JP2005502314A5 - - Google Patents
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- Publication number
- JP2005502314A5 JP2005502314A5 JP2002570736A JP2002570736A JP2005502314A5 JP 2005502314 A5 JP2005502314 A5 JP 2005502314A5 JP 2002570736 A JP2002570736 A JP 2002570736A JP 2002570736 A JP2002570736 A JP 2002570736A JP 2005502314 A5 JP2005502314 A5 JP 2005502314A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- human
- sequence
- self
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 30
- 102000003839 Human Proteins Human genes 0.000 claims 18
- 108090000144 Human Proteins Proteins 0.000 claims 18
- 210000003719 b-lymphocyte Anatomy 0.000 claims 13
- 229960005486 vaccine Drugs 0.000 claims 12
- 230000028993 immune response Effects 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 8
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 8
- 241000894007 species Species 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 5
- 108090000695 Cytokines Proteins 0.000 claims 5
- 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 claims 5
- 102000019207 human interleukin-13 Human genes 0.000 claims 5
- 230000006058 immune tolerance Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 108090000176 Interleukin-13 Proteins 0.000 claims 4
- 102000003816 Interleukin-13 Human genes 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 230000004962 physiological condition Effects 0.000 claims 3
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 102000008300 Mutant Proteins Human genes 0.000 claims 1
- 108010021466 Mutant Proteins Proteins 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940023143 protein vaccine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0105360.2A GB0105360D0 (en) | 2001-03-03 | 2001-03-03 | Chimaeric immunogens |
| PCT/GB2002/000900 WO2002070711A1 (en) | 2001-03-03 | 2002-03-01 | Vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502314A JP2005502314A (ja) | 2005-01-27 |
| JP2005502314A5 true JP2005502314A5 (enExample) | 2005-12-22 |
| JP4238031B2 JP4238031B2 (ja) | 2009-03-11 |
Family
ID=9909970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002570736A Expired - Fee Related JP4238031B2 (ja) | 2001-03-03 | 2002-03-01 | ワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20050260216A1 (enExample) |
| EP (1) | EP1368477A1 (enExample) |
| JP (1) | JP4238031B2 (enExample) |
| KR (1) | KR20030081490A (enExample) |
| CN (1) | CN1543504A (enExample) |
| AU (1) | AU2002233560B2 (enExample) |
| BR (1) | BR0207819A (enExample) |
| CA (1) | CA2439628A1 (enExample) |
| CZ (1) | CZ20032373A3 (enExample) |
| GB (1) | GB0105360D0 (enExample) |
| HU (1) | HUP0303372A3 (enExample) |
| IL (1) | IL157498A0 (enExample) |
| MX (1) | MXPA03007915A (enExample) |
| NO (1) | NO20033882L (enExample) |
| NZ (1) | NZ527873A (enExample) |
| PL (1) | PL365066A1 (enExample) |
| WO (1) | WO2002070711A1 (enExample) |
| ZA (1) | ZA200306647B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA77152C2 (en) * | 1999-09-25 | 2006-11-15 | Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma | |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| CA2496409A1 (en) * | 2002-08-30 | 2004-03-11 | Glaxo Group Limited | Immunogenic composition comprising an il-13 element and t cell epitopes, and its therapeutic use |
| JP2006503018A (ja) * | 2002-08-30 | 2006-01-26 | グラクソ グループ リミテッド | ワクチン |
| EP1539232A1 (en) * | 2002-09-12 | 2005-06-15 | Pharmexa A/S | Immunization against autologous ghrelin |
| US9259459B2 (en) * | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| EP1594533B1 (en) * | 2003-01-31 | 2012-04-11 | Celldex Research Corporation | Antibody vaccine conjugates and uses therefor |
| JP2007525436A (ja) * | 2003-03-24 | 2007-09-06 | マーシア・ファーマ・インコーポレイテッド | 炎症症状を処置および予防するための方法および組成物 |
| WO2004096849A2 (en) * | 2003-04-25 | 2004-11-11 | University Of Manitoba | Peptide-based cytokine/chemokine vaccines against allergy |
| US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| US20090098142A1 (en) * | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| EP1767216B1 (en) * | 2004-06-11 | 2012-07-11 | Riken | Drug having regulatory cell ligand contained in liposome |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US8273361B2 (en) | 2006-09-26 | 2012-09-25 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| RU2009140134A (ru) * | 2007-04-23 | 2011-05-27 | Вайет (Us) | Способы и композиции для лечения и мониторинга лечения связанных с ил-13 нарушений |
| JP2010527633A (ja) * | 2007-05-25 | 2010-08-19 | セントコア・オーソ・バイオテツク・インコーポレーテツド | Ｔｏｌｌ様受容体３モジュレーター及びその使用 |
