JP2001512748A5 - - Google Patents
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- Publication number
- JP2001512748A5 JP2001512748A5 JP2000506324A JP2000506324A JP2001512748A5 JP 2001512748 A5 JP2001512748 A5 JP 2001512748A5 JP 2000506324 A JP2000506324 A JP 2000506324A JP 2000506324 A JP2000506324 A JP 2000506324A JP 2001512748 A5 JP2001512748 A5 JP 2001512748A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- antigen
- cell
- vaccine
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 description 26
- 102000036639 antigens Human genes 0.000 description 26
- 108091007433 antigens Proteins 0.000 description 26
- 206010022000 influenza Diseases 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 11
- 229960005486 vaccine Drugs 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 102000018697 Membrane Proteins Human genes 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 229940021995 DNA vaccine Drugs 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 208000007089 vaccinia Diseases 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000002480 immunoprotective effect Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 208000037798 influenza B Diseases 0.000 description 1
- 208000037799 influenza C Diseases 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 108010044241 tetanus toxin fragment C Proteins 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202434 | 1997-08-05 | ||
| EP97202434.3 | 1997-08-05 | ||
| PCT/EP1998/005106 WO1999007839A2 (en) | 1997-08-05 | 1998-08-05 | Immunoprotective influenza antigen and its use in vaccination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009239092A Division JP2010059164A (ja) | 1997-08-05 | 2009-10-16 | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001512748A JP2001512748A (ja) | 2001-08-28 |
| JP2001512748A5 true JP2001512748A5 (enExample) | 2006-01-12 |
| JP5132851B2 JP5132851B2 (ja) | 2013-01-30 |
Family
ID=8228624
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000506324A Expired - Lifetime JP5132851B2 (ja) | 1997-08-05 | 1998-08-05 | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
| JP2009239092A Pending JP2010059164A (ja) | 1997-08-05 | 2009-10-16 | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009239092A Pending JP2010059164A (ja) | 1997-08-05 | 2009-10-16 | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7732130B2 (enExample) |
| EP (1) | EP0996717B1 (enExample) |
| JP (2) | JP5132851B2 (enExample) |
| AT (1) | ATE312172T1 (enExample) |
| AU (1) | AU745951B2 (enExample) |
| CA (1) | CA2297786C (enExample) |
| DE (1) | DE69832706T2 (enExample) |
| DK (1) | DK0996717T3 (enExample) |
| ES (1) | ES2255181T3 (enExample) |
| WO (1) | WO1999007839A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7731972B1 (en) | 2000-02-04 | 2010-06-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| ES2255181T3 (es) | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
| DE69939836D1 (de) | 1998-11-30 | 2008-12-11 | Cytos Biotechnology Ag | Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung |
| GB0008582D0 (en) * | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
| JP4927290B2 (ja) * | 2000-04-14 | 2012-05-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 変異イオンチャンネルタンパク質を含んで成るウイルス |
| WO2001083528A2 (en) * | 2000-05-01 | 2001-11-08 | Powderject Vaccines, Inc. | Nucleic acid immunization |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| GB0025229D0 (en) * | 2000-10-14 | 2000-11-29 | Adprotech Ltd | Veterinary immunisation vectors |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US7351413B2 (en) | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| GB0204154D0 (en) * | 2002-02-22 | 2002-04-10 | Adprotech Ltd | Cat immunisation vectors |
| JP2005519619A (ja) * | 2002-03-13 | 2005-07-07 | 麒麟麦酒株式会社 | インフルエンザｍ２タンパク質に対するヒトモノクローナル抗体および上記抗体を作製しかつ利用する方法 |
| EP1532167B1 (en) | 2002-07-17 | 2012-01-25 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
| KR101228376B1 (ko) | 2002-07-18 | 2013-01-31 | 사이토스 바이오테크놀로지 아게 | 합텐-캐리어 컨쥬게이트 및 그의 용도 |
| AU2003250110C1 (en) | 2002-07-19 | 2008-05-29 | Novartis Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| RU2351651C2 (ru) * | 2003-04-23 | 2009-04-10 | Висконсин Эламни Рисеч Фаундэйшн | Выделенный рекомбинантный вирус гриппа и способы его получения |
| WO2005000346A1 (en) * | 2003-06-23 | 2005-01-06 | Baxter International Inc. | Carrier proteins for vaccines |
| US7968101B2 (en) | 2004-11-19 | 2011-06-28 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with tandem transcription units |
| JP4881874B2 (ja) | 2004-12-06 | 2012-02-22 | 協和発酵キリン株式会社 | インフルエンザｍ２タンパク質に対するヒトモノクローナル抗体及びその生産方法及びその使用 |
| US20090162400A1 (en) * | 2004-12-21 | 2009-06-25 | Powell Thomas J | Compositions of influenza viral proteins and methods of use thereof |
