JP2003510584A5 - - Google Patents
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- JP2003510584A5 JP2003510584A5 JP2001526285A JP2001526285A JP2003510584A5 JP 2003510584 A5 JP2003510584 A5 JP 2003510584A5 JP 2001526285 A JP2001526285 A JP 2001526285A JP 2001526285 A JP2001526285 A JP 2001526285A JP 2003510584 A5 JP2003510584 A5 JP 2003510584A5
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- 238000002493 microarray Methods 0.000 description 35
- 238000000034 method Methods 0.000 description 13
- 230000003204 osmotic effect Effects 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 150000007970 thio esters Chemical class 0.000 description 7
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- 150000003573 thiols Chemical class 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 108010090804 Streptavidin Proteins 0.000 description 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- -1 halo-acetamide Chemical class 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 150000002118 epoxides Chemical class 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- HBROZNQEVUILML-UHFFFAOYSA-N salicylhydroxamic acid Chemical compound ONC(=O)C1=CC=CC=C1O HBROZNQEVUILML-UHFFFAOYSA-N 0.000 description 2
- JFTAPSBIODPQJN-UHFFFAOYSA-N 2-(2,6-dimethylanilino)-2-oxoacetic acid Chemical compound CC1=CC=CC(C)=C1NC(=O)C(O)=O JFTAPSBIODPQJN-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical group N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001336 alkenes Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000005215 alkyl ethers Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- VZDYWEUILIUIDF-UHFFFAOYSA-J cerium(4+);disulfate Chemical compound [Ce+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O VZDYWEUILIUIDF-UHFFFAOYSA-J 0.000 description 1
- 229910000355 cerium(IV) sulfate Inorganic materials 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 229940099500 cystamine Drugs 0.000 description 1
- 125000002228 disulfide group Chemical group 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000007944 thiolates Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41036899A | 1999-09-30 | 1999-09-30 | |
| US09/410,368 | 1999-09-30 | ||
| PCT/US2000/026725 WO2001023082A2 (en) | 1999-09-30 | 2000-09-29 | Biomolecular attachment sites on microelectronic arrays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003510584A JP2003510584A (ja) | 2003-03-18 |
| JP2003510584A5 true JP2003510584A5 (enExample) | 2007-11-29 |
| JP5181157B2 JP5181157B2 (ja) | 2013-04-10 |
Family
ID=23624422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001526285A Expired - Fee Related JP5181157B2 (ja) | 1999-09-30 | 2000-09-29 | マイクロエレクトロニックアレイ上の生体分子付着部位 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8288155B2 (enExample) |
| EP (1) | EP1221050A2 (enExample) |
| JP (1) | JP5181157B2 (enExample) |
| KR (1) | KR20020048425A (enExample) |
| AU (1) | AU7730500A (enExample) |
| CA (1) | CA2386622A1 (enExample) |
| WO (1) | WO2001023082A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001032935A2 (en) * | 1999-11-02 | 2001-05-10 | Celine Hu | Molecular microarrays and methods for production and use thereof |
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| EP2789383B1 (en) * | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| US20060102471A1 (en) * | 2004-11-18 | 2006-05-18 | Karl Maurer | Electrode array device having an adsorbed porous reaction layer |
| CA2599364A1 (en) * | 2005-03-03 | 2006-09-08 | Iowa State University Research Foundation, Inc. | Fluorous-based microarrays |
| US20070034513A1 (en) | 2005-03-25 | 2007-02-15 | Combimatrix Corporation | Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array |
| US9394167B2 (en) | 2005-04-15 | 2016-07-19 | Customarray, Inc. | Neutralization and containment of redox species produced by circumferential electrodes |
| US20070065877A1 (en) | 2005-09-19 | 2007-03-22 | Combimatrix Corporation | Microarray having a base cleavable succinate linker |
| US8563297B2 (en) * | 2006-08-31 | 2013-10-22 | Technion Research & Development Foundation Limited | Controllable binding and dissociation of chemical entities and electrode devices therefore |
| FR2927170B1 (fr) * | 2008-02-04 | 2014-07-18 | Protneteomix | Dispositifs de puces a molecules et leurs utilisations. |
| US8234905B2 (en) * | 2008-08-04 | 2012-08-07 | Sharp Laboratories Of America, Inc. | Selectively functionized transducer microarray |
| DE102009015114B4 (de) * | 2009-03-31 | 2014-05-22 | Siemens Aktiengesellschaft | Vorrichtung nach Art einer elektrochemischen Kamera sowie Verfahren zur Herstellung und Verwendung der Vorrichtung |
| WO2011090793A2 (en) | 2010-01-20 | 2011-07-28 | Customarray, Inc. | Multiplex microarray of serially deposited biomolecules on a microarray |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| US20190351409A1 (en) | 2016-12-29 | 2019-11-21 | Ador Diagnostics S.R.L. | Cartridge for use in in-vitro diagnostics and method of use thereof |
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| US6631085B2 (en) * | 2000-04-28 | 2003-10-07 | Matrix Semiconductor, Inc. | Three-dimensional memory array incorporating serial chain diode stack |
| JP3709919B2 (ja) * | 2000-08-01 | 2005-10-26 | 日本電気株式会社 | 液体試料中の成分の測定装置 |
| KR100458389B1 (ko) * | 2000-09-29 | 2004-11-26 | 산요덴키가부시키가이샤 | 통신단말장치 및 표시방법 |
| US6824974B2 (en) * | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| US6444318B1 (en) * | 2001-07-17 | 2002-09-03 | Surmodics, Inc. | Self assembling monolayer compositions |
| US6960298B2 (en) | 2001-12-10 | 2005-11-01 | Nanogen, Inc. | Mesoporous permeation layers for use on active electronic matrix devices |
| US6841379B2 (en) * | 2002-05-15 | 2005-01-11 | Beckman Coulter, Inc. | Conductive microplate |
| EP1679508B1 (en) * | 2003-10-30 | 2010-07-21 | Arkray, Inc. | Biosensor and method for preparation thereof |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
-
2000
- 2000-09-29 KR KR1020027004096A patent/KR20020048425A/ko not_active Withdrawn
- 2000-09-29 AU AU77305/00A patent/AU7730500A/en not_active Abandoned
- 2000-09-29 EP EP00967048A patent/EP1221050A2/en not_active Withdrawn
- 2000-09-29 JP JP2001526285A patent/JP5181157B2/ja not_active Expired - Fee Related
- 2000-09-29 WO PCT/US2000/026725 patent/WO2001023082A2/en not_active Ceased
- 2000-09-29 CA CA002386622A patent/CA2386622A1/en not_active Abandoned
-
2007
- 2007-07-13 US US11/777,919 patent/US8288155B2/en not_active Expired - Fee Related
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