JP2003512827A5 - - Google Patents
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- JP2003512827A5 JP2003512827A5 JP2001533840A JP2001533840A JP2003512827A5 JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5 JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5
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- Prior art keywords
- receptor
- fusion protein
- vector
- nucleic acid
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 description 69
- 108020001507 fusion proteins Proteins 0.000 description 69
- 239000002773 nucleotide Substances 0.000 description 33
- 125000003729 nucleotide group Chemical group 0.000 description 33
- 238000000034 method Methods 0.000 description 27
- 239000013598 vector Substances 0.000 description 27
- 102000039446 nucleic acids Human genes 0.000 description 25
- 108020004707 nucleic acids Proteins 0.000 description 25
- 150000007523 nucleic acids Chemical class 0.000 description 25
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 21
- 239000011701 zinc Substances 0.000 description 21
- 229910052725 zinc Inorganic materials 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 19
- 239000003446 ligand Substances 0.000 description 17
- 230000014509 gene expression Effects 0.000 description 16
- 108020001756 ligand binding domains Proteins 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000005962 receptors Human genes 0.000 description 16
- 108020003175 receptors Proteins 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 238000013518 transcription Methods 0.000 description 11
- 230000035897 transcription Effects 0.000 description 11
- 102000027411 intracellular receptors Human genes 0.000 description 10
- 108091008582 intracellular receptors Proteins 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 9
- 230000004913 activation Effects 0.000 description 8
- 239000013603 viral vector Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102000011252 Krueppel-associated box Human genes 0.000 description 6
- 108050001491 Krueppel-associated box Proteins 0.000 description 6
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 6
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- 239000006274 endogenous ligand Substances 0.000 description 4
- 102000015694 estrogen receptors Human genes 0.000 description 4
- 108010038795 estrogen receptors Proteins 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 102000003998 progesterone receptors Human genes 0.000 description 4
- 108090000468 progesterone receptors Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 102000005969 steroid hormone receptors Human genes 0.000 description 4
- 102000004217 thyroid hormone receptors Human genes 0.000 description 4
- 108090000721 thyroid hormone receptors Proteins 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 3
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 description 3
- 108091008747 NR2F3 Proteins 0.000 description 3
- 108091007494 Nucleic acid- binding domains Proteins 0.000 description 3
- 102000016978 Orphan receptors Human genes 0.000 description 3
- 108070000031 Orphan receptors Proteins 0.000 description 3
- 108091027981 Response element Proteins 0.000 description 3
- 102000034527 Retinoid X Receptors Human genes 0.000 description 3
- 108010038912 Retinoid X Receptors Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 108010080146 androgen receptors Proteins 0.000 description 3
- 102000001307 androgen receptors Human genes 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 108010009483 glucocorticoid receptor alpha Proteins 0.000 description 3
- 108010044321 glucocorticoid receptor beta Proteins 0.000 description 3
- 108091008039 hormone receptors Proteins 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 102000009310 vitamin D receptors Human genes 0.000 description 3
- 108050000156 vitamin D receptors Proteins 0.000 description 3
- 241000702421 Dependoparvovirus Species 0.000 description 2
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 108010085012 Steroid Receptors Proteins 0.000 description 2
