JP2003528859A5 - - Google Patents
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- Publication number
- JP2003528859A5 JP2003528859A5 JP2001570627A JP2001570627A JP2003528859A5 JP 2003528859 A5 JP2003528859 A5 JP 2003528859A5 JP 2001570627 A JP2001570627 A JP 2001570627A JP 2001570627 A JP2001570627 A JP 2001570627A JP 2003528859 A5 JP2003528859 A5 JP 2003528859A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- group
- compound
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 47
- -1 carbamoyloxy Chemical group 0.000 description 41
- 229910052739 hydrogen Inorganic materials 0.000 description 38
- 239000001257 hydrogen Substances 0.000 description 38
- 125000000217 alkyl group Chemical group 0.000 description 31
- 150000002431 hydrogen Chemical class 0.000 description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 24
- 125000001072 heteroaryl group Chemical group 0.000 description 18
- 125000003342 alkenyl group Chemical group 0.000 description 15
- 125000000304 alkynyl group Chemical group 0.000 description 15
- 125000003118 aryl group Chemical group 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 13
- 125000001475 halogen functional group Chemical group 0.000 description 12
- 125000004093 cyano group Chemical group *C#N 0.000 description 11
- 125000000547 substituted alkyl group Chemical group 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 10
- 125000003282 alkyl amino group Chemical group 0.000 description 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 10
- 125000004103 aminoalkyl group Chemical group 0.000 description 10
- 125000004181 carboxyalkyl group Chemical group 0.000 description 10
- 125000004663 dialkyl amino group Chemical group 0.000 description 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 10
- 239000000651 prodrug Substances 0.000 description 10
- 229940002612 prodrug Drugs 0.000 description 10
- 239000012453 solvate Substances 0.000 description 10
- 150000003573 thiols Chemical class 0.000 description 10
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 description 9
- 229910052717 sulfur Inorganic materials 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 125000004423 acyloxy group Chemical group 0.000 description 7
- 125000006323 alkenyl amino group Chemical group 0.000 description 7
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- 150000001340 alkali metals Chemical class 0.000 description 6
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 6
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 6
- 125000003710 aryl alkyl group Chemical group 0.000 description 6
- 125000005100 aryl amino carbonyl group Chemical group 0.000 description 6
- 125000004658 aryl carbonyl amino group Chemical group 0.000 description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 6
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 5
- 125000004414 alkyl thio group Chemical group 0.000 description 5
- 150000001356 alkyl thiols Chemical class 0.000 description 5
- 150000001408 amides Chemical class 0.000 description 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 5
- 125000005018 aryl alkenyl group Chemical group 0.000 description 5
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 description 5
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 description 5
- 125000005015 aryl alkynyl group Chemical group 0.000 description 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 125000001188 haloalkyl group Chemical group 0.000 description 5
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 description 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 4
- 150000001540 azides Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000000094 Chronic Pain Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108010052164 Sodium Channels Proteins 0.000 description 2
- 102000018674 Sodium Channels Human genes 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 238000002690 local anesthesia Methods 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 230000000626 neurodegenerative effect Effects 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 description 1
