JP2005521380A5 - - Google Patents

Info

Publication number

JP2005521380A5

JP2005521380A5 JP2003525580A JP2003525580A JP2005521380A5 JP 2005521380 A5 JP2005521380 A5 JP 2005521380A5 JP 2003525580 A JP2003525580 A JP 2003525580A JP 2003525580 A JP2003525580 A JP 2003525580A JP 2005521380 A5 JP2005521380 A5 JP 2005521380A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

expression cassette

vector

cell

Prior art date

2002-07-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims 38
• 108090000765 processed proteins & peptides Proteins 0.000 claims 38
• 102000004196 processed proteins & peptides Human genes 0.000 claims 38
• 238000000034 method Methods 0.000 claims 28
• 108091033319 polynucleotide Proteins 0.000 claims 26
• 102000040430 polynucleotide Human genes 0.000 claims 26
• 239000002157 polynucleotide Substances 0.000 claims 26
• 210000004027 cell Anatomy 0.000 claims 24
• 239000013598 vector Substances 0.000 claims 23
• 238000001476 gene delivery Methods 0.000 claims 7
• 239000013603 viral vector Substances 0.000 claims 6
• 238000003259 recombinant expression Methods 0.000 claims 5
• 241000238631 Hexapoda Species 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 3
• 241000710929 Alphavirus Species 0.000 claims 2
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
• 239000010931 gold Substances 0.000 claims 2
• 229910052737 gold Inorganic materials 0.000 claims 2
• 239000002502 liposome Substances 0.000 claims 2
• 210000004698 lymphocyte Anatomy 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 230000001177 retroviral effect Effects 0.000 claims 2
• 210000000130 stem cell Anatomy 0.000 claims 2
• 230000035897 transcription Effects 0.000 claims 2
• 238000013518 transcription Methods 0.000 claims 2
• 238000001890 transfection Methods 0.000 claims 2
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 2
• 229910052721 tungsten Inorganic materials 0.000 claims 2
• 239000010937 tungsten Substances 0.000 claims 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 1
• 108090000157 Metallothionein Proteins 0.000 claims 1
• 102000003792 Metallothionein Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 101710149951 Protein Tat Proteins 0.000 claims 1
• 230000024932 T cell mediated immunity Effects 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 241000255993 Trichoplusia ni Species 0.000 claims 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 210000004443 dendritic cell Anatomy 0.000 claims 1
• 230000028996 humoral immune response Effects 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 229940065638 intron a Drugs 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 230000008488 polyadenylation Effects 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1
• 230000005030 transcription termination Effects 0.000 claims 1
• 230000002103 transcriptional effect Effects 0.000 claims 1
• 230000014621 translational initiation Effects 0.000 claims 1
• 210000003501 vero cell Anatomy 0.000 claims 1
• 210000005253 yeast cell Anatomy 0.000 claims 1