- -1 VP64 Proteins 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 108010057988 ecdysone receptor Proteins 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 239000006277 exogenous ligand Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 108020003113 steroid hormone receptors Proteins 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 230000004568 DNA-binding Effects 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 101001006782 Homo sapiens Kinesin-associated protein 3 Proteins 0.000 description 1
- 101000753286 Homo sapiens Transcription intermediary factor 1-beta Proteins 0.000 description 1
- 101000818735 Homo sapiens Zinc finger protein 10 Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010034634 Repressor Proteins Proteins 0.000 description 1
- 102000009661 Repressor Proteins Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102100022012 Transcription intermediary factor 1-beta Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100021112 Zinc finger protein 10 Human genes 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001638 lipofection Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001818 nuclear effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 108090000064 retinoic acid receptors Proteins 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43304299A | 1999-10-25 | 1999-10-25 | |
| US09/433,042 | 1999-10-25 | ||
| US09/586,625 US7329728B1 (en) | 1999-10-25 | 2000-06-02 | Ligand activated transcriptional regulator proteins |
| US09/586,625 | 2000-06-02 | ||
| PCT/EP2000/010430 WO2001030843A1 (en) | 1999-10-25 | 2000-10-23 | Ligand activated transcriptional regulator proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Division JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512827A JP2003512827A (ja) | 2003-04-08 |
| JP2003512827A5 true JP2003512827A5 (enExample) | 2007-11-22 |
Family
ID=27029724
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001533840A Withdrawn JP2003512827A (ja) | 1999-10-25 | 2000-10-23 | リガンド活性化転写レギュレータータンパク質 |
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7329728B1 (enExample) |
| EP (1) | EP1226168A1 (enExample) |
| JP (2) | JP2003512827A (enExample) |
| AU (1) | AU775988B2 (enExample) |
| CA (1) | CA2388535A1 (enExample) |
| IL (2) | IL149142A0 (enExample) |
| NZ (1) | NZ518218A (enExample) |
| WO (1) | WO2001030843A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1181360A1 (en) * | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Molecular switches |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| WO2001053480A1 (en) * | 2000-01-24 | 2001-07-26 | Sangamo Biosciences, Inc. | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| EP1908835A3 (en) * | 2000-07-18 | 2008-06-18 | Novartis AG | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| AU2002213431A1 (en) * | 2000-09-29 | 2002-04-08 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| US7273923B2 (en) | 2001-01-22 | 2007-09-25 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| EP1967590A3 (en) | 2001-03-13 | 2008-09-17 | Novartis AG | Lentiviral packaging constructs |
| WO2002097050A2 (en) | 2001-05-31 | 2002-12-05 | Novartis Ag | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
| CA2485939C (en) | 2002-05-29 | 2013-10-29 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| US20050003347A1 (en) * | 2003-05-06 | 2005-01-06 | Daniel Calarese | Domain-exchanged binding molecules, methods of use and methods of production |
| US20070087346A1 (en) * | 2003-10-24 | 2007-04-19 | Gennaro Ciliberto | Orthogonal gene switches |
| US7829528B2 (en) * | 2004-09-14 | 2010-11-09 | The Rockefeller University | Compositions and methods for treating STAT-6 associated diseases or conditions |
| EP2185725A4 (en) * | 2007-08-02 | 2011-01-12 | Biodesic | COMPOSITIONS AND METHODS FOR IDENTIFYING AND QUANTIFYING ANALYTES |
| PL2441774T3 (pl) | 2010-10-15 | 2019-05-31 | Fund Centre De Regulacio Genòmica | Peptydy zawierające motywy palców cynkowych i ich zastosowania |
| US10801017B2 (en) | 2011-11-30 | 2020-10-13 | The Broad Institute, Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| US20130137173A1 (en) * | 2011-11-30 | 2013-05-30 | Feng Zhang | Nucleotide-specific recognition sequences for designer tal effectors |
| CA3151103C (en) * | 2012-02-02 | 2024-02-13 | Corteva Agriscience Llc | Plant transactivation interaction motifs and uses thereof |
| SG10201604810UA (en) | 2012-02-07 | 2016-08-30 | Global Bio Therapeutics Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| CN105813579B (zh) | 2013-08-08 | 2019-05-07 | 全球生物疗法有限公司 | 用于微创手术过程的夹具装置和其应用 |
