JP2003523394A - 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその使用 - Google Patents
第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその使用Info
- Publication number
- JP2003523394A JP2003523394A JP2001561327A JP2001561327A JP2003523394A JP 2003523394 A JP2003523394 A JP 2003523394A JP 2001561327 A JP2001561327 A JP 2001561327A JP 2001561327 A JP2001561327 A JP 2001561327A JP 2003523394 A JP2003523394 A JP 2003523394A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- group
- intercalated
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000007704 transition Effects 0.000 title claims abstract description 23
- 150000001875 compounds Chemical class 0.000 title abstract description 47
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- 230000004792 oxidative damage Effects 0.000 claims abstract description 8
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- 229910052751 metal Inorganic materials 0.000 claims abstract description 7
- 239000002184 metal Substances 0.000 claims abstract description 7
- 208000024693 gingival disease Diseases 0.000 claims abstract description 5
- 239000000126 substance Substances 0.000 claims description 232
- 125000000217 alkyl group Chemical group 0.000 claims description 170
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- 125000003342 alkenyl group Chemical group 0.000 claims description 112
- 125000003118 aryl group Chemical group 0.000 claims description 99
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- 125000004171 alkoxy aryl group Chemical group 0.000 claims description 61
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 54
- 125000005001 aminoaryl group Chemical group 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 53
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 44
- 125000004414 alkyl thio group Chemical group 0.000 claims description 43
- 125000005021 aminoalkenyl group Chemical group 0.000 claims description 43
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 43
- 125000004104 aryloxy group Chemical group 0.000 claims description 43
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims description 43
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 43
- 125000005108 alkenylthio group Chemical group 0.000 claims description 42
- 125000005843 halogen group Chemical group 0.000 claims description 34
- 125000005110 aryl thio group Chemical group 0.000 claims description 33
- 125000005027 hydroxyaryl group Chemical group 0.000 claims description 33
- 229910052736 halogen Inorganic materials 0.000 claims description 30
- 125000004122 cyclic group Chemical group 0.000 claims description 24
- 239000000539 dimer Substances 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
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- LLKJIZGVRHHRQB-UHFFFAOYSA-N [4,7-bis(phosphonomethyl)-1,4,7-triazonan-1-yl]methylphosphonic acid Chemical group OP(O)(=O)CN1CCN(CP(O)(O)=O)CCN(CP(O)(O)=O)CC1 LLKJIZGVRHHRQB-UHFFFAOYSA-N 0.000 claims description 11
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
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- 125000005647 linker group Chemical group 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 5
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- 239000007983 Tris buffer Substances 0.000 description 50
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- 238000000338 in vitro Methods 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 235000019645 odor Nutrition 0.000 description 9
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 7
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
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- 241000700159 Rattus Species 0.000 description 7
- 238000004587 chromatography analysis Methods 0.000 description 7
