 2001-07-09 TW TW090116726A patent/TWI280282B/zh not_active IP Right Cessation
-
2003
- 2003-01-08 IL IL153848A patent/IL153848A/en not_active IP Right Cessation
- 2003-01-09 NO NO20030101A patent/NO20030101L/no not_active Application Discontinuation
- 2003-01-09 IS IS6674A patent/IS2651B/is unknown
-
2004
- 2004-11-05 US US10/981,829 patent/US20050153318A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004502441A5 (https=) | ||
| US10760123B2 (en) | Sequential sequencing | |
| US6306643B1 (en) | Methods of using an array of pooled probes in genetic analysis | |
| US6027880A (en) | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis | |
| US20040096853A1 (en) | Isothermal amplification of nucleic acids on a solid support | |
| JP2004531274A5 (https=) | ||
| US6221635B1 (en) | Methods for solid-phase amplification of DNA template (SPADT) using multiarrays | |
| CA2374406A1 (en) | Microarray-based analysis of polynucleotide sequence variations | |
| CA2414105A1 (en) | Microarray method of genotyping multiple samples at multiple loci | |
| JPH08510910A (ja) | ヒトゲノムの延長ヌクレオチド反復配列の直接検出 | |
| EP1151136A1 (en) | Method for detecting variant nucleotides using arms multiplex amplification | |
| CN102373265B (zh) | 一种检测遗传性耳聋的试剂盒 | |
| WO2000047767A1 (en) | Oligonucleotide array and methods of use | |
| JP2002525127A5 (https=) | ||
| Kwok et al. | Single‐molecule analysis for molecular haplotyping | |
| JP2007530026A (ja) | 核酸配列決定 | |
| CN108291254B (zh) | 用于检测单核苷酸多态性的试剂盒和方法 | |
| EP1620536A4 (en) | MOLECULAR HAPLOTPIZATION OF GENOMIC DNA | |
| Pastinen | Single nucleotide polymorphism genotyping using microarrays | |
| Brès et al. | New method for DNA microarrays development: applied to human platelet antigens polymorphisms | |
| JP4283578B2 (ja) | 不一致増幅物質を含むプローブ核酸を用いる標的配列の検出方法、プローブ核酸および標的配列検出用アッセイキット | |
| CA2393874C (en) | Method for selectively isolating a nucleic acid | |
| US20240167088A1 (en) | Methods and devices of generating clusters of amplicons | |
| WO2002079518A1 (en) | A method for genotyping individuals for multiple snps | |
| JP5530185B2 (ja) | 核酸検出方法及び核酸検出用キット |