JP2002508923A5 - - Google Patents
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- JP2002508923A5 JP2002508923A5 JP2000520565A JP2000520565A JP2002508923A5 JP 2002508923 A5 JP2002508923 A5 JP 2002508923A5 JP 2000520565 A JP2000520565 A JP 2000520565A JP 2000520565 A JP2000520565 A JP 2000520565A JP 2002508923 A5 JP2002508923 A5 JP 2002508923A5
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- protein
- nucleic acid
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- pharmaceutical composition
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- 108090000623 proteins and genes Proteins 0.000 description 92
- 102000004169 proteins and genes Human genes 0.000 description 79
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 42
- 108020004707 nucleic acids Proteins 0.000 description 41
- 102000039446 nucleic acids Human genes 0.000 description 41
- 150000007523 nucleic acids Chemical class 0.000 description 41
- 239000008194 pharmaceutical composition Substances 0.000 description 25
- 201000010099 disease Diseases 0.000 description 21
- 208000035475 disorder Diseases 0.000 description 21
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 12
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 12
- 208000006029 Cardiomegaly Diseases 0.000 description 12
- 239000012634 fragment Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 239000000523 sample Substances 0.000 description 9
- 239000003937 drug carrier Substances 0.000 description 8
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 6
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 6
- 230000005714 functional activity Effects 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 102000037865 fusion proteins Human genes 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 108020004463 18S ribosomal RNA Proteins 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 108020004565 5.8S Ribosomal RNA Proteins 0.000 description 3
- 102100038910 Alpha-enolase Human genes 0.000 description 3
- 102000004954 Biglycan Human genes 0.000 description 3
- 108090001138 Biglycan Proteins 0.000 description 3
- 102000014914 Carrier Proteins Human genes 0.000 description 3
- 102000002431 Cyclin G Human genes 0.000 description 3
- 108090000404 Cyclin G1 Proteins 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 102100036912 Desmin Human genes 0.000 description 3
- 108010044052 Desmin Proteins 0.000 description 3
- 102000003839 Human Proteins Human genes 0.000 description 3
- 108090000144 Human Proteins Proteins 0.000 description 3
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 3
- 102100038931 Proenkephalin-A Human genes 0.000 description 3
- 101001081222 Rattus norvegicus RanBP-type and C3HC4-type zinc finger-containing protein 1 Proteins 0.000 description 3
- 108091008324 binding proteins Proteins 0.000 description 3
- 210000005045 desmin Anatomy 0.000 description 3
- 102000013370 fibrillin Human genes 0.000 description 3
- 108060002895 fibrillin Proteins 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 108010042502 laminin A Proteins 0.000 description 3
- 108010074732 preproenkephalin Proteins 0.000 description 3
- 101000652725 Drosophila melanogaster Transcription initiation factor TFIID subunit 5 Proteins 0.000 description 2
- 101000752722 Homo sapiens Apoptosis-stimulating of p53 protein 1 Proteins 0.000 description 2
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 description 2
- 101001120097 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit beta Proteins 0.000 description 2
- 101001116549 Homo sapiens Protein CBFA2T2 Proteins 0.000 description 2
- 101001000998 Homo sapiens Protein phosphatase 1 regulatory subunit 12C Proteins 0.000 description 2
- 101000927796 Homo sapiens Rho guanine nucleotide exchange factor 7 Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002743 insertional mutagenesis Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6504897P | 1997-11-10 | 1997-11-10 | |
| US09/189,618 | 1998-11-09 | ||
| US60/065,048 | 1998-11-09 | ||
