JP2003528917A - 抗高血圧薬および抗血管新生薬の治療的組合せ - Google Patents
抗高血圧薬および抗血管新生薬の治療的組合せInfo
- Publication number
- JP2003528917A JP2003528917A JP2001572104A JP2001572104A JP2003528917A JP 2003528917 A JP2003528917 A JP 2003528917A JP 2001572104 A JP2001572104 A JP 2001572104A JP 2001572104 A JP2001572104 A JP 2001572104A JP 2003528917 A JP2003528917 A JP 2003528917A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pat
- methoxy
- quinazoline
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| GB0008269.3 | 2000-04-05 | ||
| GBGB0008269.3A GB0008269D0 (en) | 2000-04-05 | 2000-04-05 | Combination chemotherapy |
| PCT/GB2001/001522 WO2001074360A1 (en) | 2000-04-05 | 2001-04-02 | Therapeutic combinations of antihypertensive and antiangiogenic agents |
Publications (2)
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| JP2003528917A true JP2003528917A (ja) | 2003-09-30 |
| JP2003528917A5 JP2003528917A5 (https=) | 2008-01-31 |
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Country Status (29)
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| US (1) | US7829573B2 (https=) |
| EP (3) | EP1658849A3 (https=) |
| JP (1) | JP2003528917A (https=) |
| KR (2) | KR100849149B1 (https=) |
| CN (1) | CN1431902A (https=) |
| AT (1) | ATE355065T1 (https=) |
| AU (2) | AU2001244386B2 (https=) |
| BR (1) | BR0109729A (https=) |
| CA (1) | CA2401854A1 (https=) |
| CY (1) | CY1107615T1 (https=) |
| CZ (1) | CZ299410B6 (https=) |
| DE (1) | DE60126923T2 (https=) |
| DK (1) | DK1272186T3 (https=) |
| EE (1) | EE200200578A (https=) |
| ES (1) | ES2280349T3 (https=) |
| GB (1) | GB0008269D0 (https=) |
| HU (1) | HUP0300426A2 (https=) |
| IL (1) | IL151503A0 (https=) |
| IS (2) | IS2455B (https=) |
| MX (1) | MXPA02009743A (https=) |
| NO (2) | NO323467B1 (https=) |
| NZ (2) | NZ520938A (https=) |
| PL (1) | PL357605A1 (https=) |
| PT (1) | PT1272186E (https=) |
| RU (1) | RU2002129353A (https=) |
| SI (1) | SI1272186T1 (https=) |
| SK (1) | SK14302002A3 (https=) |
| WO (1) | WO2001074360A1 (https=) |
| ZA (1) | ZA200206959B (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516273A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・インク | 新規キノリン誘導体 |
| JP2007517008A (ja) * | 2003-12-24 | 2007-06-28 | アストラゼネカ アクチボラグ | 抗血管形成薬として有用なキナゾリン誘導体のマレイン酸塩 |
| JP2007532536A (ja) * | 2004-04-06 | 2007-11-15 | アンジオジェネティクス・スウェーデン・アクチボラゲット | 血管新生に作用する化合物およびその使用方法 |
| JP2008537538A (ja) * | 2005-02-11 | 2008-09-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆ拮抗剤及び降圧剤の治療的組み合わせ |
| JP2016510000A (ja) * | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
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| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| KR100881105B1 (ko) * | 1999-11-05 | 2009-02-02 | 아스트라제네카 아베 | Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체 |
| AU2001235804A1 (en) | 2000-03-06 | 2001-09-17 | Astrazeneca Ab | Therapy |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| SI1474420T1 (sl) * | 2002-02-01 | 2012-06-29 | Astrazeneca Ab | Spojine kinazolina |
| BR0309226A (pt) * | 2002-04-16 | 2005-02-09 | Astrazeneca Ab | Métodos para a produção de um efeito de danificação vascular em um animal de sangue quente, e para o tratamento de um câncer envolvendo um tumor sólido em um animal de sangue quente, composição farmacêutica, kit, e, usos de zd6126 ou de um seu sal farmaceuticamente aceitável, e de zd1839 ou de um seu sal farmaceuticamente aceitável |
| US7358236B1 (en) * | 2002-06-21 | 2008-04-15 | Oxigene, Inc. | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents |
| US7576074B2 (en) | 2002-07-15 | 2009-08-18 | Rice Kenneth D | Receptor-type kinase modulators and methods of use |
| US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
| KR101215701B1 (ko) * | 2002-07-19 | 2012-12-26 | 베스 이스라엘 데코니스 메디칼 센터 | 자간전증 또는 자간의 진단 및 치료 방법 |
| US7335362B2 (en) * | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| AU2003278383B2 (en) | 2002-11-04 | 2007-06-14 | Astrazeneca Ab | Quinazoline derivatives as Src tyrosine kinase inhibitors |
