MXPA02011319A - Analogos antitumorales de ecteinascidina 743. - Google Patents
Analogos antitumorales de ecteinascidina 743.Info
- Publication number
- MXPA02011319A MXPA02011319A MXPA02011319A MXPA02011319A MXPA02011319A MX PA02011319 A MXPA02011319 A MX PA02011319A MX PA02011319 A MXPA02011319 A MX PA02011319A MX PA02011319 A MXPA02011319 A MX PA02011319A MX PA02011319 A MXPA02011319 A MX PA02011319A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- optionally protected
- derivatised
- antitumoral
- analogs
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 abstract 1
- -1 hydroxymethylene group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02011319A true MXPA02011319A (es) | 2003-06-06 |
Family
ID=29415238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02011319A MXPA02011319A (es) | 2000-05-15 | 2000-05-15 | Analogos antitumorales de ecteinascidina 743. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7247629B2 (https=) |
| JP (1) | JP5008812B2 (https=) |
| AT (1) | ATE282624T1 (https=) |
| BG (1) | BG65897B1 (https=) |
| CA (1) | CA2405002C (https=) |
| HU (1) | HU230699B1 (https=) |
| IL (1) | IL152126A (https=) |
| MX (1) | MXPA02011319A (https=) |
| SK (1) | SK287833B6 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1077698B1 (en) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| JP5219323B2 (ja) * | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| EP1365808B1 (en) * | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| DK1827500T3 (da) * | 2004-10-26 | 2009-08-31 | Pharma Mar Sa | Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| US20090325971A1 (en) * | 2005-03-02 | 2009-12-31 | The Trustees Of Columbia University In The City Of New York | Pentacyclic Alkaloid Compounds and Methods of Use Thereof |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| CA2724325A1 (en) * | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| CA2724206A1 (en) * | 2008-05-16 | 2009-11-19 | Pharma Mar S.A. | Multiple myeloma treatments |
| CN107033164A (zh) | 2010-05-25 | 2017-08-11 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| ME02395B (me) | 2010-11-12 | 2016-09-20 | Pharma Mar Sa | Kombinovana terapija sa antitumorskim alkaloidima |
| GB2519773C (en) * | 2013-10-29 | 2018-01-03 | Solus Tech Limited | Mode-locking semiconductor disk laser (SDL) |
| CN107522698B (zh) * | 2016-06-20 | 2021-12-28 | 浙江海正药业股份有限公司 | 一种曲贝替定的制备方法及其中间体 |
| HRP20231233T1 (hr) * | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| JP2023503318A (ja) | 2019-11-21 | 2023-01-27 | ファルマ、マール、ソシエダード、アノニマ | ルルビネクテジン製剤で小細胞肺がんを処置する方法 |
| US20240197726A1 (en) * | 2021-03-03 | 2024-06-20 | The University Of Tokyo | Novel tetrahydroisoquinoline alkaloid compound containing macrocycle |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| JP2562162B2 (ja) | 1986-06-09 | 1996-12-11 | ユニバーシティ・オブ・イリノイ | エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０ |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| DE3635711A1 (de) | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| EP0309744A3 (de) * | 1987-09-29 | 1989-06-28 | Siemens Aktiengesellschaft | Anordnung mit einem flächig sich erstreckenden Dünnfilmwellenleiter |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| ATE203534T1 (de) * | 1996-01-15 | 2001-08-15 | Janssen Pharmaceutica Nv | Angiogenesis hemmende pyridazinamine |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| CN1157189C (zh) | 1998-04-06 | 2004-07-14 | 伊利诺伊大学评议会 | 半合成海鞘素 |
| EP1076486B1 (en) | 1998-05-05 | 2005-08-31 | Pharma Mar, S.A. | Culture of sessile marine animals |
