EA005273B1 - Циклические замещенные конденсированные пирролкарбазолы и изоиндолоны - Google Patents
Циклические замещенные конденсированные пирролкарбазолы и изоиндолоны Download PDFInfo
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- EA005273B1 EA005273B1 EA200100887A EA200100887A EA005273B1 EA 005273 B1 EA005273 B1 EA 005273B1 EA 200100887 A EA200100887 A EA 200100887A EA 200100887 A EA200100887 A EA 200100887A EA 005273 B1 EA005273 B1 EA 005273B1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
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- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11983499P | 1999-02-12 | 1999-02-12 | |
| US09/500,849 US6841567B1 (en) | 1999-02-12 | 2000-02-10 | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| PCT/US2000/003476 WO2000047583A1 (en) | 1999-02-12 | 2000-02-11 | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100887A1 EA200100887A1 (ru) | 2002-02-28 |
| EA005273B1 true EA005273B1 (ru) | 2004-12-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100887A EA005273B1 (ru) | 1999-02-12 | 2000-02-11 | Циклические замещенные конденсированные пирролкарбазолы и изоиндолоны |
Country Status (18)
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|---|---|
| US (3) | US6841567B1 (https=) |
| EP (1) | EP1165562A1 (https=) |
| JP (1) | JP2003529537A (https=) |
| KR (1) | KR100697732B1 (https=) |
| CN (1) | CN1350537A (https=) |
| AU (1) | AU773335B2 (https=) |
| BR (1) | BR0008056A (https=) |
| CA (1) | CA2359772C (https=) |
| CZ (1) | CZ20012878A3 (https=) |
| EA (1) | EA005273B1 (https=) |
| HR (1) | HRP20010583A2 (https=) |
| IS (1) | IS6015A (https=) |
| NO (1) | NO322210B1 (https=) |
| NZ (1) | NZ513097A (https=) |
| PL (1) | PL352530A1 (https=) |
| SK (1) | SK11292001A3 (https=) |
| TR (1) | TR200102338T2 (https=) |
| WO (1) | WO2000047583A1 (https=) |
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| US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
| US6841567B1 (en) * | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| US7122679B2 (en) * | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| MXPA03001218A (es) * | 2000-08-11 | 2003-05-27 | Cephalon Inc | Metodos para modular proteinas kinasa de linaje multiple y para estudiar compuestos que modulan proteinas kinasa de linaje multiple. |
| US6630500B2 (en) | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
| US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| DE10164581A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte Aminoalkohole |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| US7241779B2 (en) | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US7169802B2 (en) * | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| US20060058250A1 (en) * | 2004-09-10 | 2006-03-16 | Cephalon, Inc. | Methods of treating proliferative skin diseases using carbazole derivatives |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| WO2008076394A1 (en) * | 2006-12-14 | 2008-06-26 | Tautatis, Inc. | Compositions and methods for the treatment of cancer |
| WO2008077064A2 (en) * | 2006-12-19 | 2008-06-26 | Board Of Regents, The University Of Texas System | Biomarker identifying the reactivation of stat3 after src inhibition |
| US9061009B2 (en) * | 2007-06-08 | 2015-06-23 | University Of Massachusetts | Mixed lineage kinases and metabolic disorders |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CA2742790C (en) | 2008-11-19 | 2018-02-13 | Cephalon, Inc. | Novel forms of an indazolo[5,4-a]pyrrolo [3,4-c] carbazole compound |
| CN106420756A (zh) * | 2009-07-28 | 2017-02-22 | 里格尔药品股份有限公司 | 抑制jak途径的组合物和方法 |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| MX2013011589A (es) * | 2011-04-07 | 2013-12-16 | Ariad Pharma Inc | Metodos y composiciones para tratar enfermedad de parkinson. |
| MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
| ES3018133T3 (en) | 2011-11-30 | 2025-05-14 | Univ Emory | Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| WO2014145485A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Map kinase modulators and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US473939A (en) * | 1892-05-03 | mason | ||
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ucn―01 |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US4923986A (en) | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | K−252誘導体 |
