JP2003520813A - コンタクトレンズでの使用に適する眼の抗アレルギー組成物 - Google Patents
コンタクトレンズでの使用に適する眼の抗アレルギー組成物Info
- Publication number
- JP2003520813A JP2003520813A JP2001554671A JP2001554671A JP2003520813A JP 2003520813 A JP2003520813 A JP 2003520813A JP 2001554671 A JP2001554671 A JP 2001554671A JP 2001554671 A JP2001554671 A JP 2001554671A JP 2003520813 A JP2003520813 A JP 2003520813A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- olopatadine
- emedastine
- effective amount
- quaternary ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 23
- 229960000325 emedastine Drugs 0.000 claims abstract description 32
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 claims abstract description 28
- KBUZBQVCBVDWKX-UHFFFAOYSA-N emedastine Chemical compound N=1C2=CC=CC=C2N(CCOCC)C=1N1CCCN(C)CC1 KBUZBQVCBVDWKX-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960004114 olopatadine Drugs 0.000 claims abstract description 27
- 239000003755 preservative agent Substances 0.000 claims abstract description 17
- 230000002335 preservative effect Effects 0.000 claims abstract description 15
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 10
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 13
- FWLKKPKZQYVAFR-LVEZLNDCSA-N (e)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole Chemical group OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.N=1C2=CC=CC=C2N(CCOCC)C=1N1CCCN(C)CC1 FWLKKPKZQYVAFR-LVEZLNDCSA-N 0.000 claims description 8
- HVRLZEKDTUEKQH-NOILCQHBSA-N Olopatadine hydrochloride Chemical group Cl.C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 HVRLZEKDTUEKQH-NOILCQHBSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229960003139 olopatadine hydrochloride Drugs 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 5
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- 239000006172 buffering agent Substances 0.000 claims description 3
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 230000007815 allergy Effects 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 235000010338 boric acid Nutrition 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 6
- 239000004327 boric acid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229940054534 ophthalmic solution Drugs 0.000 description 3
- 239000002997 ophthalmic solution Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000003732 agents acting on the eye Substances 0.000 description 2
- 239000000043 antiallergic agent Substances 0.000 description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940073602 emadine Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 229940023490 ophthalmic product Drugs 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- -1 3-dimethylaminopropylidene Chemical group 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003868 ammonium compounds Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000005619 boric acid group Chemical class 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229940097078 patanol Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17780400P | 2000-01-25 | 2000-01-25 | |
| US60/177,804 | 2000-01-25 | ||
| PCT/US2001/002418 WO2001054687A1 (en) | 2000-01-25 | 2001-01-24 | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011080095A Division JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003520813A true JP2003520813A (ja) | 2003-07-08 |
| JP2003520813A5 JP2003520813A5 (enExample) | 2012-05-31 |
Family
ID=22650044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001554671A Ceased JP2003520813A (ja) | 2000-01-25 | 2001-01-24 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
| JP2011080095A Pending JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011080095A Pending JP2011132259A (ja) | 2000-01-25 | 2011-03-31 | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6375973B2 (enExample) |
| EP (1) | EP1250133B1 (enExample) |
| JP (2) | JP2003520813A (enExample) |
| AT (1) | ATE291913T1 (enExample) |
| AU (1) | AU776789B2 (enExample) |
| CA (1) | CA2395866C (enExample) |
| DE (1) | DE60109742T2 (enExample) |
| ES (1) | ES2236180T3 (enExample) |
| PT (1) | PT1250133E (enExample) |
| WO (1) | WO2001054687A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013535451A (ja) * | 2010-07-21 | 2013-09-12 | アルコン リサーチ， リミテッド | 増強された溶解度特徴を有する薬学的組成物 |
| JP2014515355A (ja) * | 2011-05-19 | 2014-06-30 | アルコン リサーチ， リミテッド | 高濃度オロパタジンの眼用組成物 |
