JP2003515533A5 - - Google Patents
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- Publication number
- JP2003515533A5 JP2003515533A5 JP2001537359A JP2001537359A JP2003515533A5 JP 2003515533 A5 JP2003515533 A5 JP 2003515533A5 JP 2001537359 A JP2001537359 A JP 2001537359A JP 2001537359 A JP2001537359 A JP 2001537359A JP 2003515533 A5 JP2003515533 A5 JP 2003515533A5
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- mammal
- mutations
- kilodaltons
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010054147 Hemoglobins Proteins 0.000 description 36
- 102000001554 Hemoglobins Human genes 0.000 description 36
- 230000035772 mutation Effects 0.000 description 16
- 241000124008 Mammalia Species 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 150000003278 haem Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 208000001953 Hypotension Diseases 0.000 description 3
- 208000021822 hypotensive Diseases 0.000 description 3
- 230000001077 hypotensive effect Effects 0.000 description 3
- 101710187052 Flavohemoprotein Proteins 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010059484 Haemodilution Diseases 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
- 108010085682 Hemoglobin A Proteins 0.000 description 1
- 102000007513 Hemoglobin A Human genes 0.000 description 1
- 102100027685 Hemoglobin subunit alpha Human genes 0.000 description 1
- 108091005902 Hemoglobin subunit alpha Proteins 0.000 description 1
- 102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
- 102100039894 Hemoglobin subunit delta Human genes 0.000 description 1
- 108091005903 Hemoglobin subunit delta Proteins 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033661 Pancytopenia Diseases 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 208000024389 cytopenia Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528999P | 1999-11-12 | 1999-11-12 | |
| US60/165,289 | 1999-11-12 | ||
| PCT/US2000/030857 WO2001034648A1 (en) | 1999-11-12 | 2000-11-10 | Reduced side-effect hemoglobin compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011030290A Division JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515533A JP2003515533A (ja) | 2003-05-07 |
| JP2003515533A5 true JP2003515533A5 (https=) | 2007-12-27 |
| JP5099951B2 JP5099951B2 (ja) | 2012-12-19 |
Family
ID=22598286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537359A Expired - Fee Related JP5099951B2 (ja) | 1999-11-12 | 2000-11-10 | 副作用が減少されたヘモグロビン組成物 |
| JP2011030290A Pending JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011030290A Pending JP2011098985A (ja) | 1999-11-12 | 2011-02-15 | 副作用が減少されたヘモグロビン組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6670323B1 (https=) |
| EP (2) | EP2292657A1 (https=) |
| JP (2) | JP5099951B2 (https=) |
| AU (1) | AU784195B2 (https=) |
| CA (1) | CA2391226A1 (https=) |
| NO (1) | NO20022229L (https=) |
| WO (1) | WO2001034648A1 (https=) |
| ZA (1) | ZA200203817B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2292657A1 (en) * | 1999-11-12 | 2011-03-09 | Baxter Biotech Technology S.A.R.L. | Reduced side-effect hemoglobin compositions |
| DE10224750A1 (de) | 2002-06-04 | 2003-12-24 | Fresenius Medical Care De Gmbh | Vorrichtung zur Behandlung einer medizinischen Flüssigkeit |
| US7092752B2 (en) * | 2002-07-27 | 2006-08-15 | Sheng-Xing Ma | Skin acupoint/meridian nitric oxide collection kit and method thereof |
| US9138707B2 (en) | 2002-12-10 | 2015-09-22 | Sy Kimball | Portable, nitric oxide generator |
| DK1449535T3 (da) * | 2003-02-18 | 2006-09-11 | Clinique La Prairie Res Sa | Præparater der omfatter fötalt hæmoglobin og bakterieendotoksin samt eventuelt fötale leverbestanddele |
| AU2005279780B2 (en) * | 2004-08-31 | 2011-02-03 | Sangart, Inc. | Methods to enhance hemodynamic stability using oxygen carrying compositions |
| US7976866B2 (en) * | 2004-12-06 | 2011-07-12 | Opremcak E Mitchel | Bandage and method for vital bleaching of skin |
| US7935074B2 (en) | 2005-02-28 | 2011-05-03 | Fresenius Medical Care Holdings, Inc. | Cassette system for peritoneal dialysis machine |
| US8741832B2 (en) * | 2005-06-10 | 2014-06-03 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated albumin and uses thereof |
