JP2003517462A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003517462A5 JP2003517462A5 JP2001511958A JP2001511958A JP2003517462A5 JP 2003517462 A5 JP2003517462 A5 JP 2003517462A5 JP 2001511958 A JP2001511958 A JP 2001511958A JP 2001511958 A JP2001511958 A JP 2001511958A JP 2003517462 A5 JP2003517462 A5 JP 2003517462A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- benzethonium chloride
- vial
- added
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960001950 benzethonium chloride Drugs 0.000 description 39
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 39
- 238000000034 method Methods 0.000 description 27
- 239000000203 mixture Substances 0.000 description 23
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 18
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 18
- 229960005323 phenoxyethanol Drugs 0.000 description 18
- NDTDVKKGYBULHF-UHFFFAOYSA-N 2-(1-hydroxy-3-phenylnaphthalen-2-yl)-3-phenylnaphthalen-1-ol Chemical compound C=1C2=CC=CC=C2C(O)=C(C=2C(=CC3=CC=CC=C3C=2O)C=2C=CC=CC=2)C=1C1=CC=CC=C1 NDTDVKKGYBULHF-UHFFFAOYSA-N 0.000 description 15
- 229940067107 phenylethyl alcohol Drugs 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 102000003951 Erythropoietin Human genes 0.000 description 4
- 108090000394 Erythropoietin Proteins 0.000 description 4
- 229940105423 erythropoietin Drugs 0.000 description 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19821699P | 1999-07-22 | 1999-07-22 | |
| US60/198,216 | 1999-07-22 | ||
| PCT/US2000/040446 WO2001007075A2 (en) | 1999-07-22 | 2000-07-21 | Multi-dose erythropoietin formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003517462A JP2003517462A (ja) | 2003-05-27 |
| JP2003517462A5 true JP2003517462A5 (enExample) | 2007-08-30 |
Family
ID=22732468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001511958A Pending JP2003517462A (ja) | 1999-07-22 | 2000-07-21 | 複数回投与用エリスロポエチン製剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7432360B2 (enExample) |
| EP (1) | EP1200115B9 (enExample) |
| JP (1) | JP2003517462A (enExample) |
| KR (1) | KR100693263B1 (enExample) |
| CN (2) | CN101091792A (enExample) |
| AT (1) | ATE304863T1 (enExample) |
| AU (1) | AU777397B2 (enExample) |
| BR (1) | BR0012667A (enExample) |
| CA (1) | CA2378945C (enExample) |
| CZ (1) | CZ302750B6 (enExample) |
| DE (1) | DE60022759T2 (enExample) |
| DK (1) | DK1200115T3 (enExample) |
| EA (1) | EA006220B1 (enExample) |
| EE (1) | EE200200037A (enExample) |
| ES (1) | ES2248110T3 (enExample) |
| HK (1) | HK1050318A1 (enExample) |
| HR (1) | HRP20020159B1 (enExample) |
| HU (1) | HUP0202246A3 (enExample) |
| IL (2) | IL147755A0 (enExample) |
| NO (1) | NO20020303L (enExample) |
| NZ (1) | NZ516735A (enExample) |
| PL (1) | PL202945B1 (enExample) |
| RS (1) | RS50355B (enExample) |
| WO (1) | WO2001007075A2 (enExample) |
| ZA (1) | ZA200200742B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020032534A (ko) | 1999-07-22 | 2002-05-03 | 게리 디. 스트리트, 스티븐 엘. 네스비트 | 보존 제약 제형 |
| PL219131B1 (pl) | 2000-05-15 | 2015-03-31 | Hoffmann La Roche | Ciekła kompozycja farmaceutyczna, sposób jej wytwarzania oraz jej zastosowanie |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20050267026A1 (en) * | 2004-03-26 | 2005-12-01 | Cheung Wing K | Combination dosing regimen for erythropoietin |