- LGWCODVBNJMICU-UHFFFAOYSA-N 1-(4-phenoxyphenyl)pyrazole-3-carboxamide Chemical compound N1=C(C(=O)N)C=CN1C(C=C1)=CC=C1OC1=CC=CC=C1 LGWCODVBNJMICU-UHFFFAOYSA-N 0.000 description 1
- VOSXPJNVZDWDCS-UHFFFAOYSA-N 1-[4-(4-fluorophenoxy)phenyl]-3-methylpyrazole Chemical compound N1=C(C)C=CN1C(C=C1)=CC=C1OC1=CC=C(F)C=C1 VOSXPJNVZDWDCS-UHFFFAOYSA-N 0.000 description 1
- YOUSWIIJVNLNGX-UHFFFAOYSA-N 1-[4-(4-nitrophenoxy)phenyl]-1,2,4-triazole Chemical compound C1=CC([N+](=O)[O-])=CC=C1OC1=CC=C(N2N=CN=C2)C=C1 YOUSWIIJVNLNGX-UHFFFAOYSA-N 0.000 description 1
- SSPWLONPNZFINW-UHFFFAOYSA-N 2-(4-phenoxyphenyl)pyrazole-3-carboxamide Chemical compound NC(=O)C1=CC=NN1C(C=C1)=CC=C1OC1=CC=CC=C1 SSPWLONPNZFINW-UHFFFAOYSA-N 0.000 description 1
- 0 C*c1ccc(*c2ccccc2)cc1 Chemical compound C*c1ccc(*c2ccccc2)cc1 0.000 description 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical class N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000006727 cell loss Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19175700P | 2000-03-24 | 2000-03-24 | |
| US60/191,757 | 2000-03-24 | ||
| PCT/US2001/008972 WO2001072714A2 (en) | 2000-03-24 | 2001-03-22 | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012153718A Division JP2012193194A (ja) | 2000-03-24 | 2012-07-09 | ナトリウムチャネル遮断薬としてのアリール置換ピラゾール、トリアゾールおよびテトラゾール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528859A JP2003528859A (ja) | 2003-09-30 |
| JP2003528859A5 true JP2003528859A5 (enExample) | 2008-05-08 |
| JP5132861B2 JP5132861B2 (ja) | 2013-01-30 |
Family
ID=22706817
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570627A Expired - Fee Related JP5132861B2 (ja) | 2000-03-24 | 2001-03-22 | ナトリウムチャネル遮断薬としてのアリール置換ピラゾール、トリアゾールおよびテトラゾール |
| JP2012153718A Pending JP2012193194A (ja) | 2000-03-24 | 2012-07-09 | ナトリウムチャネル遮断薬としてのアリール置換ピラゾール、トリアゾールおよびテトラゾール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012153718A Pending JP2012193194A (ja) | 2000-03-24 | 2012-07-09 | ナトリウムチャネル遮断薬としてのアリール置換ピラゾール、トリアゾールおよびテトラゾール |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7078426B2 (enExample) |
| EP (1) | EP1292577B1 (enExample) |
| JP (2) | JP5132861B2 (enExample) |
| KR (1) | KR100776934B1 (enExample) |
| CN (1) | CN1321112C (enExample) |
| AU (2) | AU4589701A (enExample) |
| BR (1) | BR0108819A (enExample) |
| CA (1) | CA2400778C (enExample) |
| CZ (1) | CZ303632B6 (enExample) |
| ES (1) | ES2398093T3 (enExample) |
| HK (1) | HK1056164B (enExample) |
| HU (1) | HU229371B1 (enExample) |
| IL (2) | IL151418A0 (enExample) |
| MX (1) | MXPA02009279A (enExample) |
| NO (1) | NO324054B1 (enExample) |
| NZ (1) | NZ520875A (enExample) |
| PL (1) | PL214230B1 (enExample) |
| RU (1) | RU2276141C9 (enExample) |
| UA (1) | UA75883C2 (enExample) |
| WO (1) | WO2001072714A2 (enExample) |
| ZA (1) | ZA200206534B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04000411A (es) * | 2001-07-16 | 2004-03-18 | Euro Celtique Sa | Tiazolidinonas arilo sustituidas y uso de las mismas. |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| WO2003037900A2 (en) * | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazolopyrimidines |
| KR20040099324A (ko) * | 2002-03-13 | 2004-11-26 | 유로-셀티큐 에스.에이. | 아릴 치환된 피리미딘 및 이것의 용도 |
| KR20050026031A (ko) * | 2002-07-31 | 2005-03-14 | 유로-셀티큐 에스.에이. | 아릴 치환된 벤즈이미다졸 및 나트륨 채널 차단제로서이의 용도 |
| US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
| US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
| RU2372339C2 (ru) * | 2003-11-10 | 2009-11-10 | Мерк Энд Ко., Инк. | Замещенные триазолы в качестве блокаторов натриевых каналов |
| EP1593671A1 (en) * | 2004-03-05 | 2005-11-09 | Graffinity Pharmaceuticals AG | DPP-IV inhibitors |
| US7531560B2 (en) | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| WO2009102893A2 (en) | 2008-02-14 | 2009-08-20 | Amira Pharmaceuticals, Inc. | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors |
| RU2368613C1 (ru) * | 2008-02-19 | 2009-09-27 | Институт молекулярной генетики Российской Академии наук (ИМГ РАН) (Статус Государственного учреждения) | Равномерно меченный тритием 4,4-дифтор-n-{(1s)-3-[3-(3-изопропил-5-метил-4н-1,2,4-триазол-4-ил)-8-азабицикло[3.2.1]окт-8-ил]-1-фенилпропил}циклогексан карбодиимид |