| BRPI0820270A2 (pt) * | 2007-11-07 | 2015-06-16 | Celldex Therapeutics Inc | Anticorpo monoclonal, vetor de expressão, célula, conjugado molecular, composição, uso da composição, método para detectar a presença ou ausência de dec-205 em uma amostra biológica, e, uso de um conjugado molecular. |
| LT2850431T (lt) | 2012-05-16 | 2018-06-25 | Immune Design Corp. | Vakcinos, skirtos hsv-2 |
| KR102039520B1 (ko) | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| AU2022212600A1 (en) * | 2021-01-29 | 2023-08-17 | Bayer Animal Health Gmbh | Vaccine composition for breaking self-tolerance |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) * | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4877611A (en) * | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US5278302A (en) * | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5697901A (en) * | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| AU661684B2 (en) * | 1991-06-18 | 1995-08-03 | Regents Of The University Of California, The | Cloned glutamic acid decarboxylase |
| DE4137333A1 (de) * | 1991-11-13 | 1993-05-19 | W Prof Dr Sebald | Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung |
| EP0772619B2 (en) * | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| AU3382595A (en) * | 1994-07-29 | 1996-03-04 | Smithkline Beecham Corporation | Novel compounds |
| US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
| ES2289751T3 (es) * | 1995-02-20 | 2008-02-01 | The Walter And Eliza Hall Institute Of Medical Research | Moleculas inmunorreactivas e inmunoterapeuticas que interaccionan en sujetos con diabetes mellitus insulinodependientes (dmid). |
| US6518061B1 (en) * | 1995-03-15 | 2003-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
| US5614191A (en) * | 1995-03-15 | 1997-03-25 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
| EP0759468A1 (en) * | 1995-08-10 | 1997-02-26 | Laboratoires Virbac | Feline interleukin-4 |
| US5666153A (en) * | 1995-10-03 | 1997-09-09 | Virtual Shopping, Inc. | Retractable teleconferencing apparatus |
| US6664227B1 (en) * | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| US5843449A (en) * | 1996-03-25 | 1998-12-01 | Akzo Nobel N.V. | Proteins and novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases |
| US5856462A (en) * | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| EP1012184B1 (en) * | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| EP0911401A1 (en) * | 1997-10-21 | 1999-04-28 | Bayer Ag | Muteins of interleukin 4 showing low-affinity and short-term interaction with the common gamma chain |
| EP1071333A4 (en) * | 1998-03-20 | 2005-02-23 | Genzyme Corp | INDUCTION OF IMMUNITY AGAINST TUMOR AUTOANTIGENS |
| US6576232B1 (en) * | 1998-04-03 | 2003-06-10 | The Penn State Research Foundation | IL13 mutants |
| AU5617900A (en) * | 1999-06-17 | 2001-01-09 | Robert C. Gallo | Chimeric chemokine-antigen polypeptides and uses therefor |
| AU1599301A (en) * | 1999-11-11 | 2001-06-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Modulating IL-13 activity using mutated IL-13 molecules that are antagonists or agonists of IL-13 |
-
2001
- 2001-03-03 GB GBGB0105360.2A patent/GB0105360D0/en not_active Ceased
-
2002
- 2002-03-01 BR BR0207819-8A patent/BR0207819A/pt not_active IP Right Cessation
- 2002-03-01 AU AU2002233560A patent/AU2002233560B2/en not_active Ceased
- 2002-03-01 HU HU0303372A patent/HUP0303372A3/hu unknown
- 2002-03-01 JP JP2002570736A patent/JP4238031B2/ja not_active Expired - Fee Related
- 2002-03-01 KR KR10-2003-7011573A patent/KR20030081490A/ko not_active Ceased
- 2002-03-01 EP EP02700490A patent/EP1368477A1/en not_active Withdrawn
- 2002-03-01 CZ CZ20032373A patent/CZ20032373A3/cs unknown
- 2002-03-01 CA CA002439628A patent/CA2439628A1/en not_active Abandoned
- 2002-03-01 IL IL15749802A patent/IL157498A0/xx unknown
- 2002-03-01 WO PCT/GB2002/000900 patent/WO2002070711A1/en not_active Ceased
- 2002-03-01 PL PL02365066A patent/PL365066A1/xx unknown
- 2002-03-01 US US10/469,561 patent/US20050260216A1/en not_active Abandoned
- 2002-03-01 CN CNA028093240A patent/CN1543504A/zh active Pending
- 2002-03-01 MX MXPA03007915A patent/MXPA03007915A/es not_active Application Discontinuation
- 2002-03-01 NZ NZ527873A patent/NZ527873A/en unknown
- 2002-09-03 US US10/233,902 patent/US20030194391A1/en not_active Abandoned
-
2003
- 2003-08-26 ZA ZA200306647A patent/ZA200306647B/en unknown
- 2003-09-02 NO NO20033882A patent/NO20033882L/no not_active Application Discontinuation
-
2005
- 2005-01-24 US US11/041,636 patent/US20050186209A1/en not_active Abandoned
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