KR100838545B1 - 트리플루살 또는 ｈｔｂ 를 수반하는 신규한 생체적합성중합체 시스템 - Google Patents

트리플루살 또는 ｈｔｂ 를 수반하는 신규한 생체적합성중합체 시스템 Download PDF

Info

Publication number
KR100838545B1
KR100838545B1 KR1020027002856A KR20027002856A KR100838545B1 KR 100838545 B1 KR100838545 B1 KR 100838545B1 KR 1020027002856 A KR1020027002856 A KR 1020027002856A KR 20027002856 A KR20027002856 A KR 20027002856A KR 100838545 B1 KR100838545 B1 KR 100838545B1
Authority
KR
South Korea
Prior art keywords
compound
polymer
triflusal
formula
htb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020027002856A
Other languages
English (en)
Korean (ko)
Other versions
KR20020059387A (ko
Inventor
가야르도루이즈알베르또
로드리구에즈끄레스뽀헤마
산로만델바리오훌리오
Original Assignee
팔라우 파르마 에스에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 팔라우 파르마 에스에이 filed Critical 팔라우 파르마 에스에이
Publication of KR20020059387A publication Critical patent/KR20020059387A/ko
Application granted granted Critical
Publication of KR100838545B1 publication Critical patent/KR100838545B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/302—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and two or more oxygen atoms in the alcohol moiety
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/305—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
    • C08F220/306—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety and polyethylene oxide chain in the alcohol moiety

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Paints Or Removers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020027002856A 1999-09-03 2000-09-01 트리플루살 또는 ｈｔｂ 를 수반하는 신규한 생체적합성중합체 시스템 Expired - Fee Related KR100838545B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP9902013 1999-09-03
ES009902013A ES2154242B1 (es) 1999-09-03 1999-09-03 Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb.

Publications (2)

Publication Number Publication Date
KR20020059387A KR20020059387A (ko) 2002-07-12
KR100838545B1 true KR100838545B1 (ko) 2008-06-17

Family

ID=8309883

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002856A Expired - Fee Related KR100838545B1 (ko) 1999-09-03 2000-09-01 트리플루살 또는 ｈｔｂ 를 수반하는 신규한 생체적합성중합체 시스템

Country Status (17)

Country Link
US (2) US6979465B1 (enExample)
EP (1) EP1210954B1 (enExample)
JP (1) JP2003508592A (enExample)
KR (1) KR100838545B1 (enExample)
AR (1) AR033343A1 (enExample)
AT (1) ATE294001T1 (enExample)
AU (1) AU6843600A (enExample)
BR (1) BR0013760A (enExample)
CA (1) CA2383780A1 (enExample)
DE (1) DE60019766T2 (enExample)
DK (1) DK1210954T3 (enExample)
ES (2) ES2154242B1 (enExample)
MX (1) MXPA02002288A (enExample)
NO (1) NO20021027L (enExample)
PT (1) PT1210954E (enExample)
TR (1) TR200200591T2 (enExample)
WO (1) WO2001017578A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1767552A1 (en) * 2005-09-21 2007-03-28 Palau Pharma, S.A. Triflusal-containing polymers for stent coating

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096252A (en) 1976-06-10 1978-06-20 J. Uriach & Cia S.A. 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
EP0351314A2 (en) * 1988-07-11 1990-01-17 Terumo Kabushiki Kaisha Medical material and medical implement
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167665A (en) * 1984-12-04 1986-06-04 Univ Liverpool Platelet aggregation inhibitor for use in polymeric surgical devices
JPH0221875A (ja) * 1988-07-11 1990-01-24 Terumo Corp 医療用材料ならびに医療用器具
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
ES2136581B1 (es) * 1998-05-27 2000-09-16 Uriach & Cia Sa J Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096252A (en) 1976-06-10 1978-06-20 J. Uriach & Cia S.A. 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
EP0351314A2 (en) * 1988-07-11 1990-01-17 Terumo Kabushiki Kaisha Medical material and medical implement
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers

Also Published As

Publication number Publication date
PT1210954E (pt) 2005-07-29
ES2154242B1 (es) 2001-10-16
EP1210954A1 (en) 2002-06-05
KR20020059387A (ko) 2002-07-12
US7445789B2 (en) 2008-11-04
CA2383780A1 (en) 2001-03-15
DE60019766T2 (de) 2006-01-19
US6979465B1 (en) 2005-12-27
AR033343A1 (es) 2003-12-17
EP1210954B1 (en) 2005-04-27
AU6843600A (en) 2001-04-10
NO20021027D0 (no) 2002-03-01
JP2003508592A (ja) 2003-03-04
MXPA02002288A (es) 2002-07-30
US20060067955A1 (en) 2006-03-30
ES2154242A1 (es) 2001-03-16
NO20021027L (no) 2002-04-10
WO2001017578A1 (es) 2001-03-15
TR200200591T2 (tr) 2002-06-21
ATE294001T1 (de) 2005-05-15
DK1210954T3 (da) 2005-08-15
DE60019766D1 (de) 2005-06-02
ES2241641T3 (es) 2005-11-01
BR0013760A (pt) 2002-07-02

Similar Documents

Publication Publication Date Title
JP2890316B2 (ja) 生体適合性医療デバイス用材料
JP5175383B2 (ja) 生物学的反応成分を有する潜伏反応性ポリマー
JP4961133B2 (ja) 医療用材料
Wetzels et al. Photoimmobilisation of poly (N-vinylpyrrolidinone) as a means to improve haemocompatibility of polyurethane biomaterials
EP0714417B1 (en) Polymer surface coatings
JPH093132A (ja) ２−メタクリロイルオキシエチルホスホリルコリン共重合体
US8163302B2 (en) Methods of making and using surfactant polymers
JP6462278B2 (ja) 生体適合性コポリマー、これを利用する抗血栓コーティング剤及び医療用具
JP7158993B2 (ja) ホスホリルコリン基含有共重合体、および生体用医療基材
JP2004161954A (ja) 血液適合性高分子およびそれを用いた医療用器具
KR100838545B1 (ko) 트리플루살 또는 ｈｔｂ 를 수반하는 신규한 생체적합성중합체 시스템
Rodri´ guez et al. New resorbable polymeric systems with antithrombogenic activity
JPH0311787B2 (enExample)
JP3580022B2 (ja) ブロック共重合体および医療用材料
US8236913B2 (en) (Meth)acrylate copolymer, a method for producing the same and a medical device
JP2004298223A (ja) 生体適合性材料
WO2023013410A1 (ja) 高分子組成物
Aguilar et al. Polymeric active coatings with functionality in vascular applications
CA1334470C (en) Antithrombogenic and antibiotic compositions and methods of preparation thereof
JP2018028029A (ja) 星型ポリマーおよびその設計方法
KR100431245B1 (ko) 항혈전성 삼성분계 공중합체
JPH06212078A (ja) 抗血栓性ポリマ組成物およびその製造方法
CN119391250A (zh) 一种高分子功能性涂层材料、高分子功能性涂层及其制备方法与应用
JP2018058984A (ja) 高分子化合物、抗血栓性高分子材料、およびそれを用いた医療機器
MXPA00001596A (en) Latent reactive polymers with biologically active moieties

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20110611

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20110611

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301