JP2003519176A - 痛みを緩和する方法および組成物 - Google Patents

痛みを緩和する方法および組成物

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Publication number
JP2003519176A
JP2003519176A JP2001549643A JP2001549643A JP2003519176A JP 2003519176 A JP2003519176 A JP 2003519176A JP 2001549643 A JP2001549643 A JP 2001549643A JP 2001549643 A JP2001549643 A JP 2001549643A JP 2003519176 A JP2003519176 A JP 2003519176A
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group
nitrate
groups
substituted
optionally
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JP2001549643A
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JP2003519176A5 (https=
Inventor
グレゴリー アール． ジェイ． サッチャー
ブライアン エム． ベネット
ジェイムズ エヌ． レイノルズ
キーン ジャマンダ
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Queens University at Kingston
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Queens University at Kingston
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Publication of JP2003519176A publication Critical patent/JP2003519176A/ja
Publication of JP2003519176A5 publication Critical patent/JP2003519176A5/ja
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5120968B2 (ja) * 2007-10-05 2013-01-16 国立大学法人九州工業大学 誘電泳動装置および方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US20040077702A1 (en) * 2001-09-14 2004-04-22 Wen-Mei Fu Treatment of nuerodegenerative diseases
US7049334B2 (en) * 2001-09-14 2006-05-23 Carlsbad Technology, Inc. Enhancement of learning and memory and treatment of amnesia
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
US7498445B2 (en) 2004-05-05 2009-03-03 Renopharm Ltd. Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
WO2005105065A2 (en) 2004-05-05 2005-11-10 Renopharm Ltd. Thiazole-based nitric oxide donors for treating inflammatory bowel diseases
US7189750B2 (en) * 2004-05-05 2007-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
US7968575B2 (en) 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
US8134010B2 (en) 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
AR054181A1 (es) 2004-08-26 2007-06-06 Nicholas Piramal India Ltd Prodrogas que contienen enlaces bio-divisibles. composiiciones farmaceuticas
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
CA2580627A1 (en) * 2004-09-17 2006-03-23 Queen's University At Kingston Nitrate esters and their use for mitigating cellular damage
US20100035929A1 (en) * 2008-06-09 2010-02-11 Lindsley Craig W Unnatural dispyrin analogues, preparation and uses thereof
EP2379070A4 (en) * 2008-07-21 2013-11-13 Imi Internat Medical Innovations D B A Procris Pharmaceuticals WATER BASED TOPICAL STABLE PHARMACEUTICAL CREAMES AND METHODS FOR PREPARING AND USING SAME
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
AU2011248124B2 (en) * 2010-05-05 2016-07-21 The Board Of Trustees Of The University Of Illinois Compounds and methods of treating brain disorders
WO2014013338A2 (en) * 2012-07-16 2014-01-23 Sgc Pharma, Inc. Compounds for the treatment of alzheimer's disease
US11964956B2 (en) 2012-09-06 2024-04-23 Northeastern University Cannabinergic compounds and uses thereof
WO2014039042A1 (en) 2012-09-06 2014-03-13 Northeastern University Novel cannabinergic compounds and uses thereof
WO2014134127A1 (en) * 2013-02-26 2014-09-04 Northeastern University Cannabinergic nitrate esters and related analogs
US10456405B2 (en) 2015-09-07 2019-10-29 Zhejiang Huahai Pharmaceutical Co., Ltd Nitric oxide-releasing prodrug molecule of substituted quinazolines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046521A1 (en) * 1996-06-04 1997-12-11 Queen's University At Kingston Nitrate esters and their use for neurological conditions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1376892A (en) 1970-11-12 1974-12-11 Glaxo Lab Ltd 2beta-substituted-3alpha-hydroxysteroids and their esters
DE3443998A1 (de) 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
JPS62205052A (ja) 1986-03-05 1987-09-09 Terumo Corp 硝酸エステル誘導体およびこれを含有する血管拡張剤
NL8802276A (nl) 1988-09-15 1990-04-02 Cedona Pharm Bv Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.
US5428061A (en) 1988-09-15 1995-06-27 Schwarz Pharma Ag Organic nitrates and method for their preparation
US5284872A (en) 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
DE4321306A1 (de) 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
DE69412109T2 (de) 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
JP3276762B2 (ja) 1993-12-28 2002-04-22 日本臓器製薬株式会社 イソキノリン誘導体を含有する医薬組成物
SI0759899T1 (en) 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
JP3211892B2 (ja) 1994-05-27 2001-09-25 セイジィ ファーマスーティカルス インコーポレーテッド 肛門疾患を治療する窒素酸化物供与体及び方法
TW458776B (en) * 1995-08-15 2001-10-11 Chugai Pharmaceutical Co Ltd Pharmaceutical composition for the treatment of anxiety neurosis
IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046521A1 (en) * 1996-06-04 1997-12-11 Queen's University At Kingston Nitrate esters and their use for neurological conditions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5120968B2 (ja) * 2007-10-05 2013-01-16 国立大学法人九州工業大学 誘電泳動装置および方法
US8864972B2 (en) 2007-10-05 2014-10-21 Kyushu Institute Of Technology Dielectrophoresis apparatus and method

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