| FR2631199B1 (fr) | 1988-05-09 | 1991-03-15 | Centre Nat Rech Scient | Reacteur a plasma |
| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| US5461146A (en) | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621101A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| AU679752B2 (en) | 1993-05-28 | 1997-07-10 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| CA2179650C (en) | 1993-12-23 | 2007-10-30 | William Francis Heath, Jr. | Bisindolemaleimides and their use as protein kinase c inhibitors |
| US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5591855A (en) | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5705511A (en) | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5594009A (en) | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5475110A (en) | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
| WO1997007081A2 (en) | 1995-08-11 | 1997-02-27 | Yale University | Glycosylated indolocarbazole synthesis |
| SI0776895T1 (en) | 1995-11-20 | 1999-04-30 | Eli Lilly And Company | Protein kinase C inhibitor |
| US5808060A (en) | 1995-12-11 | 1998-09-15 | Cephalon, Inc. | Fused isoindolones |
| US5616724A (en) | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
| NZ333536A (en) | 1996-08-22 | 1999-10-28 | Bristol Myers Squibb Co | Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles, and use as antitumour agents |
| ATE251624T1 (de) | 1998-03-13 | 2003-10-15 | Univ British Columbia | Granulatimide-derivate zur behandlung von krebs |
| US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| JP2002523780A (ja) | 1998-08-26 | 2002-07-30 | セフアロン・インコーポレーテツド | 多系統キナーゼタンパク質の調節 |
| US6841567B1 (en) * | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
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2000
- 2000-02-10 US US09/500,849 patent/US6841567B1/en not_active Expired - Lifetime
- 2000-02-11 CZ CZ20012878A patent/CZ20012878A3/cs unknown
- 2000-02-11 CN CN00803647A patent/CN1350537A/zh active Pending
- 2000-02-11 KR KR1020017010212A patent/KR100697732B1/ko not_active Expired - Fee Related
- 2000-02-11 EA EA200100887A patent/EA005273B1/ru not_active IP Right Cessation
- 2000-02-11 CA CA002359772A patent/CA2359772C/en not_active Expired - Fee Related
- 2000-02-11 SK SK1129-2001A patent/SK11292001A3/sk unknown
- 2000-02-11 WO PCT/US2000/003476 patent/WO2000047583A1/en not_active Ceased
- 2000-02-11 TR TR2001/02338T patent/TR200102338T2/xx unknown
- 2000-02-11 AU AU33604/00A patent/AU773335B2/en not_active Ceased
- 2000-02-11 JP JP2000598503A patent/JP2003529537A/ja active Pending
- 2000-02-11 NZ NZ513097A patent/NZ513097A/en not_active IP Right Cessation
- 2000-02-11 BR BR0008056-0A patent/BR0008056A/pt not_active Application Discontinuation
- 2000-02-11 PL PL00352530A patent/PL352530A1/xx not_active Application Discontinuation
- 2000-02-11 EP EP00911759A patent/EP1165562A1/en not_active Ceased
- 2000-02-11 HR HR20010583A patent/HRP20010583A2/hr not_active Application Discontinuation
-
2001
- 2001-07-20 IS IS6015A patent/IS6015A/is unknown
- 2001-08-09 NO NO20013887A patent/NO322210B1/no not_active IP Right Cessation
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2004
- 2004-01-12 US US10/755,505 patent/US7074793B2/en not_active Expired - Fee Related
-
2006
- 2006-02-02 US US11/346,524 patent/US7288650B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2359772A1 (en) | 2000-08-17 |
| NO20013887D0 (no) | 2001-08-09 |
| HRP20010583A2 (en) | 2002-08-31 |
| NO20013887L (no) | 2001-10-11 |
| NO322210B1 (no) | 2006-08-28 |
| WO2000047583A1 (en) | 2000-08-17 |
| EA200100887A1 (ru) | 2002-02-28 |
| SK11292001A3 (sk) | 2002-04-04 |
| CZ20012878A3 (cs) | 2002-08-14 |
| AU773335B2 (en) | 2004-05-20 |
| US7288650B2 (en) | 2007-10-30 |
| CN1350537A (zh) | 2002-05-22 |
| AU3360400A (en) | 2000-08-29 |
| US20040186157A1 (en) | 2004-09-23 |
| JP2003529537A (ja) | 2003-10-07 |
| US20060128780A1 (en) | 2006-06-15 |
| KR20010102085A (ko) | 2001-11-15 |
| NZ513097A (en) | 2004-05-28 |
| IS6015A (is) | 2001-07-20 |
| TR200102338T2 (tr) | 2002-07-22 |
| BR0008056A (pt) | 2002-04-09 |
| KR100697732B1 (ko) | 2007-03-22 |
| US7074793B2 (en) | 2006-07-11 |
| WO2000047583A8 (en) | 2001-03-29 |
| US6841567B1 (en) | 2005-01-11 |
| EP1165562A1 (en) | 2002-01-02 |
| WO2000047583A9 (en) | 2001-09-20 |
| PL352530A1 (en) | 2003-08-25 |
| CA2359772C (en) | 2009-08-11 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |