JP2003531583A5 - - Google Patents
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- JP2003531583A5 JP2003531583A5 JP2001565759A JP2001565759A JP2003531583A5 JP 2003531583 A5 JP2003531583 A5 JP 2003531583A5 JP 2001565759 A JP2001565759 A JP 2001565759A JP 2001565759 A JP2001565759 A JP 2001565759A JP 2003531583 A5 JP2003531583 A5 JP 2003531583A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- polypeptide
- composition
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18785400P | 2000-03-08 | 2000-03-08 | |
| US60/187,854 | 2000-03-08 | ||
| US23336800P | 2000-09-18 | 2000-09-18 | |
| US60/233,368 | 2000-09-18 | ||
| US25165000P | 2000-12-05 | 2000-12-05 | |
| US60/251,650 | 2000-12-05 | ||
| PCT/US2001/007468 WO2001066595A2 (en) | 2000-03-08 | 2001-03-07 | Human fgf-23 gene and gene expression products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003531583A JP2003531583A (ja) | 2003-10-28 |
| JP2003531583A5 true JP2003531583A5 (https=) | 2008-04-24 |
Family
ID=27392307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001565759A Pending JP2003531583A (ja) | 2000-03-08 | 2001-03-07 | ヒトｆｇｆ−２３遺伝子および遺伝子発現産物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20020082205A1 (https=) |
| EP (2) | EP2075255A1 (https=) |
| JP (1) | JP2003531583A (https=) |
| AU (1) | AU2001249125A1 (https=) |
| WO (1) | WO2001066595A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| ES2340662T3 (es) | 2000-07-19 | 2010-06-08 | Advanced Research And Technology Institute | Factor de crecimiento de fibroblastos (fgf23) nuevo procedimiento para el uso. |
| KR100886276B1 (ko) | 2000-08-11 | 2009-03-04 | 기린 파마 가부시끼가이샤 | 인산 대사, 칼슘 대사, 석회화 및 비타민 ｄ 대사를조절하는 폴리펩티드 및 그것을 코딩하는 ｄｎａ |
| CA2443719A1 (en) * | 2001-04-26 | 2002-11-07 | Geneprot, Inc. | Human fibroblast growth factor-related compositions |
| DE60329070D1 (de) * | 2001-12-28 | 2009-10-15 | Kyowa Hakko Kirin Co Ltd | Antikörper gegen den fibroblastenwachstumsfaktor 23 |
| US7094551B2 (en) | 2002-09-17 | 2006-08-22 | Zahradnik Richard J | Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 |
| WO2005045044A2 (en) * | 2003-11-07 | 2005-05-19 | Novartis Ag | Use of fibroblast growth factor fragments |
| JP2006347979A (ja) * | 2005-06-17 | 2006-12-28 | National Institute Of Advanced Industrial & Technology | 創傷治療及び／又は創傷治癒促進のための薬剤 |
| US7883705B2 (en) | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| US20110015345A1 (en) * | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| US20110195077A1 (en) | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| HK1214832A1 (zh) | 2012-11-28 | 2016-08-05 | 恩格姆生物制药公司 | 用於代謝病症和疾病治療的組合物和方法 |
| MX383664B (es) | 2012-12-27 | 2025-03-14 | Ngm Biopharmaceuticals Inc | Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares. |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
| WO2015065897A1 (en) | 2013-10-28 | 2015-05-07 | Ngm Biopharmaceuticals, Inc. | Cancer models and associated methods |
| PT3097122T (pt) | 2014-01-24 | 2020-07-21 | Ngm Biopharmaceuticals Inc | Anticorpos de ligação de domínio 2 de beta klotho e métodos de utilização dos mesmos |
| AU2015237176A1 (en) | 2014-03-28 | 2016-10-20 | New York University | FGF23 fusion proteins |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| CN114129709A (zh) | 2014-10-23 | 2022-03-04 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CN107810201A (zh) | 2014-12-04 | 2018-03-16 | 诺华股份有限公司 | 使用klotho变体多肽的方法和组合物 |
| JP6714263B2 (ja) * | 2015-05-25 | 2020-06-24 | 公立大学法人和歌山県立医科大学 | 免疫調節剤及びスクリーニング方法 |
| WO2017019957A2 (en) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| EP3503882A4 (en) | 2016-08-26 | 2020-07-29 | NGM Biopharmaceuticals, Inc. | METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS |
| WO2020047505A1 (en) * | 2018-08-30 | 2020-03-05 | The Uab Research Foundation | Production and detection of bioactive soluble klotho protein |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586772T2 (de) | 1984-07-24 | 1993-03-04 | Coselco Mimotopes Pty Ltd | Verfahren zur bestimmung von mimotopen. |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
| US5206152A (en) | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
| JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| ES2116269T3 (es) | 1989-03-21 | 1998-07-16 | Vical Inc | Expresion de secuencias exogenas de polinucleotidos en un vertebrado. |
| US5185440A (en) | 1989-06-20 | 1993-02-09 | North Carolina State University | cDNA clone coding for Venezuelan equine encephalitis virus and attenuating mutations thereof |
| JP4041535B2 (ja) | 1989-08-18 | 2008-01-30 | オックスフォード バイオメディカ（ユーケー）リミテッド | 標的細胞にベクター構造体を運搬する組換レトロウィルス |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| SE8903799D0 (sv) | 1989-11-13 | 1989-11-13 | Ericsson Telefon Ab L M | Foerfarande och anordning foer att variera slingbandbredden hos en faslaast slinga |
| ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
| US5252296A (en) | 1990-05-15 | 1993-10-12 | Chiron Corporation | Method and apparatus for biopolymer synthesis |
| US5149655A (en) | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
| EP1285967A3 (en) | 1990-09-21 | 2005-03-02 | Chiron Corporation | Human retroviral packaging cell line |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| CA2098849C (en) | 1990-12-20 | 2007-07-10 | Dana-Farber Cancer Institute | Control of gene expression by ionizing radiation |
| JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| CA2137361A1 (en) | 1992-06-10 | 1993-12-23 | W. French Anderson | Vector particles resistant to inactivation by human serum |
| GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
| AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
| PT695169E (pt) | 1993-04-22 | 2003-04-30 | Skyepharma Inc | Lipossomas multivesiculares de ciclodextrina encapsulando compostos farmacologicos e metodos para a sua utilizacao |
| ES2249761T3 (es) | 1993-06-24 | 2006-04-01 | Advec Inc. | Vectores de adenovirus para terapia genica. |
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| ES2328424T3 (es) | 1993-09-15 | 2009-11-12 | Novartis Vaccines And Diagnostics, Inc. | Vectores de alfavirus recombinantes. |
| EP1637608B1 (en) | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
| PT729351E (pt) | 1993-11-16 | 2000-12-29 | Skyepharma Inc | Vesiculas com libertacao controlada de activos |
| SE9401091D0 (sv) | 1994-03-31 | 1994-03-31 | Bioption Ab | Alphavirus cDNA vectors |
| GB9406498D0 (en) | 1994-03-31 | 1994-05-25 | Smithkline Beecham Biolog | Novel compounds |
| WO1995030763A2 (en) | 1994-05-09 | 1995-11-16 | Chiron Viagene, Inc. | Retroviral vectors having a reduced recombination rate |
| WO1997025345A1 (en) | 1996-01-05 | 1997-07-17 | Eli Lilly And Company | Fusion proteins comprising cell cycle regulatory proteins |
| AU761340B2 (en) * | 1998-06-02 | 2003-06-05 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU3924300A (en) * | 1999-04-02 | 2000-10-23 | Millennium Pharmaceuticals, Inc. | Fibroblast growth factor-20 |
| ATE478145T1 (de) * | 1999-06-02 | 2010-09-15 | Genentech Inc | Sekretierte und transmembran polypeptide und dafür kodierende nukleinsäuren |
| WO2001049740A1 (en) * | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf12 |
| WO2001060850A1 (en) * | 2000-02-14 | 2001-08-23 | Smithkline Beecham Corporation | Novel compounds |
| CA2398603A1 (en) * | 2000-02-15 | 2001-08-23 | Amgen, Inc. | Fibroblast growth factor-23 molecules and uses thereof |
| ES2340662T3 (es) * | 2000-07-19 | 2010-06-08 | Advanced Research And Technology Institute | Factor de crecimiento de fibroblastos (fgf23) nuevo procedimiento para el uso. |
-
2001
- 2001-03-07 AU AU2001249125A patent/AU2001249125A1/en not_active Abandoned
- 2001-03-07 EP EP09002470A patent/EP2075255A1/en not_active Withdrawn
- 2001-03-07 EP EP01922308A patent/EP1261638A2/en not_active Withdrawn
- 2001-03-07 JP JP2001565759A patent/JP2003531583A/ja active Pending
- 2001-03-07 WO PCT/US2001/007468 patent/WO2001066595A2/en not_active Ceased
- 2001-03-07 US US09/801,968 patent/US20020082205A1/en not_active Abandoned
-
2005
- 2005-12-28 US US11/322,185 patent/US20060281679A1/en not_active Abandoned
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