| JP2015509933A (ja) * | 2012-02-10 | 2015-04-02 | アルコン リサーチ， リミテッド | 安定性が強化された水性医薬組成物 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7977376B2 (en) | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
| US8388995B1 (en) | 2006-02-03 | 2013-03-05 | Auburn University | Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform |
| US8349352B2 (en) * | 2005-02-04 | 2013-01-08 | Auburn University | Therapeutic contact lenses with anti-fungal delivery |
| WO2006084275A2 (en) * | 2005-02-04 | 2006-08-10 | Auburn University | Contact drug delivery system |
| US9238003B2 (en) | 2005-02-04 | 2016-01-19 | Auburn University | Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules |
| US7947010B2 (en) | 2005-07-08 | 2011-05-24 | Depuy Products, Inc. | Composition and system for wound decontamination |
| US7247623B2 (en) * | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| US20080138408A1 (en) * | 2006-11-13 | 2008-06-12 | Siddharth Venkatesh | Drug delivery system and method |
| HUE026162T2 (en) * | 2007-02-07 | 2016-05-30 | Novartis Ag | Olopatadine preparation for topical nasal administration |
| WO2014150899A1 (en) * | 2013-03-15 | 2014-09-25 | Chapin Matthew J | Topical ophthalmic formulations for treating migraine |
| WO2015065576A1 (en) * | 2013-10-31 | 2015-05-07 | Nephron Pharmaceuticals Corporation | Formulation of olopatadine |
| EP3037094A1 (en) * | 2014-12-23 | 2016-06-29 | Poifa Warszawa SA | Ophthalmic pharmaceutical composition |
| CN107875119B (zh) * | 2017-11-22 | 2021-03-12 | 山东绅联药业有限公司 | 一种富马酸依美斯汀水性药物组合物及其制备方法 |
| WO2025137749A1 (pt) * | 2023-12-27 | 2025-07-03 | Eurofarma Laboratórios S.A. | Processo de solubilização de olopatadina e seu uso |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58501515A (ja) * | 1981-09-28 | 1983-09-08 | アルコン・ラボラトリ−ズ・インコ−ポレ−テッド | 眼用溶液 |
| JPS62153217A (ja) * | 1985-12-25 | 1987-07-08 | Takeda Chem Ind Ltd | 眼科用組成物 |
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| JPH049339A (ja) * | 1989-12-18 | 1992-01-14 | Alcon Lab Inc | 抗アレルギー及び抗ヒスタミン組成物 |
| JPH06172179A (ja) * | 1992-12-09 | 1994-06-21 | Rohto Pharmaceut Co Ltd | 抗アレルギー点眼剤 |
| JPH08503084A (ja) * | 1993-08-27 | 1996-04-02 | アルコン ラボラトリーズ，インコーポレイテッド | コンタクトレンズの洗浄および滅菌方法 |
| JPH08175974A (ja) * | 1994-12-26 | 1996-07-09 | Lion Corp | 点眼剤 |
| JPH09503791A (ja) * | 1994-11-16 | 1997-04-15 | アルコン ラボラトリーズ， インコーポレイテッド | 高分子４級アンモニウム化合物を含有する保存された眼科用薬剤組成物 |
| WO1998011875A1 (en) * | 1996-09-20 | 1998-03-26 | Bausch & Lomb Incorporated | Method and composition for rewetting contact lenses and relieving eye dryness |
| WO1999032158A2 (en) * | 1997-12-19 | 1999-07-01 | Alcon Laboratories, Inc. | Aminobiguanides to disinfect contact lenses and preserve pharmaceutical compositions |
| WO1999051273A1 (en) * | 1998-04-07 | 1999-10-14 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| JPH11292793A (ja) * | 1998-04-14 | 1999-10-26 | Lion Corp | 眼科用組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| JPS5879983A (ja) | 1981-11-06 | 1983-05-13 | Kanebo Ltd | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| US5037647A (en) * | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5192780A (en) | 1989-12-18 | 1993-03-09 | Alcon Laboratories, Inc. | Methods using antiallergics and antihistamines |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| DE69333850T3 (de) | 1992-05-06 | 2011-03-17 | Alcon Laboratories, Inc., Fort Worth | Anwendung von boral-polyol-komplexen für ophthalmische arzneizusammensetzungen |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| US5668133A (en) | 1992-12-09 | 1997-09-16 | Alcon Laboratories, Inc. | Ophthalmic compositions comprising emedastine and methods for their use |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| US6146622A (en) * | 1998-10-27 | 2000-11-14 | Alcon Laboratories, Inc. | Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions |
-
2001
- 2001-01-24 PT PT01906672T patent/PT1250133E/pt unknown
- 2001-01-24 AU AU34556/01A patent/AU776789B2/en not_active Ceased
- 2001-01-24 JP JP2001554671A patent/JP2003520813A/ja not_active Ceased
- 2001-01-24 EP EP01906672A patent/EP1250133B1/en not_active Expired - Lifetime
- 2001-01-24 ES ES01906672T patent/ES2236180T3/es not_active Expired - Lifetime
- 2001-01-24 CA CA002395866A patent/CA2395866C/en not_active Expired - Fee Related
- 2001-01-24 DE DE60109742T patent/DE60109742T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/US2001/002418 patent/WO2001054687A1/en not_active Ceased
