WO2001060412A3 - Modification of biopolymers for improved drug delivery - Google Patents

Modification of biopolymers for improved drug delivery Download PDF

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Publication number
WO2001060412A3
WO2001060412A3 PCT/US2001/004925 US0104925W WO0160412A3 WO 2001060412 A3 WO2001060412 A3 WO 2001060412A3 US 0104925 W US0104925 W US 0104925W WO 0160412 A3 WO0160412 A3 WO 0160412A3
Authority
WO
WIPO (PCT)
Prior art keywords
biopolymers
modification
drug delivery
improved drug
conjugate
Prior art date
Application number
PCT/US2001/004925
Other languages
French (fr)
Other versions
WO2001060412A2 (en
Inventor
Pericles Calias
Robert J Miller
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority to AU2001238346A priority Critical patent/AU2001238346A1/en
Priority to IL15102401A priority patent/IL151024A0/en
Priority to CA002400205A priority patent/CA2400205A1/en
Priority to JP2001559507A priority patent/JP2003522806A/en
Priority to EP01910775A priority patent/EP1263472A2/en
Publication of WO2001060412A2 publication Critical patent/WO2001060412A2/en
Publication of WO2001060412A3 publication Critical patent/WO2001060412A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be targeted to a variety of cells, tissues and organs.
PCT/US2001/004925 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery WO2001060412A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001238346A AU2001238346A1 (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery
IL15102401A IL151024A0 (en) 2000-02-15 2001-02-15 Conjugates of a biopolymer and a therapeutic agent
CA002400205A CA2400205A1 (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery
JP2001559507A JP2003522806A (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery
EP01910775A EP1263472A2 (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18255800P 2000-02-15 2000-02-15
US60/182,558 2000-02-15
US21150800P 2000-06-14 2000-06-14
US60/211,508 2000-06-14

Publications (2)

Publication Number Publication Date
WO2001060412A2 WO2001060412A2 (en) 2001-08-23
WO2001060412A3 true WO2001060412A3 (en) 2002-01-24

Family

ID=26878197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/004925 WO2001060412A2 (en) 2000-02-15 2001-02-15 Modification of biopolymers for improved drug delivery

Country Status (6)

Country Link
EP (1) EP1263472A2 (en)
JP (1) JP2003522806A (en)
AU (1) AU2001238346A1 (en)
CA (1) CA2400205A1 (en)
IL (1) IL151024A0 (en)
WO (1) WO2001060412A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108440684A (en) * 2018-03-22 2018-08-24 华侨大学 A kind of NI-Cys-Alg self-assembled nanometers carrier and its preparation method and application

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
JP2004525621A (en) * 2001-01-18 2004-08-26 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング Bifunctional fusion protein having glucocerebrosidase activity
WO2004060404A1 (en) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha Drug carrier
WO2005000884A1 (en) * 2003-06-05 2005-01-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
EP1643958A4 (en) * 2003-06-18 2010-09-01 Nst Neurosurvival Technologies Method for selective targeting of apoptotic cells and small molecule ligands used thereof
AU2004281694B2 (en) * 2003-10-10 2012-05-03 Cellular Bioengineering, Inc. Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants
US7625736B2 (en) 2004-06-04 2009-12-01 The United States Of America As Represented By The Department Of Health And Human Services Methods for preparing immunogenic conjugates
WO2006028110A1 (en) 2004-09-07 2006-03-16 Chugai Seiyaku Kabushiki Kaisha Process for producing water-soluble hyaluronic acid modification
EP1877099B1 (en) 2005-04-06 2012-09-19 Genzyme Corporation Therapeutic conjugates comprising a lysosomal enzyme, polysialic acid and a targeting moiety
US20080206276A1 (en) 2005-07-08 2008-08-28 Michael Otto Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections
LT2457920T (en) 2007-01-18 2018-02-12 Genzyme Corporation Oligosaccharides comprising an aminooxy group and conjugates thereof
CA2747230C (en) 2008-12-16 2019-06-11 Genzyme Corporation Oligosaccharide-protein conjugates
WO2012118189A1 (en) 2011-03-03 2012-09-07 中外製薬株式会社 Hyaluronic acid derivative modified by amino-carbonic acid
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
CN104603156B (en) 2012-09-05 2016-10-26 中外制药株式会社 Introduce and have aminoacid and the derivatives of hyaluronic acids of steroid base
KR102049568B1 (en) * 2013-04-01 2019-11-27 삼성전자주식회사 Composition for nucleic acid delivery containing hyaluronic acid
GB201602359D0 (en) * 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014696A1 (en) * 1990-03-29 1991-10-03 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
WO1993008842A1 (en) * 1991-11-08 1993-05-13 Somatogen, Inc. Hemoglobins as drug delivery agents
WO1998052614A2 (en) * 1997-05-21 1998-11-26 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
WO1999066063A2 (en) * 1998-06-16 1999-12-23 Isis Pharmaceuticals, Inc. Nucleosidic and non-nucleosidic folate conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902795A (en) 1992-06-16 1999-05-11 Trustees Of Tufts College Oligosaccharides reactive with hyaluronan-binding protein and their methods of use
US5329029A (en) 1992-11-05 1994-07-12 Wan Barbara Y Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates
EP0693924B2 (en) * 1993-02-22 2008-04-09 Abraxis BioScience, Inc. Methods for (in vivo) delivery of biologics and compositions useful therefor
US5354853A (en) 1993-03-12 1994-10-11 Genzyme Corporation Phospholipid-saccharide conjugates
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014696A1 (en) * 1990-03-29 1991-10-03 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
WO1993008842A1 (en) * 1991-11-08 1993-05-13 Somatogen, Inc. Hemoglobins as drug delivery agents
WO1998052614A2 (en) * 1997-05-21 1998-11-26 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
WO1999066063A2 (en) * 1998-06-16 1999-12-23 Isis Pharmaceuticals, Inc. Nucleosidic and non-nucleosidic folate conjugates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DADLEY-MOORE D L ET AL: "Synthetic peptide antigens induce antibodies to Taenia ovis oncospheres", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 17, no. 11-12, March 1999 (1999-03-01), pages 1506 - 1515, XP004158279, ISSN: 0264-410X *
GEORGE Y. WU AND CATHERINE H. WU: "Receptor-mediated in Vitro Gene Transformation by a Soluble DNA Carrier System", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 10, 5 April 1987 (1987-04-05), pages 4429 - 4432, XP002176177 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108440684A (en) * 2018-03-22 2018-08-24 华侨大学 A kind of NI-Cys-Alg self-assembled nanometers carrier and its preparation method and application

Also Published As

Publication number Publication date
AU2001238346A1 (en) 2001-08-27
EP1263472A2 (en) 2002-12-11
IL151024A0 (en) 2003-02-12
WO2001060412A2 (en) 2001-08-23
CA2400205A1 (en) 2001-08-23
JP2003522806A (en) 2003-07-29

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