JP2003519651A - 微紛化凍結乾燥粒子 - Google Patents

微紛化凍結乾燥粒子

Info

Publication number
JP2003519651A
JP2003519651A JP2001551456A JP2001551456A JP2003519651A JP 2003519651 A JP2003519651 A JP 2003519651A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2003519651 A JP2003519651 A JP 2003519651A
Authority
JP
Japan
Prior art keywords
solvent
particles
polymer
drug
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001551456A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003519651A5 (enExample
Inventor
エディス マシオウィッツ，
ヨング エス． ジョング，
ジュールズ ジャコブ，
Original Assignee
ブラウン ユニバーシティ リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブラウン ユニバーシティ リサーチ ファウンデーション filed Critical ブラウン ユニバーシティ リサーチ ファウンデーション
Publication of JP2003519651A publication Critical patent/JP2003519651A/ja
Publication of JP2003519651A5 publication Critical patent/JP2003519651A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001551456A 2000-01-14 2001-01-12 微紛化凍結乾燥粒子 Pending JP2003519651A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17619300P 2000-01-14 2000-01-14
US60/176,193 2000-01-14
PCT/US2001/001183 WO2001051032A2 (en) 2000-01-14 2001-01-12 Micronized freeze-dried particles

Publications (2)

Publication Number Publication Date
JP2003519651A true JP2003519651A (ja) 2003-06-24
JP2003519651A5 JP2003519651A5 (enExample) 2008-02-28

Family

ID=22643372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001551456A Pending JP2003519651A (ja) 2000-01-14 2001-01-12 微紛化凍結乾燥粒子

Country Status (7)

Country Link
EP (1) EP1246609B1 (enExample)
JP (1) JP2003519651A (enExample)
AT (1) ATE462413T1 (enExample)
AU (1) AU773735B2 (enExample)
CA (1) CA2397404C (enExample)
DE (1) DE60141680D1 (enExample)
WO (1) WO2001051032A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005023282A1 (ja) * 2003-09-03 2005-03-17 Ltt Bio-Pharma Co., Ltd. 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
JP2005519944A (ja) * 2002-03-13 2005-07-07 ノバルティス アクチエンゲゼルシャフト 医薬微粒子
JP2007514490A (ja) * 2003-12-19 2007-06-07 アルク−アベッロ エイ／エス 有効医薬成分の寒冷顆粒化及び貯蔵の方法
JP2008530206A (ja) * 2005-02-17 2008-08-07 メディバス エルエルシー ポリマー粒子送達組成物および使用法
JP2009523843A (ja) * 2006-01-23 2009-06-25 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム 活性薬剤用のデリバリーシステム
US8459046B2 (en) 2003-12-19 2013-06-11 Alk-Abello A/S Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product
JP2017524743A (ja) * 2014-08-14 2017-08-31 ブラウン ユニバーシティ タンパク質を安定化させ、送達するための組成物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809309B1 (fr) * 2000-05-23 2004-06-11 Mainelab Microspheres a liberation prolongee pour administration injectable
WO2003013683A1 (en) 2001-08-08 2003-02-20 Brown University Research Foundation Methods for micronization of hydrophobic drugs
CA2469718A1 (en) * 2001-12-10 2003-06-19 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
SI21222A (sl) * 2002-05-28 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo nanodelcev
US7670627B2 (en) * 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CN108379243A (zh) * 2018-03-22 2018-08-10 福州大学 一种载基因多孔磁性微球的制备方法
CN115005320B (zh) * 2022-05-07 2023-09-05 中国农业大学 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物
CN116982619B (zh) * 2023-08-04 2026-05-26 洛阳奇泓生物科技有限公司 丙交酯-Nisin固体分散体及其制备

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046212A1 (en) * 1997-04-17 1998-10-22 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225162B1 (en) * 1985-11-27 1992-01-22 Ethicon, Inc. Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug
ES2032831T5 (es) * 1986-08-19 2001-02-16 Genentech Inc Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas.
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
JPH11510142A (ja) * 1995-07-21 1999-09-07 ブラウン・ユニバーシティ・リサーチ・ファンデーション 核酸負荷ポリマー微粒子を使用した遺伝子治療法
US6190702B1 (en) * 1996-03-28 2001-02-20 Takeda Chemical Industries, Ltd. Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase
JP3918248B2 (ja) * 1997-09-26 2007-05-23 ソニー株式会社 固体撮像素子およびその駆動方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046212A1 (en) * 1997-04-17 1998-10-22 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005519944A (ja) * 2002-03-13 2005-07-07 ノバルティス アクチエンゲゼルシャフト 医薬微粒子
JP2010248271A (ja) * 2002-03-13 2010-11-04 Novartis Ag 医薬微粒子
WO2005023282A1 (ja) * 2003-09-03 2005-03-17 Ltt Bio-Pharma Co., Ltd. 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
JP2007514490A (ja) * 2003-12-19 2007-06-07 アルク−アベッロ エイ／エス 有効医薬成分の寒冷顆粒化及び貯蔵の方法
JP4755992B2 (ja) * 2003-12-19 2011-08-24 アルク−アベッロ エイ／エス 有効医薬成分の寒冷顆粒化及び貯蔵の方法
US8459046B2 (en) 2003-12-19 2013-06-11 Alk-Abello A/S Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product
US8551491B2 (en) 2003-12-19 2013-10-08 Alk-Abello A/S Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product
JP2008530206A (ja) * 2005-02-17 2008-08-07 メディバス エルエルシー ポリマー粒子送達組成物および使用法
JP2009523843A (ja) * 2006-01-23 2009-06-25 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム 活性薬剤用のデリバリーシステム
JP2017524743A (ja) * 2014-08-14 2017-08-31 ブラウン ユニバーシティ タンパク質を安定化させ、送達するための組成物

Also Published As

Publication number Publication date
WO2001051032A3 (en) 2002-03-28
CA2397404A1 (en) 2001-07-19
EP1246609B1 (en) 2010-03-31
AU773735B2 (en) 2004-06-03
ATE462413T1 (de) 2010-04-15
WO2001051032A2 (en) 2001-07-19
DE60141680D1 (de) 2010-05-12
AU2790201A (en) 2001-07-24
EP1246609A2 (en) 2002-10-09
CA2397404C (en) 2008-12-02

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