| US09/189,618 US6610480B1 (en) | 1997-11-10 | 1998-11-09 | Treatment and diagnosis of cardiac hypertrophy |
| PCT/US1998/023953 WO1999024571A2 (en) | 1997-11-10 | 1998-11-10 | Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508923A JP2002508923A (ja) | 2002-03-26 |
| JP2002508923A5 true JP2002508923A5 (https=) | 2006-03-02 |
Family
ID=26745148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520565A Pending JP2002508923A (ja) | 1997-11-10 | 1998-11-10 | 心肥大において差示的に発現される遺伝子、ならびに処置および診断におけるそれらの使用 |
| JP2006323823A Withdrawn JP2007135219A (ja) | 1997-11-10 | 2006-11-30 | 通信システムにおけるビデオフレーム転送方法と装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006323823A Withdrawn JP2007135219A (ja) | 1997-11-10 | 2006-11-30 | 通信システムにおけるビデオフレーム転送方法と装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6610480B1 (https=) |
| EP (1) | EP1030916A2 (https=) |
| JP (2) | JP2002508923A (https=) |
| AU (1) | AU1395399A (https=) |
| CA (1) | CA2309360A1 (https=) |
| WO (1) | WO1999024571A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875567B1 (en) * | 1997-11-10 | 2005-04-05 | Genentech, Inc. | Method of detecting cardiac hypertrophy through probe hybridization and gene expression analysis |
| EP1872797A3 (en) | 1999-08-24 | 2008-04-02 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
| AU7408301A (en) * | 2000-05-30 | 2001-12-11 | Medigene Aktiengesellschaft | Novel target genes for diseases of the heart |
| DE10126371A1 (de) * | 2001-05-30 | 2003-02-27 | Medigene Ag | Verfahren zur Identifizierung von Substanzen gegen Herzmuskelzellen-Hypertrophie |
| WO2002103355A1 (fr) * | 2001-06-18 | 2002-12-27 | Takeda Chemical Industries, Ltd. | Agents prophylactiques/remedes pour maladies cardiaques |
| WO2003006687A2 (en) * | 2001-07-10 | 2003-01-23 | Medigene Ag | Novel target genes for diseases of the heart |
| ITMI20012205A1 (it) * | 2001-10-22 | 2003-04-22 | Nanorganics Llc | Metodo e mezzi per l'identificazione precoce di rischi di scompenso cardiaco |
| US7482132B2 (en) | 2001-12-13 | 2009-01-27 | Sanofi-Aventis Deutschland Gmbh | Method for determining the activity of ornithine decarboxylase and for identifying effectors of ornithine decarboxylase activity |
| DE10161412A1 (de) * | 2001-12-13 | 2003-07-03 | Aventis Pharma Gmbh | Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität |
| WO2003059948A1 (en) * | 2002-01-15 | 2003-07-24 | Medigene Ag | Dilated cardiomyopathy associated gene-2 (dcmag-2): a cytoplasmatic inducer of sarcomeric remodeling in cardiomyocytes |
| JP4814875B2 (ja) | 2004-05-11 | 2011-11-16 | アキシオジェネシス エージー | ｉｎｖｉｔｒｏ分化細胞に基づく薬物発見のための検定 |
| US20070179815A1 (en) * | 2006-01-20 | 2007-08-02 | Heartscreen America, Inc. | Medical screening system and method |
| EP2046997A2 (en) * | 2006-07-25 | 2009-04-15 | Deutsches Krebsforschungszentrum | A common gene expression signature in dilated cardiomyopathy |
| CA2738417A1 (en) * | 2008-10-17 | 2010-04-22 | F. Hoffmann-La Roche Ag | Use of biglycan in the assessment of heart failure |
| ES2690782T3 (es) | 2012-10-24 | 2018-11-22 | Nyu Winthrop Hospital | Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro |
| US20200264188A1 (en) | 2017-09-13 | 2020-08-20 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECLAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR TESTS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0755446T3 (da) * | 1994-04-25 | 2007-01-29 | Genentech Inc | Cardiotrophin og anvendelser deraf |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
-
1998
- 1998-11-09 US US09/189,618 patent/US6610480B1/en not_active Expired - Fee Related
- 1998-11-10 AU AU13953/99A patent/AU1395399A/en not_active Abandoned
- 1998-11-10 WO PCT/US1998/023953 patent/WO1999024571A2/en not_active Ceased
- 1998-11-10 EP EP98957774A patent/EP1030916A2/en not_active Withdrawn
- 1998-11-10 JP JP2000520565A patent/JP2002508923A/ja active Pending
- 1998-11-10 CA CA002309360A patent/CA2309360A1/en not_active Abandoned
-
2006
- 2006-11-30 JP JP2006323823A patent/JP2007135219A/ja not_active Withdrawn
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