JP2003523721A5 - - Google Patents

Info

Publication number

JP2003523721A5

JP2003523721A5 JP2000591195A JP2000591195A JP2003523721A5 JP 2003523721 A5 JP2003523721 A5 JP 2003523721A5 JP 2000591195 A JP2000591195 A JP 2000591195A JP 2000591195 A JP2000591195 A JP 2000591195A JP 2003523721 A5 JP2003523721 A5 JP 2003523721A5

Authority

JP

Japan

Prior art keywords

cell

expression cassette

sequence

polypeptide

polynucleotide

Prior art date

1999-12-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 description 44
• 102000004196 processed proteins & peptides Human genes 0.000 description 44
• 108090000765 processed proteins & peptides Proteins 0.000 description 44
• 239000002157 polynucleotide Substances 0.000 description 42
• 210000004027 cell Anatomy 0.000 description 41
• 108091033319 polynucleotide Proteins 0.000 description 40
• 102000040430 polynucleotide Human genes 0.000 description 40
• 239000002773 nucleotide Substances 0.000 description 15
• 125000003729 nucleotide group Chemical group 0.000 description 14
• 239000003814 drug Substances 0.000 description 6
• 230000028993 immune response Effects 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• 238000003259 recombinant expression Methods 0.000 description 4
• 241000238631 Hexapoda Species 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 238000013518 transcription Methods 0.000 description 3
• 230000035897 transcription Effects 0.000 description 3
• 239000013598 vector Substances 0.000 description 3
• 102100034343 Integrase Human genes 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 210000000130 stem cell Anatomy 0.000 description 2
• 239000013603 viral vector Substances 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 108091026890 Coding region Proteins 0.000 description 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
• 108010010369 HIV Protease Proteins 0.000 description 1
• 108010061833 Integrases Proteins 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 241000255993 Trichoplusia ni Species 0.000 description 1
• 210000000612 antigen-presenting cell Anatomy 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 239000013604 expression vector Substances 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 210000001822 immobilized cell Anatomy 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 229940065638 intron a Drugs 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 210000003501 vero cell Anatomy 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1