JP2003519082A5 - - Google Patents
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- Publication number
- JP2003519082A5 JP2003519082A5 JP2000573757A JP2000573757A JP2003519082A5 JP 2003519082 A5 JP2003519082 A5 JP 2003519082A5 JP 2000573757 A JP2000573757 A JP 2000573757A JP 2000573757 A JP2000573757 A JP 2000573757A JP 2003519082 A5 JP2003519082 A5 JP 2003519082A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor antagonist
- chemokine receptor
- cyclosporin
- pharmaceutical composition
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 19
- 108010036949 Cyclosporine Proteins 0.000 description 19
- 229960001265 ciclosporin Drugs 0.000 description 19
- 229940122444 Chemokine receptor antagonist Drugs 0.000 description 17
- 239000002559 chemokine receptor antagonist Substances 0.000 description 17
- 229930182912 cyclosporin Natural products 0.000 description 15
- 229930105110 Cyclosporin A Natural products 0.000 description 12
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 108010055166 Chemokine CCL5 Proteins 0.000 description 2
- 102000001327 Chemokine CCL5 Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010023347 Met- RANTES Proteins 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98117697.7 | 1998-09-18 | ||
| EP98117697A EP1000626A1 (en) | 1998-09-18 | 1998-09-18 | Chemokine receptor antagonist and cyclosporin in combined therapy |
| PCT/EP1999/006844 WO2000016796A1 (en) | 1998-09-18 | 1999-09-16 | Chemokine receptor antagonist and cyclosporin in combined therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519082A JP2003519082A (ja) | 2003-06-17 |
| JP2003519082A5 true JP2003519082A5 (enExample) | 2006-05-25 |
Family
ID=8232654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000573757A Withdrawn JP2003519082A (ja) | 1998-09-18 | 1999-09-16 | ケモカイン受容体アンタゴニストとシクロスポリンを組み合わせた治療 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6902728B1 (enExample) |
| EP (2) | EP1000626A1 (enExample) |
| JP (1) | JP2003519082A (enExample) |
| KR (1) | KR100613950B1 (enExample) |
| CN (1) | CN1177613C (enExample) |
| AR (1) | AR021810A1 (enExample) |
| AT (1) | ATE227582T1 (enExample) |
| AU (1) | AU766595B2 (enExample) |
| BR (1) | BR9913846A (enExample) |
| CA (1) | CA2344370A1 (enExample) |
| DE (1) | DE69903964T2 (enExample) |
| DK (1) | DK1113811T3 (enExample) |
| EA (1) | EA003181B1 (enExample) |
| EE (1) | EE04705B1 (enExample) |
| ES (1) | ES2186411T3 (enExample) |
| HK (1) | HK1041225B (enExample) |
| IL (2) | IL141899A0 (enExample) |
| NO (1) | NO20011371L (enExample) |
| PT (1) | PT1113811E (enExample) |
| SI (1) | SI1113811T1 (enExample) |
| UA (1) | UA60379C2 (enExample) |
| WO (1) | WO2000016796A1 (enExample) |
| ZA (1) | ZA200101909B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259136B2 (en) | 1999-04-30 | 2007-08-21 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating peripheral vascular disease |
| US6740636B2 (en) * | 2000-07-31 | 2004-05-25 | Schering Aktiengesellschaft | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
| LT5132B (lt) | 2000-07-31 | 2004-05-25 | Schering Aktiengesellschaft | Nepeptidiniai ccr1 receptorių antagonistai derinyje su ciklosporinu a širdies transplanto atmetimui gydyti |
| EP2185719B1 (en) | 2007-08-02 | 2013-11-13 | NovImmune SA | Anti-rantes antibodies and methods of use thereof |
| WO2017040515A1 (en) * | 2015-08-31 | 2017-03-09 | Hitachi Chemical Co., Ltd. | Molecular methods for assessing post kidney transplant complications |
| JP6624704B2 (ja) | 2015-08-31 | 2019-12-25 | 日立化成株式会社 | 尿路上皮疾患の評価のための分子法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU221089B1 (en) * | 1994-12-08 | 2002-08-28 | Glaxo Group Ltd | Rantes peptide derivates with antagonistic effect and uses thereof |
| EP0845994A1 (en) * | 1995-08-09 | 1998-06-10 | Schering Corporation | Combined use of interleukin-10 and cyclosporin for immunosuppression therapy |
| US6184235B1 (en) * | 1996-08-14 | 2001-02-06 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as MCP-1 antagonists |
| WO1998006751A1 (en) * | 1996-08-16 | 1998-02-19 | Research Corporation Technologies, Inc. | Mcp-3, rantes and mip-1alpha receptor antagonists |
-
1998
- 1998-09-18 EP EP98117697A patent/EP1000626A1/en not_active Withdrawn
-
1999
- 1999-09-16 AR ARP990104655A patent/AR021810A1/es unknown
- 1999-09-16 ZA ZA200101909A patent/ZA200101909B/xx unknown
- 1999-09-16 CN CNB998111252A patent/CN1177613C/zh not_active Expired - Fee Related
- 1999-09-16 IL IL141899??A patent/IL141899A0/xx active IP Right Grant
- 1999-09-16 EP EP99948760A patent/EP1113811B1/en not_active Expired - Lifetime
- 1999-09-16 EA EA200100366A patent/EA003181B1/ru not_active IP Right Cessation
- 1999-09-16 SI SI9930157T patent/SI1113811T1/xx unknown
- 1999-09-16 WO PCT/EP1999/006844 patent/WO2000016796A1/en not_active Ceased
- 1999-09-16 DE DE69903964T patent/DE69903964T2/de not_active Expired - Lifetime
- 1999-09-16 ES ES99948760T patent/ES2186411T3/es not_active Expired - Lifetime
- 1999-09-16 HK HK02103034.0A patent/HK1041225B/zh not_active IP Right Cessation
- 1999-09-16 US US09/787,335 patent/US6902728B1/en not_active Expired - Fee Related
- 1999-09-16 DK DK99948760T patent/DK1113811T3/da active
- 1999-09-16 KR KR1020017003199A patent/KR100613950B1/ko not_active Expired - Fee Related
- 1999-09-16 AT AT99948760T patent/ATE227582T1/de active
- 1999-09-16 AU AU61914/99A patent/AU766595B2/en not_active Ceased
- 1999-09-16 CA CA002344370A patent/CA2344370A1/en not_active Abandoned
- 1999-09-16 PT PT99948760T patent/PT1113811E/pt unknown
- 1999-09-16 EE EEP200100159A patent/EE04705B1/xx not_active IP Right Cessation
- 1999-09-16 UA UA2001042570A patent/UA60379C2/uk unknown
- 1999-09-16 JP JP2000573757A patent/JP2003519082A/ja not_active Withdrawn
- 1999-09-16 BR BR9913846-8A patent/BR9913846A/pt not_active Application Discontinuation
-
2001
- 2001-03-08 IL IL141899A patent/IL141899A/en not_active IP Right Cessation
- 2001-03-16 NO NO20011371A patent/NO20011371L/no not_active Application Discontinuation
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