JP2003519651A - 微紛化凍結乾燥粒子 - Google Patents
微紛化凍結乾燥粒子Info
- Publication number
- JP2003519651A JP2003519651A JP2001551456A JP2001551456A JP2003519651A JP 2003519651 A JP2003519651 A JP 2003519651A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2001551456 A JP2001551456 A JP 2001551456A JP 2003519651 A JP2003519651 A JP 2003519651A
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- Japan
- Prior art keywords
- solvent
- particles
- polymer
- drug
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17619300P | 2000-01-14 | 2000-01-14 | |
| US60/176,193 | 2000-01-14 | ||
| PCT/US2001/001183 WO2001051032A2 (en) | 2000-01-14 | 2001-01-12 | Micronized freeze-dried particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519651A true JP2003519651A (ja) | 2003-06-24 |
| JP2003519651A5 JP2003519651A5 (enExample) | 2008-02-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551456A Pending JP2003519651A (ja) | 2000-01-14 | 2001-01-12 | 微紛化凍結乾燥粒子 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1246609B1 (enExample) |
| JP (1) | JP2003519651A (enExample) |
| AT (1) | ATE462413T1 (enExample) |
| AU (1) | AU773735B2 (enExample) |
| CA (1) | CA2397404C (enExample) |
| DE (1) | DE60141680D1 (enExample) |
| WO (1) | WO2001051032A2 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023282A1 (ja) * | 2003-09-03 | 2005-03-17 | Ltt Bio-Pharma Co., Ltd. | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
| JP2005519944A (ja) * | 2002-03-13 | 2005-07-07 | ノバルティス アクチエンゲゼルシャフト | 医薬微粒子 |
| JP2007514490A (ja) * | 2003-12-19 | 2007-06-07 | アルク−アベッロ エイ／エス | 有効医薬成分の寒冷顆粒化及び貯蔵の方法 |
| JP2008530206A (ja) * | 2005-02-17 | 2008-08-07 | メディバス エルエルシー | ポリマー粒子送達組成物および使用法 |
| JP2009523843A (ja) * | 2006-01-23 | 2009-06-25 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 活性薬剤用のデリバリーシステム |
| US8459046B2 (en) | 2003-12-19 | 2013-06-11 | Alk-Abello A/S | Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product |
| JP2017524743A (ja) * | 2014-08-14 | 2017-08-31 | ブラウン ユニバーシティ | タンパク質を安定化させ、送達するための組成物 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809309B1 (fr) * | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
| CA2456806C (en) | 2001-08-08 | 2011-10-18 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
| AU2002360549A1 (en) * | 2001-12-10 | 2003-06-23 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
| SI21222A (sl) * | 2002-05-28 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo nanodelcev |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
| CN108379243A (zh) * | 2018-03-22 | 2018-08-10 | 福州大学 | 一种载基因多孔磁性微球的制备方法 |
| CN115005320B (zh) * | 2022-05-07 | 2023-09-05 | 中国农业大学 | 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物 |
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| WO1998046212A1 (en) * | 1997-04-17 | 1998-10-22 | Amgen Inc. | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
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| JPH0798755B2 (ja) * | 1985-11-27 | 1995-10-25 | エチコン・インコ−ポレ−テツド | 局所的投与により術後の癒着形成を抑制するための組成物 |
| DE3779221D1 (de) * | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| AU714584B2 (en) * | 1995-07-21 | 2000-01-06 | Brown University Research Foundation | A method for gene therapy using nucleic acid loaded polymeric microparticles |
| EP0889722B1 (en) * | 1996-03-28 | 2002-11-20 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and its production |
| JP3918248B2 (ja) * | 1997-09-26 | 2007-05-23 | ソニー株式会社 | 固体撮像素子およびその駆動方法 |
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2001
- 2001-01-12 EP EP01902059A patent/EP1246609B1/en not_active Expired - Lifetime
- 2001-01-12 WO PCT/US2001/001183 patent/WO2001051032A2/en not_active Ceased
- 2001-01-12 JP JP2001551456A patent/JP2003519651A/ja active Pending
- 2001-01-12 AT AT01902059T patent/ATE462413T1/de not_active IP Right Cessation
- 2001-01-12 AU AU27902/01A patent/AU773735B2/en not_active Ceased
- 2001-01-12 CA CA002397404A patent/CA2397404C/en not_active Expired - Lifetime
- 2001-01-12 DE DE60141680T patent/DE60141680D1/de not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998046212A1 (en) * | 1997-04-17 | 1998-10-22 | Amgen Inc. | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005519944A (ja) * | 2002-03-13 | 2005-07-07 | ノバルティス アクチエンゲゼルシャフト | 医薬微粒子 |
| JP2010248271A (ja) * | 2002-03-13 | 2010-11-04 | Novartis Ag | 医薬微粒子 |
| WO2005023282A1 (ja) * | 2003-09-03 | 2005-03-17 | Ltt Bio-Pharma Co., Ltd. | 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤 |
| JP2007514490A (ja) * | 2003-12-19 | 2007-06-07 | アルク−アベッロ エイ／エス | 有効医薬成分の寒冷顆粒化及び貯蔵の方法 |
| JP4755992B2 (ja) * | 2003-12-19 | 2011-08-24 | アルク−アベッロ エイ／エス | 有効医薬成分の寒冷顆粒化及び貯蔵の方法 |
| US8459046B2 (en) | 2003-12-19 | 2013-06-11 | Alk-Abello A/S | Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product |
| US8551491B2 (en) | 2003-12-19 | 2013-10-08 | Alk-Abello A/S | Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product |
| JP2008530206A (ja) * | 2005-02-17 | 2008-08-07 | メディバス エルエルシー | ポリマー粒子送達組成物および使用法 |
| JP2009523843A (ja) * | 2006-01-23 | 2009-06-25 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 活性薬剤用のデリバリーシステム |
| JP2017524743A (ja) * | 2014-08-14 | 2017-08-31 | ブラウン ユニバーシティ | タンパク質を安定化させ、送達するための組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1246609A2 (en) | 2002-10-09 |
| CA2397404C (en) | 2008-12-02 |
| CA2397404A1 (en) | 2001-07-19 |
| AU773735B2 (en) | 2004-06-03 |
| ATE462413T1 (de) | 2010-04-15 |
| DE60141680D1 (de) | 2010-05-12 |
| AU2790201A (en) | 2001-07-24 |
| WO2001051032A2 (en) | 2001-07-19 |
| EP1246609B1 (en) | 2010-03-31 |
| WO2001051032A3 (en) | 2002-03-28 |
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