JP2003533532A5 - - Google Patents
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- JP2003533532A5 JP2003533532A5 JP2001584288A JP2001584288A JP2003533532A5 JP 2003533532 A5 JP2003533532 A5 JP 2003533532A5 JP 2001584288 A JP2001584288 A JP 2001584288A JP 2001584288 A JP2001584288 A JP 2001584288A JP 2003533532 A5 JP2003533532 A5 JP 2003533532A5
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- JP
- Japan
- Prior art keywords
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- compound
- formula
- alkyl
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 Cc(cc(CC(C1)N(C)C2[C@](C3)N1C(*)c1c3c(*)c(C)c3c1OCO3)c2c1*)c1OC Chemical compound Cc(cc(CC(C1)N(C)C2[C@](C3)N1C(*)c1c3c(*)c(C)c3c1OCO3)c2c1*)c1OC 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBPCT/GB00/01852 | 2000-05-15 | ||
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| GB00/01852 | 2000-05-15 | ||
| PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003533532A JP2003533532A (ja) | 2003-11-11 |
| JP2003533532A5 true JP2003533532A5 (https=) | 2008-07-03 |
| JP5008812B2 JP5008812B2 (ja) | 2012-08-22 |
Family
ID=29415238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001584288A Expired - Lifetime JP5008812B2 (ja) | 2000-05-15 | 2001-05-15 | Ｅｔ−７４３の抗腫瘍性類似体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7247629B2 (https=) |
| JP (1) | JP5008812B2 (https=) |
| AT (1) | ATE282624T1 (https=) |
| BG (1) | BG65897B1 (https=) |
| CA (1) | CA2405002C (https=) |
| HU (1) | HU230699B1 (https=) |
| IL (1) | IL152126A (https=) |
| MX (1) | MXPA02011319A (https=) |
| SK (1) | SK287833B6 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1077698B1 (en) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| JP5219323B2 (ja) * | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| EP1365808B1 (en) * | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| DK1827500T3 (da) * | 2004-10-26 | 2009-08-31 | Pharma Mar Sa | Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| US20090325971A1 (en) * | 2005-03-02 | 2009-12-31 | The Trustees Of Columbia University In The City Of New York | Pentacyclic Alkaloid Compounds and Methods of Use Thereof |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| CA2724325A1 (en) * | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| CA2724206A1 (en) * | 2008-05-16 | 2009-11-19 | Pharma Mar S.A. | Multiple myeloma treatments |
| CN107033164A (zh) | 2010-05-25 | 2017-08-11 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| ME02395B (me) | 2010-11-12 | 2016-09-20 | Pharma Mar Sa | Kombinovana terapija sa antitumorskim alkaloidima |
| GB2519773C (en) * | 2013-10-29 | 2018-01-03 | Solus Tech Limited | Mode-locking semiconductor disk laser (SDL) |
| CN107522698B (zh) * | 2016-06-20 | 2021-12-28 | 浙江海正药业股份有限公司 | 一种曲贝替定的制备方法及其中间体 |
| HRP20231233T1 (hr) * | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| JP2023503318A (ja) | 2019-11-21 | 2023-01-27 | ファルマ、マール、ソシエダード、アノニマ | ルルビネクテジン製剤で小細胞肺がんを処置する方法 |
| US20240197726A1 (en) * | 2021-03-03 | 2024-06-20 | The University Of Tokyo | Novel tetrahydroisoquinoline alkaloid compound containing macrocycle |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| JP2562162B2 (ja) | 1986-06-09 | 1996-12-11 | ユニバーシティ・オブ・イリノイ | エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０ |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| DE3635711A1 (de) | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| EP0309744A3 (de) * | 1987-09-29 | 1989-06-28 | Siemens Aktiengesellschaft | Anordnung mit einem flächig sich erstreckenden Dünnfilmwellenleiter |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| ATE203534T1 (de) * | 1996-01-15 | 2001-08-15 | Janssen Pharmaceutica Nv | Angiogenesis hemmende pyridazinamine |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| CN1157189C (zh) | 1998-04-06 | 2004-07-14 | 伊利诺伊大学评议会 | 半合成海鞘素 |
| EP1076486B1 (en) | 1998-05-05 | 2005-08-31 | Pharma Mar, S.A. | Culture of sessile marine animals |
| EP1077698B1 (en) | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| AU1325001A (en) * | 1999-07-23 | 2001-02-13 | American Superconductor Corporation | Methods of making a superconductor |
| JP2003520801A (ja) | 2000-01-19 | 2003-07-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成 |
| US6815544B2 (en) | 2000-02-11 | 2004-11-09 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
| US6569859B1 (en) | 2000-02-22 | 2003-05-27 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| JP5219323B2 (ja) | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| US20020137663A1 (en) | 2000-08-11 | 2002-09-26 | Forman Barry M. | The anti-neoplastic agent ET-743 inhibits trans activation by SXR |
| EP1365808B1 (en) | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| WO2002064843A1 (en) | 2001-02-09 | 2002-08-22 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| BR0213424A (pt) | 2001-10-19 | 2004-12-14 | Pharma Mar Sa | Uso aperfeiçoado de composto antitumoral na terapia contra câncer |
| US20040019027A1 (en) | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0218813D0 (en) | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | DNA sequences from an endosymbiont and their uses |
| GB0312407D0 (en) | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| DE602004016376D1 (de) | 2003-11-13 | 2008-10-16 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs |
| GB0326486D0 (en) | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| CA2545054A1 (en) | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| AU2005288696A1 (en) | 2004-09-28 | 2006-04-06 | Pharma Mar S.A., Sociedad Unipersonal | Ecteinascidin compounds as anti -inflammatory agents |
| DK1827500T3 (da) | 2004-10-26 | 2009-08-31 | Pharma Mar Sa | Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| JP2011500046A (ja) | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Ｅｔ−７４３治療のための予後分子マーカー |
| CA2724325A1 (en) | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| CA2724206A1 (en) | 2008-05-16 | 2009-11-19 | Pharma Mar S.A. | Multiple myeloma treatments |
-
2000
- 2000-05-15 MX MXPA02011319A patent/MXPA02011319A/es active IP Right Grant
-
2001
- 2001-05-15 HU HUP0302327A patent/HU230699B1/hu unknown
- 2001-05-15 CA CA2405002A patent/CA2405002C/en not_active Expired - Lifetime
- 2001-05-15 IL IL152126A patent/IL152126A/en active IP Right Grant
- 2001-05-15 US US10/257,857 patent/US7247629B2/en not_active Expired - Lifetime
- 2001-05-15 SK SK1601-2002A patent/SK287833B6/sk not_active IP Right Cessation
- 2001-05-15 JP JP2001584288A patent/JP5008812B2/ja not_active Expired - Lifetime
- 2001-05-15 AT AT01929813T patent/ATE282624T1/de active
-
2002
- 2002-11-20 BG BG107302A patent/BG65897B1/bg unknown
-
2005
- 2005-01-26 US US11/045,595 patent/US7410969B2/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/645,356 patent/US8012975B2/en not_active Expired - Fee Related
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