| WO2009145989A2 (en) | 2008-04-02 | 2009-12-03 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| CN106243037A (zh) * | 2009-05-07 | 2016-12-21 | 格吕伦塔尔有限公司 | 作为香草类化合物受体之配体的取代的苯基脲及苯基酰胺 |
| EP2582666B1 (en) * | 2010-06-16 | 2014-08-13 | Purdue Pharma L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
| WO2012007836A1 (en) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Pyridine compounds as sodium channel blockers |
| EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| JP2013540130A (ja) | 2010-10-05 | 2013-10-31 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのキナゾリン化合物 |
| CA2822789A1 (en) | 2010-12-22 | 2012-06-28 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| TW201331186A (zh) | 2011-09-02 | 2013-08-01 | Purdue Pharma Lp | 作為鈉通道阻斷劑之嘧啶類 |
| WO2013064883A1 (en) * | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| WO2013064884A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| US9206127B2 (en) | 2012-03-16 | 2015-12-08 | Purdue Pharm, L.P. | Substituted pyridines as sodium channel blockers |
| US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| EP3293184B1 (en) | 2013-03-04 | 2020-12-16 | Purdue Pharma L.P. | Pyrimidine carboxamides as sodium channel blockers |
| CA3082427A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| EP3039019B1 (en) | 2013-08-26 | 2020-04-22 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
| US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| WO2015099841A1 (en) | 2013-12-23 | 2015-07-02 | Purdue Pharma L.P. | Indazoles and use thereof |
| US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| JP6526023B2 (ja) | 2014-01-24 | 2019-06-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン類及びピリミジン類並びにその使用 |
| CA2939501C (en) | 2014-02-12 | 2020-07-07 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| WO2015161014A1 (en) * | 2014-04-17 | 2015-10-22 | Merck Sharp & Dohme Corp. | Heterocyclic cgrp receptor antagonists |
| CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
| EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| AU2016219879A1 (en) | 2015-02-19 | 2017-08-24 | Purdue Pharma L.P. | Methods and compositions for decreasing gastric emptying |
| WO2019195777A1 (en) | 2018-04-06 | 2019-10-10 | Aquinox Pharmaceuticals (Canada) Inc. | Indene derivatives useful in treating pain and inflammation |
| CN109369617B (zh) * | 2018-12-13 | 2020-07-31 | 中国科学院福建物质结构研究所 | 一种1-(2-吡啶基)-吡唑-3-甲酸及其衍生物的合成方法 |
| EP4003009A4 (en) | 2019-07-24 | 2023-07-26 | Oregon Health & Science University | SECOND GENERATION MITOCHONDRIAL PERMEABILITY TRANSITION PORE (MTPTP) INHIBITORS WITH IMPROVED PLASMA STABILITY |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3058989A (en) | 1957-11-26 | 1962-10-16 | American Cyanamid Co | Pyridotriazole brighteners |
| US3049438A (en) | 1957-11-26 | 1962-08-14 | American Cyanamid Co | Pyridotriazole brighteners |
| CH498902A (de) * | 1968-07-19 | 1970-11-15 | Geigy Ag J R | Verwendung von Triazolylcumarinen als optische Aufheller in nicht textilen Materialien |
| NZ178996A (en) | 1974-11-15 | 1978-06-02 | Kornis G | Pyrfazole amides and thioamides;herbicidal compositions |
| DE2910330A1 (de) | 1979-03-16 | 1980-10-02 | Hoechst Ag | 1-phenyl-3-amino-5-hydroxy-1,2,4-triazolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4394514A (en) | 1981-04-30 | 1983-07-19 | Smithkline Beckman Corporation | Processes for preparing 4-substituted indoles |
| US4454337A (en) | 1981-06-29 | 1984-06-12 | Smithkline Beckman Corporation | Semicarbazide intermediates for preparing 4-substituted indoles |
| GB2105327A (en) | 1981-08-17 | 1983-03-23 | Ciba Geigy Ag | Novel 2-phenyl-2H-1,2,3-triazoles and their use in the preparation of fluorescent whitening agents |
| DE3215967A1 (de) * | 1982-04-29 | 1983-11-03 | Basf Ag, 6700 Ludwigshafen | Elektrographische aufzeichnungsmaterialien mit speziellen ladungstraeger transportierenden verbindungen |
| US4618681A (en) * | 1983-03-18 | 1986-10-21 | The University Of Kentucky Research Foundation | Aryl substituted 1H-4,5-dihydro-1,2,3-triazoles as anticonvulsants |
| DE3525205A1 (de) | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