| EP1077698B1 (en) | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| AU1325001A (en) * | 1999-07-23 | 2001-02-13 | American Superconductor Corporation | Methods of making a superconductor |
| JP2003520801A (ja) | 2000-01-19 | 2003-07-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成 |
| US6815544B2 (en) | 2000-02-11 | 2004-11-09 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
| US6569859B1 (en) | 2000-02-22 | 2003-05-27 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| JP5219323B2 (ja) | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| US20020137663A1 (en) | 2000-08-11 | 2002-09-26 | Forman Barry M. | The anti-neoplastic agent ET-743 inhibits trans activation by SXR |
| EP1365808B1 (en) | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| WO2002064843A1 (en) | 2001-02-09 | 2002-08-22 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| BR0213424A (pt) | 2001-10-19 | 2004-12-14 | Pharma Mar Sa | Uso aperfeiçoado de composto antitumoral na terapia contra câncer |
| US20040019027A1 (en) | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0218813D0 (en) | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | DNA sequences from an endosymbiont and their uses |
| GB0312407D0 (en) | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| DE602004016376D1 (de) | 2003-11-13 | 2008-10-16 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs |
| GB0326486D0 (en) | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| CA2545054A1 (en) | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| AU2005288696A1 (en) | 2004-09-28 | 2006-04-06 | Pharma Mar S.A., Sociedad Unipersonal | Ecteinascidin compounds as anti -inflammatory agents |
| DK1827500T3 (da) | 2004-10-26 | 2009-08-31 | Pharma Mar Sa | Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| JP2011500046A (ja) | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Ｅｔ−７４３治療のための予後分子マーカー |
| CA2724325A1 (en) | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| CA2724206A1 (en) | 2008-05-16 | 2009-11-19 | Pharma Mar S.A. | Multiple myeloma treatments |
-
2000
- 2000-05-15 MX MXPA02011319A patent/MXPA02011319A/es active IP Right Grant
-
2001
- 2001-05-15 HU HUP0302327A patent/HU230699B1/hu unknown
- 2001-05-15 CA CA2405002A patent/CA2405002C/en not_active Expired - Lifetime
- 2001-05-15 IL IL152126A patent/IL152126A/en active IP Right Grant
- 2001-05-15 US US10/257,857 patent/US7247629B2/en not_active Expired - Lifetime
- 2001-05-15 SK SK1601-2002A patent/SK287833B6/sk not_active IP Right Cessation
- 2001-05-15 JP JP2001584288A patent/JP5008812B2/ja not_active Expired - Lifetime
- 2001-05-15 AT AT01929813T patent/ATE282624T1/de active
-
2002
- 2002-11-20 BG BG107302A patent/BG65897B1/bg unknown
-
2005
- 2005-01-26 US US11/045,595 patent/US7410969B2/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/645,356 patent/US8012975B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL152126A0 (en) | 2003-05-29 |
| IL152126A (en) | 2013-04-30 |
| US20080051407A1 (en) | 2008-02-28 |
| HU230699B1 (hu) | 2017-09-28 |
| ATE282624T1 (de) | 2004-12-15 |
| SK287833B6 (sk) | 2011-11-04 |
| JP5008812B2 (ja) | 2012-08-22 |
| US7410969B2 (en) | 2008-08-12 |
| HUP0302327A3 (en) | 2006-05-29 |
| HUP0302327A2 (hu) | 2003-10-28 |
| BG65897B1 (bg) | 2010-04-30 |
| SK16012002A3 (sk) | 2003-05-02 |
| US20060019960A1 (en) | 2006-01-26 |
| US20040019056A1 (en) | 2004-01-29 |
| HK1053653A1 (en) | 2003-10-31 |
| CA2405002A1 (en) | 2001-11-22 |
| JP2003533532A (ja) | 2003-11-11 |
| CA2405002C (en) | 2010-09-21 |
| US7247629B2 (en) | 2007-07-24 |
| BG107302A (bg) | 2003-07-31 |
| US8012975B2 (en) | 2011-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |