JP2004194588A5 - - Google Patents
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- Publication number
- JP2004194588A5 JP2004194588A5 JP2002368360A JP2002368360A JP2004194588A5 JP 2004194588 A5 JP2004194588 A5 JP 2004194588A5 JP 2002368360 A JP2002368360 A JP 2002368360A JP 2002368360 A JP2002368360 A JP 2002368360A JP 2004194588 A5 JP2004194588 A5 JP 2004194588A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- nitrile hydratase
- gene
- subunit
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010024026 Nitrile hydratase Proteins 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 230000035772 mutation Effects 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- 230000000717 retained effect Effects 0.000 description 4
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002368360A JP2004194588A (ja) | 2002-12-19 | 2002-12-19 | 新規なニトリルヒドラターゼ |
| KR1020057011335A KR100825147B1 (ko) | 2002-12-19 | 2003-12-15 | 신규의 니트릴히드라타제 |
| CNA2003801069930A CN1729288A (zh) | 2002-12-19 | 2003-12-15 | 新型腈水合酶 |
| CN2012105742761A CN103103175A (zh) | 2002-12-19 | 2003-12-15 | 新型腈水合酶 |
| US10/539,560 US7595184B2 (en) | 2002-12-19 | 2003-12-15 | Nitrile hydratase variant |
| CN2012105742117A CN103215242A (zh) | 2002-12-19 | 2003-12-15 | 新型腈水合酶 |
| KR1020067026866A KR100785548B1 (ko) | 2002-12-19 | 2003-12-15 | 신규의 니트릴히드라타제 |
| EP03780752.6A EP1586637B1 (en) | 2002-12-19 | 2003-12-15 | Novel nitrile hydratase |
| KR1020077024119A KR100819228B1 (ko) | 2002-12-19 | 2003-12-15 | 신규의 니트릴히드라타제 |
| CN2010101672031A CN101892211A (zh) | 2002-12-19 | 2003-12-15 | 新型腈水合酶 |
| AU2003289338A AU2003289338A1 (en) | 2002-12-19 | 2003-12-15 | Novel nitrile hydratase |
| KR1020067026865A KR100785549B1 (ko) | 2002-12-19 | 2003-12-15 | 신규의 니트릴히드라타제 |
| PCT/JP2003/016014 WO2004056990A1 (ja) | 2002-12-19 | 2003-12-15 | 新規なニトリルヒドラターゼ |
| KR1020077015994A KR100794001B1 (ko) | 2002-12-19 | 2003-12-15 | 신규의 니트릴히드라타제 |
| AU2010202683A AU2010202683B2 (en) | 2002-12-19 | 2010-06-28 | Novel nitrile hydratase |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002368360A JP2004194588A (ja) | 2002-12-19 | 2002-12-19 | 新規なニトリルヒドラターゼ |
| JP2003379280 | 2003-11-10 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008265557A Division JP2009077722A (ja) | 2008-10-14 | 2008-10-14 | 新規なニトリルヒドラターゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004194588A JP2004194588A (ja) | 2004-07-15 |
| JP2004194588A5 true JP2004194588A5 (https=) | 2005-04-07 |
Family
ID=32684188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002368360A Pending JP2004194588A (ja) | 2002-12-19 | 2002-12-19 | 新規なニトリルヒドラターゼ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7595184B2 (https=) |
| EP (1) | EP1586637B1 (https=) |
| JP (1) | JP2004194588A (https=) |
| KR (5) | KR100819228B1 (https=) |
| CN (4) | CN101892211A (https=) |
| AU (2) | AU2003289338A1 (https=) |
| WO (1) | WO2004056990A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1767624B1 (en) * | 2004-05-26 | 2013-11-06 | Mitsubishi Rayon Co., Ltd. | Improved nitrile hydratase |
| EP1842907A1 (en) | 2006-04-07 | 2007-10-10 | B.R.A.I.N. Ag | A group of novel enantioselective microbial nitrile hydratases with broad substrate specificity |
| JP5069032B2 (ja) * | 2007-04-04 | 2012-11-07 | ダイヤニトリックス株式会社 | 改良型ニトリルヒドラターゼ |
| AU2009315170C1 (en) * | 2008-11-14 | 2014-10-23 | Mitsui Chemicals, Inc. | Nitrile hydratase variant |
| JP5532618B2 (ja) * | 2009-01-30 | 2014-06-25 | 三菱レイヨン株式会社 | 改良型ニトリルヒドラターゼ及びその製造方法 |
| WO2010125829A1 (ja) | 2009-04-30 | 2010-11-04 | 三井化学株式会社 | ３-メルカプトプロピオン酸またはその塩を製造する方法 |
