JP2004501181A5 - - Google Patents
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- Publication number
- JP2004501181A5 JP2004501181A5 JP2002504977A JP2002504977A JP2004501181A5 JP 2004501181 A5 JP2004501181 A5 JP 2004501181A5 JP 2002504977 A JP2002504977 A JP 2002504977A JP 2002504977 A JP2002504977 A JP 2002504977A JP 2004501181 A5 JP2004501181 A5 JP 2004501181A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mucoadhesive
- pharmaceutically acceptable
- acceptable salt
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 17
- 230000003232 mucoadhesive effect Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000003589 local anesthetic agent Substances 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 229960003150 bupivacaine Drugs 0.000 description 1
- 229960002023 chloroprocaine Drugs 0.000 description 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
- 229960001747 cinchocaine Drugs 0.000 description 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 1
- 229960003976 etidocaine Drugs 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- 229960002409 mepivacaine Drugs 0.000 description 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960001549 ropivacaine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22216400P | 2000-06-26 | 2000-06-26 | |
| PCT/US2001/020322 WO2002000195A2 (en) | 2000-06-26 | 2001-06-26 | Methods and compositions for treating pain of the mucous membrane |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008163375A Division JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501181A JP2004501181A (ja) | 2004-01-15 |
| JP2004501181A5 true JP2004501181A5 (enExample) | 2008-08-14 |
Family
ID=22831130
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504977A Pending JP2004501181A (ja) | 2000-06-26 | 2001-06-26 | 粘膜の痛みを治療するための方法および組成物 |
| JP2008163375A Pending JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008163375A Pending JP2009001574A (ja) | 2000-06-26 | 2008-06-23 | 粘膜の痛みを治療するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20020013331A1 (enExample) |
| EP (1) | EP1296650B1 (enExample) |
| JP (2) | JP2004501181A (enExample) |
| AT (1) | ATE289802T1 (enExample) |
| AU (1) | AU2001270177A1 (enExample) |
| CA (1) | CA2413545A1 (enExample) |
| DE (1) | DE60109164T2 (enExample) |
| ES (1) | ES2239144T3 (enExample) |
| IL (2) | IL153656A0 (enExample) |
| PT (1) | PT1296650E (enExample) |
| WO (1) | WO2002000195A2 (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030158111A1 (en) * | 1999-10-01 | 2003-08-21 | David Bar-Or | Methods and products for oral care |
| US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US9616150B2 (en) * | 1999-10-29 | 2017-04-11 | Children's Hospital Los Angeles | Bone hemostasis method and materials |
| US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| JP4898073B2 (ja) | 2000-07-31 | 2012-03-14 | ニュコメデ ダンマルク アンパーツセルスカブ | 鼻内投与用フェンタニル組成物 |
| BRPI0115531B1 (pt) * | 2000-11-22 | 2015-10-13 | Rxkinetix Inc | composição terapêutica útil para o tratamento de mucosite em um local de mucosa como efeito colateral de terapia de câncer |
| US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US20030166732A1 (en) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
| US6602490B1 (en) * | 2002-03-04 | 2003-08-05 | Richard A. Cloonan | Dental cleaning formulation and manufacturing process |
| US7666876B2 (en) | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| GB0213869D0 (en) * | 2002-06-17 | 2002-07-31 | Arakis Ltd | The treatment of pain |
| EP1539132A4 (en) * | 2002-07-25 | 2007-10-31 | Advanced Life Sciences Inc | USE OF 2,3-ALKYLCARBONYLOXYBENZOIC ACIDS, DERIVATIVES THEREOF AND ANALOGS FOR THE TREATMENT OF TISSUES AND DYSFUNCTIONS, ALTERATIONS AND CELLULAR LESIONS IN MAMMALS |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| GB0300531D0 (en) * | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
| US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US20040213828A1 (en) * | 2003-04-23 | 2004-10-28 | Smith David J. | Pain relief lollipop compositions and methods |
| US20050266090A1 (en) * | 2003-04-29 | 2005-12-01 | Ales Prokop | Nanoparticular targeting and therapy |
| AU2004238285A1 (en) * | 2003-05-07 | 2004-11-25 | Dmi Biosciences, Inc | Oral care methods and products |
| US20050118261A1 (en) * | 2003-06-12 | 2005-06-02 | Oien Hal J. | Compositions and methods of administering doxepin to mucosal tissue |
| US7106483B2 (en) * | 2003-06-12 | 2006-09-12 | Ricoh Company, Limited | Optical scanner and image forming apparatus |
| GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
| US20050136116A1 (en) * | 2003-12-18 | 2005-06-23 | Keith Whitehead | Stabilized prednisolone sodium phosphate solutions |
| GB0330049D0 (en) * | 2003-12-24 | 2004-02-04 | Arakis Ltd | The treatment of neuropathic pain conditions |
| WO2005067865A1 (en) * | 2004-01-15 | 2005-07-28 | Oral Bioscience Pty. Limited | Oral anaesthetic gel |
| US20060115782A1 (en) * | 2004-11-30 | 2006-06-01 | Chunhua Li | Systems and methods for coating a dental appliance |
| US7766658B2 (en) * | 2004-11-30 | 2010-08-03 | Align Technology, Inc. | Systems and methods for intra-oral diagnosis |
| US20060115785A1 (en) | 2004-11-30 | 2006-06-01 | Chunhua Li | Systems and methods for intra-oral drug delivery |
| US7947508B2 (en) * | 2004-11-30 | 2011-05-24 | Align Technology, Inc. | Systems and methods for intra-oral diagnosis |
| US20090035385A1 (en) * | 2004-12-22 | 2009-02-05 | Drugtech Corporation | Compositions including iron |
| US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
| AU2005322305B2 (en) * | 2004-12-23 | 2010-09-16 | Roxro Pharma, Inc. | Therapeutic compositions for intranasal administration of ketorolac |
| US20080248090A1 (en) * | 2005-05-09 | 2008-10-09 | Sunnen Gerard V | Graduated concentration sodium chloride patches for the treatment of dental conditions |
| US20060252010A1 (en) * | 2005-05-09 | 2006-11-09 | Sunnen Gerard V | Sodium chloride pad for treatment of dental conditions |
| US20070020186A1 (en) * | 2005-07-22 | 2007-01-25 | Alpex Pharma S.A. | Solid dosage formulations of narcotic drugs having improved buccal adsorption |
| EP1749528A1 (en) | 2005-08-05 | 2007-02-07 | Pharma C S.A. | Pharmaceutical combinations containing a mu opioid agonist and an inhibitor of NO production |
| US8623334B1 (en) | 2005-09-29 | 2014-01-07 | Alan J. Wickenhauser | Topical anesthetic |
| US8263047B2 (en) * | 2005-09-29 | 2012-09-11 | Wickenhauser Alan J | Topical anesthetic for dental procedures |
| JP5217136B2 (ja) * | 2005-10-18 | 2013-06-19 | 大正製薬株式会社 | 直腸、尿道および膣適用用半固形状製剤。 |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| PT1965787E (pt) * | 2005-11-30 | 2013-07-05 | Endo Pharmaceuticals Inc | Tratamento de xerostomia com um antioxidante que contém enxofre |
| CA2645073A1 (en) * | 2006-03-08 | 2007-09-13 | Nuviance, Inc. | Transdermal drug delivery compositions and topical compositions for application on the skin |
| US20070231396A1 (en) * | 2006-03-29 | 2007-10-04 | Ray Charles D | Medication spray formulation |
| US20070248657A1 (en) * | 2006-04-25 | 2007-10-25 | Smith David J | Multi-compartment transdermal pain control device |
| US9155758B2 (en) * | 2006-08-01 | 2015-10-13 | Phrixus Pharmaceuticals, Inc. | Treatment of chronic progressive heart failure |
| WO2008060764A2 (en) * | 2006-10-05 | 2008-05-22 | Drugtech Corporation | Topical therapies for oral mucositis and other conditions |
| EP2129372A2 (en) * | 2007-03-02 | 2009-12-09 | Combe International Ltd. | Anesthetic spray composition |
| DE602007002154D1 (de) * | 2007-03-02 | 2009-10-08 | Flamek Corp Oue | Analgesische Zusammensetzung von topisch angewendeten, nichtsteroiden und entzündungshemmenden Arzneimitteln und Opioiden |
| EP2167044A1 (en) * | 2007-06-11 | 2010-03-31 | BioCure, Inc. | Mucoadhesive vesicles for drug delivery |
| US20090004248A1 (en) * | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
| US10512597B2 (en) * | 2007-09-06 | 2019-12-24 | Colgate-Palmolive Company | Controlled surface gelling of mucoadhesive polymers on oral mucosa |
| WO2009033684A1 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Minigastrin as a therapeutic agent |
| US20090093547A1 (en) * | 2007-10-09 | 2009-04-09 | Sciele Pharma, Inc. | Compositions and Methods for Treating Premature Ejaculation |
| US8865692B2 (en) * | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| WO2009064819A2 (en) * | 2007-11-13 | 2009-05-22 | Meritage Pharma, Inc. | Compositions for the treatment of gastrointestinal inflammation |
| EP2234625B8 (en) | 2007-12-17 | 2013-10-30 | The Regents of the University of Michigan | Compositions and methods for treating and preventing skeletal muscle deficiencies |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| EP2278999B1 (en) | 2008-04-21 | 2025-01-29 | Dompé farmaceutici S.p.A. | Auris formulations for treating otic diseases and conditions |
| US10092580B2 (en) | 2008-07-21 | 2018-10-09 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| DE102008037682A1 (de) | 2008-08-14 | 2010-04-08 | Strackharn, Klaus, Dr.med. | Verwendung äquipotenter Dosierungen von Lokalanästetika oder Derivaten davon zur Therapie chronischer Schmerzen |
| ES2811051T3 (es) | 2008-08-20 | 2021-03-10 | Univ California | Corticosteroides para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal |
| US20100221313A1 (en) * | 2008-12-01 | 2010-09-02 | Innovative Pharmaceuticals, Llc | Transdermal reservoir patch |
| CA2765033C (en) * | 2009-06-12 | 2020-07-14 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| US20110091618A1 (en) * | 2009-10-16 | 2011-04-21 | Frito-Lay North America, Inc. | Method for preventing oxidation and off flavors in high carotenoid foods |
| US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
| US20110117175A1 (en) * | 2009-11-18 | 2011-05-19 | Rosenbaum Richard J | Sweet analgesic for use in medical procedures or treatments |
| US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
| WO2011066201A2 (en) * | 2009-11-25 | 2011-06-03 | The Regents Of The University Of Michigan | Methods and systems for treating and preventing cardiac injury in dystrophic subjects |
| US20110150955A1 (en) | 2009-12-23 | 2011-06-23 | Shannon Elizabeth Klingman | Products and Methods for Reducing Malodor from the Pudendum |
| GB2477545B (en) * | 2010-02-05 | 2011-12-21 | Special Products Ltd | A liquid morphine composition for buccal administration |
| WO2012068147A1 (en) | 2010-11-15 | 2012-05-24 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| PL2701681T3 (pl) | 2011-04-29 | 2017-03-31 | Moberg Pharma Ab | Kompozycje farmaceutyczne zawierające środek miejscowo znieczulający, taki jak bupiwakaina, do podawania miejscowego do jamy ustnej lub gardła |