| US7772182B2 (en) | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| WO2006081969A1 (de) * | 2005-02-03 | 2006-08-10 | Clariant Produkte (Deutschland) Gmbh | Konservierungsmittel |
| JP2011116752A (ja) * | 2009-10-29 | 2011-06-16 | Jcr Pharmaceuticals Co Ltd | エリスロポエチン含有水性液剤 |
| KR101805087B1 (ko) | 2010-09-16 | 2017-12-05 | 주식회사 엘지화학 | 높은 방부력을 제공하는 오일 주사 제형 |
| CN108135841B (zh) * | 2015-10-22 | 2024-03-05 | 艾尔图制药公司 | Il-2的药物组合物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489837A (en) * | 1968-07-11 | 1970-01-13 | Leroy J Hyman | Synergistic antiseptic composition consisting of 9-aminoacridine hydrochloride and benzethonium chloride |
| JPS6045849B2 (ja) | 1980-08-25 | 1985-10-12 | 林原 健 | ヒトエリトロポエチンの製造方法 |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| JPS6191131A (ja) * | 1984-10-09 | 1986-05-09 | Chugai Pharmaceut Co Ltd | 医薬品の吸着防止方法および組成物 |
| JPS6197229A (ja) | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| JPH0651637B2 (ja) * | 1985-03-28 | 1994-07-06 | エーザイ株式会社 | ペプタイドの吸着防止組成物 |
| US5045529A (en) * | 1989-03-27 | 1991-09-03 | Bionostics, Inc. | Tonometric fluid for blood gas and co-oximetry instruments |
| JP3249147B2 (ja) * | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| CA2050425A1 (en) * | 1990-09-03 | 1992-03-04 | Yoshiaki Uda | Pharmaceutical composition and its mucous use |
| DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
| US5661125A (en) | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| JP2532025B2 (ja) * | 1993-07-23 | 1996-09-11 | 株式会社林原生物化学研究所 | 新リンホカインｉｉｉを有効成分とする抗腫瘍作用を有するリンホカインの活性増強剤 |
| EP0803255A4 (en) * | 1994-06-03 | 1999-06-30 | Tsumura & Co | MEDICINAL COMPOSITION |
| WO1997026004A1 (en) * | 1996-01-19 | 1997-07-24 | Eli Lilly And Company | Obesity protein formulations |
| CA2265743A1 (en) * | 1996-09-13 | 1998-03-19 | Advanced Medicine Research Institute | Ophthalmic composition of neurotrophic factor, optic nerve functional disorder-treating agent and method for treating optic nerve functional disorder |
| JPH1112193A (ja) * | 1997-06-19 | 1999-01-19 | Sankyo Co Ltd | ヒトカルシトニン含有水溶液製剤 |
| GB9726555D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Vaccine |
-
2000
- 2000-07-21 AT AT00960177T patent/ATE304863T1/de active
- 2000-07-21 EE EEP200200037A patent/EE200200037A/xx unknown
- 2000-07-21 HU HU0202246A patent/HUP0202246A3/hu unknown
- 2000-07-21 CA CA2378945A patent/CA2378945C/en not_active Expired - Fee Related
- 2000-07-21 PL PL353569A patent/PL202945B1/pl not_active IP Right Cessation
- 2000-07-21 NZ NZ516735A patent/NZ516735A/en not_active IP Right Cessation
- 2000-07-21 HR HR20020159A patent/HRP20020159B1/xx not_active IP Right Cessation
- 2000-07-21 WO PCT/US2000/040446 patent/WO2001007075A2/en not_active Ceased
- 2000-07-21 ES ES00960177T patent/ES2248110T3/es not_active Expired - Lifetime
- 2000-07-21 KR KR1020027000944A patent/KR100693263B1/ko not_active Expired - Fee Related
- 2000-07-21 HK HK03102133.1A patent/HK1050318A1/zh unknown
- 2000-07-21 CZ CZ20020264A patent/CZ302750B6/cs not_active IP Right Cessation
