JP2003508592A - トリフルサルまたはｈｔｂを有する新規な生物相容性重合体系 - Google Patents

トリフルサルまたはｈｔｂを有する新規な生物相容性重合体系

Info

Publication number
JP2003508592A
JP2003508592A JP2001521365A JP2001521365A JP2003508592A JP 2003508592 A JP2003508592 A JP 2003508592A JP 2001521365 A JP2001521365 A JP 2001521365A JP 2001521365 A JP2001521365 A JP 2001521365A JP 2003508592 A JP2003508592 A JP 2003508592A
Authority
JP
Japan
Prior art keywords
compound
formula
triflusal
htb
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001521365A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003508592A5 (enExample
Inventor
アルベルト、ガラルド、ルイス
ヘマ、ロドリゲス、クレスポ
フリオ、サン、ローマン、デル、バリオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Publication of JP2003508592A publication Critical patent/JP2003508592A/ja
Publication of JP2003508592A5 publication Critical patent/JP2003508592A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/302—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and two or more oxygen atoms in the alcohol moiety
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/305—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
    • C08F220/306—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety and polyethylene oxide chain in the alcohol moiety

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Paints Or Removers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2001521365A 1999-09-03 2000-09-01 トリフルサルまたはｈｔｂを有する新規な生物相容性重合体系 Pending JP2003508592A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES9902013 1999-09-03
ES009902013A ES2154242B1 (es) 1999-09-03 1999-09-03 Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb.
PCT/ES2000/000335 WO2001017578A1 (es) 1999-09-03 2000-09-01 Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb

Publications (2)

Publication Number Publication Date
JP2003508592A true JP2003508592A (ja) 2003-03-04
JP2003508592A5 JP2003508592A5 (enExample) 2007-10-11

Family

ID=8309883

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001521365A Pending JP2003508592A (ja) 1999-09-03 2000-09-01 トリフルサルまたはｈｔｂを有する新規な生物相容性重合体系

Country Status (17)

Country Link
US (2) US6979465B1 (enExample)
EP (1) EP1210954B1 (enExample)
JP (1) JP2003508592A (enExample)
KR (1) KR100838545B1 (enExample)
AR (1) AR033343A1 (enExample)
AT (1) ATE294001T1 (enExample)
AU (1) AU6843600A (enExample)
BR (1) BR0013760A (enExample)
CA (1) CA2383780A1 (enExample)
DE (1) DE60019766T2 (enExample)
DK (1) DK1210954T3 (enExample)
ES (2) ES2154242B1 (enExample)
MX (1) MXPA02002288A (enExample)
NO (1) NO20021027L (enExample)
PT (1) PT1210954E (enExample)
TR (1) TR200200591T2 (enExample)
WO (1) WO2001017578A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1767552A1 (en) * 2005-09-21 2007-03-28 Palau Pharma, S.A. Triflusal-containing polymers for stent coating

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52156831A (en) * 1976-06-10 1977-12-27 Uriach & Cia Sa J Production of 44 trifluoromethyl benzoic acid derivatives and pharmaceutical composition containing same
JPH0221875A (ja) * 1988-07-11 1990-01-24 Terumo Corp 医療用材料ならびに医療用器具
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers
WO1999061030A1 (es) * 1998-05-27 1999-12-02 J. Uriach & Cia, S.A. USO DE DERIVADOS DEL ACIDO 2-HIDROXI-4-TRIFLUOROMETILBENZOICO COMO INHIBIDORES DE LA ACTIVACION DEL FACTOR DE TRANSCRIPCION NUCLEAR NF-λB

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167665A (en) * 1984-12-04 1986-06-04 Univ Liverpool Platelet aggregation inhibitor for use in polymeric surgical devices
EP0351314B1 (en) * 1988-07-11 1995-02-01 Terumo Kabushiki Kaisha Medical material and medical implement
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52156831A (en) * 1976-06-10 1977-12-27 Uriach & Cia Sa J Production of 44 trifluoromethyl benzoic acid derivatives and pharmaceutical composition containing same
JPH0221875A (ja) * 1988-07-11 1990-01-24 Terumo Corp 医療用材料ならびに医療用器具
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers
WO1999061030A1 (es) * 1998-05-27 1999-12-02 J. Uriach & Cia, S.A. USO DE DERIVADOS DEL ACIDO 2-HIDROXI-4-TRIFLUOROMETILBENZOICO COMO INHIBIDORES DE LA ACTIVACION DEL FACTOR DE TRANSCRIPCION NUCLEAR NF-λB

Also Published As

Publication number Publication date
PT1210954E (pt) 2005-07-29
ES2154242B1 (es) 2001-10-16
EP1210954A1 (en) 2002-06-05
KR20020059387A (ko) 2002-07-12
US7445789B2 (en) 2008-11-04
KR100838545B1 (ko) 2008-06-17
CA2383780A1 (en) 2001-03-15
DE60019766T2 (de) 2006-01-19
US6979465B1 (en) 2005-12-27
AR033343A1 (es) 2003-12-17
EP1210954B1 (en) 2005-04-27
AU6843600A (en) 2001-04-10
NO20021027D0 (no) 2002-03-01
MXPA02002288A (es) 2002-07-30
US20060067955A1 (en) 2006-03-30
ES2154242A1 (es) 2001-03-16
NO20021027L (no) 2002-04-10
WO2001017578A1 (es) 2001-03-15
TR200200591T2 (tr) 2002-06-21
ATE294001T1 (de) 2005-05-15
DK1210954T3 (da) 2005-08-15
DE60019766D1 (de) 2005-06-02
ES2241641T3 (es) 2005-11-01
BR0013760A (pt) 2002-07-02

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