JP2003508592A5 - - Google Patents
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- Publication number
- JP2003508592A5 JP2003508592A5 JP2001521365A JP2001521365A JP2003508592A5 JP 2003508592 A5 JP2003508592 A5 JP 2003508592A5 JP 2001521365 A JP2001521365 A JP 2001521365A JP 2001521365 A JP2001521365 A JP 2001521365A JP 2003508592 A5 JP2003508592 A5 JP 2003508592A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- triflusal
- htb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 17
- 229920000642 polymer Polymers 0.000 description 9
- RMWVZGDJPAKBDE-UHFFFAOYSA-N 2-acetyloxy-4-(trifluoromethyl)benzoic acid Chemical compound CC(=O)OC1=CC(C(F)(F)F)=CC=C1C(O)=O RMWVZGDJPAKBDE-UHFFFAOYSA-N 0.000 description 7
- 229960002268 triflusal Drugs 0.000 description 7
- 239000000178 monomer Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 210000003709 heart valve Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 2
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000002348 vinylic group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902013 | 1999-09-03 | ||
| ES009902013A ES2154242B1 (es) | 1999-09-03 | 1999-09-03 | Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb. |
| PCT/ES2000/000335 WO2001017578A1 (es) | 1999-09-03 | 2000-09-01 | Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508592A JP2003508592A (ja) | 2003-03-04 |
| JP2003508592A5 true JP2003508592A5 (enExample) | 2007-10-11 |
Family
ID=8309883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001521365A Pending JP2003508592A (ja) | 1999-09-03 | 2000-09-01 | トリフルサルまたはｈｔｂを有する新規な生物相容性重合体系 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6979465B1 (enExample) |
| EP (1) | EP1210954B1 (enExample) |
| JP (1) | JP2003508592A (enExample) |
| KR (1) | KR100838545B1 (enExample) |
| AR (1) | AR033343A1 (enExample) |
| AT (1) | ATE294001T1 (enExample) |
| AU (1) | AU6843600A (enExample) |
| BR (1) | BR0013760A (enExample) |
| CA (1) | CA2383780A1 (enExample) |
| DE (1) | DE60019766T2 (enExample) |
| DK (1) | DK1210954T3 (enExample) |
| ES (2) | ES2154242B1 (enExample) |
| MX (1) | MXPA02002288A (enExample) |
| NO (1) | NO20021027L (enExample) |
| PT (1) | PT1210954E (enExample) |
| TR (1) | TR200200591T2 (enExample) |
| WO (1) | WO2001017578A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1767552A1 (en) * | 2005-09-21 | 2007-03-28 | Palau Pharma, S.A. | Triflusal-containing polymers for stent coating |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096252A (en) * | 1976-06-10 | 1978-06-20 | J. Uriach & Cia S.A. | 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents |
| GB2167665A (en) * | 1984-12-04 | 1986-06-04 | Univ Liverpool | Platelet aggregation inhibitor for use in polymeric surgical devices |
| JPH0221875A (ja) * | 1988-07-11 | 1990-01-24 | Terumo Corp | 医療用材料ならびに医療用器具 |
| EP0351314B1 (en) * | 1988-07-11 | 1995-02-01 | Terumo Kabushiki Kaisha | Medical material and medical implement |
| US5344455A (en) * | 1992-10-30 | 1994-09-06 | Medtronic, Inc. | Graft polymer articles having bioactive surfaces |
| GB9608882D0 (en) * | 1996-04-30 | 1996-07-03 | Luthra Ajay K | Non-thrombogenic and anti-thrombogenic polymers |
| ES2136581B1 (es) * | 1998-05-27 | 2000-09-16 | Uriach & Cia Sa J | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
-
1999
- 1999-09-03 ES ES009902013A patent/ES2154242B1/es not_active Expired - Fee Related
-
2000
- 2000-08-18 AR ARP000104307A patent/AR033343A1/es active IP Right Grant
- 2000-09-01 CA CA002383780A patent/CA2383780A1/en not_active Abandoned
- 2000-09-01 BR BR0013760-0A patent/BR0013760A/pt not_active IP Right Cessation
- 2000-09-01 PT PT00956531T patent/PT1210954E/pt unknown
- 2000-09-01 DE DE60019766T patent/DE60019766T2/de not_active Expired - Lifetime
- 2000-09-01 DK DK00956531T patent/DK1210954T3/da active
- 2000-09-01 US US10/070,244 patent/US6979465B1/en not_active Expired - Fee Related
- 2000-09-01 AT AT00956531T patent/ATE294001T1/de not_active IP Right Cessation
- 2000-09-01 JP JP2001521365A patent/JP2003508592A/ja active Pending
- 2000-09-01 KR KR1020027002856A patent/KR100838545B1/ko not_active Expired - Fee Related
- 2000-09-01 TR TR2002/00591T patent/TR200200591T2/xx unknown
- 2000-09-01 AU AU68436/00A patent/AU6843600A/en not_active Abandoned
- 2000-09-01 ES ES00956531T patent/ES2241641T3/es not_active Expired - Lifetime
- 2000-09-01 WO PCT/ES2000/000335 patent/WO2001017578A1/es not_active Ceased
- 2000-09-01 EP EP00956531A patent/EP1210954B1/en not_active Expired - Lifetime
- 2000-09-01 MX MXPA02002288A patent/MXPA02002288A/es active IP Right Grant
-
2002
- 2002-03-01 NO NO20021027A patent/NO20021027L/no not_active Application Discontinuation
-
2005
- 2005-11-07 US US11/267,209 patent/US7445789B2/en not_active Expired - Fee Related
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