| JP2009514536A (ja) * | 2005-11-07 | 2009-04-09 | シドニー キンメル キャンサー センター | Ｃｄ４０リガンド融合蛋白質ワクチン |
| ATE552846T1 (de) | 2005-12-06 | 2012-04-15 | Yeda Res & Dev | Verbesserter grippeimpfstoff |
| US20070224205A1 (en) * | 2006-03-07 | 2007-09-27 | Powell Thomas J | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US9254318B2 (en) | 2006-03-31 | 2016-02-09 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| US20100184832A1 (en) | 2006-07-14 | 2010-07-22 | Sanofi Pasteur Biologics Co. | Construction of Recombinant Virus Vaccines by Direct Transposon-Mediated Insertion of Foreign Immunologic Determinants into Vector Virus Proteins |
| US20100239605A1 (en) | 2006-09-29 | 2010-09-23 | Sanofi Pasteur Biologics Co. | Recombinant Rhinovirus Vectors |
| WO2008058396A1 (en) * | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| PL2173376T3 (pl) | 2007-08-02 | 2015-08-31 | Biondvax Pharmaceuticals Ltd | Multimeryczne wieloepitopowe szczepionki przeciwko grypie |
| CN101877965B (zh) | 2007-11-12 | 2014-08-20 | 宾夕法尼亚大学托管会 | 针对流感病毒的多种亚型的疫苗 |
| JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
| CA2742288A1 (en) * | 2008-07-30 | 2010-02-04 | Folia Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| EP2168987A1 (en) * | 2008-09-22 | 2010-03-31 | Mucosis B.V. | Multifunctional linker protein containing an antibody against hemagglutinin, a conserved influenza antigen and an immunostimulating carrier binding domain |
| AU2010278797A1 (en) | 2009-07-31 | 2012-03-15 | Paxvax, Inc. | Adenoviral-based vectors |
| CN102612559B (zh) | 2009-08-28 | 2015-06-10 | 一般财团法人化学及血清疗法研究所 | 源自流感m2的修饰的肽疫苗 |
| US20110097358A1 (en) * | 2009-10-12 | 2011-04-28 | Techno Vax, Inc. | RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs) |
| WO2011056591A1 (en) | 2009-10-26 | 2011-05-12 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| WO2011054995A2 (es) | 2009-11-06 | 2011-05-12 | Chimera Pharma, S. L. U. | VACUNAS PROFILACTICAS DE GRIPE A PARTIR DE CAPSIDAS VIRALES DE BIRNAVIRUS CONTENIENDO EL ANTIGENO M2e DEL VIRUS DE LA GRIPE |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CA2828068C (en) | 2011-02-22 | 2019-03-19 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| EP2747778B1 (en) | 2011-08-26 | 2017-12-06 | Wisconsin Alumni Research Foundation | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| EP3103474A1 (en) * | 2015-06-12 | 2016-12-14 | Institut Pasteur | Live recombinant measles-m2 virus and its use in eliciting immunity against influenza viruses |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| JP2021500891A (ja) | 2017-10-25 | 2021-01-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| WO2020167432A2 (en) | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919044A (en) | 1973-03-28 | 1975-11-11 | Armour Pharma | Processes for concentrating and purifying viruses and viral antigens |
| NZ219516A (en) * | 1987-02-10 | 1991-02-26 | Wellcome Found | Fusion proteins of hbcag (hepatitis b virus core antigen) |
| CA2108263A1 (en) * | 1991-06-19 | 1992-12-20 | Amrit K. Judd | M-protein peptides of influenza virus as antiviral agents |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| EP0708656B1 (en) * | 1993-04-27 | 2002-07-31 | United Biomedical, Inc. | Immunogenic lhrh peptide constructs and synthetic universal immune stimulators for vaccines |
| DE69430246T2 (de) * | 1993-07-30 | 2002-12-12 | Medeva Holdings B.V., Amsterdam | Rekombinante tetc-fusionsprotein enthaltene impfstoffzusammensetzungen |
| US5691189A (en) * | 1994-01-19 | 1997-11-25 | Bristol-Myers Squibb Company | Saccharomyces cerevisiae expressing M2 protein of influenza A virus |
| GB9424631D0 (en) * | 1994-12-06 | 1995-01-25 | Lynxvale Ltd | Modulating the immune response |
| GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| AU736318B2 (en) | 1996-11-26 | 2001-07-26 | Nventa Biopharmaceuticals Corporation | Immune responses using compositions containing stress proteins |
| ES2255181T3 (es) | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
1998
- 1998-08-05 ES ES98946321T patent/ES2255181T3/es not_active Expired - Lifetime
- 1998-08-05 AT AT98946321T patent/ATE312172T1/de active
- 1998-08-05 DK DK98946321T patent/DK0996717T3/da active
- 1998-08-05 JP JP2000506324A patent/JP5132851B2/ja not_active Expired - Lifetime
- 1998-08-05 CA CA2297786A patent/CA2297786C/en not_active Expired - Lifetime
- 1998-08-05 AU AU93416/98A patent/AU745951B2/en not_active Expired
- 1998-08-05 WO PCT/EP1998/005106 patent/WO1999007839A2/en not_active Ceased
- 1998-08-05 DE DE69832706T patent/DE69832706T2/de not_active Expired - Lifetime
- 1998-08-05 EP EP98946321A patent/EP0996717B1/en not_active Revoked
-
2006
- 2006-03-14 US US11/374,922 patent/US7732130B2/en active Active
-
2009
- 2009-10-16 JP JP2009239092A patent/JP2010059164A/ja active Pending
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