| US8071546B2 (en) * | 2005-06-10 | 2011-12-06 | La Jolla Bioengineering Institute | Uses of pegylated albumin |
| US8197231B2 (en) | 2005-07-13 | 2012-06-12 | Purity Solutions Llc | Diaphragm pump and related methods |
| US8720436B2 (en) * | 2008-01-31 | 2014-05-13 | Genosys, Inc. | Nitric oxide gel apparatus and method |
| US9649467B2 (en) | 2008-01-31 | 2017-05-16 | Syk Technologies, Llc | Nitric oxide reactor and distributor apparatus and method |
| US8434475B2 (en) | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US20090247619A1 (en) * | 2008-03-06 | 2009-10-01 | University Of Kentucky | Cannabinoid-Containing Compositions and Methods for Their Use |
| US8501090B2 (en) * | 2008-03-24 | 2013-08-06 | Christian S. Minton | Anti-microbial gas apparatus and method |
| US8192401B2 (en) | 2009-03-20 | 2012-06-05 | Fresenius Medical Care Holdings, Inc. | Medical fluid pump systems and related components and methods |
| CN102497895A (zh) | 2009-07-15 | 2012-06-13 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体盒及相关系统和方法 |
| US8720913B2 (en) | 2009-08-11 | 2014-05-13 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis carts and related systems |
| US8685467B2 (en) | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
| US8609815B2 (en) * | 2010-09-02 | 2013-12-17 | Sangart, Inc. | Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant |
| DE102010053973A1 (de) | 2010-12-09 | 2012-06-14 | Fresenius Medical Care Deutschland Gmbh | Medizinisches Gerät mit einer Heizung |
| EP2654825B1 (en) | 2010-12-20 | 2017-08-02 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9624915B2 (en) | 2011-03-09 | 2017-04-18 | Fresenius Medical Care Holdings, Inc. | Medical fluid delivery sets and related systems and methods |
| CN103648540B (zh) | 2011-04-21 | 2016-06-01 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体泵送系统及相关装置和方法 |
| ES2432075T3 (es) | 2011-07-23 | 2013-11-29 | Sastomed Gmbh | Espray para heridas |
| JP6066356B2 (ja) | 2011-09-23 | 2017-01-25 | ブルーバード バイオ， インコーポレイテッド | 改善された遺伝子治療方法 |
| PT2760994T (pt) | 2011-09-30 | 2017-08-24 | Bluebird Bio Inc | Compostos para melhor transdução viral |
| US9186449B2 (en) | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
| EP2827887A4 (en) | 2012-03-20 | 2016-04-20 | Einstein Coll Med | METHOD FOR IMPROVING THE EFFECTIVENESS OF BLOOD TRANSFUSIONS |
| US20130261412A1 (en) * | 2012-03-28 | 2013-10-03 | II Robert Lawrence Reed | System and method for managing fluid levels in patients based upon creatinine clearance |
| US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| JP2014062050A (ja) * | 2012-09-19 | 2014-04-10 | Fujifilm Corp | 多価官能マレイミド系重合性化合物、これを含む硬化組成物およびインク組成物 |
| US9561323B2 (en) | 2013-03-14 | 2017-02-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassette leak detection methods and devices |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US10117985B2 (en) | 2013-08-21 | 2018-11-06 | Fresenius Medical Care Holdings, Inc. | Determining a volume of medical fluid pumped into or out of a medical fluid cassette |
| AR102048A1 (es) | 2014-08-12 | 2017-02-01 | Baxalta Inc | Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furina |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| WO2017139561A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| WO2017139576A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| US11504417B2 (en) | 2017-07-18 | 2022-11-22 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| GB201721503D0 (en) * | 2017-12-20 | 2018-01-31 | Univ Essex | Modified globin proteins |
| US10752672B1 (en) * | 2019-02-01 | 2020-08-25 | Cheer Global Limited | Recombinant hemoglobins and methods of preparation and use thereof |
| JP7593609B2 (ja) * | 2020-02-28 | 2024-12-03 | 学校法人 中央大学 | ヘモグロビン微粒子及び人工酸素運搬体 |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
| WO2022184005A1 (en) | 2021-03-01 | 2022-09-09 | Billion King International Limited | Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof |
| EP4402242A4 (en) * | 2021-09-17 | 2025-08-06 | Univ Yale | METHODS, SYSTEMS AND COMPOSITIONS FOR RESTORING AND PRESERVING INTACT ORGANS IN A MAMMAL |