| FR2607503B1 (fr) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE3643403A1 (de) | 1986-12-19 | 1988-06-30 | Shell Agrar Gmbh & Co Kg | Benzophenone und verfahren zu ihrer herstellung |
| DE3717038A1 (de) | 1987-05-21 | 1988-12-08 | Basf Ag | Photopolymerisierbare aufzeichnungsmaterialien sowie photoresistschichten und flachdruckplatten auf basis dieser aufzeichnungsmaterialien |
| US5015651A (en) | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| EP0488959A3 (en) | 1990-11-28 | 1992-08-05 | Sandoz Ltd. | New uses of competitive nmda receptor antagonists |
| IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5550147A (en) | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| SE9302332D0 (sv) * | 1993-07-06 | 1993-07-06 | Ab Astra | New compounds |
| DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US5602156A (en) | 1993-09-17 | 1997-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for inhibiting metalloproteinase expression |
| US5744492A (en) | 1993-09-17 | 1998-04-28 | United States Of America | Method for inhibiting angiogenesis |
| SK281577B6 (sk) * | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
| US6057346A (en) | 1994-12-12 | 2000-05-02 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of retroviral LTR promoters by calcium response modifiers |
| US5741818A (en) * | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
| GB9601128D0 (en) | 1995-08-11 | 1996-03-20 | Pfizer Ltd | Parasiticidal compounds |
| JPH11199566A (ja) * | 1997-04-03 | 1999-07-27 | Mitsubishi Chemical Corp | １−置換−ピラゾール−３−カルボキサミド誘導体およびこれを有効成分とする殺菌剤 |
| JP4385414B2 (ja) * | 1997-10-13 | 2009-12-16 | アステラス製薬株式会社 | アミド若しくはアミン誘導体 |
| EP1042290A1 (en) * | 1997-11-14 | 2000-10-11 | G.D. SEARLE & CO. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| CA2332957A1 (en) * | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
| UA72244C2 (en) | 1999-03-26 | 2005-02-15 | Aryl-substituted pyrazols, imidazols, oxazols, thiazols, pyrrols and their use | |
| US6344563B1 (en) * | 1999-08-31 | 2002-02-05 | Timothy Norris | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
-
2001
- 2001-03-22 WO PCT/US2001/008972 patent/WO2001072714A2/en not_active Ceased
- 2001-03-22 IL IL15141801A patent/IL151418A0/xx unknown
- 2001-03-22 RU RU2002128916/04A patent/RU2276141C9/ru not_active IP Right Cessation
- 2001-03-22 NZ NZ520875A patent/NZ520875A/en not_active IP Right Cessation
- 2001-03-22 PL PL360534A patent/PL214230B1/pl unknown
- 2001-03-22 AU AU4589701A patent/AU4589701A/xx active Pending
- 2001-03-22 US US09/814,123 patent/US7078426B2/en not_active Expired - Lifetime
- 2001-03-22 KR KR1020027012598A patent/KR100776934B1/ko not_active Expired - Fee Related
- 2001-03-22 EP EP01918874A patent/EP1292577B1/en not_active Expired - Lifetime
- 2001-03-22 MX MXPA02009279A patent/MXPA02009279A/es active IP Right Grant
- 2001-03-22 HK HK03106683.6A patent/HK1056164B/en not_active IP Right Cessation
- 2001-03-22 HU HU0300867A patent/HU229371B1/hu not_active IP Right Cessation
- 2001-03-22 CA CA2400778A patent/CA2400778C/en not_active Expired - Fee Related
- 2001-03-22 JP JP2001570627A patent/JP5132861B2/ja not_active Expired - Fee Related
- 2001-03-22 CN CNB018068561A patent/CN1321112C/zh not_active Expired - Fee Related
- 2001-03-22 UA UA2002108393A patent/UA75883C2/uk unknown
- 2001-03-22 BR BR0108819-0A patent/BR0108819A/pt not_active IP Right Cessation
- 2001-03-22 ES ES01918874T patent/ES2398093T3/es not_active Expired - Lifetime
- 2001-03-22 AU AU2001245897A patent/AU2001245897B2/en not_active Ceased
- 2001-03-22 CZ CZ20023486A patent/CZ303632B6/cs not_active IP Right Cessation
-
2002
- 2002-08-15 ZA ZA200206534A patent/ZA200206534B/en unknown
- 2002-08-22 IL IL151418A patent/IL151418A/en not_active IP Right Cessation
- 2002-09-16 NO NO20024426A patent/NO324054B1/no not_active IP Right Cessation
-
2003
- 2003-06-09 US US10/456,735 patent/US6919363B2/en not_active Expired - Lifetime
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2012
- 2012-07-09 JP JP2012153718A patent/JP2012193194A/ja active Pending
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