JP2003510029A5 - - Google Patents
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- Publication number
- JP2003510029A5 JP2003510029A5 JP2001518744A JP2001518744A JP2003510029A5 JP 2003510029 A5 JP2003510029 A5 JP 2003510029A5 JP 2001518744 A JP2001518744 A JP 2001518744A JP 2001518744 A JP2001518744 A JP 2001518744A JP 2003510029 A5 JP2003510029 A5 JP 2003510029A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polypeptide
- seq
- amino acids
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 description 35
- 102000004196 processed proteins & peptides Human genes 0.000 description 35
- 108090000765 processed proteins & peptides Proteins 0.000 description 35
- 150000001413 amino acids Chemical class 0.000 description 30
- 108091033319 polynucleotide Proteins 0.000 description 19
- 102000040430 polynucleotide Human genes 0.000 description 19
- 239000002157 polynucleotide Substances 0.000 description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010011903 Deafness traumatic Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 208000002946 Noise-Induced Hearing Loss Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000010886 Peripheral nerve injury Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 208000028412 nervous system injury Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14998699P | 1999-08-20 | 1999-08-20 | |
| US60/149,986 | 1999-08-20 | ||
| PCT/US2000/022326 WO2001014415A2 (en) | 1999-08-20 | 2000-08-15 | Egfh2 genes and gene products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003510029A JP2003510029A (ja) | 2003-03-18 |
| JP2003510029A5 true JP2003510029A5 (https=) | 2007-08-30 |
Family
ID=22532642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518744A Pending JP2003510029A (ja) | 1999-08-20 | 2000-08-15 | Egfh2遺伝子および遺伝子産物 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1208198A2 (https=) |
| JP (1) | JP2003510029A (https=) |
| AU (1) | AU6773200A (https=) |
| WO (1) | WO2001014415A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544759B1 (en) | 2000-04-21 | 2003-04-08 | Yeda Research And Development Co. Ltd | Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine |
| US7094882B2 (en) | 2000-04-21 | 2006-08-22 | Yeda Research And Development Co. Ltd. | Growth factor which acts through erb b-4 rtk |
| AU2003237367A1 (en) | 2002-06-03 | 2003-12-19 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
| EP2976094B1 (en) * | 2013-03-21 | 2019-08-28 | The Regents of The University of Michigan | Methods of treating metabolic disorders |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6121415A (en) * | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
-
2000
- 2000-08-15 WO PCT/US2000/022326 patent/WO2001014415A2/en not_active Ceased
- 2000-08-15 JP JP2001518744A patent/JP2003510029A/ja active Pending
- 2000-08-15 AU AU67732/00A patent/AU6773200A/en not_active Abandoned
- 2000-08-15 EP EP00955542A patent/EP1208198A2/en not_active Withdrawn
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