JP2004500303A5 - - Google Patents
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- Publication number
- JP2004500303A5 JP2004500303A5 JP2000517942A JP2000517942A JP2004500303A5 JP 2004500303 A5 JP2004500303 A5 JP 2004500303A5 JP 2000517942 A JP2000517942 A JP 2000517942A JP 2000517942 A JP2000517942 A JP 2000517942A JP 2004500303 A5 JP2004500303 A5 JP 2004500303A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fluoro
- hydrogen
- substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95773697A | 1997-10-24 | 1997-10-24 | |
| PCT/US1998/022585 WO1999021830A1 (en) | 1997-10-24 | 1998-10-26 | Process for stereoselective synthesis of prostacyclin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500303A JP2004500303A (ja) | 2004-01-08 |
| JP2004500303A5 true JP2004500303A5 (https=) | 2005-01-20 |
| JP3717053B2 JP3717053B2 (ja) | 2005-11-16 |
Family
ID=25500067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000517942A Expired - Fee Related JP3717053B2 (ja) | 1997-10-24 | 1998-10-26 | プロスタサイクリン誘導体の立体選択的合成法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1025083B1 (https=) |
| JP (1) | JP3717053B2 (https=) |
| KR (1) | KR100447022B1 (https=) |
| CN (1) | CN1264819C (https=) |
| AT (1) | ATE245628T1 (https=) |
| CA (2) | CA2307163C (https=) |
| DE (1) | DE69816642T2 (https=) |
| DK (1) | DK1025083T3 (https=) |
| ES (1) | ES2198760T3 (https=) |
| PT (1) | PT1025083E (https=) |
| WO (1) | WO1999021830A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2622471T5 (es) | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| CN103181893A (zh) | 2007-09-07 | 2013-07-03 | 联合治疗公司 | 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法 |
| CN101903324B (zh) | 2007-12-17 | 2013-07-03 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| JP6046034B2 (ja) | 2010-06-03 | 2016-12-14 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの製造 |
| CA2710725C (en) | 2010-07-22 | 2017-08-01 | Alphora Research Inc. | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation |
| CA2726599C (en) | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| US20130345471A1 (en) * | 2011-03-02 | 2013-12-26 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| US8524939B2 (en) * | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN103193627B (zh) * | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) * | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| JP2016517410A (ja) | 2013-03-14 | 2016-06-16 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの固体形態 |
| HU231186B1 (hu) | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE19708496A1 (de) * | 1997-03-03 | 1998-09-10 | Hoechst Ag | Verfahren zur enantionmerenreinen Anthracylin-Synthese |
-
1998
- 1998-10-26 WO PCT/US1998/022585 patent/WO1999021830A1/en not_active Ceased
- 1998-10-26 JP JP2000517942A patent/JP3717053B2/ja not_active Expired - Fee Related
- 1998-10-26 DK DK98953972T patent/DK1025083T3/da active
- 1998-10-26 KR KR10-2000-7004300A patent/KR100447022B1/ko not_active Expired - Lifetime
- 1998-10-26 CA CA2307163A patent/CA2307163C/en not_active Expired - Lifetime
- 1998-10-26 CA CA2847985A patent/CA2847985C/en not_active Expired - Lifetime
- 1998-10-26 PT PT98953972T patent/PT1025083E/pt unknown
- 1998-10-26 AT AT98953972T patent/ATE245628T1/de active
- 1998-10-26 CN CNB988126397A patent/CN1264819C/zh not_active Expired - Lifetime
- 1998-10-26 ES ES98953972T patent/ES2198760T3/es not_active Expired - Lifetime
- 1998-10-26 DE DE69816642T patent/DE69816642T2/de not_active Expired - Lifetime
- 1998-10-26 EP EP98953972A patent/EP1025083B1/en not_active Expired - Lifetime
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