JP2003522806A - 改良された薬物送達のための生体高分子の修飾 - Google Patents

改良された薬物送達のための生体高分子の修飾

Info

Publication number
JP2003522806A
JP2003522806A JP2001559507A JP2001559507A JP2003522806A JP 2003522806 A JP2003522806 A JP 2003522806A JP 2001559507 A JP2001559507 A JP 2001559507A JP 2001559507 A JP2001559507 A JP 2001559507A JP 2003522806 A JP2003522806 A JP 2003522806A
Authority
JP
Japan
Prior art keywords
biopolymer
group
conjugate
therapeutic agent
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001559507A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003522806A5 (https=
Inventor
ペリクルス、カリアス
ロバート、ジェイ．ミラー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of JP2003522806A publication Critical patent/JP2003522806A/ja
Publication of JP2003522806A5 publication Critical patent/JP2003522806A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2001559507A 2000-02-15 2001-02-15 改良された薬物送達のための生体高分子の修飾 Withdrawn JP2003522806A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18255800P 2000-02-15 2000-02-15
US60/182,558 2000-02-15
US21150800P 2000-06-14 2000-06-14
US60/211,508 2000-06-14
PCT/US2001/004925 WO2001060412A2 (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery

Publications (2)

Publication Number Publication Date
JP2003522806A true JP2003522806A (ja) 2003-07-29
JP2003522806A5 JP2003522806A5 (https=) 2008-02-21

Family

ID=26878197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001559507A Withdrawn JP2003522806A (ja) 2000-02-15 2001-02-15 改良された薬物送達のための生体高分子の修飾

Country Status (6)

Country Link
EP (1) EP1263472A2 (https=)
JP (1) JP2003522806A (https=)
AU (1) AU2001238346A1 (https=)
CA (1) CA2400205A1 (https=)
IL (1) IL151024A0 (https=)
WO (1) WO2001060412A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509643A (ja) * 2003-10-10 2007-04-19 ゲ・ミン・ルイ 角膜内皮および関連細胞のバイオポリマー上での増殖のための方法および組成物ならびに人工角膜移植片の作成
JP2008535842A (ja) * 2005-04-06 2008-09-04 ジェンザイム・コーポレイション 治療ターゲティングのための酸不安定リンカーを介するｐｅｇおよびポリシアルリソソーム酵素のコンジュゲート
KR20140119513A (ko) * 2013-04-01 2014-10-10 삼성전자주식회사 히알루론산을 포함하는 핵산전달용 조성물
JP2019504852A (ja) * 2016-02-10 2019-02-21 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン複合体

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
KR20030067755A (ko) * 2001-01-18 2003-08-14 메르크 파텐트 게엠베하 글루코세레브로시다제 활성을 갖는 이관능성 융합 단백질
WO2004060404A1 (ja) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha 薬物担体
WO2005000884A1 (en) * 2003-06-05 2005-01-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
CA2529486A1 (en) * 2003-06-18 2004-12-23 Nst Neurosurvival Technologies Ltd. Method for selective targeting of apoptotic cells and small molecule ligands used thereof
US7625736B2 (en) 2004-06-04 2009-12-01 The United States Of America As Represented By The Department Of Health And Human Services Methods for preparing immunogenic conjugates
TW200612991A (en) 2004-09-07 2006-05-01 Chugai Pharmaceutical Co Ltd Process for producing water-soluble hyaluronic acid modification
WO2007008904A2 (en) 2005-07-08 2007-01-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeting poly-gamma-glutamic acid to treat staphylococcus epidermidis and related infections
SI2457920T1 (en) 2007-01-18 2018-02-28 Genzyme Corporation Oligosaccharides containing the amino acid group and their conjugates
CA3040973A1 (en) 2008-12-16 2010-07-01 Genzyme Corporation Oligosaccharide-protein conjugates
WO2012118189A1 (ja) 2011-03-03 2012-09-07 中外製薬株式会社 アミノ－カルボン酸により修飾されたヒアルロン酸誘導体
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
JP6275044B2 (ja) 2012-09-05 2018-02-07 中外製薬株式会社 アミノ酸およびステリル基が導入されたヒアルロン酸誘導体
CN108440684A (zh) * 2018-03-22 2018-08-24 华侨大学 一种NI-Cys-Alg自组装纳米载体及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2079109A1 (en) * 1990-03-29 1991-09-30 John A. Latham Oligonucleotide-transport agent disulfide conjugates
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
US6335434B1 (en) * 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
EP0611306B1 (en) * 1991-11-08 1998-07-08 Somatogen, Inc. Hemoglobins as drug delivery agents
US5902795A (en) 1992-06-16 1999-05-11 Trustees Of Tufts College Oligosaccharides reactive with hyaluronan-binding protein and their methods of use
US5329029A (en) 1992-11-05 1994-07-12 Wan Barbara Y Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates
BR9405798A (pt) * 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
US5354853A (en) 1993-03-12 1994-10-11 Genzyme Corporation Phospholipid-saccharide conjugates
IL132941A0 (en) * 1997-05-21 2001-03-19 Univ Leland Stanford Junior Composition and method for enhancing transport across biological membranes
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509643A (ja) * 2003-10-10 2007-04-19 ゲ・ミン・ルイ 角膜内皮および関連細胞のバイオポリマー上での増殖のための方法および組成物ならびに人工角膜移植片の作成
JP2008535842A (ja) * 2005-04-06 2008-09-04 ジェンザイム・コーポレイション 治療ターゲティングのための酸不安定リンカーを介するｐｅｇおよびポリシアルリソソーム酵素のコンジュゲート
KR20140119513A (ko) * 2013-04-01 2014-10-10 삼성전자주식회사 히알루론산을 포함하는 핵산전달용 조성물
KR102049568B1 (ko) 2013-04-01 2019-11-27 삼성전자주식회사 히알루론산을 포함하는 핵산전달용 조성물
JP2019504852A (ja) * 2016-02-10 2019-02-21 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン複合体

Also Published As

Publication number Publication date
WO2001060412A2 (en) 2001-08-23
AU2001238346A1 (en) 2001-08-27
WO2001060412A3 (en) 2002-01-24
CA2400205A1 (en) 2001-08-23
IL151024A0 (en) 2003-02-12
EP1263472A2 (en) 2002-12-11

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