- LXCYSACZTOKNNS-UHFFFAOYSA-N diethoxy(oxo)phosphanium Chemical compound CCO[P+](=O)OCC LXCYSACZTOKNNS-UHFFFAOYSA-N 0.000 description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
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- NDSKVKDJJFCGRP-UHFFFAOYSA-N 1,4,7-triazonan-1-ylmethylphosphonic acid Chemical compound OP(O)(=O)CN1CCNCCNCC1 NDSKVKDJJFCGRP-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- NJQLCHWGWNGGIT-UHFFFAOYSA-N trimethyl(3-methylidenepentan-2-yloxy)silane Chemical compound CCC(=C)C(C)O[Si](C)(C)C NJQLCHWGWNGGIT-UHFFFAOYSA-N 0.000 description 1
- BMJHTFWPTJVYJV-UHFFFAOYSA-N trimethyl(pent-2-en-3-yloxy)silane Chemical compound CCC(=CC)O[Si](C)(C)C BMJHTFWPTJVYJV-UHFFFAOYSA-N 0.000 description 1
- AALUTIYNYXEFNT-UHFFFAOYSA-N trimethylsilane hydroiodide Chemical compound C[SiH](C)C.I AALUTIYNYXEFNT-UHFFFAOYSA-N 0.000 description 1
- VFJYIHQDILEQNR-UHFFFAOYSA-M trimethylsulfanium;iodide Chemical compound [I-].C[S+](C)C VFJYIHQDILEQNR-UHFFFAOYSA-M 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/510,134 | 2000-02-22 | ||
| US09/510,134 US6264966B1 (en) | 2000-02-22 | 2000-02-22 | Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury |
| PCT/US2001/004977 WO2001062262A1 (en) | 2000-02-22 | 2001-02-14 | Compounds with chelation affinity and selectivity for first transition series elements and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523394A true JP2003523394A (ja) | 2003-08-05 |
| JP2003523394A5 JP2003523394A5 (enExample) | 2005-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561327A Pending JP2003523394A (ja) | 2000-02-22 | 2001-02-14 | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6264966B1 (enExample) |
| EP (2) | EP2011501A1 (enExample) |
| JP (1) | JP2003523394A (enExample) |
| AT (1) | ATE406902T1 (enExample) |
| AU (1) | AU2001237038A1 (enExample) |
| CA (1) | CA2399299C (enExample) |
| DE (2) | DE01909263T1 (enExample) |
| ES (1) | ES2239924T1 (enExample) |
| IL (2) | IL151031A0 (enExample) |
| WO (1) | WO2001062262A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030158111A1 (en) * | 1999-10-01 | 2003-08-21 | David Bar-Or | Methods and products for oral care |
| US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US7632803B2 (en) * | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US20030130185A1 (en) * | 2000-09-29 | 2003-07-10 | David Bar-Or | Metal-binding compounds and uses therefor |
| HRP20020547B1 (hr) | 1999-12-24 | 2011-06-30 | Aventis Pharma Limited | Azaindoli |
| US6264966B1 (en) * | 2000-02-22 | 2001-07-24 | Concat, Ltd. | Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury |
| US6881732B2 (en) * | 2002-06-13 | 2005-04-19 | Chelator Llc | Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements |
| BRPI0410505A (pt) * | 2003-05-07 | 2006-06-20 | Dmi Biosciences Inc | métodos e produtos para cuidados orais |
| US20050112066A1 (en) * | 2003-11-26 | 2005-05-26 | Concat Lp, A California Limited Partnership | Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity |
| US7659233B2 (en) * | 2004-10-25 | 2010-02-09 | Conopco, Inc. | Personal care compositions with silicones and dihydroxypropyl trialkyl ammonium salts |
| US8476251B2 (en) | 2010-07-29 | 2013-07-02 | Conopco, Inc. | Skin care compositions comprising substituted diamines |
| US8293218B2 (en) | 2010-07-29 | 2012-10-23 | Conopco, Inc. | Skin care compositions comprising substituted monoamines |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CN103086922A (zh) * | 2013-02-07 | 2013-05-08 | 东华大学 | 一种n-烷氧基-4-戊烯酰胺类化合物及其制备方法 |
| KR101709124B1 (ko) * | 2015-08-19 | 2017-02-22 | 기초과학연구원 | 신규한 키랄 금속 착물 및 분광법에 의해 전하를 띤 화합물의 키랄성을 분석하기 위한 이의 용도 |
| KR20180095871A (ko) | 2015-12-16 | 2018-08-28 | 프리오스타 피티와이 엘티디 | 덴드리머 및 그의 배합물 |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| CA3062553C (en) | 2017-05-05 | 2024-02-06 | Fusion Pharmaceuticals Inc. | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| WO2018204872A2 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Igf-1r monoclonal antibodies and uses thereof |