- 2001-01-24 AT AT01906672T patent/ATE291913T1/de active
- 2001-01-24 US US09/768,444 patent/US6375973B2/en not_active Expired - Lifetime
-
2011
- 2011-03-31 JP JP2011080095A patent/JP2011132259A/ja active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58501515A (ja) * | 1981-09-28 | 1983-09-08 | アルコン・ラボラトリ−ズ・インコ−ポレ−テッド | 眼用溶液 |
| JPS62153217A (ja) * | 1985-12-25 | 1987-07-08 | Takeda Chem Ind Ltd | 眼科用組成物 |
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| JPH049339A (ja) * | 1989-12-18 | 1992-01-14 | Alcon Lab Inc | 抗アレルギー及び抗ヒスタミン組成物 |
| JPH06172179A (ja) * | 1992-12-09 | 1994-06-21 | Rohto Pharmaceut Co Ltd | 抗アレルギー点眼剤 |
| JPH08503084A (ja) * | 1993-08-27 | 1996-04-02 | アルコン ラボラトリーズ，インコーポレイテッド | コンタクトレンズの洗浄および滅菌方法 |
| JPH09503791A (ja) * | 1994-11-16 | 1997-04-15 | アルコン ラボラトリーズ， インコーポレイテッド | 高分子４級アンモニウム化合物を含有する保存された眼科用薬剤組成物 |
| JPH08175974A (ja) * | 1994-12-26 | 1996-07-09 | Lion Corp | 点眼剤 |
| WO1998011875A1 (en) * | 1996-09-20 | 1998-03-26 | Bausch & Lomb Incorporated | Method and composition for rewetting contact lenses and relieving eye dryness |
| JP2001501605A (ja) * | 1996-09-20 | 2001-02-06 | ボシュ アンド ロム インコーポレイテッド | コンタクトレンズの再湿潤および眼の乾燥の緩和のための方法および組成物 |
| WO1999032158A2 (en) * | 1997-12-19 | 1999-07-01 | Alcon Laboratories, Inc. | Aminobiguanides to disinfect contact lenses and preserve pharmaceutical compositions |
| JP2001526090A (ja) * | 1997-12-19 | 2001-12-18 | アルコン ラボラトリーズ，インコーポレイテッド | アミノビグアニド化合物ならびにコンタクトレンズの消毒および医薬組成物の保存におけるその使用。 |
| WO1999051273A1 (en) * | 1998-04-07 | 1999-10-14 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| JPH11292793A (ja) * | 1998-04-14 | 1999-10-26 | Lion Corp | 眼科用組成物 |
Non-Patent Citations (1)
| Title |
|---|
| JPN6012023445; Ｂｒ． Ｊ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｏｌ．８０， Ｎｏ．７, 1996, ５８３-５８４ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013535451A (ja) * | 2010-07-21 | 2013-09-12 | アルコン リサーチ， リミテッド | 増強された溶解度特徴を有する薬学的組成物 |
| JP2016169237A (ja) * | 2010-07-21 | 2016-09-23 | アルコン リサーチ， リミテッド | 増強された溶解度特徴を有する薬学的組成物 |
| JP2014515355A (ja) * | 2011-05-19 | 2014-06-30 | アルコン リサーチ， リミテッド | 高濃度オロパタジンの眼用組成物 |
| US9533053B2 (en) | 2011-05-19 | 2017-01-03 | Alcon Research, Ltd. | High concentration olopatadine ophthalmic composition |
| KR101821518B1 (ko) * | 2011-05-19 | 2018-01-23 | 알콘 리서치, 리미티드 | 고농도 올로파타딘 안과용 조성물 |
| JP2015509933A (ja) * | 2012-02-10 | 2015-04-02 | アルコン リサーチ， リミテッド | 安定性が強化された水性医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3455601A (en) | 2001-08-07 |
| DE60109742T2 (de) | 2005-08-18 |
| CA2395866A1 (en) | 2001-08-02 |
| AU776789B2 (en) | 2004-09-23 |
| EP1250133B1 (en) | 2005-03-30 |
| DE60109742D1 (de) | 2005-05-04 |
| WO2001054687A1 (en) | 2001-08-02 |
| ES2236180T3 (es) | 2005-07-16 |
| PT1250133E (pt) | 2005-05-31 |
| ATE291913T1 (de) | 2005-04-15 |
| CA2395866C (en) | 2009-10-13 |
| US20010056093A1 (en) | 2001-12-27 |
| EP1250133A1 (en) | 2002-10-23 |
| US6375973B2 (en) | 2002-04-23 |
| JP2011132259A (ja) | 2011-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011132259A (ja) | コンタクトレンズでの使用に適する眼の抗アレルギー組成物 | |
| JP5328947B2 (ja) | 局所投与のためのオロパタジン処方物 | |
| JP2954356B2 (ja) | 高分子４級アンモニウム化合物を含有する保存された眼科用薬剤組成物 | |
| AU776609B2 (en) | Topical suspension formulations containing ciprofloxacin and dexamethasone | |
| CN1098678C (zh) | 以双氯灭痛和妥布霉素为基础的眼用溶液及其应用 | |
| JP2017019846A (ja) | 点眼剤 | |
| JP2001187728A (ja) | 眼科用組成物 | |
| JP2003520813A5 (enExample) | ||
| KR100776577B1 (ko) | 점안제 | |
| JP5149308B2 (ja) | 局所的鼻腔投与のためのオロパタジンの製剤 | |
| JP2004002364A (ja) | 眼科用組成物、及び眼科製剤用防腐組成物 | |
| JP2003509474A (ja) | 局所的薬学的組成物の抗菌効果を増強させるための脂肪酸／アミノ酸石鹸の使用 | |
| HK1012556B (en) | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds | |
| JP2008110981A (ja) | 点眼剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071219 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071219 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110209 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110331 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20111220 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20120319 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120319 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20120411 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120508 |
|
| A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20120917 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20121012 |