JP2003512827A - リガンド活性化転写レギュレータータンパク質 - Google Patents

リガンド活性化転写レギュレータータンパク質

Info

Publication number
JP2003512827A
JP2003512827A JP2001533840A JP2001533840A JP2003512827A JP 2003512827 A JP2003512827 A JP 2003512827A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A JP2003512827 A JP 2003512827A
Authority
JP
Japan
Prior art keywords
fusion protein
receptor
vector
zinc finger
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001533840A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003512827A5 (enExample
Inventor
カルロス・エフ・バルバス
マイケル・カダン
ロジャー・ベールリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2003512827A publication Critical patent/JP2003512827A/ja
Publication of JP2003512827A5 publication Critical patent/JP2003512827A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2001533840A 1999-10-25 2000-10-23 リガンド活性化転写レギュレータータンパク質 Withdrawn JP2003512827A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43304299A 1999-10-25 1999-10-25
US09/433,042 1999-10-25
US09/586,625 US7329728B1 (en) 1999-10-25 2000-06-02 Ligand activated transcriptional regulator proteins
US09/586,625 2000-06-02
PCT/EP2000/010430 WO2001030843A1 (en) 1999-10-25 2000-10-23 Ligand activated transcriptional regulator proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009147520A Division JP2009273463A (ja) 1999-10-25 2009-06-22 リガンド活性化転写レギュレータータンパク質

Publications (2)

Publication Number Publication Date
JP2003512827A true JP2003512827A (ja) 2003-04-08
JP2003512827A5 JP2003512827A5 (enExample) 2007-11-22

Family

ID=27029724

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001533840A Withdrawn JP2003512827A (ja) 1999-10-25 2000-10-23 リガンド活性化転写レギュレータータンパク質
JP2009147520A Pending JP2009273463A (ja) 1999-10-25 2009-06-22 リガンド活性化転写レギュレータータンパク質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009147520A Pending JP2009273463A (ja) 1999-10-25 2009-06-22 リガンド活性化転写レギュレータータンパク質

Country Status (8)

Country Link
US (3) US7329728B1 (enExample)
EP (1) EP1226168A1 (enExample)
JP (2) JP2003512827A (enExample)
AU (1) AU775988B2 (enExample)
CA (1) CA2388535A1 (enExample)
IL (2) IL149142A0 (enExample)
NZ (1) NZ518218A (enExample)
WO (1) WO2001030843A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2022536257A (ja) * 2019-05-28 2022-08-15 オクタント，インク． 転写リレー系
JP2025062594A (ja) * 2013-06-05 2025-04-14 デューク ユニバーシティ Ｒｎａガイド遺伝子編集及び遺伝子調節
US12629428B2 (en) 2019-04-14 2026-05-19 Duke University AAV vector-mediated deletion of large mutational hotspot for treatment of Duchenne muscular dystrophy

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AU2002213431A1 (en) * 2000-09-29 2002-04-08 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
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US20130137173A1 (en) * 2011-11-30 2013-05-30 Feng Zhang Nucleotide-specific recognition sequences for designer tal effectors
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CN105813579B (zh) 2013-08-08 2019-05-07 全球生物疗法有限公司 用于微创手术过程的夹具装置和其应用
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MX2019010887A (es) 2017-03-16 2019-10-15 Alpine Immune Sciences Inc Proteinas inmunomoduladoras de cb80 variante y usos de estas.
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JP2020511144A (ja) 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Ｐｄ−ｌ２バリアント免疫調節タンパク質及びその使用
CN117821509A (zh) 2017-04-03 2024-04-05 编码治疗公司 组织选择性转基因表达
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JP7282760B2 (ja) 2017-10-18 2023-05-29 アルパイン イミューン サイエンシズ インコーポレイテッド バリアントｉｃｏｓリガンド免疫調節タンパク質ならびに関連する組成物および方法
CN118345115A (zh) 2017-12-01 2024-07-16 编码治疗公司 工程化的dna结合蛋白
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025062594A (ja) * 2013-06-05 2025-04-14 デューク ユニバーシティ Ｒｎａガイド遺伝子編集及び遺伝子調節
JP7854214B2 (ja) 2013-06-05 2026-05-01 デューク ユニバーシティ Ｒｎａガイド遺伝子編集及び遺伝子調節
US12629428B2 (en) 2019-04-14 2026-05-19 Duke University AAV vector-mediated deletion of large mutational hotspot for treatment of Duchenne muscular dystrophy
JP2022536257A (ja) * 2019-05-28 2022-08-15 オクタント，インク． 転写リレー系
JP7545999B2 (ja) 2019-05-28 2024-09-05 オクタント，インク． 転写リレー系

Also Published As

Publication number Publication date
NZ518218A (en) 2004-04-30
IL149142A (en) 2010-05-31
JP2009273463A (ja) 2009-11-26
AU775988B2 (en) 2004-08-19
WO2001030843A1 (en) 2001-05-03
AU1143801A (en) 2001-05-08
WO2001030843A9 (en) 2002-09-19
US20080318839A1 (en) 2008-12-25
US7329728B1 (en) 2008-02-12
EP1226168A1 (en) 2002-07-31
US20030186841A1 (en) 2003-10-02
IL149142A0 (en) 2002-11-10
CA2388535A1 (en) 2001-05-03
US7442784B2 (en) 2008-10-28

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