- 2000-07-21 JP JP2001511958A patent/JP2003517462A/ja active Pending
- 2000-07-21 CN CNA2006100710932A patent/CN101091792A/zh active Pending
- 2000-07-21 CN CN00812138A patent/CN1371284A/zh active Pending
- 2000-07-21 DK DK00960177T patent/DK1200115T3/da active
- 2000-07-21 IL IL14775500A patent/IL147755A0/xx unknown
- 2000-07-21 DE DE60022759T patent/DE60022759T2/de not_active Expired - Lifetime
- 2000-07-21 EA EA200200073A patent/EA006220B1/ru not_active IP Right Cessation
- 2000-07-21 EP EP00960177A patent/EP1200115B9/en not_active Expired - Lifetime
- 2000-07-21 AU AU71374/00A patent/AU777397B2/en not_active Ceased
- 2000-07-21 BR BR0012667-5A patent/BR0012667A/pt not_active IP Right Cessation
- 2000-07-21 RS YUP-47/02A patent/RS50355B/sr unknown
-
2002
- 2002-01-21 IL IL147755A patent/IL147755A/en not_active IP Right Cessation
- 2002-01-21 NO NO20020303A patent/NO20020303L/no not_active Application Discontinuation
- 2002-01-28 ZA ZA200200742A patent/ZA200200742B/xx unknown
-
2005
- 2005-06-27 US US11/167,818 patent/US7432360B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003506416A5 (enExample) | ||
| EA200200072A1 (ru) | Пресервированные фармацевтические составы | |
| CA2223747A1 (en) | Antifungal compositions | |
| ATE179884T1 (de) | Viskoelastische zusammensetzungen aus organischen fluorierten verbindungen | |
| ES2155043B1 (es) | Composiciones farmaceuticas comprendiendo acido pirimidin-5-il(3r, 5s)-3,5-dihidroxihept-6-enoico o una sal suya, su estabilizacion con sal fosfato tribasico y su preparacion. | |
| EE05382B1 (et) | MandelhappeÁderivaadid,ÁnendeÁvalmistamiseÁmeetod,ÁnendeÁkasutamineÁtrombiiniÁinhibiitoritenaÁjaÁneidÁsisaldavadÁravimkoostised | |
| HRP20010243B1 (hr) | Pripravci koji sadrže difosfonske kiseline | |
| EA200400777A1 (ru) | Фармацевтические композиции соединения платины | |
| ATE331525T1 (de) | Salzformarme polyallylamine | |
| AU2001296865A1 (en) | (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents | |
| SE9904413D0 (sv) | Comminuted form | |
| JP2002528404A (ja) | 脂肪酸／アミノ酸セッケンを含む局所投与可能薬学的組成物のための保存系 | |
| JP2003517462A5 (enExample) | ||
| BR0213066A (pt) | Compostos de cianoacetila | |
| ATE367165T1 (de) | Xanthangummi enthaltende reepithelialisierende pharmazeutische zubereitungen | |
| BR0315320A (pt) | Composto ou sais farmaceuticamente aceitáveis dos mesmos, uso de um composto, composição farmacêutica, e, métodos para a terapia de dor em um animal de sangue quente e para produzir um composto | |
| SE0102440D0 (sv) | New compound | |
| EP1275646A4 (en) | INDOLYLPYRROL DERIVATIVES AND CELL DEATH INHIBITORS | |
| HRP20020181B1 (hr) | Farmaceutski pripravci koji sadrže derivat benzamida kao aktivan sastojak | |
| DE60131416D1 (de) | Chirale fluorochinolizinon arginine salze | |
| JP2002537232A5 (enExample) | ||
| HUP9801712A2 (hu) | Racemizálás ellen stabilizált, cilansetrontartalmú gyógyászati készítmények, előállításuk és a stabilizáló adalékanyagok alkalmazása | |
| KR930001903A (ko) | 유비데카레논 경구용 수용액 제제 | |
| EP1301203A4 (en) | VACCINE CONTAINING AZYL-GLYCERYL PHOSPHATIDYLINOSITOL MANNO-OLIGOSACCHARIDE AS AN ACTIVE SUBSTANCE | |
| CA2378945A1 (en) | Multi-dose erythropoietin formulations |