JP2003529537A - 環状置換縮合ピロロカルバゾール類及びイソインドロン類 - Google Patents
環状置換縮合ピロロカルバゾール類及びイソインドロン類Info
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- JP2003529537A JP2003529537A JP2000598503A JP2000598503A JP2003529537A JP 2003529537 A JP2003529537 A JP 2003529537A JP 2000598503 A JP2000598503 A JP 2000598503A JP 2000598503 A JP2000598503 A JP 2000598503A JP 2003529537 A JP2003529537 A JP 2003529537A
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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Landscapes
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| US09/500,849 US6841567B1 (en) | 1999-02-12 | 2000-02-10 | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| US09/500,849 | 2000-02-10 | ||
| PCT/US2000/003476 WO2000047583A1 (en) | 1999-02-12 | 2000-02-11 | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
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| EP (1) | EP1165562A1 (https=) |
| JP (1) | JP2003529537A (https=) |
| KR (1) | KR100697732B1 (https=) |
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| CA (1) | CA2359772C (https=) |
| CZ (1) | CZ20012878A3 (https=) |
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| TR (1) | TR200102338T2 (https=) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516293A (ja) * | 2003-12-23 | 2007-06-21 | セフアロン・インコーポレーテツド | 新規な縮合ピロロカルバゾール |
| JP2007526909A (ja) * | 2003-12-23 | 2007-09-20 | セフアロン・インコーポレーテツド | 新規な縮合ピロロカルバゾール |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
| US6841567B1 (en) * | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| US7122679B2 (en) * | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| MXPA03001218A (es) * | 2000-08-11 | 2003-05-27 | Cephalon Inc | Metodos para modular proteinas kinasa de linaje multiple y para estudiar compuestos que modulan proteinas kinasa de linaje multiple. |
| US6630500B2 (en) | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
| US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| DE10164581A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte Aminoalkohole |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| US20060058250A1 (en) * | 2004-09-10 | 2006-03-16 | Cephalon, Inc. | Methods of treating proliferative skin diseases using carbazole derivatives |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| WO2008076394A1 (en) * | 2006-12-14 | 2008-06-26 | Tautatis, Inc. | Compositions and methods for the treatment of cancer |
| WO2008077064A2 (en) * | 2006-12-19 | 2008-06-26 | Board Of Regents, The University Of Texas System | Biomarker identifying the reactivation of stat3 after src inhibition |
| US9061009B2 (en) * | 2007-06-08 | 2015-06-23 | University Of Massachusetts | Mixed lineage kinases and metabolic disorders |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CA2742790C (en) | 2008-11-19 | 2018-02-13 | Cephalon, Inc. | Novel forms of an indazolo[5,4-a]pyrrolo [3,4-c] carbazole compound |
| CN106420756A (zh) * | 2009-07-28 | 2017-02-22 | 里格尔药品股份有限公司 | 抑制jak途径的组合物和方法 |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| MX2013011589A (es) * | 2011-04-07 | 2013-12-16 | Ariad Pharma Inc | Metodos y composiciones para tratar enfermedad de parkinson. |
| MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
| ES3018133T3 (en) | 2011-11-30 | 2025-05-14 | Univ Emory | Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| WO2014145485A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Map kinase modulators and uses thereof |
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| WO1996011933A1 (en) * | 1994-10-14 | 1996-04-25 | Cephalon, Inc. | Fused pyrrolocarbazoles |
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| US473939A (en) * | 1892-05-03 | mason | ||
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US4923986A (en) | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
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- 2000-02-11 CZ CZ20012878A patent/CZ20012878A3/cs unknown
- 2000-02-11 CN CN00803647A patent/CN1350537A/zh active Pending
- 2000-02-11 KR KR1020017010212A patent/KR100697732B1/ko not_active Expired - Fee Related
- 2000-02-11 EA EA200100887A patent/EA005273B1/ru not_active IP Right Cessation
- 2000-02-11 CA CA002359772A patent/CA2359772C/en not_active Expired - Fee Related
- 2000-02-11 SK SK1129-2001A patent/SK11292001A3/sk unknown
- 2000-02-11 WO PCT/US2000/003476 patent/WO2000047583A1/en not_active Ceased
- 2000-02-11 TR TR2001/02338T patent/TR200102338T2/xx unknown
- 2000-02-11 AU AU33604/00A patent/AU773335B2/en not_active Ceased
- 2000-02-11 JP JP2000598503A patent/JP2003529537A/ja active Pending
- 2000-02-11 NZ NZ513097A patent/NZ513097A/en not_active IP Right Cessation
- 2000-02-11 BR BR0008056-0A patent/BR0008056A/pt not_active Application Discontinuation
- 2000-02-11 PL PL00352530A patent/PL352530A1/xx not_active Application Discontinuation
- 2000-02-11 EP EP00911759A patent/EP1165562A1/en not_active Ceased
- 2000-02-11 HR HR20010583A patent/HRP20010583A2/hr not_active Application Discontinuation
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2001
- 2001-07-20 IS IS6015A patent/IS6015A/is unknown
- 2001-08-09 NO NO20013887A patent/NO322210B1/no not_active IP Right Cessation
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2004
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2006
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| WO1996011933A1 (en) * | 1994-10-14 | 1996-04-25 | Cephalon, Inc. | Fused pyrrolocarbazoles |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516293A (ja) * | 2003-12-23 | 2007-06-21 | セフアロン・インコーポレーテツド | 新規な縮合ピロロカルバゾール |
| JP2007526909A (ja) * | 2003-12-23 | 2007-09-20 | セフアロン・インコーポレーテツド | 新規な縮合ピロロカルバゾール |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2359772A1 (en) | 2000-08-17 |
| NO20013887D0 (no) | 2001-08-09 |
| HRP20010583A2 (en) | 2002-08-31 |
| NO20013887L (no) | 2001-10-11 |
| NO322210B1 (no) | 2006-08-28 |
| WO2000047583A1 (en) | 2000-08-17 |
| EA200100887A1 (ru) | 2002-02-28 |
| SK11292001A3 (sk) | 2002-04-04 |
| CZ20012878A3 (cs) | 2002-08-14 |
| AU773335B2 (en) | 2004-05-20 |
| US7288650B2 (en) | 2007-10-30 |
| CN1350537A (zh) | 2002-05-22 |
| AU3360400A (en) | 2000-08-29 |
| US20040186157A1 (en) | 2004-09-23 |
| US20060128780A1 (en) | 2006-06-15 |
| KR20010102085A (ko) | 2001-11-15 |
| NZ513097A (en) | 2004-05-28 |
| IS6015A (is) | 2001-07-20 |
| TR200102338T2 (tr) | 2002-07-22 |
| EA005273B1 (ru) | 2004-12-30 |
| BR0008056A (pt) | 2002-04-09 |
| KR100697732B1 (ko) | 2007-03-22 |
| US7074793B2 (en) | 2006-07-11 |
| WO2000047583A8 (en) | 2001-03-29 |
| US6841567B1 (en) | 2005-01-11 |
| EP1165562A1 (en) | 2002-01-02 |
| WO2000047583A9 (en) | 2001-09-20 |
| PL352530A1 (en) | 2003-08-25 |
| CA2359772C (en) | 2009-08-11 |
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