| US10022083B2 (en) | 2011-06-02 | 2018-07-17 | Abdulmohsen E. A. H. Al-Terki | Multiple oral and nasal surgical procedures method and kit |
| US8387798B1 (en) | 2012-04-27 | 2013-03-05 | Abdulmohsen E. A. H. Al-Terki | Mutiple oral and nasal surgical procedures method and kit |
| EP2819674A2 (en) * | 2012-02-27 | 2015-01-07 | Eye Therapies LLC | Compositions and methods for the treatment of migraine |
| FR2994844B1 (fr) * | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | Formulation gelifiante a base de ketamine |
| AU2012397211B2 (en) | 2012-12-20 | 2016-03-10 | Colgate-Palmolive Company | Oral care composition containing ionic liquids |
| DK2957282T3 (en) | 2013-02-07 | 2021-07-05 | Ingalfarma Spa | Oral antiseptic composition for treating oral mucositis |
| US20140371305A1 (en) * | 2013-06-14 | 2014-12-18 | Professional Compounding Centers Of America | Mupirocin Antibiotic Composition |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| CN106659676A (zh) * | 2014-11-05 | 2017-05-10 | 四川海思科制药有限公司 | 一种罗哌卡因缓释凝胶制剂及其制备与应用 |
| BR102014028009B1 (pt) | 2014-11-10 | 2023-04-18 | Universidade Federal De Pelotas | Composições filmogênicas para bioadesivos anestésicos tópicos (bats) para liberação controlada de princípios ativos e bioadesivos anestésicos tópicos |
| US9943074B2 (en) * | 2015-02-27 | 2018-04-17 | Stanley James Balgaard | Hinging and rotating coupler mechanism for avian spinning wing decoy |
| CN108699160A (zh) | 2015-07-28 | 2018-10-23 | 奥德纳米有限公司 | 用于治疗耳部病况的TrkB或TrkC激动剂组合物和方法 |
| US10821185B2 (en) | 2016-06-29 | 2020-11-03 | Otonomy Inc. | Triglyceride otic formulations and uses thereof |
| EP3628314B1 (en) | 2017-04-19 | 2023-07-26 | Otsuka Pharmaceutical Factory, Inc. | Olanexidine as anti-inflammatory agent |
| SMT202500279T1 (it) | 2018-01-09 | 2025-09-12 | Dompe Farm Spa | Formulazioni del fattore di crescita auricolare |
| WO2019154895A1 (en) | 2018-02-08 | 2019-08-15 | Strekin Ag | Gel formulation for preventing or treating hearing loss |
| US12157869B2 (en) | 2019-07-10 | 2024-12-03 | Jeffrey Dean Lindsay | Methods and compositions for reducing persistent odor in clothing and mitigating biofilms on various materials |
| MX2022009050A (es) | 2020-01-22 | 2022-10-27 | Seelos Therapeutics Inc | Reduccion de los efectos secundarios de los antagonistas de nmda. |
| JP6886551B1 (ja) * | 2020-11-06 | 2021-06-16 | 医療法人祥和会 | 歯科用の局所麻酔液 |
| WO2024227098A1 (en) * | 2023-04-27 | 2024-10-31 | Citius Pharmaceuticals, Inc. | Halobetasol propionate-lidocaine formulations |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051234A (en) | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| GB2042888B (en) | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
| US5225196A (en) | 1983-11-14 | 1993-07-06 | Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
| DE3522550A1 (de) | 1985-06-24 | 1987-01-02 | Klinge Co Chem Pharm Fab | Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung |
| US4764378A (en) | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
| US4855142A (en) | 1987-02-27 | 1989-08-08 | Ciba-Geigy Corporation | Pharmaceutical plaster |
| US5906810A (en) | 1987-03-17 | 1999-05-25 | Turner; Robert E. | Formulations and uses thereof in the prevention and treatment of oral lesions |
| IL87710A (en) * | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| US4900552A (en) | 1988-03-30 | 1990-02-13 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
| US5219861A (en) | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| US5292362A (en) | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| US5112620A (en) * | 1990-09-20 | 1992-05-12 | Mikkur, Inc. | Polyethylene glycol ointment for apthous ulcers |
| SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| US5662924A (en) | 1991-03-21 | 1997-09-02 | Smith & Nephew Plc | Wound dressing |
| IT1248014B (it) * | 1991-06-07 | 1995-01-05 | Inverni Della Beffa Spa | Preparazioni oftalmiche a rilascio protratto |
| US5206248A (en) * | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| US5972906A (en) | 1991-07-03 | 1999-10-26 | Hyal Pharmaceutical Corporation | Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof |
| US5589840A (en) | 1991-11-05 | 1996-12-31 | Seiko Epson Corporation | Wrist-type wireless instrument and antenna apparatus |
| GB9202464D0 (en) | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| DE4223004A1 (de) | 1992-07-13 | 1994-01-20 | Liedtke Pharmed Gmbh | Einzeldosierte halbfeste topische Arzneiform zur Transdermaltherapie |
| US5234929A (en) * | 1992-07-20 | 1993-08-10 | William Chelen | Method of treating motion sickness with anticonvulsants and antitussive agents |
| US5496811A (en) | 1992-08-28 | 1996-03-05 | Pharmos Corp. | Submicron emulsions as ocular drug delivery vehicles |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| US5817625A (en) | 1992-09-21 | 1998-10-06 | Oncogene Science, Inc. | Methods of prevention of oral mucositis with transforming growth factor beta |
| PT689438E (pt) | 1993-03-26 | 2003-10-31 | Franciscus Wilhelmus He Merkus | Composicoes farmaceuticas para administracao intranasal de apomorfina |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
| US5395318A (en) | 1994-01-24 | 1995-03-07 | Kaprelian; Edward K. | Method and apparatus for wound treatment |
| US5458879A (en) | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
| TW438601B (en) | 1994-05-18 | 2001-06-07 | Janssen Pharmaceutica Nv | New mucoadhesive emulsion compositions and a process for the preparation thereof |
| US5460826A (en) | 1994-06-27 | 1995-10-24 | Alza Corporation | Morphine therapy |
| IT1273742B (it) | 1994-08-01 | 1997-07-09 | Lifegroup Spa | Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose |
| DE19536246A1 (de) | 1994-09-30 | 1996-04-04 | Juergen Dr Regenold | Pharmazeutische Zusammensetzung |
| US5635540A (en) | 1994-12-09 | 1997-06-03 | The University Of Virginia Patent Foundation | Stabilized topical pharmaceutical preparations |
| US5626878A (en) * | 1995-01-10 | 1997-05-06 | Warner Lambert Company | Reduction of electrostatic forces between magnesium trisilicate adsorbates |
| US5866143A (en) | 1995-03-24 | 1999-02-02 | El Khoury And Stein, Ltd. | Topical application of opioid drugs such as morphine for relief of itching and skin disease |
| US5948389A (en) * | 1995-06-07 | 1999-09-07 | El Khoury & Stein, Ltd. | Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
| US5713852A (en) | 1995-06-07 | 1998-02-03 | Alza Corporation | Oral dosage and method for treating painful conditions of the oral cavity |
| JP2002516617A (ja) * | 1995-06-16 | 2002-06-04 | メドロジック グローバル コーポレイション | 反応性ポリマー網状構造体及びその使用法 |
| AU6385796A (en) * | 1995-06-16 | 1997-01-15 | Medlogic Global Corporation | Responsive polymer networks and methods of their use |
| US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US5849322A (en) | 1995-10-23 | 1998-12-15 | Theratech, Inc. | Compositions and methods for buccal delivery of pharmaceutical agents |
| FR2742989B1 (fr) | 1995-12-29 | 1998-01-23 | Adir | Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs |
| US5646151A (en) | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5667773A (en) | 1996-03-12 | 1997-09-16 | Adolor Corporation | Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith |
| US5972932A (en) * | 1996-03-25 | 1999-10-26 | Eli Lilly And Company | Anesthetic method and composition |
| US5747060A (en) | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| SE9601421D0 (sv) * | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
| US5846971A (en) | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| US5976573A (en) | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| EP0829481A1 (en) | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
| US5955097A (en) | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US5942243A (en) | 1996-11-12 | 1999-08-24 | Polytherapeutics, Inc. | Mucoadhesive compositions for administration of biologically active agents to animal tissue |
| WO1998026770A2 (en) * | 1996-12-16 | 1998-06-25 | Alcon Laboratories, Inc. | The topical use of kappa opioid agonists to treat ocular pain |
| US5811078A (en) | 1997-03-14 | 1998-09-22 | Adolor Corporation | Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith |
| US5798093A (en) | 1997-03-14 | 1998-08-25 | Adolor Corporation | Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith |
| US5855907A (en) | 1997-03-24 | 1999-01-05 | Peyman; Gholam A. | Method of treatment of migraine |
| US5760023A (en) | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| US5849762A (en) | 1997-07-14 | 1998-12-15 | Adolor Corporation | Peripherally acting anti-pruritic opiates |
| US5989535A (en) | 1997-08-15 | 1999-11-23 | Soma Technologies | Polymeric bioadhesive emulsions and suspensions and methods of treatment |
| DK1021204T3 (da) * | 1997-09-26 | 2006-05-08 | Noven Pharma | Bioadhæsive præparater og fremgangsmåder til topisk administration af aktive midler |
| US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
| RU2241458C2 (ru) * | 1997-12-22 | 2004-12-10 | Эро-Селтик, С.А. | Комбинации агонист/антагонист опиоида |
| EP1061924A1 (en) * | 1998-03-09 | 2000-12-27 | Trustees Of Tufts College | Treatment of compulsive behaviours in man and animals |
| KR100762018B1 (ko) | 1998-07-16 | 2007-10-04 | 메모리얼 슬로안-케터링 캔서 센터 | 오피오이드 진통제 및 엔엠디에이 길항제를 함유하는 국소조성물 |
| FR2781156B1 (fr) * | 1998-07-20 | 2001-06-29 | Lafon Labor | Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites |
| US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
-
2001
- 2001-06-25 US US09/888,466 patent/US20020013331A1/en not_active Abandoned
- 2001-06-26 IL IL15365601A patent/IL153656A0/xx unknown
- 2001-06-26 AT AT01948733T patent/ATE289802T1/de not_active IP Right Cessation
- 2001-06-26 PT PT01948733T patent/PT1296650E/pt unknown
- 2001-06-26 CA CA002413545A patent/CA2413545A1/en not_active Abandoned
- 2001-06-26 JP JP2002504977A patent/JP2004501181A/ja active Pending
- 2001-06-26 ES ES01948733T patent/ES2239144T3/es not_active Expired - Lifetime
- 2001-06-26 WO PCT/US2001/020322 patent/WO2002000195A2/en not_active Ceased
- 2001-06-26 AU AU2001270177A patent/AU2001270177A1/en not_active Abandoned
- 2001-06-26 EP EP01948733A patent/EP1296650B1/en not_active Expired - Lifetime
- 2001-06-26 DE DE60109164T patent/DE60109164T2/de not_active Expired - Fee Related
-
2002
- 2002-06-17 US US10/172,455 patent/US6509028B2/en not_active Expired - Lifetime
- 2002-12-25 IL IL153656A patent/IL153656A/en not_active IP Right Cessation
-
2003
- 2003-01-21 US US10/347,385 patent/US20030124190A1/en not_active Abandoned
-
2008
- 2008-06-23 JP JP2008163375A patent/JP2009001574A/ja active Pending
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