JP2004175807A5 - - Google Patents
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- Publication number
- JP2004175807A5 JP2004175807A5 JP2004027473A JP2004027473A JP2004175807A5 JP 2004175807 A5 JP2004175807 A5 JP 2004175807A5 JP 2004027473 A JP2004027473 A JP 2004027473A JP 2004027473 A JP2004027473 A JP 2004027473A JP 2004175807 A5 JP2004175807 A5 JP 2004175807A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- formula
- ring
- pharmaceutically acceptable
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000651 prodrug Substances 0.000 claims 33
- 229940002612 prodrug Drugs 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 33
- 239000012453 solvate Substances 0.000 claims 32
- 125000001424 substituent group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000002947 alkylene group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000003107 substituted aryl group Chemical group 0.000 claims 14
- 125000004429 atom Chemical group 0.000 claims 13
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- -1 hydroxy, mercapto Chemical group 0.000 claims 11
- 150000001540 azides Chemical class 0.000 claims 10
- 125000004450 alkenylene group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000004509 1,3,4-oxadiazol-2-yl group Chemical group O1C(=NN=C1)* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- YIBBMDDEXKBIAM-UHFFFAOYSA-M potassium;pentoxymethanedithioate Chemical compound [K+].CCCCCOC([S-])=S YIBBMDDEXKBIAM-UHFFFAOYSA-M 0.000 claims 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 4
- 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000005368 heteroarylthio group Chemical group 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000005164 aryl thioalkyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 2
- IRSGOAFJPADUHK-UHFFFAOYSA-N 1-(5-benzyl-8-hydroxyquinolin-7-yl)ethanone Chemical compound C=12C=CC=NC2=C(O)C(C(=O)C)=CC=1CC1=CC=CC=C1 IRSGOAFJPADUHK-UHFFFAOYSA-N 0.000 claims 1
- JZVCTHJWXFRYKG-UHFFFAOYSA-N 1-(8-hydroxy-5-phenylquinolin-7-yl)ethanone Chemical compound C=12C=CC=NC2=C(O)C(C(=O)C)=CC=1C1=CC=CC=C1 JZVCTHJWXFRYKG-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000003084 hiv integrase inhibitor Substances 0.000 claims 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
- LHKVDVFVJMYULK-UHFFFAOYSA-N nitrosylazide Chemical compound [N-]=[N+]=NN=O LHKVDVFVJMYULK-UHFFFAOYSA-N 0.000 claims 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000000464 thioxo group Chemical group S=* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004027473A JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001057037 | 2001-03-01 | ||
| JP2001243530 | 2001-08-10 | ||
| JP2001395022 | 2001-12-26 | ||
| JP2004027473A JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Division JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004175807A JP2004175807A (ja) | 2004-06-24 |
| JP2004175807A5 true JP2004175807A5 (cg-RX-API-DMAC10.html) | 2005-06-23 |
| JP4367762B2 JP4367762B2 (ja) | 2009-11-18 |
Family
ID=27346141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Expired - Fee Related JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
| JP2004027473A Expired - Fee Related JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Expired - Fee Related JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Country Status (16)
Families Citing this family (71)
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| NZ511255A (en) * | 2001-04-20 | 2003-12-19 | Deep Video Imaging Ltd | Multi-focal plane display having an optical retarder and a diffuser interposed between its screens |
| EP2181985B1 (en) | 2001-08-10 | 2011-10-26 | Shionogi & Co., Ltd. | Antiviral Agent |
| DE10145457A1 (de) * | 2001-09-14 | 2003-04-03 | Basf Ag | Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen |
| HRP20040373B1 (en) * | 2001-10-26 | 2012-09-30 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase |
| CA2463975A1 (en) * | 2001-10-26 | 2003-05-01 | Maria Emilia Di Francesco | Dihydroxypyrimidine carboxamide inhibitors of hiv integrase |
