JP2003519651A5 - - Google Patents
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- Publication number
- JP2003519651A5 JP2003519651A5 JP2001551456A JP2001551456A JP2003519651A5 JP 2003519651 A5 JP2003519651 A5 JP 2003519651A5 JP 2001551456 A JP2001551456 A JP 2001551456A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2003519651 A5 JP2003519651 A5 JP 2003519651A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- drug
- particles
- solid
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 36
- 239000003814 drug Substances 0.000 description 22
- 239000002904 solvent Substances 0.000 description 22
- 239000002245 particle Substances 0.000 description 17
- 239000007787 solid Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 13
- 239000000463 material Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 239000002861 polymer material Substances 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 229920002732 Polyanhydride Polymers 0.000 description 2
- 239000012867 bioactive agent Substances 0.000 description 2
- 229920000249 biocompatible polymer Polymers 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 238000012696 Interfacial polycondensation Methods 0.000 description 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- -1 poly (Hydroxy Chemical group 0.000 description 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001306 poly(lactide-co-caprolactone) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17619300P | 2000-01-14 | 2000-01-14 | |
| US60/176,193 | 2000-01-14 | ||
| PCT/US2001/001183 WO2001051032A2 (en) | 2000-01-14 | 2001-01-12 | Micronized freeze-dried particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519651A JP2003519651A (ja) | 2003-06-24 |
| JP2003519651A5 true JP2003519651A5 (enExample) | 2008-02-28 |
Family
ID=22643372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551456A Pending JP2003519651A (ja) | 2000-01-14 | 2001-01-12 | 微紛化凍結乾燥粒子 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1246609B1 (enExample) |
| JP (1) | JP2003519651A (enExample) |
| AT (1) | ATE462413T1 (enExample) |
| AU (1) | AU773735B2 (enExample) |
| CA (1) | CA2397404C (enExample) |
| DE (1) | DE60141680D1 (enExample) |
| WO (1) | WO2001051032A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
| CA2456806C (en) | 2001-08-08 | 2011-10-18 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
| AU2002360549A1 (en) * | 2001-12-10 | 2003-06-23 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
| JP4679822B2 (ja) * | 2002-03-13 | 2011-05-11 | ノバルティス アーゲー | 医薬微粒子 |
| SI21222A (sl) * | 2002-05-28 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo nanodelcev |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| JP2006199589A (ja) * | 2003-09-03 | 2006-08-03 | Ltt Bio-Pharma Co Ltd | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
| WO2006088647A1 (en) * | 2005-02-17 | 2006-08-24 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| JP4755992B2 (ja) * | 2003-12-19 | 2011-08-24 | アルク−アベッロ エイ／エス | 有効医薬成分の寒冷顆粒化及び貯蔵の方法 |
| AU2004298719B8 (en) | 2003-12-19 | 2011-04-07 | Alk-Abello A/S | Cryogranulation and storage method for active pharmaceutical agents |
| EP2026771B1 (en) * | 2006-01-23 | 2009-10-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Microspheres comprising nanocapsules containing a lipophilic drug |
| CA2957966C (en) * | 2014-08-14 | 2021-11-30 | Brown University | Compositions for stabilizing and delivering proteins |
| CN108379243A (zh) * | 2018-03-22 | 2018-08-10 | 福州大学 | 一种载基因多孔磁性微球的制备方法 |
| CN115005320B (zh) * | 2022-05-07 | 2023-09-05 | 中国农业大学 | 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物 |
| CN116982619A (zh) * | 2023-08-04 | 2023-11-03 | 洛阳奇泓生物科技有限公司 | 丙交酯-Nisin固体分散体及其制备 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0798755B2 (ja) * | 1985-11-27 | 1995-10-25 | エチコン・インコ−ポレ−テツド | 局所的投与により術後の癒着形成を抑制するための組成物 |
| DE3779221D1 (de) * | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| AU714584B2 (en) * | 1995-07-21 | 2000-01-06 | Brown University Research Foundation | A method for gene therapy using nucleic acid loaded polymeric microparticles |
| EP0889722B1 (en) * | 1996-03-28 | 2002-11-20 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and its production |
| EP0975334B1 (en) * | 1997-04-17 | 2003-10-22 | Amgen Inc., | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
| JP3918248B2 (ja) * | 1997-09-26 | 2007-05-23 | ソニー株式会社 | 固体撮像素子およびその駆動方法 |
-
2001
- 2001-01-12 EP EP01902059A patent/EP1246609B1/en not_active Expired - Lifetime
- 2001-01-12 WO PCT/US2001/001183 patent/WO2001051032A2/en not_active Ceased
- 2001-01-12 JP JP2001551456A patent/JP2003519651A/ja active Pending
- 2001-01-12 AT AT01902059T patent/ATE462413T1/de not_active IP Right Cessation
- 2001-01-12 AU AU27902/01A patent/AU773735B2/en not_active Ceased
- 2001-01-12 CA CA002397404A patent/CA2397404C/en not_active Expired - Lifetime
- 2001-01-12 DE DE60141680T patent/DE60141680D1/de not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
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