JP2003514799A - ニューロン活性を有するアザ化合物 - Google Patents
ニューロン活性を有するアザ化合物Info
- Publication number
- JP2003514799A JP2003514799A JP2001538878A JP2001538878A JP2003514799A JP 2003514799 A JP2003514799 A JP 2003514799A JP 2001538878 A JP2001538878 A JP 2001538878A JP 2001538878 A JP2001538878 A JP 2001538878A JP 2003514799 A JP2003514799 A JP 2003514799A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- aryl
- substituted
- heterocycle
- carbocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16495099P | 1999-11-12 | 1999-11-12 | |
| US60/164,950 | 1999-11-12 | ||
| US09/551,618 | 2000-04-17 | ||
| US09/551,618 US6417189B1 (en) | 1999-11-12 | 2000-04-17 | AZA compounds, pharmaceutical compositions and methods of use |
| PCT/US2000/023603 WO2001036388A1 (en) | 1999-11-12 | 2000-08-28 | Aza compounds having neuronal activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514799A true JP2003514799A (ja) | 2003-04-22 |
| JP2003514799A5 JP2003514799A5 (enExample) | 2007-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001538878A Pending JP2003514799A (ja) | 1999-11-12 | 2000-08-28 | ニューロン活性を有するアザ化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6417189B1 (enExample) |
| EP (1) | EP1242383A1 (enExample) |
| JP (1) | JP2003514799A (enExample) |
| AU (1) | AU781740B2 (enExample) |
| CA (1) | CA2390071A1 (enExample) |
| HK (1) | HK1048312A1 (enExample) |
| MX (1) | MXPA02004710A (enExample) |
| WO (1) | WO2001036388A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
| US7253169B2 (en) * | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670503A (en) * | 1993-02-26 | 1997-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| WO1998005333A1 (en) * | 1996-08-05 | 1998-02-12 | Molecumetics Ltd. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| WO1999020272A1 (en) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3706743A (en) | 1970-10-16 | 1972-12-19 | Upjohn Co | 1,2-pyridazinedicarboximidophosphorous insecticides |
| EP0042100A1 (de) | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
| US4766110A (en) | 1981-08-21 | 1988-08-23 | Ryan James W | Novel complex amido and imido derivatives of carboxyalkyl peptides |
| EP0075267B1 (en) | 1981-09-19 | 1986-01-15 | Sumitomo Chemical Company, Limited | 4-(2-fluoro-4-halo-5-substituted phenyl)urazols, and their production and use |
| US4431644A (en) | 1982-03-08 | 1984-02-14 | Schering Corporation | Antihypertensive agents |
| AU1787783A (en) | 1982-09-02 | 1984-03-08 | Nippon Kayaku Kabushiki Kaisha | Nitrogen containing heterocyclic |
| US4581220A (en) | 1982-11-04 | 1986-04-08 | Imperial Chemical Industries, Plc | Process for the extraction of metal values and novel metal extractants |
| US4659711A (en) | 1983-01-31 | 1987-04-21 | Usv Pharmaceutical Corporation | 1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension |
| ZW11586A1 (en) | 1985-07-01 | 1987-12-30 | Hoffmann La Roche | Bicyclic compounds |
| US5714510A (en) | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical proxyl composition and method |
| US5214034A (en) | 1986-09-26 | 1993-05-25 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same |
| DE3636278A1 (de) | 1986-10-24 | 1988-05-05 | Hoechst Ag | Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung |
| IT1206078B (it) | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
| EP0380592A4 (en) * | 1988-01-19 | 1991-10-09 | E.R. Squibb & Sons, Inc. | 2-oxo-1-substituted pyrazolo 1,5-a¨pyrimidine-6-carboxylic acid esters |
| US5232923A (en) | 1988-03-18 | 1993-08-03 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives and pharmaceutical preparations containing same |
| US5274097A (en) | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
| IT1218223B (it) | 1988-04-21 | 1990-04-12 | Enichem Anic Spa | Procedimento per la sintesi di ossalil-ed ossamil-idrazidi |
| US4801706A (en) * | 1988-04-28 | 1989-01-31 | American Home Products Corporation | N-substituted-hexahydro-1,2,5-triazepines |
| US5002964A (en) | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
| JPH0215082A (ja) | 1988-07-04 | 1990-01-18 | Nippon Tokushu Noyaku Seizo Kk | 新規ヘテロ環式化合物及び除草剤 |
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Also Published As
| Publication number | Publication date |
|---|---|
| US6417189B1 (en) | 2002-07-09 |
| HK1048312A1 (zh) | 2003-03-28 |
| EP1242383A1 (en) | 2002-09-25 |
| WO2001036388A1 (en) | 2001-05-25 |
| AU6942800A (en) | 2001-05-30 |
| MXPA02004710A (es) | 2002-09-02 |
| CA2390071A1 (en) | 2001-05-25 |
| AU781740B2 (en) | 2005-06-09 |
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