JP2003528826A5 - - Google Patents
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- Publication number
- JP2003528826A5 JP2003528826A5 JP2001562556A JP2001562556A JP2003528826A5 JP 2003528826 A5 JP2003528826 A5 JP 2003528826A5 JP 2001562556 A JP2001562556 A JP 2001562556A JP 2001562556 A JP2001562556 A JP 2001562556A JP 2003528826 A5 JP2003528826 A5 JP 2003528826A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- gly
- preparation
- arrhythmia
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 6
- 206010003119 arrhythmia Diseases 0.000 description 4
- 230000006793 arrhythmia Effects 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 206010049447 Tachyarrhythmia Diseases 0.000 description 2
- 208000001871 Tachycardia Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 206010049765 Bradyarrhythmia Diseases 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200000288 | 2000-02-23 | ||
| DKPA200000288 | 2000-02-23 | ||
| DKPA200000738 | 2000-05-04 | ||
| DK200000738 | 2000-05-04 | ||
| PCT/DK2001/000127 WO2001062775A2 (en) | 2000-02-23 | 2001-02-22 | Novel antiarrhythmic peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528826A JP2003528826A (ja) | 2003-09-30 |
| JP2003528826A5 true JP2003528826A5 (https=) | 2006-02-16 |
| JP4327398B2 JP4327398B2 (ja) | 2009-09-09 |
Family
ID=26068776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562556A Expired - Fee Related JP4327398B2 (ja) | 2000-02-23 | 2001-02-22 | 新規な抗不整脈性ペプチド |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1226160B1 (https=) |
| JP (1) | JP4327398B2 (https=) |
| AT (1) | ATE284896T1 (https=) |
| AU (1) | AU781674B2 (https=) |
| CA (1) | CA2385659C (https=) |
| DE (1) | DE60107803T2 (https=) |
| ES (1) | ES2228807T3 (https=) |
| PT (1) | PT1226160E (https=) |
| WO (1) | WO2001062775A2 (https=) |
| ZA (1) | ZA200306410B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7585839B2 (en) | 2000-02-23 | 2009-09-08 | Zealand Pharma A/S | Medical uses of intercellular communication facilitating compounds |
| US7250397B2 (en) | 2000-02-23 | 2007-07-31 | Zealand Pharma A/S | Antiarrhythmic peptides |
| JP2005506295A (ja) * | 2001-02-22 | 2005-03-03 | ジーランド ファーマ アクティーゼルスカブ | 細胞間連絡促進化合物の新規医薬使用 |
| HRP20040784A2 (en) | 2002-01-29 | 2005-04-30 | Wyeth | Compositions and methods for modulating connexin hemichannels |
| US20060194947A1 (en) * | 2002-11-25 | 2006-08-31 | Larsen Bjarne D | Peptide gap junction modulators |
| US7405210B2 (en) | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| DE602005023965D1 (de) | 2004-03-08 | 2010-11-18 | Prosidion Ltd | Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| UA96283C2 (uk) | 2005-12-23 | 2011-10-25 | Зіланд Фарма А/С | Модифіковані міметики лізину |
| EP2074087A2 (en) | 2006-12-21 | 2009-07-01 | Wyeth | Synthesis of pyrrolidine compounds |
| EP2260859A1 (en) | 2009-06-12 | 2010-12-15 | Zealand Pharma A/S | Compounds acting as peptide gap junction modulators and their uses |
| EP2900684A2 (en) | 2012-09-29 | 2015-08-05 | Novartis AG | Cyclic peptides and use as medicines |
| CN103113456B (zh) * | 2013-03-05 | 2014-07-16 | 中国药科大学 | 具有抗血小板聚集活性的僵蚕多肽及其制备方法和应用 |
| CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6259296A (ja) * | 1985-09-10 | 1987-03-14 | Green Cross Corp:The | ペプタイド誘導体 |
| DE19500990A1 (de) * | 1995-01-14 | 1996-07-18 | Stefan Dr Med Dhein | Neues Peptid, seine Herstellung und Verwendung |
| DE19707854A1 (de) * | 1997-02-27 | 1998-09-03 | Dhein Stefan Priv Doz Dr Med | Neue Cyclopeptide, deren Herstellung und Verwendung |
-
2001
- 2001-02-22 DE DE60107803T patent/DE60107803T2/de not_active Expired - Lifetime
- 2001-02-22 PT PT01907393T patent/PT1226160E/pt unknown
- 2001-02-22 JP JP2001562556A patent/JP4327398B2/ja not_active Expired - Fee Related
- 2001-02-22 WO PCT/DK2001/000127 patent/WO2001062775A2/en not_active Ceased
- 2001-02-22 EP EP01907393A patent/EP1226160B1/en not_active Expired - Lifetime
- 2001-02-22 AU AU35362/01A patent/AU781674B2/en not_active Ceased
- 2001-02-22 CA CA2385659A patent/CA2385659C/en not_active Expired - Fee Related
- 2001-02-22 ES ES01907393T patent/ES2228807T3/es not_active Expired - Lifetime
- 2001-02-22 AT AT01907393T patent/ATE284896T1/de active
-
2003
- 2003-08-18 ZA ZA200306410A patent/ZA200306410B/en unknown
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