| WO2017134137A1 (en) * | 2016-02-05 | 2017-08-10 | Polygene Ag | Glucocorticoid-based gene regulation system |
| AU2017248830B2 (en) | 2016-04-15 | 2023-03-09 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
| SG11201808457PA (en) | 2016-04-15 | 2018-10-30 | Alpine Immune Sciences Inc | Icos ligand variant immunomodulatory proteins and uses thereof |
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| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
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| EP3872180A1 (en) | 2016-10-20 | 2021-09-01 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| MX2019010887A (es) | 2017-03-16 | 2019-10-15 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras de cb80 variante y usos de estas. |
| FI3596116T3 (fi) | 2017-03-16 | 2023-11-09 | Alpine Immune Sciences Inc | Immunomodulatorisia pd-l1-varianttiproteiineja ja niiden käyttöjä |
| JP2020511144A (ja) | 2017-03-16 | 2020-04-16 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｐｄ−ｌ２バリアント免疫調節タンパク質及びその使用 |
| CN117821509A (zh) | 2017-04-03 | 2024-04-05 | 编码治疗公司 | 组织选择性转基因表达 |
| EP3694870A1 (en) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| JP7282760B2 (ja) | 2017-10-18 | 2023-05-29 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントｉｃｏｓリガンド免疫調節タンパク質ならびに関連する組成物および方法 |
| CN118345115A (zh) | 2017-12-01 | 2024-07-16 | 编码治疗公司 | 工程化的dna结合蛋白 |
| SG11202006148UA (en) | 2018-01-03 | 2020-07-29 | Alpine Immune Sciences Inc | Multi-domain immunomodulatory proteins and methods of use thereof |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| CN113544144A (zh) | 2018-09-19 | 2021-10-22 | 高山免疫科学股份有限公司 | 变体cd80融合蛋白和相关构建体的方法和用途 |
| CA3120576A1 (en) | 2018-11-26 | 2020-06-04 | Massachusetts Institute Of Technology | Compositions and methods for immune tolerance |
| CN113727998A (zh) | 2018-11-30 | 2021-11-30 | 高山免疫科学股份有限公司 | Cd86变体免疫调节蛋白及其用途 |
| TWI887234B (zh) | 2019-04-14 | 2025-06-21 | 美國公爵大學 | 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除 |
| BR112021020447A2 (pt) | 2019-04-17 | 2022-05-17 | Alpine Immune Sciences Inc | Métodos e usos de proteínas de fusão de ligante icos variante (icosl) |
| JP7545999B2 (ja) * | 2019-05-28 | 2024-09-05 | オクタント，インク． | 転写リレー系 |
| SG11202113048SA (en) | 2019-05-29 | 2021-12-30 | Encoded Therapeutics Inc | Compositions and methods for selective gene regulation |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| US12202882B2 (en) | 2020-05-08 | 2025-01-21 | Alpine Immune Sciences, Inc. | APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof |
| WO2022084748A1 (en) * | 2020-10-23 | 2022-04-28 | Spindle Biotech, Inc. | Compositions and methods for rna synthesis |
| CN118139655A (zh) | 2021-08-13 | 2024-06-04 | 特里奥万斯控股公司 | 皮肤替代组合物及其产生和使用方法 |
| CN121311595A (zh) * | 2023-04-17 | 2026-01-09 | 阿斯克生物公司 | 转基因在灵长类动物中可调节的受控表达 |
| CN117756945A (zh) * | 2023-11-14 | 2024-03-26 | 维康平生(北京)生物科技有限公司 | 融合蛋白及其用途 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US81614A (en) * | 1868-09-01 | Jacob erdle | ||
| US182698A (en) * | 1876-09-26 | Improvement in machines for canceling postage-stamps and postmarking letters | ||
| US540065A (en) * | 1895-05-28 | Andrew kriegee | ||
| US147327A (en) * | 1874-02-10 | Improvement in weft-stop mechanisms for looms | ||
| US2996496A (en) | 1956-06-22 | 1961-08-15 | Central Pharmacal Company | Calcium substitution products of dextran |
| US4394443A (en) | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
| US4446235A (en) | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
| US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5317090A (en) | 1987-12-16 | 1994-05-31 | Institut Pasteur | Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor |
| US5217867A (en) * | 1988-11-30 | 1993-06-08 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
| EP0451206A4 (en) | 1988-12-23 | 1992-07-22 | The Salk Institute For Biological Studies | Receptor transcription-repression activity compositions and methods |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US4990607A (en) | 1989-03-14 | 1991-02-05 | The Rockefeller University | Alteration of gene expression in plants |
| US5140466A (en) * | 1990-12-20 | 1992-08-18 | Hughes Aircraft Company | Optical multiplexer |
