JP2003529608A5 - - Google Patents
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- Publication number
- JP2003529608A5 JP2003529608A5 JP2001572544A JP2001572544A JP2003529608A5 JP 2003529608 A5 JP2003529608 A5 JP 2003529608A5 JP 2001572544 A JP2001572544 A JP 2001572544A JP 2001572544 A JP2001572544 A JP 2001572544A JP 2003529608 A5 JP2003529608 A5 JP 2003529608A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- immunostimulatory
- composition
- protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 description 26
- 102000037865 fusion proteins Human genes 0.000 description 26
- 230000003308 immunostimulating effect Effects 0.000 description 21
- 210000004443 dendritic cell Anatomy 0.000 description 13
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 11
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 230000024932 T cell mediated immunity Effects 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19350400P | 2000-03-30 | 2000-03-30 | |
| US60/193,504 | 2000-03-30 | ||
| PCT/US2001/010515 WO2001074855A2 (en) | 2000-03-30 | 2001-03-30 | Compositions and methods for dendritic cell-based immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003529608A JP2003529608A (ja) | 2003-10-07 |
| JP2003529608A5 true JP2003529608A5 (enExample) | 2008-05-22 |
| JP5110674B2 JP5110674B2 (ja) | 2012-12-26 |
Family
ID=22713907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001572544A Expired - Fee Related JP5110674B2 (ja) | 2000-03-30 | 2001-03-30 | 樹状細胞に基づく免疫治療のための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7060279B2 (enExample) |
| EP (1) | EP1272633B1 (enExample) |
| JP (1) | JP5110674B2 (enExample) |
| AT (1) | ATE507295T1 (enExample) |
| AU (2) | AU4791901A (enExample) |
| CA (1) | CA2403964C (enExample) |
| CY (1) | CY1111718T1 (enExample) |
| DE (1) | DE60144516D1 (enExample) |
| DK (1) | DK1272633T3 (enExample) |
| ES (1) | ES2362715T3 (enExample) |
| NZ (1) | NZ522066A (enExample) |
| PT (1) | PT1272633E (enExample) |
| WO (1) | WO2001074855A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7198920B1 (en) | 1999-01-29 | 2007-04-03 | Corika Corporation | HER-2/neu fusion proteins |
| US7229623B1 (en) | 2000-08-03 | 2007-06-12 | Corixa Corporation | Her-2/neu fusion proteins |
| US7413869B2 (en) * | 2002-04-05 | 2008-08-19 | Dendreon Corporation | Method for determining potency of antigenic presenting cell based vaccines |
| MXPA04009809A (es) * | 2002-04-11 | 2004-12-13 | Amgen Inc | Moleculas de tirosina cinasa del receptor her-2 y uso de las mismas. |
| CA2514288C (en) | 2003-03-05 | 2015-07-07 | Dendreon Corporation | Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease |
| US7737253B2 (en) * | 2006-06-16 | 2010-06-15 | Bresagen, Inc. | Human cancer stem cell culture compositions comprising Erbb2 variants and methods of use thereof |
| US7972602B2 (en) * | 2006-08-11 | 2011-07-05 | Dendreon Corporation | Promiscuous HER-2/Neu CD4 T cell epitopes |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| AR064863A1 (es) * | 2007-01-15 | 2009-04-29 | Glaxosmithkline Biolog Sa | Proteina de fusion |
| PL2118128T3 (pl) * | 2007-01-15 | 2013-03-29 | Glaxosmithkline Biologicals Sa | Białka fuzyjne zawierające antygeny odrzucenia nowotworu NY-ESO-1 i LAGE-1 |
| US8309096B2 (en) | 2007-01-15 | 2012-11-13 | Glaxosmithkline Biologicals S.A. | Fusion protein |
| US8153120B2 (en) * | 2007-03-22 | 2012-04-10 | Dendreon Corporation | Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity |
| JP6426001B2 (ja) | 2011-11-17 | 2018-11-21 | グリア エスピー ゼット．オー．オー． | 神経膠腫を治療するための組成物および方法 |
| EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| WO2017096247A1 (en) | 2015-12-04 | 2017-06-08 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different mhc molecules |
| TW202216776A (zh) | 2020-07-07 | 2022-05-01 | 美商康愈有限責任公司 | Mic抗體及結合劑以及其使用方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2048981B (en) * | 1979-05-23 | 1982-11-17 | Coal Ind | Equipment for laying a layer of elongate material adjacent to an exposed rock or mineral surface in an underground mine |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| CA2158281A1 (en) * | 1993-03-15 | 1994-09-29 | Jay A. Berzofsky | Peptide coated dendritic cells as immunogens |
| US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| US5586538A (en) * | 1995-11-13 | 1996-12-24 | Caterpillar Inc. | Method of correcting engine maps based on engine temperature |
| US6080409A (en) * | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
| WO1998046769A1 (en) * | 1997-04-11 | 1998-10-22 | Dendreon Corporation | Composition and method for inducing an immune response against tumour-related antigens |
| US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| AU775767B2 (en) * | 1998-12-14 | 2004-08-12 | Dendreon Corporation | Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation |
| CN1201004C (zh) * | 1999-01-29 | 2005-05-11 | 考丽克萨有限公司 | HER－2/neu融合蛋白 |
| TR200103018T2 (tr) * | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| US6406681B1 (en) * | 2000-08-21 | 2002-06-18 | Aeropharm Technology, Inc. | Method of treating a systemic disease |
-
2001
- 2001-03-30 DE DE60144516T patent/DE60144516D1/de not_active Expired - Lifetime
- 2001-03-30 EP EP01920913A patent/EP1272633B1/en not_active Expired - Lifetime
- 2001-03-30 WO PCT/US2001/010515 patent/WO2001074855A2/en not_active Ceased
- 2001-03-30 AU AU4791901A patent/AU4791901A/xx active Pending
- 2001-03-30 DK DK01920913.9T patent/DK1272633T3/da active
- 2001-03-30 AT AT01920913T patent/ATE507295T1/de active
- 2001-03-30 JP JP2001572544A patent/JP5110674B2/ja not_active Expired - Fee Related
- 2001-03-30 NZ NZ522066A patent/NZ522066A/en not_active IP Right Cessation
- 2001-03-30 ES ES01920913T patent/ES2362715T3/es not_active Expired - Lifetime
- 2001-03-30 US US09/821,883 patent/US7060279B2/en not_active Expired - Fee Related
- 2001-03-30 CA CA2403964A patent/CA2403964C/en not_active Expired - Fee Related
- 2001-03-30 PT PT01920913T patent/PT1272633E/pt unknown
- 2001-03-30 AU AU2001247919A patent/AU2001247919B2/en not_active Ceased
-
2005
- 2005-06-03 US US11/144,912 patent/US7659117B2/en not_active Expired - Fee Related
-
2011
- 2011-07-20 CY CY20111100718T patent/CY1111718T1/el unknown
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