JP2003520813A5 - - Google Patents
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- Publication number
- JP2003520813A5 JP2003520813A5 JP2001554671A JP2001554671A JP2003520813A5 JP 2003520813 A5 JP2003520813 A5 JP 2003520813A5 JP 2001554671 A JP2001554671 A JP 2001554671A JP 2001554671 A JP2001554671 A JP 2001554671A JP 2003520813 A5 JP2003520813 A5 JP 2003520813A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic composition
- composition according
- emedastine
- olopatadine
- ophthalmic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 description 38
- 229960000325 emedastine Drugs 0.000 description 15
- 230000003266 anti-allergic effect Effects 0.000 description 13
- KBUZBQVCBVDWKX-UHFFFAOYSA-N emedastine Chemical compound N=1C2=CC=CC=C2N(CCOCC)C=1N1CCCN(C)CC1 KBUZBQVCBVDWKX-UHFFFAOYSA-N 0.000 description 13
- 229960004114 olopatadine Drugs 0.000 description 13
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 description 13
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 8
- 239000003755 preservative agent Substances 0.000 description 7
- 230000002335 preservative effect Effects 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 239000002738 chelating agent Substances 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- FWLKKPKZQYVAFR-LVEZLNDCSA-N (e)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole Chemical group OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.N=1C2=CC=CC=C2N(CCOCC)C=1N1CCCN(C)CC1 FWLKKPKZQYVAFR-LVEZLNDCSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- HVRLZEKDTUEKQH-NOILCQHBSA-N Olopatadine hydrochloride Chemical group Cl.C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 HVRLZEKDTUEKQH-NOILCQHBSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229960003139 olopatadine hydrochloride Drugs 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17780400P | 2000-01-25 | 2000-01-25 | |
| US60/177,804 | 2000-01-25 | ||
| PCT/US2001/002418 WO2001054687A1 (en) | 2000-01-25 | 2001-01-24 | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011080095A Division JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003520813A JP2003520813A (ja) | 2003-07-08 |
| JP2003520813A5 true JP2003520813A5 (enExample) | 2012-05-31 |
Family
ID=22650044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001554671A Ceased JP2003520813A (ja) | 2000-01-25 | 2001-01-24 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
| JP2011080095A Pending JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011080095A Pending JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6375973B2 (enExample) |
| EP (1) | EP1250133B1 (enExample) |
| JP (2) | JP2003520813A (enExample) |
| AT (1) | ATE291913T1 (enExample) |
| AU (1) | AU776789B2 (enExample) |
| CA (1) | CA2395866C (enExample) |
| DE (1) | DE60109742T2 (enExample) |
| ES (1) | ES2236180T3 (enExample) |
| PT (1) | PT1250133E (enExample) |
| WO (1) | WO2001054687A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7977376B2 (en) | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
| US8388995B1 (en) | 2006-02-03 | 2013-03-05 | Auburn University | Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform |
| US8349352B2 (en) * | 2005-02-04 | 2013-01-08 | Auburn University | Therapeutic contact lenses with anti-fungal delivery |
| WO2006084275A2 (en) * | 2005-02-04 | 2006-08-10 | Auburn University | Contact drug delivery system |
| US9238003B2 (en) | 2005-02-04 | 2016-01-19 | Auburn University | Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules |
| US7947010B2 (en) | 2005-07-08 | 2011-05-24 | Depuy Products, Inc. | Composition and system for wound decontamination |
| US7247623B2 (en) * | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| US20080138408A1 (en) * | 2006-11-13 | 2008-06-12 | Siddharth Venkatesh | Drug delivery system and method |