| US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
| US6416998B1 (en) | 1992-09-02 | 2002-07-09 | Baylor College Of Medicine | Plasmid encoding a modified steroid hormone |
| JPH07509694A (ja) | 1992-05-14 | 1995-10-26 | ベイラー・カレッジ・オブ・メディシン | 突然変異したステロイドホルモン受容体，その使用方法および遺伝子治療のための分子スイッチ |
| WO1998018925A2 (en) | 1996-10-29 | 1998-05-07 | Valentis, Inc. | Modified glucocorticoid receptors, glucocorticoid receptors/progesterone receptors hybrids |
| GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
| JP4012243B2 (ja) | 1994-01-18 | 2007-11-21 | ザ スクリップス リサーチ インスティチュート | 亜鉛フィンガータンパク質誘導体およびそのための方法 |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US20050084885A1 (en) | 1994-01-18 | 2005-04-21 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US6723531B2 (en) | 1996-04-05 | 2004-04-20 | The Salk Institute For Biological Studies | Method for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| DE69942334D1 (de) | 1998-03-02 | 2010-06-17 | Massachusetts Inst Technology | Poly-zinkfinger-proteine mit verbesserten linkern |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| US7151201B2 (en) * | 2000-01-21 | 2006-12-19 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| EP1276869A2 (en) | 2000-01-21 | 2003-01-22 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| AU2001295193A1 (en) | 2000-05-01 | 2001-11-12 | Novartis Ag | Vectors for ocular transduction and use thereof for genetic therapy |
| WO2002004522A2 (en) | 2000-07-10 | 2002-01-17 | Novartis Ag | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| EP1908835A3 (en) | 2000-07-18 | 2008-06-18 | Novartis AG | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
| EP1364027B1 (en) | 2001-02-21 | 2009-09-02 | Novartis AG | Zinc finger binding domains for nucleotide sequence ann |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| WO2002097050A2 (en) | 2001-05-31 | 2002-12-05 | Novartis Ag | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
| US20040224385A1 (en) * | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| EP1516055A4 (en) | 2002-01-24 | 2007-08-08 | Scripps Research Inst | FIBER OPERATING MODIFICATIONS FOR EFFICIENT TARGETS |
| AU2003215094B2 (en) | 2002-02-07 | 2008-05-29 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) * | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| EP1532178A4 (en) | 2002-06-11 | 2006-10-25 | Scripps Research Inst | Artificial transcription factors |
| WO2006010629A1 (en) * | 2004-07-28 | 2006-02-02 | Glaxo Group Limited | Piperazine derivatives useful for the treatment of gastrointestinal disorders |
| JP2009504156A (ja) * | 2005-08-11 | 2009-02-05 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎに対するジンクフィンガー結合ドメイン |
| CA2631422A1 (en) * | 2005-11-28 | 2007-05-31 | The Scripps Research Institute | Zinc finger binding domains for tnn |
| US20070154989A1 (en) * | 2006-01-03 | 2007-07-05 | The Scripps Research Institute | Zinc finger domains specifically binding agc |
| US8874746B1 (en) | 2010-05-24 | 2014-10-28 | Datacore Software Corporation | Collaboration between discrete systems and a shared system to consolidate shared storage-related services |
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2000
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- 2000-10-23 JP JP2001533840A patent/JP2003512827A/ja not_active Withdrawn
- 2000-10-23 EP EP00972849A patent/EP1226168A1/en not_active Ceased
- 2000-10-23 WO PCT/EP2000/010430 patent/WO2001030843A1/en not_active Ceased
- 2000-10-23 NZ NZ518218A patent/NZ518218A/en unknown
- 2000-10-23 CA CA002388535A patent/CA2388535A1/en not_active Abandoned
- 2000-10-23 IL IL14914200A patent/IL149142A0/xx unknown
- 2000-10-23 AU AU11438/01A patent/AU775988B2/en not_active Ceased
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2002
- 2002-04-15 IL IL149142A patent/IL149142A/en not_active IP Right Cessation
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2003
- 2003-04-23 US US10/422,934 patent/US7442784B2/en not_active Expired - Fee Related
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2008
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2009
- 2009-06-22 JP JP2009147520A patent/JP2009273463A/ja active Pending
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