| KR101734797B1 (ko) | 2011-05-31 | 2017-05-24 | 미쯔비시 케미컬 주식회사 | 개량형 니트릴 히드라타제 |
| US9193966B2 (en) | 2011-06-07 | 2015-11-24 | Mitsubishi Rayon Co., Ltd. | Nitrile hydratase |
| CN102517271B (zh) * | 2011-12-13 | 2013-04-03 | 清华大学 | 一种突变腈水合酶 |
| CN112941060B (zh) | 2014-06-06 | 2025-05-09 | 三菱化学株式会社 | 改良型腈水合酶 |
| CN104725476B (zh) * | 2015-03-31 | 2018-10-16 | 清华大学 | 一种钩状结构寡肽及其应用 |
| AU2017388945B2 (en) * | 2016-12-28 | 2021-06-03 | Mitsui Chemicals, Inc. | Mutant nitrile hydratase, nucleic acid coding said mutant nitrile hydratase, expression vector and transformant including said nucleic acid, production method for said mutant nitrile hydratase, and production method for amide compound |
| KR20190049109A (ko) | 2017-11-01 | 2019-05-09 | (주)대화정공 | 풀리 제조방법 |
| KR102068615B1 (ko) | 2019-04-08 | 2020-01-21 | (주)대화정공 | 자동차 댐퍼풀리 제조방법 |
| KR102146408B1 (ko) | 2019-04-08 | 2020-08-21 | (주)대화정공 | 단류선 개선을 위해 압연롤러를 이용한 자동차 댐퍼풀리 제조방법 |
| CN111690675B (zh) * | 2019-08-01 | 2022-07-19 | 安徽瑞邦生物科技有限公司 | 一种表达腈水合酶突变体的重组菌及其制备方法和应用 |
| CN114790452B (zh) * | 2020-11-20 | 2024-03-26 | 江南大学 | 一种对腈类化合物具有高稳定性的腈水合酶突变体 |
| CN112522245A (zh) * | 2020-12-09 | 2021-03-19 | 江南大学 | 一种腈水合酶氨基酸基序的改造及其应用 |
| CN113151234B (zh) * | 2021-04-13 | 2022-08-12 | 浙江工业大学 | 腈水合酶赖氨酸突变体hba-k2h2r、编码基因及应用 |
| CN113444714B (zh) * | 2021-07-29 | 2022-06-21 | 浙江大学杭州国际科创中心 | 一种β亚基突变的腈水合酶突变体及其应用 |
| CN114317507B (zh) * | 2021-11-30 | 2024-07-02 | 清华大学 | 腈水合酶突变体及其应用 |
| CN119343452A (zh) * | 2022-06-30 | 2025-01-21 | 三井化学株式会社 | 突变型腈水合酶、编码该突变型腈水合酶的核酸、含有该核酸的载体及转化体、该突变型腈水合酶的制造方法、及酰胺化合物的制造方法 |
| CN115772514B (zh) * | 2022-11-03 | 2025-03-04 | 无锡新晨宇生物工程有限公司 | 一种腈水合酶底物通道氨基酸基序的改造用于肉桂酰胺的制备 |
| EP4600368A1 (en) * | 2024-02-09 | 2025-08-13 | Adisseo France S.A.S. | A method for enzymatic production of an amide compound |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX169933B (es) | 1987-09-18 | 1993-08-02 | Hideaki Yamada | Procedimiento para la produccion biologica de amidas |
| AU627648B2 (en) | 1990-02-28 | 1992-08-27 | Teruhiko Beppu | Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| JPH0856684A (ja) | 1994-08-16 | 1996-03-05 | Mitsui Toatsu Chem Inc | 微生物によるアミド化合物の製造法 |
| JP3380133B2 (ja) | 1996-02-14 | 2003-02-24 | 三井化学株式会社 | 新規なニトリルヒドラターゼ |
| CN1240833C (zh) | 1996-02-14 | 2006-02-08 | 三井化学株式会社 | 新型腈水合酶 |
| JP3408737B2 (ja) * | 1998-03-16 | 2003-05-19 | 三井化学株式会社 | ニトリルヒドラターゼの活性化に関与するタンパク質及びそれをコードする遺伝子 |
-
2002
- 2002-12-19 JP JP2002368360A patent/JP2004194588A/ja active Pending
-
2003
- 2003-12-15 AU AU2003289338A patent/AU2003289338A1/en not_active Abandoned
- 2003-12-15 CN CN2010101672031A patent/CN101892211A/zh active Pending
- 2003-12-15 CN CNA2003801069930A patent/CN1729288A/zh active Pending
- 2003-12-15 KR KR1020077024119A patent/KR100819228B1/ko not_active Expired - Lifetime
- 2003-12-15 KR KR1020057011335A patent/KR100825147B1/ko not_active Expired - Lifetime
- 2003-12-15 KR KR1020077015994A patent/KR100794001B1/ko not_active Expired - Lifetime
- 2003-12-15 EP EP03780752.6A patent/EP1586637B1/en not_active Expired - Lifetime
- 2003-12-15 CN CN2012105742117A patent/CN103215242A/zh active Pending
- 2003-12-15 US US10/539,560 patent/US7595184B2/en not_active Expired - Lifetime
- 2003-12-15 KR KR1020067026866A patent/KR100785548B1/ko not_active Expired - Lifetime
- 2003-12-15 KR KR1020067026865A patent/KR100785549B1/ko not_active Expired - Lifetime
- 2003-12-15 WO PCT/JP2003/016014 patent/WO2004056990A1/ja not_active Ceased
- 2003-12-15 CN CN2012105742761A patent/CN103103175A/zh active Pending
-
2010
- 2010-06-28 AU AU2010202683A patent/AU2010202683B2/en not_active Expired