| JP4494020B2 (ja) * | 2002-03-15 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド |
| US7358249B2 (en) * | 2002-08-13 | 2008-04-15 | Shionogi & Co., Ltd. | Heterocyclic compounds having inhibitory activity against HIV integrase |
| PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
| EP3406596A1 (en) | 2002-11-20 | 2018-11-28 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| WO2004067531A1 (en) | 2003-01-27 | 2004-08-12 | Pfizer Inc. | Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use |
| JP2006528694A (ja) * | 2003-05-13 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | ナフチリジンインテグラーゼインヒビター |
| CN1318424C (zh) * | 2003-06-18 | 2007-05-30 | 复旦大学 | 芳杂环羧酸衍生物，制备方法及在药学上的应用 |
| CN1976915A (zh) | 2004-02-11 | 2007-06-06 | 史密丝克莱恩比彻姆公司 | Hiv整合酶抑制剂 |
| KR20070026414A (ko) * | 2004-03-09 | 2007-03-08 | 머크 앤드 캄파니 인코포레이티드 | Ｈｉｖ 인테그라제 억제제 |
| EP1756103A2 (en) | 2004-04-26 | 2007-02-28 | Pfizer, Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
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| US8633219B2 (en) | 2004-05-21 | 2014-01-21 | Japan Tobacco Inc. | Combination therapy |
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| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| CA2803842C (en) | 2010-06-30 | 2020-01-07 | Fujifilm Corporation | Nicotinamide derivative or salt thereof as syk-inhibitors |
| US8633200B2 (en) * | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2640705A2 (en) | 2010-11-15 | 2013-09-25 | Katholieke Universiteit Leuven | Novel antiviral compounds |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
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| CN105906563B (zh) * | 2014-11-10 | 2019-01-22 | 苏州康润医药有限公司 | 7，8-二氟喹啉-3-甲酸的合成方法 |
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| KR102884803B1 (ko) | 2018-06-01 | 2025-11-12 | 인사이트 코포레이션 | Pi3k 관련 장애의 치료를 위한 투여 요법 |
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| US6841558B2 (en) | 2000-10-12 | 2005-01-11 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors |
| WO2002030426A1 (en) | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
| WO2002036734A2 (en) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
| HUP0302367A2 (hu) | 2000-10-12 | 2003-11-28 | Merck & Co., Inc. | HIV Integráz inhibitorokként hasznos aza- és poliazanaftalenil-karboxamidok, ezeket tartalmazó gyógyszerkészítmények |
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2002
- 2002-02-27 IL IL15763802A patent/IL157638A0/xx unknown
- 2002-02-27 PL PL02365027A patent/PL365027A1/xx not_active Application Discontinuation
- 2002-02-27 CN CN028089219A patent/CN1659143A/zh active Pending
- 2002-02-27 EP EP02701583A patent/EP1375486B1/en not_active Expired - Lifetime
- 2002-02-27 EP EP08166487A patent/EP2033952B1/en not_active Expired - Lifetime
- 2002-02-27 WO PCT/JP2002/001778 patent/WO2002070486A1/ja not_active Ceased
- 2002-02-27 MX MXPA03007765A patent/MXPA03007765A/es unknown
- 2002-02-27 US US10/469,364 patent/US7148237B2/en not_active Expired - Fee Related
- 2002-02-27 AT AT02701583T patent/ATE411292T1/de not_active IP Right Cessation
- 2002-02-27 CA CA002439666A patent/CA2439666A1/en not_active Abandoned
- 2002-02-27 JP JP2002569806A patent/JP3616628B2/ja not_active Expired - Fee Related
- 2002-02-27 KR KR10-2003-7011406A patent/KR20030078958A/ko not_active Withdrawn
- 2002-02-27 HU HU0400175A patent/HUP0400175A2/hu unknown
- 2002-02-27 BR BR0207809-0A patent/BR0207809A/pt not_active Application Discontinuation
- 2002-02-27 CZ CZ20032332A patent/CZ20032332A3/cs unknown
- 2002-02-27 DE DE60229364T patent/DE60229364D1/de not_active Expired - Lifetime
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2003
- 2003-08-29 NO NO20033848A patent/NO20033848L/no not_active Application Discontinuation
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2004
- 2004-02-04 JP JP2004027473A patent/JP4367762B2/ja not_active Expired - Fee Related
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2006
- 2006-08-08 US US11/500,387 patent/US7759372B2/en not_active Expired - Fee Related