| US11373803B2 (en) | 2017-08-11 | 2022-06-28 | Applied Materials, Inc. | Method of forming a magnetic core on a substrate |
| US11344635B2 (en) | 2018-11-16 | 2022-05-31 | The Research Foundation For The State University Of New York | Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356190A (en) * | 1974-06-12 | 1982-10-26 | Personal Products Company | Inhibiting production of undesirable products on body surfaces and environs employing aminopolycarboxylic compounds |
| JPS62238213A (ja) * | 1986-04-04 | 1987-10-19 | Maab:Kk | 脱臭用清浄布収納パツク |
| JPH0825861B2 (ja) * | 1989-04-24 | 1996-03-13 | サンスター株式会社 | 歯磨組成物 |
| US5236695A (en) | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| US5147632A (en) * | 1990-10-31 | 1992-09-15 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent |
| BR9206910A (pt) * | 1991-12-10 | 1995-11-21 | Dow Chemical Co | Composições orais para inibição da formação de placas e cálculos |
| US5409689A (en) | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| US6525041B1 (en) * | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| JP3356289B2 (ja) * | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
| FR2737204B1 (fr) * | 1995-07-26 | 1997-09-12 | Oreal | Derives de n,n'-di(aralkyl)n,n'-di(carboxylakyl)alkylene di- ou triamine et de n-(aralkyl)n'-(carboxyalkyl) n,n'-di(carboxyalkyl)alkylene di- ou triamine et leur utilisation en pharmacie et en cosmetique |
| FR2749845B1 (fr) * | 1996-06-18 | 1998-08-21 | Oreal | Nouveaux derives benzyl substitue(s) de polyalkylene-polyamines et leur utilisation dans des compositions cosmetiques et pharmaceutiques |
| US6165966A (en) * | 1996-09-24 | 2000-12-26 | The Procter & Gamble Company | Liquid detergents containing proteolytic enzyme and protease inhibitors |
| GB0001129D0 (en) * | 2000-01-18 | 2000-03-08 | Unilever Plc | Anti-microbial aerosol compositions |
| CN1241538C (zh) * | 2000-01-18 | 2006-02-15 | 荷兰联合利华有限公司 | 含有过渡金属螯合剂盐的抗微生物组合物 |
| US6264966B1 (en) * | 2000-02-22 | 2001-07-24 | Concat, Ltd. | Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury |
-
2000
- 2000-02-22 US US09/510,134 patent/US6264966B1/en not_active Expired - Fee Related
-
2001
- 2001-02-14 ES ES01909263T patent/ES2239924T1/es active Pending
- 2001-02-14 DE DE0001261349T patent/DE01909263T1/de active Pending
- 2001-02-14 IL IL15103101A patent/IL151031A0/xx unknown
- 2001-02-14 DE DE60135638T patent/DE60135638D1/de not_active Expired - Lifetime
- 2001-02-14 JP JP2001561327A patent/JP2003523394A/ja active Pending
- 2001-02-14 AT AT01909263T patent/ATE406902T1/de not_active IP Right Cessation
- 2001-02-14 EP EP08162900A patent/EP2011501A1/en not_active Withdrawn
- 2001-02-14 EP EP01909263A patent/EP1261349B1/en not_active Expired - Lifetime
- 2001-02-14 CA CA002399299A patent/CA2399299C/en not_active Expired - Fee Related
- 2001-02-14 WO PCT/US2001/004977 patent/WO2001062262A1/en not_active Ceased
- 2001-02-14 AU AU2001237038A patent/AU2001237038A1/en not_active Abandoned
- 2001-04-20 US US09/839,970 patent/US6387891B2/en not_active Expired - Fee Related
-
2002
- 2002-08-01 IL IL151031A patent/IL151031A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1261349A4 (en) | 2004-09-01 |
| US6387891B2 (en) | 2002-05-14 |
| EP1261349B1 (en) | 2008-09-03 |
| IL151031A (en) | 2009-06-15 |
| EP2011501A1 (en) | 2009-01-07 |
| ATE406902T1 (de) | 2008-09-15 |
| US20010041170A1 (en) | 2001-11-15 |
| DE60135638D1 (de) | 2008-10-16 |
| DE01909263T1 (de) | 2004-08-26 |
| CA2399299C (en) | 2009-11-17 |
| IL151031A0 (en) | 2003-04-10 |
| ES2239924T1 (es) | 2005-10-16 |
| US6264966B1 (en) | 2001-07-24 |
| EP1261349A1 (en) | 2002-12-04 |
| CA2399299A1 (en) | 2001-08-30 |
| AU2001237038A1 (en) | 2001-09-03 |
| WO2001062262A1 (en) | 2001-08-30 |
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