JP2003535128A5 - - Google Patents
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- Publication number
- JP2003535128A5 JP2003535128A5 JP2002501422A JP2002501422A JP2003535128A5 JP 2003535128 A5 JP2003535128 A5 JP 2003535128A5 JP 2002501422 A JP2002501422 A JP 2002501422A JP 2002501422 A JP2002501422 A JP 2002501422A JP 2003535128 A5 JP2003535128 A5 JP 2003535128A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- cooh
- independently
- cooc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 18
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- -1 cyano, nitro, amino Chemical group 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- JMQDNLCNCDSHNC-UHFFFAOYSA-N n-piperidin-4-ylbenzamide Chemical class C=1C=CC=CC=1C(=O)NC1CCNCC1 JMQDNLCNCDSHNC-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical group [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical class [H]S* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20992600P | 2000-06-07 | 2000-06-07 | |
| US60/209,926 | 2000-06-07 | ||
| PCT/US2001/018365 WO2001093849A2 (en) | 2000-06-07 | 2001-06-07 | Treatment of gastroesophageal reflux disease using piperidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003535128A JP2003535128A (ja) | 2003-11-25 |
| JP2003535128A5 true JP2003535128A5 (https=) | 2010-06-03 |
| JP4584534B2 JP4584534B2 (ja) | 2010-11-24 |
Family
ID=22780902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501422A Expired - Fee Related JP4584534B2 (ja) | 2000-06-07 | 2001-06-07 | 胃食道逆流性疾患の治療のための材料 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6552046B2 (https=) |
| EP (1) | EP1296684A2 (https=) |
| JP (1) | JP4584534B2 (https=) |
| AU (2) | AU2001275326C1 (https=) |
| CA (1) | CA2410939C (https=) |
| WO (1) | WO2001093849A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821285B2 (en) | 1999-06-22 | 2004-11-23 | Ndo Surgical, Inc. | Tissue reconfiguration |
| US7846180B2 (en) | 1999-06-22 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Tissue fixation devices and methods of fixing tissue |
| US6663639B1 (en) * | 1999-06-22 | 2003-12-16 | Ndo Surgical, Inc. | Methods and devices for tissue reconfiguration |
| US8287554B2 (en) * | 1999-06-22 | 2012-10-16 | Ethicon Endo-Surgery, Inc. | Method and devices for tissue reconfiguration |
| US6835200B2 (en) | 1999-06-22 | 2004-12-28 | Ndo Surgical. Inc. | Method and devices for tissue reconfiguration |
| US6750238B1 (en) | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
| US7049326B2 (en) | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| BRPI0414046A (pt) * | 2003-08-29 | 2006-10-24 | Dynogen Pharmaceuticals Inc | método de tratamento de um distúrbio de motilidade gastrintestinal, de tratamento de "gerd", de "gerd" noturno, composição farmacêutica, kit que compreende um composto e método para aumentar a motilidade esofágica em um paciente |
| JP4740152B2 (ja) * | 2003-12-23 | 2011-08-03 | セロドス アクスイェ セルスカブ | 末梢性５−ｈｔ受容体の修飾因子 |
| DK2194053T3 (da) | 2004-01-07 | 2013-07-01 | Armetheon Inc | Methoxypiperidinderivater til brug i behandling af gastrointestinale forstyrrelser og forstyrrelser i centralnervesystemet. |
| US8138204B2 (en) * | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| MY147756A (en) * | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| RU2418798C2 (ru) | 2005-08-31 | 2011-05-20 | Арикс Терапьютикс, Инк. | Способы синтеза и промежуточные соединения при синтезе стереоизомерных соединений, пригодных для лечения желудочно-кишечных расстройств и расстройств центральной нервной системы |
| US20080085915A1 (en) * | 2006-06-23 | 2008-04-10 | Cyrus Becker | Compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| KR100976063B1 (ko) * | 2007-03-16 | 2010-08-17 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
| US8852216B2 (en) | 2007-03-23 | 2014-10-07 | Ethicon Endo-Surgery, Inc. | Tissue approximation methods |
| KR20100026641A (ko) * | 2008-09-01 | 2010-03-10 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
| ES2525515T3 (es) * | 2010-09-01 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Antagonistas del receptor 5-HT2B |
| JP6260531B2 (ja) | 2012-05-17 | 2018-01-17 | Jsr株式会社 | 酸拡散制御剤、感放射線性樹脂組成物及びレジストパターン形成方法 |
| US10570127B1 (en) | 2018-11-05 | 2020-02-25 | Renexxion, Llc | Material and methods for the treatment of gastro-intestinal disorders |
| CN112816528B (zh) * | 2021-02-01 | 2024-04-09 | 合肥艾创微电子科技有限公司 | 一种感知存储集成式仿生触觉纤维及其制备方法 |
| CN112966411B (zh) * | 2021-02-07 | 2022-05-24 | 华南理工大学 | 一种基于体代表单元应力的医疗植入件及制备方法与应用 |
| CN113581374B (zh) * | 2021-08-25 | 2023-01-10 | 杭州海斗量海洋仪器有限公司 | 一种用于防护监测设备的浮标 |
| CN115935635B (zh) * | 2022-11-29 | 2024-02-27 | 上海玫克生储能科技有限公司 | 基于电化学模型的锂电池路端电压计算方法、装置及介质 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE35550B1 (en) * | 1970-09-03 | 1976-03-18 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and -hydropyridine derivatives |
| GB1425706A (en) * | 1972-06-30 | 1976-02-18 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US4962115A (en) | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| US5057525A (en) | 1981-10-01 | 1991-10-15 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| JP3104142B2 (ja) * | 1991-02-15 | 2000-10-30 | 北陸製薬株式会社 | ベンズアミド誘導体 |
| US5395832A (en) | 1991-02-15 | 1995-03-07 | Hokuriku Seiyaku Co., Ltd. | Benzamide derivatives |
| TW243449B (https=) * | 1991-02-15 | 1995-03-21 | Hokuriku Pharmaceutical | |
| IT1260485B (it) * | 1992-05-29 | 1996-04-09 | Procedimento e dispositivo per il trattamento dell'obesita' di un paziente | |
| NZ257545A (en) * | 1992-11-05 | 1997-01-29 | Smithkline Beecham Plc | Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions |
| TR200000020T2 (tr) * | 1997-07-11 | 2000-09-21 | Janssen Pharmaceutica N.V. | 5-HT3 ve 5-HT4 aracılı bozuklar için faydalı (+)-norsisaprit. |
| JPH11292846A (ja) * | 1998-02-10 | 1999-10-26 | Hokuriku Seiyaku Co Ltd | ベンズアミド誘導体及びそれを含有する医薬 |
| JP3398111B2 (ja) * | 1999-02-04 | 2003-04-21 | 北陸製薬株式会社 | ベンズアミド誘導体及びそれを含有する医薬 |
| AR022338A1 (es) | 1999-02-04 | 2002-09-04 | Hokuriku Pharmaceutical | Un compuesto de benzamida, medicamento que lo contiene, y uso para la manufactura de un medicamento para el tratamiento o prevencion de una enfermedad digestiva o para mejorar la movilidad del tracto gastrointestinal. |
| DE19933926A1 (de) | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Pharma | Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US20040092511A1 (en) * | 1999-12-10 | 2004-05-13 | Billstein Stephan Anthony | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders |
-
2001
- 2001-06-07 AU AU2001275326A patent/AU2001275326C1/en not_active Ceased
- 2001-06-07 EP EP01942028A patent/EP1296684A2/en not_active Ceased
- 2001-06-07 JP JP2002501422A patent/JP4584534B2/ja not_active Expired - Fee Related
- 2001-06-07 AU AU7532601A patent/AU7532601A/xx active Pending
- 2001-06-07 CA CA2410939A patent/CA2410939C/en not_active Expired - Fee Related
- 2001-06-07 WO PCT/US2001/018365 patent/WO2001093849A2/en not_active Ceased
- 2001-06-07 US US09/876,698 patent/US6552046B2/en not_active Ceased
-
2003
- 2003-04-18 US US10/418,842 patent/US20030216387A1/en not_active Abandoned
-
2007
- 2007-12-21 US US11/962,592 patent/USRE42412E1/en not_active Expired - Lifetime
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