| KR20050100683A (ko) * | 2003-02-13 | 2005-10-19 | 아스트라제네카 아베 | 5-ｆｕ 또는/및 ｃｐｔ-11과 ｚｄ6474의 병용 요법 |
| GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
| GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| JP2006527753A (ja) * | 2003-06-18 | 2006-12-07 | アンギオジェン・ファーマシューティカルズ・リミテッド | 結腸直腸癌などの治療のための、血管損傷効果を有する、５−ｆｕ、ｃｐｔ−１１または５−ｆｕおよびｃｐｔ−１１と組み合わせたｚｄ６１２６を含んでなる組成物 |
| EP1648465B1 (en) * | 2003-07-10 | 2010-08-25 | AstraZeneca AB | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0316123D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0318422D0 (en) | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| ES2314444T3 (es) | 2003-08-29 | 2009-03-16 | Pfizer Inc. | Tienopiridina-fenilacetaminasy sus derivados utiles como nuevos agentes antiangiogenicos. |
| GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| MXPA06010755A (es) * | 2004-03-23 | 2006-12-15 | Astrazeneca Ab | Terapia de combinacion. |
| US20070142433A1 (en) * | 2004-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods of use thereof |
| US20070142308A1 (en) * | 2005-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods for use thereof |
| US8273383B2 (en) * | 2004-05-04 | 2012-09-25 | Children's Medical Center Corporation | Methods and compositions for treatment of preeclampsia |
| DE602005025755D1 (de) | 2004-06-04 | 2011-02-17 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
| EP2347765B1 (en) | 2004-09-24 | 2014-01-22 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating complications of pregnancy |
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| KR20070072543A (ko) * | 2004-09-27 | 2007-07-04 | 아스트라제네카 아베 | Ｚｄ6474 및 이마티닙을 포함하는 병합법 |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| JP4954085B2 (ja) | 2004-12-06 | 2012-06-13 | メディシノバ， インコーポレイテッド | 神経障害性疼痛及びその関連する症状を治療するためのイブジラスト |
| DE602005023216D1 (de) * | 2004-12-15 | 2010-10-07 | Beth Israel Hospital | Nukleinsäuren und polypeptide zur diagnose und behandlung von schwangerschaftskomplikationen |
| MX2007010965A (es) * | 2005-03-09 | 2007-09-19 | Merck & Co Inc | Antagonistas de canales de calcio de tipo t de quinazolinona. |
| KR20080031029A (ko) * | 2005-07-06 | 2008-04-07 | 아스트라제네카 아베 | Ａｚｄ2171 및 젬시타빈에 의한 암의 병용 요법 |
| AU2006277742B2 (en) | 2005-08-08 | 2010-08-26 | Pfizer Inc. | Salts and polymorphs of a VEGF-R inhibitor |
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| US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
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| CA2684938A1 (en) * | 2007-05-02 | 2008-11-13 | Tau Therapeutics Llc | Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions |
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| AU2008275674A1 (en) * | 2007-07-10 | 2009-01-15 | Merck & Co., Inc. | Quinazolinone T-type calcium channel antagonists |
| WO2010008554A2 (en) | 2008-07-14 | 2010-01-21 | The Regents Of The University Of Colorado | Methods and products for treating proliferative diseases |
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| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
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| JP2007516273A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・インク | 新規キノリン誘導体 |
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| US9556151B2 (en) | 2003-12-24 | 2017-01-31 | Astrazeneca Ab | Maleate salts of a quinazoline derivative useful as an antiangiogenic agent |
| US9890140B2 (en) | 2003-12-24 | 2018-02-13 | Astrazeneca Ab | Maleate salts of a quinazoline derivative useful as an antiangiogenic agent |
| JP2007532536A (ja) * | 2004-04-06 | 2007-11-15 | アンジオジェネティクス・スウェーデン・アクチボラゲット | 血管新生に作用する化合物およびその使用方法 |
| JP2008537538A (ja) * | 2005-02-11 | 2008-09-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆ拮抗剤及び降圧剤の治療的組み合わせ |
| JP2016510000A (ja) * | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
| JP2021006574A (ja) * | 2013-02-20 | 2021-01-21 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
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