| CN115317595A (zh) * | 2021-09-27 | 2022-11-11 | 中国人民解放军军事科学院军事医学研究院 | 一种聚乙二醇化牛血红蛋白氧载体及其制备方法与应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3525272A (en) | 1967-10-20 | 1970-08-25 | Westinghouse Air Brake Co | Multiposition control handle having detent means |
| DE2449885C3 (de) | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
| US4061736A (en) | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
| US4001401A (en) | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| US4001200A (en) | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
| US4053590A (en) | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| US4473496A (en) | 1981-09-14 | 1984-09-25 | The United States Of America As Represented By The Secretary Of The Army | Intramolecularly crosslinked hemoglobin |
| DE3144705C2 (de) | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| US4598064A (en) | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4600531A (en) | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4584130A (en) | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
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| US5032676A (en) | 1986-10-14 | 1991-07-16 | Immunex Corporation | Nonglycosylated analogs of human colony stimulating factors |
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| JP2562840B2 (ja) | 1988-08-01 | 1996-12-11 | 富士通株式会社 | 電界効果トランジスタ |
| IL87707A (en) | 1988-09-08 | 1994-06-24 | Technion Inst For Research And | Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof |
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| US5250665A (en) | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| US5334706A (en) | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
| IL106401A (en) | 1992-08-07 | 1997-02-18 | Donnelley & Sons Co | Method and system for converting bitmap data into page definition language commands |
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| TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| US5665869A (en) | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
| US5559907A (en) | 1994-02-17 | 1996-09-24 | Lucent Technologies Inc. | Method of controlling polarization properties of a photo-induced device in an optical waveguide and method of investigating structure of an optical waveguide |
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| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US5733869A (en) * | 1995-10-06 | 1998-03-31 | Baxter International, Inc. | Therapeutic administration of hemoglobin in cardiac arrest |
| AU4661797A (en) | 1996-10-21 | 1998-05-15 | Baxter International Inc. | Therapeutic use of hemoglobin to treat head injury |
| AU750295B2 (en) | 1997-05-02 | 2002-07-11 | Baxter Biotech Technology S.A.R.L. | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
| EP2292657A1 (en) * | 1999-11-12 | 2011-03-09 | Baxter Biotech Technology S.A.R.L. | Reduced side-effect hemoglobin compositions |
| WO2010035100A1 (en) | 2008-09-25 | 2010-04-01 | Nokia Corporation | Synchronization for device-to-device communication |
| US8148264B2 (en) | 2009-02-25 | 2012-04-03 | California Institue Of Technology | Methods for fabrication of high aspect ratio micropillars and nanopillars |
| JP5963422B2 (ja) | 2010-12-17 | 2016-08-03 | キヤノン株式会社 | 撮像装置、表示装置、コンピュータプログラムおよび立体像表示システム |
-
2000
- 2000-11-10 EP EP10075434A patent/EP2292657A1/en not_active Withdrawn
- 2000-11-10 EP EP00980318A patent/EP1233986A4/en not_active Withdrawn
- 2000-11-10 US US09/709,914 patent/US6670323B1/en not_active Expired - Fee Related
- 2000-11-10 CA CA002391226A patent/CA2391226A1/en not_active Abandoned
- 2000-11-10 WO PCT/US2000/030857 patent/WO2001034648A1/en not_active Ceased
- 2000-11-10 JP JP2001537359A patent/JP5099951B2/ja not_active Expired - Fee Related
- 2000-11-10 AU AU17597/01A patent/AU784195B2/en not_active Ceased
-
2002
- 2002-05-10 NO NO20022229A patent/NO20022229L/no not_active Application Discontinuation
- 2002-05-14 ZA ZA200203817A patent/ZA200203817B/xx unknown
-
2003
- 2003-12-29 US US10/747,580 patent/US7211560B2/en not_active Expired - Fee Related
-
2011
- 2011-02-15 JP JP2011030290A patent/JP2011098985A/ja active Pending
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