| HUE026162T2 (en) * | 2007-02-07 | 2016-05-30 | Novartis Ag | Olopatadine preparation for topical nasal administration |
| CN103140215A (zh) * | 2010-07-21 | 2013-06-05 | 爱尔康研究有限公司 | 具有提高的溶解度特征的药物组合物 |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
| WO2014150899A1 (en) * | 2013-03-15 | 2014-09-25 | Chapin Matthew J | Topical ophthalmic formulations for treating migraine |
| WO2015065576A1 (en) * | 2013-10-31 | 2015-05-07 | Nephron Pharmaceuticals Corporation | Formulation of olopatadine |
| EP3037094A1 (en) * | 2014-12-23 | 2016-06-29 | Poifa Warszawa SA | Ophthalmic pharmaceutical composition |
| CN107875119B (zh) * | 2017-11-22 | 2021-03-12 | 山东绅联药业有限公司 | 一种富马酸依美斯汀水性药物组合物及其制备方法 |
| WO2025137749A1 (pt) * | 2023-12-27 | 2025-07-03 | Eurofarma Laboratórios S.A. | Processo de solubilização de olopatadina e seu uso |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| JPS5879983A (ja) | 1981-11-06 | 1983-05-13 | Kanebo Ltd | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| JPH08770B2 (ja) * | 1985-12-25 | 1996-01-10 | 千寿製薬株式会社 | 眼科用組成物 |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| US5037647A (en) * | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5192780A (en) | 1989-12-18 | 1993-03-09 | Alcon Laboratories, Inc. | Methods using antiallergics and antihistamines |
| AU636685B2 (en) * | 1989-12-18 | 1993-05-06 | Alcon Laboratories, Inc. | Compositions of antiallergics and antihistamines and methods for their use |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| DE69333850T3 (de) | 1992-05-06 | 2011-03-17 | Alcon Laboratories, Inc., Fort Worth | Anwendung von boral-polyol-komplexen für ophthalmische arzneizusammensetzungen |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| JP3527256B2 (ja) | 1992-12-09 | 2004-05-17 | ロート製薬株式会社 | 抗アレルギー点眼剤 |
| US5668133A (en) | 1992-12-09 | 1997-09-16 | Alcon Laboratories, Inc. | Ophthalmic compositions comprising emedastine and methods for their use |
| US5370744B1 (en) * | 1993-08-27 | 1999-11-09 | Alcon Lab Inc | Process for cleaning and disinfecting contact lenses |
| US5603929A (en) | 1994-11-16 | 1997-02-18 | Alcon Laboratories, Inc. | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds |
| JP3297969B2 (ja) * | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| AU721273B2 (en) * | 1996-09-20 | 2000-06-29 | Bausch & Lomb Incorporated | Method and composition for rewetting contact lenses and relieving eye dryness |
| ZA9811445B (en) * | 1997-12-19 | 1999-08-16 | Alcon Lab Inc | Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions. |
| JP4545927B2 (ja) * | 1998-04-07 | 2010-09-15 | アルコン ラボラトリーズ， インコーポレイテッド | キサンタンガムを含有するゲル化眼科用組成物 |
| JP3407654B2 (ja) * | 1998-04-14 | 2003-05-19 | ライオン株式会社 | 眼科用組成物 |
| US6146622A (en) * | 1998-10-27 | 2000-11-14 | Alcon Laboratories, Inc. | Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions |
-
2001
- 2001-01-24 PT PT01906672T patent/PT1250133E/pt unknown
- 2001-01-24 AU AU34556/01A patent/AU776789B2/en not_active Ceased
- 2001-01-24 JP JP2001554671A patent/JP2003520813A/ja not_active Ceased
- 2001-01-24 EP EP01906672A patent/EP1250133B1/en not_active Expired - Lifetime
- 2001-01-24 ES ES01906672T patent/ES2236180T3/es not_active Expired - Lifetime
- 2001-01-24 CA CA002395866A patent/CA2395866C/en not_active Expired - Fee Related
- 2001-01-24 DE DE60109742T patent/DE60109742T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/US2001/002418 patent/WO2001054687A1/en not_active Ceased
- 2001-01-24 AT AT01906672T patent/ATE291913T1/de active
- 2001-01-24 US US09/768,444 patent/US6375973B2/en not_active Expired - Lifetime
-
2011
- 2011-03-31 JP JP2011080095A patent/JP2011132259A/ja active Pending
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